{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T16:20:48Z","timestamp":1790526048500,"version":"4.1.0"},"reference-count":158,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T00:00:00Z","timestamp":1595462400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Catalan government","award":["ACCI\u00d3-Eurecat"],"award-info":[{"award-number":["ACCI\u00d3-Eurecat"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The development of anticancer therapies that involve natural drugs has undergone exponential growth in recent years. Among the natural compounds that produce beneficial effects on human health, polyphenols have shown potential therapeutic applications in cancer due to their protective functions in plants, their use as food additives, and their excellent antioxidant properties. The possibility of combining conventional drugs\u2014which are usually more aggressive than natural compounds\u2014with polyphenols offers very valuable advantages such as the building of more efficient anticancer therapies with less side effects on human health. This review shows a wide range of trials in which polyphenolic compounds play a crucial role as anticancer medicines alone or in combination with other drugs at different stages of cancer: cancer initiation, promotion, and growth or progression. Moreover, the future directions in applications of various polyphenols in cancer therapy are emphasized.<\/jats:p>","DOI":"10.3390\/molecules25153342","type":"journal-article","created":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T11:26:01Z","timestamp":1595503561000},"page":"3342","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":126,"title":["Current Perspectives of the Applications of Polyphenols and Flavonoids in Cancer Therapy"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1426-239X","authenticated-orcid":false,"given":"Xavier","family":"Montan\u00e9","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering, University Rovira i Virgili, Av. Pa\u00efsos Catalans 26, Campus Sescelades, 43007 Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliwia","family":"Kowalczyk","sequence":"additional","affiliation":[{"name":"Research and Education Unit for Communication in Healthcare Department of Cardiac Surgery, Ludwik Rydygier Collegium Medicum in Bydgoszcz Nicolaus Copernicus University in Torun, M. Curie Sklodowskiej St. 9, 85-094 Bydgoszcz, Poland"},{"name":"Kazimierz Wielki University, Jagiellonska St. 11, 95-067 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6402-4499","authenticated-orcid":false,"given":"Belen","family":"Reig-Vano","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, University Rovira i Virgili, Av. 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Curie Sklodowskiej St. 9, 85-094 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Pawliszak","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Ludwik Rydygier Collegium Medicum in Bydgoszcz Nicolaus Copernicus University in Torun, M. Curie Sklodowskiej St. 9, 85-094 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8278-3552","authenticated-orcid":false,"given":"Marta","family":"Giamberini","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, University Rovira i Virgili, Av. Pa\u00efsos Catalans 26, Campus Sescelades, 43007 Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Mocek-P\u0142\u00f3ciniak","sequence":"additional","affiliation":[{"name":"Department of General and Environmental Microbiology, University of Life Sciences Poznan, ul. 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