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The onset of bacterial strains resistant to conventional antibiotics and the scarcity of new drugs have prompted scientific research to re-evaluate natural products as molecules with high biological and chemical potential. A class of natural compounds of significant importance is represented by alkaloids derived from higher plants. In this review, we have collected data obtained from various research groups on the antimicrobial activities of these alkaloids against conventional antibiotic-resistant strains. In addition, the structure\u2013function relationship was described and commented on, highlighting the high potential of alkaloids as antimicrobials.<\/jats:p>","DOI":"10.3390\/molecules25163619","type":"journal-article","created":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T09:04:16Z","timestamp":1597050256000},"page":"3619","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":93,"title":["Naturally-Occurring Alkaloids of Plant Origin as Potential Antimicrobials against Antibiotic-Resistant Infections"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1295-1084","authenticated-orcid":false,"given":"Bruno","family":"Casciaro","sequence":"first","affiliation":[{"name":"Center For Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Viale Regina Elena 291, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9937-4365","authenticated-orcid":false,"given":"Laura","family":"Mangiardi","sequence":"additional","affiliation":[{"name":"Center For Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Viale Regina Elena 291, 00161 Rome, Italy"},{"name":"Department of Chemistry and Technology of Drugs, \u201cDepartment of Excellence 2018\u22122022\u201d, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floriana","family":"Cappiello","sequence":"additional","affiliation":[{"name":"Laboratory affiliated to Pasteur Italia-Fondazione Cenci Bolognetti, Department of Biochemical Sciences, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Romeo","sequence":"additional","affiliation":[{"name":"Center For Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Viale Regina Elena 291, 00161 Rome, Italy"},{"name":"Department of Chemistry and Technology of Drugs, \u201cDepartment of Excellence 2018\u22122022\u201d, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rosa","family":"Loffredo","sequence":"additional","affiliation":[{"name":"Laboratory affiliated to Pasteur Italia-Fondazione Cenci Bolognetti, Department of Biochemical Sciences, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Iazzetti","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Technology of Drugs, \u201cDepartment of Excellence 2018\u22122022\u201d, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7036-6620","authenticated-orcid":false,"given":"Andrea","family":"Calcaterra","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Technology of Drugs, \u201cDepartment of Excellence 2018\u22122022\u201d, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Goggiamani","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Technology of Drugs, \u201cDepartment of Excellence 2018\u22122022\u201d, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Ghirga","sequence":"additional","affiliation":[{"name":"Center For Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Viale Regina Elena 291, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5991-5868","authenticated-orcid":false,"given":"Maria Luisa","family":"Mangoni","sequence":"additional","affiliation":[{"name":"Laboratory affiliated to Pasteur Italia-Fondazione Cenci Bolognetti, Department of Biochemical Sciences, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8707-4333","authenticated-orcid":false,"given":"Bruno","family":"Botta","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Technology of Drugs, \u201cDepartment of Excellence 2018\u22122022\u201d, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Quaglio","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Technology of Drugs, \u201cDepartment of 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Med. Public Health"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S1473-3099(18)30605-4","article-title":"Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: A population-level modelling analysis","volume":"19","author":"Cassini","year":"2019","journal-title":"Lancet Infect. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3855\/jidc.3573","article-title":"Bacteriophage therapy: A potential solution for the antibiotic resistance crisis","volume":"8","author":"Golkar","year":"2014","journal-title":"J. Infect. Dev. Ctries."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3389\/fcimb.2020.00107","article-title":"Prevalence and Therapies of Antibiotic-Resistance in Staphylococcus aureus","volume":"10","author":"Guo","year":"2020","journal-title":"Front. Cell Infect. Microbiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"R1063","DOI":"10.1016\/j.cub.2013.11.057","article-title":"Antibiotics in crisis","volume":"23","author":"Gross","year":"2013","journal-title":"Curr. Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.ijmm.2013.02.007","article-title":"Community-associated MRSA: What makes them special?","volume":"303","author":"Otto","year":"2013","journal-title":"Int. J. Med. Microbiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.ijmm.2013.02.005","article-title":"Hospital-associated MRSA and antibiotic resistance-what have we learned from genomics?","volume":"303","author":"Lindsay","year":"2013","journal-title":"Int. J. Med. Microbiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.coph.2014.09.006","article-title":"Update on the antibiotic resistance crisis","volume":"18","author":"Rossolini","year":"2014","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_9","unstructured":"Levitus, M., Rewane, A., and Perera, T.B. (2020). Vancomycin-Resistant Enterococci (VRE), StatPearls."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s40265-019-01112-1","article-title":"New Drugs for Multidrug-Resistant Gram-Negative Organisms: Time for Stewardship","volume":"79","author":"Jean","year":"2019","journal-title":"Drugs"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Duval, R.E., Grare, M., and Demore, B. (2019). Fight against Antimicrobial Resistance: We Always Need New Antibacterials but for Right Bacteria. Molecules, 24.","DOI":"10.3390\/molecules24173152"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.2174\/0929866525666181101104649","article-title":"Esculentin-1a Derived Antipseudomonal Peptides: Limited Induction of Resistance and Synergy with Aztreonam","volume":"25","author":"Casciaro","year":"2018","journal-title":"Protein Pept. Lett."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S1473-3099(16)00140-7","article-title":"New antimicrobials--lots of talk, where is the action?","volume":"16","author":"Kirby","year":"2016","journal-title":"Lancet Infect. Dis."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Marinelli, F., and Genilloud, O. (2014). Oxazolidin-2-Ones: Antibacterial Activity and Chemistry. Antimicrobials: New and Old Molecules in the Fight Against Multi-resistant Bacteria, Springer Berlin Heidelberg.","DOI":"10.1007\/978-3-642-39968-8"},{"key":"ref_15","first-page":"277","article-title":"The antibiotic resistance crisis: Part 1: Causes and threats","volume":"40","author":"Ventola","year":"2015","journal-title":"Pharm. Ther."},{"key":"ref_16","first-page":"344","article-title":"The antibiotic resistance crisis: Part 2: Management strategies and new agents","volume":"40","author":"Ventola","year":"2015","journal-title":"Pharm. Ther."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Barbosa, F., Pinto, E., Kijjoa, A., Pinto, M., and Sousa, E. (2020). Targeting Antimicrobial Drug Resistance with Marine Natural Products. Int. J. Antimicrob. Agents, 106005.","DOI":"10.1016\/j.ijantimicag.2020.106005"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nrd4510","article-title":"The re-emergence of natural products for drug discovery in the genomics era","volume":"14","author":"Harvey","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Ghirga, F., Bonamore, A., Calisti, L., D\u2019Acquarica, I., Mori, M., Botta, B., Boffi, A., and Macone, A. (2017). Green Routes for the Production of Enantiopure Benzylisoquinoline Alkaloids. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18112464"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1021\/acs.biomac.8b01829","article-title":"Poly(lactide-co-glycolide) Nanoparticles for Prolonged Therapeutic Efficacy of Esculentin-1a-Derived Antimicrobial Peptides against Pseudomonas aeruginosa Lung Infection: In Vitro and in Vivo Studies","volume":"20","author":"Casciaro","year":"2019","journal-title":"Biomacromolecules"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.2174\/0929867326666190722095408","article-title":"The Potential of Frog Skin Peptides for Anti-Infective Therapies: The Case of Esculentin-1a(1-21)NH2","volume":"27","author":"Casciaro","year":"2020","journal-title":"Curr. Med. Chem."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Lazzaro, B.P., Zasloff, M., and Rolff, J. (2020). Antimicrobial peptides: Application informed by evolution. Science, 368.","DOI":"10.1126\/science.aau5480"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Falanga, A., Nigro, E., De Biasi, M.G., Daniele, A., Morelli, G., Galdiero, S., and Scudiero, O. (2017). Cyclic Peptides as Novel Therapeutic Microbicides: Engineering of Human Defensin Mimetics. Molecules, 22.","DOI":"10.3390\/molecules22071217"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3874","DOI":"10.1111\/febs.14940","article-title":"Inhibition of Pseudomonas aeruginosa biofilm formation and expression of virulence genes by selective epimerization in the peptide Esculentin-1a(1-21)NH2","volume":"286","author":"Casciaro","year":"2019","journal-title":"FEBS J."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Musale, V., Casciaro, B., Mangoni, M.L., Abdel-Wahab, Y.H.A., Flatt, P.R., and Conlon, J.M. (2018). Assessment of the potential of temporin peptides from the frog Rana temporaria (Ranidae) as anti-diabetic agents. J. Pept. Sci., 24.","DOI":"10.1002\/psc.3065"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"675391","DOI":"10.1155\/2013\/675391","article-title":"Antimicrobial peptides: Versatile biological properties","volume":"2013","author":"Pushpanathan","year":"2013","journal-title":"Int. J. Pept."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Quaglio, D., Corradi, S., Erazo, S., Vergine, V., Berardozzi, S., Sciubba, F., Cappiello, F., Crestoni, M.E., Ascenzioni, F., and Imperi, F. (2020). Structural Elucidation and Antimicrobial Characterization of Novel Diterpenoids from Fabiana densa var. ramulosa. ACS Med. Chem. Lett.","DOI":"10.1021\/acsmedchemlett.9b00605"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.micres.2016.12.003","article-title":"Phytochemicals for human disease: An update on plant-derived compounds antibacterial activity","volume":"196","author":"Barbieri","year":"2017","journal-title":"Microbiol. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"979","DOI":"10.2217\/fmb.12.68","article-title":"Plant-derived antimicrobial compounds: Alternatives to antibiotics","volume":"7","author":"Savoia","year":"2012","journal-title":"Future Microbiol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Ghirga, F., Stefanelli, R., Cavinato, L., Lo Sciuto, A., Corradi, S., Quaglio, D., Calcaterra, A., Casciaro, B., Loffredo, M.R., and Cappiello, F. (2020). A novel colistin adjuvant identified by virtual screening for ArnT inhibitors. J. Antimicrob. Chemother.","DOI":"10.1093\/jac\/dkaa200"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Cappiello, F., Loffredo, M.R., Del Plato, C., Cammarone, S., Casciaro, B., Quaglio, D., Mangoni, M.L., Botta, B., and Ghirga, F. (2020). The Revaluation of Plant-Derived Terpenes to Fight Antibiotic-Resistant Infections. Antibiotics, 9.","DOI":"10.3390\/antibiotics9060325"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.ejmech.2018.07.017","article-title":"Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold","volume":"156","author":"Berardozzi","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1021\/acsmedchemlett.8b00608","article-title":"Chalcones and Chalcone-mimetic Derivatives as Notch Inhibitors in a Model of T-cell Acute Lymphoblastic Leukemia","volume":"10","author":"Quaglio","year":"2019","journal-title":"ACS Med. Chem. Lett."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Lospinoso Severini, L., Quaglio, D., Basili, I., Ghirga, F., Bufalieri, F., Caimano, M., Balducci, S., Moretti, M., Romeo, I., and Loricchio, E. (2019). A Smo\/Gli Multitarget Hedgehog Pathway Inhibitor Impairs Tumor Growth. Cancers, 11.","DOI":"10.3390\/cancers11101518"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/s13205-017-0848-9","article-title":"Plant-derived antimicrobials to fight against multi-drug-resistant human pathogens","volume":"7","author":"Subramani","year":"2017","journal-title":"3 Biotech."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Osbourn, A.E., and Lanzotti, V. (2009). Plant.-Derived Natural Products, Springer US.","DOI":"10.1007\/978-0-387-85498-4"},{"key":"ref_37","first-page":"420","article-title":"Natural products as reservoirs of novel therapeutic agents","volume":"17","author":"Mushtaq","year":"2018","journal-title":"EXCLI J."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s13756-019-0559-6","article-title":"Review on plant antimicrobials: A mechanistic viewpoint","volume":"8","author":"Khameneh","year":"2019","journal-title":"Antimicrob. Resist. Infect. Control."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.cell.2007.08.021","article-title":"Molecular understanding and modern application of traditional medicines: Triumphs and trials","volume":"130","author":"Corson","year":"2007","journal-title":"Cell"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/j.biotechadv.2015.08.001","article-title":"Discovery and resupply of pharmacologically active plant-derived natural products: A review","volume":"33","author":"Atanasov","year":"2015","journal-title":"Biotechnol. Adv."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"654","DOI":"10.2174\/1381612824666180115105850","article-title":"Isolating Colchicine in 19th Century: An Old Drug Revisited","volume":"24","author":"Karamanou","year":"2018","journal-title":"Curr. Pharm. Des."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Anand, U., Jacobo-Herrera, N., Altemimi, A., and Lakhssassi, N. (2019). A Comprehensive Review on Medicinal Plants as Antimicrobial Therapeutics: Potential Avenues of Biocompatible Drug Discovery. Metabolites, 9.","DOI":"10.3390\/metabo9110258"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Thawabteh, A., Juma, S., Bader, M., Karaman, D., Scrano, L., Bufo, S.A., and Karaman, R. (2019). The Biological Activity of Natural Alkaloids against Herbivores, Cancerous Cells and Pathogens. Toxins, 11.","DOI":"10.3390\/toxins11110656"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1080\/13543784.2019.1636030","article-title":"Investigational drugs currently in phase II clinical trials for actinic keratosis","volume":"28","author":"Lozzi","year":"2019","journal-title":"Expert Opin. Investig. Drugs"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3389\/fmicb.2012.00130","article-title":"Secondary Metabolites from Plants Inhibiting ABC Transporters and Reversing Resistance of Cancer Cells and Microbes to Cytotoxic and Antimicrobial Agents","volume":"3","author":"Wink","year":"2012","journal-title":"Front. Microbiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1080\/17460441.2019.1582639","article-title":"Are we seeing a resurgence in the use of natural products for new drug discovery?","volume":"14","author":"Li","year":"2019","journal-title":"Expert Opin. Drug Discov."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","article-title":"Natural Products as Sources of New Drugs over the Nearly Four Decades from 01\/1981 to 09\/2019","volume":"83","author":"Newman","year":"2020","journal-title":"J. Nat. Prod."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Evans, W.C., and Evans, D. (2009). Chapter 26-Alkaloids. Trease and Evans\u2019 Pharmacognosy (Sixteenth Edition), W.B. Saunders.","DOI":"10.1016\/B978-0-7020-2933-2.00026-5"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1007\/s11745-005-1473-2","article-title":"Astonishing diversity of natural surfactants: 6. Biologically active marine and terrestrial alkaloid glycosides","volume":"40","author":"Dembitsky","year":"2005","journal-title":"Lipids"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"911","DOI":"10.3389\/fmicb.2019.00911","article-title":"Antimicrobial Activity of Polyphenols and Alkaloids in Middle Eastern Plants","volume":"10","author":"Othman","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_51","unstructured":"Tyler, V.E., Speedie, M.K., and Robbers, J.E. (1996). Pharmacognosy and Pharmacobiotechnology, Williams & Wilkins."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.mtchem.2018.05.001","article-title":"Role of plant alkaloids on human health: A review of biological activities","volume":"9","author":"Debnath","year":"2018","journal-title":"Mater. Today Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.ijantimicag.2005.09.002","article-title":"Antimicrobial activity of flavonoids","volume":"26","author":"Cushnie","year":"2005","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"xlviii","DOI":"10.1016\/j.phytol.2014.06.015","article-title":"Alkaloids as drug leads\u2014A predictive structural and biodiversity-based analysis","volume":"10","author":"Amirkia","year":"2014","journal-title":"Phytochem. Lett."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"989","DOI":"10.3109\/03639045.2014.920025","article-title":"Investigation of the antibacterial activity and efflux pump inhibitory effect of co-loaded piperine and gentamicin nanoliposomes in methicillin-resistant Staphylococcus aureus","volume":"41","author":"Khameneh","year":"2015","journal-title":"Drug Dev. Ind. Pharm."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/chir.22566","article-title":"Occurrence of Enantioselectivity in Nature: The Case of (S)-Norcoclaurine","volume":"28","author":"Ghirga","year":"2016","journal-title":"Chirality"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.2174\/1381612822666151231100247","article-title":"The Pictet-Spengler Reaction Still on Stage","volume":"22","author":"Ingallina","year":"2016","journal-title":"Curr. Pharm. Des."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Wang, B., and Cechinel-Filho, V. (2012). Production of Bioactives Compounds: The Importance of Pictet\u2013Spengler Reaction in the XXI Century. Plant Bioactives and Drug Discovery: Principles, Practice, and Perspectives, John Wiley & Sons, Inc.","DOI":"10.1002\/9781118260005"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Calcaterra, A., Mangiardi, L., Delle Monache, G., Quaglio, D., Balducci, S., Berardozzi, S., Iazzetti, A., Franzini, R., Botta, B., and Ghirga, F. (2020). The Pictet-Spengler Reaction Updates Its Habits. Molecules, 25.","DOI":"10.3390\/molecules25020414"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1039\/C8QO00728D","article-title":"Olefin metathesis reaction as a locking tool for macrocycle and mechanomolecule construction","volume":"5","author":"Quaglio","year":"2018","journal-title":"Org. Chem. Front."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1039\/C7QO01037K","article-title":"Carbonyl\u2013olefin metathesis: A key review","volume":"5","author":"Ravindar","year":"2018","journal-title":"Org. Chem. Front."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.2174\/138527205774370478","article-title":"Ring-Closing Metathesis as a Construct for the Synthesis of Polycyclic Alkaloids","volume":"9","author":"Jehrod","year":"2005","journal-title":"Curr. Org. Chem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"104558","DOI":"10.1016\/j.fitote.2020.104558","article-title":"Indole alkaloids: 2012 until now, highlighting the new chemical structures and biological activities","volume":"143","author":"Rosales","year":"2020","journal-title":"Fitoterapia"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.ijantimicag.2014.06.001","article-title":"Alkaloids: An overview of their antibacterial, antibiotic-enhancing and antivirulence activities","volume":"44","author":"Cushnie","year":"2014","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_65","unstructured":"Badal, S., and Delgoda, R. (2017). Chapter 9-Alkaloids. Pharmacognosy, Academic Press."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s00284-009-9416-9","article-title":"Inhibitory and resistance-modifying potential of plant-based alkaloids against methicillin-resistant Staphylococcus aureus (MRSA)","volume":"59","author":"Mohtar","year":"2009","journal-title":"Curr. Microbiol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1002\/ptr.2136","article-title":"Antibacterial activity of two canthin-6-one alkaloids from Allium neapolitanum","volume":"21","author":"Gibbons","year":"2007","journal-title":"Phytother. Res."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Casciaro, B., Calcaterra, A., Cappiello, F., Mori, M., Loffredo, M.R., Ghirga, F., Mangoni, M.L., Botta, B., and Quaglio, D. (2019). Nigritanine as a New Potential Antimicrobial Alkaloid for the Treatment of Staphylococcus aureus-Induced Infections. Toxins, 11.","DOI":"10.3390\/toxins11090511"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.fitote.2012.04.026","article-title":"Antibacterial carbazole alkaloids from Clausena harmandiana twigs","volume":"83","author":"Maneerat","year":"2012","journal-title":"Fitoterapia"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1021\/np3000365","article-title":"Bioactive carbazole alkaloids from Clausena wallichii roots","volume":"75","author":"Maneerat","year":"2012","journal-title":"J. Nat. Prod."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.phytochem.2012.12.014","article-title":"Clausenawallines G-K, carbazole alkaloids from Clausena wallichii twigs","volume":"88","author":"Maneerat","year":"2013","journal-title":"Phytochemistry"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"9651","DOI":"10.3390\/molecules16119651","article-title":"Biological activity of carbazole alkaloids and essential oil of Murraya koenigii against antibiotic resistant microbes and cancer cell lines","volume":"16","author":"Nagappan","year":"2011","journal-title":"Molecules"},{"key":"ref_73","first-page":"161","article-title":"Restraining the multidrug efflux transporter STY4874 of Salmonella Typhi by reserpine and plant extracts","volume":"69","author":"Tariq","year":"2019","journal-title":"Lett. Appl. Microbiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/cbdd.12103","article-title":"Antibacterial and synergy of clavine alkaloid lysergol and its derivatives against nalidixic acid-resistant Escherichia coli","volume":"81","author":"Maurya","year":"2013","journal-title":"Chem. Biol. Drug Des."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1080\/07391102.2018.1458654","article-title":"Synergy of clavine alkaloid \u2018chanoclavine\u2019 with tetracycline against multi-drug-resistant E. coli","volume":"37","author":"Dwivedi","year":"2019","journal-title":"J. Biomol. Struct. Dyn."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"500","DOI":"10.3109\/00365541003713630","article-title":"Indirubin potentiates ciprofloxacin activity in the NorA efflux pump of Staphylococcus aureus","volume":"42","author":"Ponnusamy","year":"2010","journal-title":"Scand. J. Infect. Dis."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Aniszewski, T. (2007). CHAPTER 1-Definition, Typology and Occurrence of Alkaloids. Alkaloids-Secrets of Life, Elsevier.","DOI":"10.1016\/B978-044452736-3\/50003-9"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.ejmech.2018.08.027","article-title":"beta-Carboline alkaloid monomers and dimers: Occurrence, structural diversity, and biological activities","volume":"157","author":"Dai","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"ref_79","first-page":"252","article-title":"Antibacterial activity of different parts of Peganum harmala L. growing in Iran against multi-drug resistant bacteria","volume":"10","author":"Darabpour","year":"2011","journal-title":"EXCLI J."},{"key":"ref_80","first-page":"131","article-title":"On the alkaloids of two African Strychnos, Strychnos nigritana Bak and Strychnos barteri Sol. Carbon-13 NMR spectroscopy of nigritanins","volume":"51","author":"Nicoletti","year":"1980","journal-title":"Fitoterapia"},{"key":"ref_81","first-page":"1","article-title":"Chapter 1 Simple Indole Alkaloids Including \u00df-Carbolines and Carbazoles","volume":"Volume 26","author":"Brossi","year":"1985","journal-title":"The Alkaloids: Chemistry and Pharmacology"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/jlac.19435540108","article-title":"Zur Konstitution des Yohimbins und seiner Abbauprodukte","volume":"554","author":"Witkop","year":"1943","journal-title":"Justus Lieb. Ann. d. Chem."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1021\/jacs.9b12319","article-title":"A Concise, Enantioselective Approach for the Synthesis of Yohimbine Alkaloids","volume":"142","author":"Miller","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"ref_84","first-page":"144","article-title":"Most drugs that reverse multidrug resistance also inhibit photoaffinity labeling of P-glycoprotein by a vinblastine analog","volume":"33","author":"Akiyama","year":"1988","journal-title":"Mol. Pharmacol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"4781","DOI":"10.1073\/pnas.88.11.4781","article-title":"Efflux-mediated multidrug resistance in Bacillus subtilis: Similarities and dissimilarities with the mammalian system","volume":"88","author":"Neyfakh","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1242\/jeb.196.1.251","article-title":"Biochemistry and molecular biology of the vesicular monoamine transporter from chromaffin granules","volume":"196","author":"Henry","year":"1994","journal-title":"J. Exp. Biol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"10079","DOI":"10.3390\/ijerph120810079","article-title":"Prevalence of Genes of OXA-23 Carbapenemase and AdeABC Efflux Pump Associated with Multidrug Resistance of Acinetobacter baumannii Isolates in the ICU of a Comprehensive Hospital of Northwestern China","volume":"12","author":"Jia","year":"2015","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1128\/AAC.37.1.128","article-title":"Fluoroquinolone resistance protein NorA of Staphylococcus aureus is a multidrug efflux transporter","volume":"37","author":"Neyfakh","year":"1993","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.1128\/AAC.00853-09","article-title":"Two distinct major facilitator superfamily drug efflux pumps mediate chloramphenicol resistance in Streptomyces coelicolor","volume":"53","author":"Vecchione","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1128\/AAC.47.2.704-708.2003","article-title":"Efflux pump Lde is associated with fluoroquinolone resistance in Listeria monocytogenes","volume":"47","author":"Godreuil","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"5406","DOI":"10.1128\/AAC.00580-10","article-title":"LmrS is a multidrug efflux pump of the major facilitator superfamily from Staphylococcus aureus","volume":"54","author":"Floyd","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/(SICI)1099-1573(200003)14:2<139::AID-PTR608>3.0.CO;2-8","article-title":"The effect of reserpine, a modulator of multidrug efflux pumps, on the in vitro activity of tetracycline against clinical isolates of methicillin resistant Staphylococcus aureus (MRSA) possessing the tet(K) determinant","volume":"14","author":"Gibbons","year":"2000","journal-title":"Phytother. Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1134\/S0026893319040113","article-title":"Reserpine Is the New Addition into the Repertoire of AcrB Efflux Pump Inhibitors","volume":"53","author":"Shaheen","year":"2019","journal-title":"Mol. Biol. (Mosk)"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1073\/pnas.030540597","article-title":"Synergy in a medicinal plant: Antimicrobial action of berberine potentiated by 5\u2019-methoxyhydnocarpin, a multidrug pump inhibitor","volume":"97","author":"Stermitz","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1128\/AAC.50.2.810-812.2006","article-title":"Piperine, a phytochemical potentiator of ciprofloxacin against Staphylococcus aureus","volume":"50","author":"Khan","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/cbdd.12491","article-title":"Drug Resistance Reversal Potential of Ursolic Acid Derivatives against Nalidixic Acid- and Multidrug-resistant Escherichia coli","volume":"86","author":"Dwivedi","year":"2015","journal-title":"Chem. Biol. Drug Des."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0021-9673(01)99495-6","article-title":"A direct densitometric method on thin-layer plates for the determination of lysergic acid amide, isolysergic acid amide and clavine alkaloids in morning glory seeds","volume":"19","author":"Genest","year":"1965","journal-title":"J. Chromatogr. A"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1002\/bmc.1753","article-title":"Quantitative determination of bioactive alkaloids lysergol and chanoclavine in Ipomoea muricata by reversed-phase high-performance liquid chromatography","volume":"26","author":"Maurya","year":"2012","journal-title":"Biomed. Chromatogr."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.jep.2010.07.050","article-title":"In vitro antifungal activity of indirubin isolated from a South Indian ethnomedicinal plant Wrightia tinctoria R. Br","volume":"132","author":"Ponnusamy","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1089\/jmf.2005.8.454","article-title":"Antimicrobial activity of berberine alone and in combination with ampicillin or oxacillin against methicillin-resistant Staphylococcus aureus","volume":"8","author":"Yu","year":"2005","journal-title":"J. Med. Food"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1021\/acs.jnatprod.9b00317","article-title":"Natural Alkaloid Berberine Activity against Pseudomonas aeruginosa MexXY-Mediated Aminoglycoside Resistance: In Silico and in Vitro Studies","volume":"82","author":"Laudadio","year":"2019","journal-title":"J. Nat. Prod."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2174\/187231280802150212100742","article-title":"Synergistic antimicrobial activity of combinations of sanguinarine and EDTA with vancomycin against multidrug resistant bacteria","volume":"8","author":"Hamoud","year":"2014","journal-title":"Drug Metab. Lett."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1007\/s12010-009-8698-5","article-title":"Antibacterial activity of Hylomecon hylomeconoides against methicillin-resistant Staphylococcus aureus","volume":"160","author":"Choi","year":"2010","journal-title":"Appl. Biochem. Biotechnol."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Tzeng, H.E., Tsai, C.H., Ho, T.Y., Hsieh, C.T., Chou, S.C., Lee, Y.J., Tsay, G.J., Huang, P.H., and Wu, Y.Y. (2018). Radix Paeoniae Rubra stimulates osteoclast differentiation by activation of the NF-kappaB and mitogen-activated protein kinase pathways. BMC Complement. Altern. Med., 18.","DOI":"10.1186\/s12906-018-2196-7"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1055\/s-0030-1270782","article-title":"Chemical constituents, antimicrobial and antimalarial activities of Zanthoxylum monophyllum","volume":"77","author":"Fulks","year":"2011","journal-title":"Planta Med."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.bjp.2016.11.001","article-title":"In vitro antibacterial effects of Zanthoxylum tingoassuiba root bark extracts and two of its alkaloids against multiresistant Staphylococcus aureus","volume":"27","author":"Costa","year":"2017","journal-title":"Rev. Brasileira Farmacogn."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"90","DOI":"10.18433\/J3D30Q","article-title":"Antibacterial alkaloids from chelidonium majus linn (papaveraceae) against clinical isolates of methicillin-resistant Staphylococcus aureus","volume":"11","author":"Zuo","year":"2008","journal-title":"J. Pharm. Pharm. Sci."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"9819","DOI":"10.3390\/molecules16129819","article-title":"Synergistic antibacterial and antibiotic effects of bisbenzylisoquinoline alkaloids on clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA)","volume":"16","author":"Zuo","year":"2011","journal-title":"Molecules"},{"key":"ref_109","first-page":"298","article-title":"Separation and Activity against Drug-resistant Bacteria of Tetrandrine andFangchinoline in Lipophilic Akaloids from Stephania tetrandra","volume":"8","author":"Fu","year":"2017","journal-title":"Der. Chem. Sinica"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Yin, S., Rao, G., Wang, J., Luo, L., He, G., Wang, C., Ma, C., Luo, X., Hou, Z., and Xu, G. (2015). Roemerine Improves the Survival Rate of Septicemic BALB\/c Mice by Increasing the Cell Membrane Permeability of Staphylococcus aureus. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0143863"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"104371","DOI":"10.1016\/j.fitote.2019.104371","article-title":"Repurposing bioactive aporphine alkaloids as efflux pump inhibitors","volume":"139","author":"Avci","year":"2019","journal-title":"Fitoterapia"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.3389\/fmicb.2016.01223","article-title":"Berberine Is a Novel Type Efflux Inhibitor Which Attenuates the MexXY-Mediated Aminoglycoside Resistance in Pseudomonas aeruginosa","volume":"7","author":"Morita","year":"2016","journal-title":"Front. Microbiol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.1128\/AAC.46.10.3133-3141.2002","article-title":"Multidrug pump inhibitors uncover remarkable activity of plant antimicrobials","volume":"46","author":"Tegos","year":"2002","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1080\/07391102.2003.10506887","article-title":"Spectroscopic and thermodynamic studies on the binding of sanguinarine and berberine to triple and double helical DNA and RNA structures","volume":"20","author":"Das","year":"2003","journal-title":"J. Biomol. Struct. Dyn."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.bbagen.2008.05.005","article-title":"Berberine-DNA complexation: New insights into the cooperative binding and energetic aspects","volume":"1780","author":"Bhadra","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.bmc.2004.09.045","article-title":"Berberine, a strong polyriboadenylic acid binding plant alkaloid: Spectroscopic, viscometric, and thermodynamic study","volume":"13","author":"Yadav","year":"2005","journal-title":"Bioorg. Med. Chem."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.1021\/bi7018546","article-title":"Berberine targets assembly of Escherichia coli cell division protein FtsZ","volume":"47","author":"Domadia","year":"2008","journal-title":"Biochemistry"},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Boberek, J.M., Stach, J., and Good, L. (2010). Genetic evidence for inhibition of bacterial division protein FtsZ by berberine. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0013745"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/ja.2016.15","article-title":"In vitro characterization and inhibition of the interaction between ciprofloxacin and berberine against multidrug-resistant Klebsiella pneumoniae","volume":"69","author":"Zhou","year":"2016","journal-title":"J. Antibiot. (Tokyo)"},{"key":"ref_120","first-page":"2","article-title":"The Effects of Berberine and Palmatine on Efflux Pumps Inhibition with Different Gene Patterns in Pseudomonas aeruginosa Isolated from Burn Infections","volume":"9","author":"Aghayan","year":"2017","journal-title":"Avicenna J. Med. Biotechnol."},{"key":"ref_121","first-page":"467","article-title":"Berberine inhibits the MexXY-OprM efflux pump to reverse imipenem resistance in a clinical carbapenem-resistant Pseudomonas aeruginosa isolate in a planktonic state","volume":"15","author":"Su","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"ref_122","first-page":"19","article-title":"New perspectives on Sanguinaria clinicals: Individual toothpaste and oral rinse testing","volume":"56","author":"Laster","year":"1990","journal-title":"J. Can. Dent. Assoc."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"16584","DOI":"10.1021\/bi050767+","article-title":"Sanguinarine blocks cytokinesis in bacteria by inhibiting FtsZ assembly and bundling","volume":"44","author":"Beuria","year":"2005","journal-title":"Biochemistry"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"277","DOI":"10.2131\/jts.36.277","article-title":"The mechanism of action of sanguinarine against methicillin-resistant Staphylococcus aureus","volume":"36","author":"Kang","year":"2011","journal-title":"J. Toxicol. Sci."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1089\/fpd.2010.0759","article-title":"In vitro potentiation of ampicillin, oxacillin, norfloxacin, ciprofloxacin, and vancomycin by sanguinarine against methicillin-resistant Staphylococcus aureus","volume":"8","author":"Kang","year":"2011","journal-title":"Foodborne Pathog. Dis."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"6962","DOI":"10.1016\/j.bmcl.2012.08.123","article-title":"Antibacterial activity of substituted dibenzo[a,g]quinolizin-7-ium derivatives","volume":"22","author":"Parhi","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1111\/jphp.12326","article-title":"Synergistic antibacterial activity of the combination of the alkaloid sanguinarine with EDTA and the antibiotic streptomycin against multidrug resistant bacteria","volume":"67","author":"Hamoud","year":"2015","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.phymed.2014.11.019","article-title":"Pharmacological synergism of bee venom and melittin with antibiotics and plant secondary metabolites against multi-drug resistant microbial pathogens","volume":"22","author":"Zimmermann","year":"2015","journal-title":"Phytomedicine"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.phymed.2013.10.016","article-title":"Synergistic interactions in two-drug and three-drug combinations (thymol, EDTA and vancomycin) against multi drug resistant bacteria including E. coli","volume":"21","author":"Hamoud","year":"2014","journal-title":"Phytomedicine"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0378-8741(98)00182-2","article-title":"Two antimicrobial alkaloids from Bocconia arborea","volume":"66","author":"Navarro","year":"1999","journal-title":"J. Ethnopharmacol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1055\/s-0028-1097271","article-title":"Antimicrobial alkaloids from a Nigerian chewing stick (Fagara zanthoxyloides)","volume":"36","author":"Odebiyi","year":"1979","journal-title":"Planta Med."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Tavares Lde, C., Zanon, G., Weber, A.D., Neto, A.T., Mostardeiro, C.P., Da Cruz, I.B., Oliveira, R.M., Ilha, V., Dalcol, I.I., and Morel, A.F. (2014). Structure-activity relationship of benzophenanthridine alkaloids from Zanthoxylum rhoifolium having antimicrobial activity. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0097000"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1080\/14786419.2010.482055","article-title":"Structural modification of sanguinarine and chelerythrine and their antibacterial activity","volume":"25","author":"Miao","year":"2011","journal-title":"Nat. Prod. Res."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Khin, M., Jones, A.M., Cech, N.B., and Caesar, L.K. (2018). Phytochemical Analysis and Antimicrobial Efficacy of Macleaya cordata against Extensively Drug-Resistant Staphylococcus aureus. Nat. Prod. Commun., 13.","DOI":"10.1177\/1934578X1801301117"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1124\/jpet.102.034728","article-title":"Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4","volume":"302","author":"Bhardwaj","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_136","first-page":"488","article-title":"Piperine-mediated inhibition of glucuronidation activity in isolated epithelial cells of the guinea-pig small intestine: Evidence that piperine lowers the endogeneous UDP-glucuronic acid content","volume":"236","author":"Singh","year":"1986","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1093\/jac\/dkq186","article-title":"Piperine as an inhibitor of Rv1258c, a putative multidrug efflux pump of Mycobacterium tuberculosis","volume":"65","author":"Sharma","year":"2010","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1099\/jmm.0.033167-0","article-title":"Piperine as an inhibitor of the MdeA efflux pump of Staphylococcus aureus","volume":"60","author":"Mirza","year":"2011","journal-title":"J. Med. Microbiol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/ptr.4987","article-title":"Quinolone alkaloids from Fructus Euodiae show activity against methicillin-resistant Staphylococcus aureus","volume":"28","author":"Pan","year":"2014","journal-title":"Phytother Res."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1111\/jam.12753","article-title":"Antagonistic effects of indoloquinazoline alkaloids on antimycobacterial activity of evocarpine","volume":"118","author":"Hochfellner","year":"2015","journal-title":"J. Appl. Microbiol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1348-0421.2000.tb01240.x","article-title":"Highly selective antibacterial activity of novel alkyl quinolone alkaloids from a Chinese herbal medicine, Gosyuyu (Wu-Chu-Yu), against Helicobacter pylori in vitro","volume":"44","author":"Hamasaki","year":"2000","journal-title":"Microbiol. Immunol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1093\/jac\/dkf159","article-title":"In vivo action of novel alkyl methyl quinolone alkaloids against Helicobacter pylori","volume":"50","author":"Tominaga","year":"2002","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1093\/jac\/dkr203","article-title":"Interaction of N-methyl-2-alkenyl-4-quinolones with ATP-dependent MurE ligase of Mycobacterium tuberculosis: Antibacterial activity, molecular docking and inhibition kinetics","volume":"66","author":"Guzman","year":"2011","journal-title":"J. Antimicrob. Chemother."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/25\/16\/3619\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:58:26Z","timestamp":1760176706000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/25\/16\/3619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,9]]},"references-count":143,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2020,8]]}},"alternative-id":["molecules25163619"],"URL":"https:\/\/doi.org\/10.3390\/molecules25163619","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,9]]}}}