{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:01:33Z","timestamp":1792072893740,"version":"4.4.0"},"reference-count":94,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T00:00:00Z","timestamp":1597622400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Phenolic compounds, the most widely distributed class of natural products in the plants, show several biological properties including antifungal activity. Phenolics contained in grapes can be classified in two main groups, flavonoids and non-flavonoids compounds. Variability and yield extraction of phenolic and polyphenolic compounds from different matrices of Vitis vinifera depends of cultivar, climate, soil condition and process technology. Unripe grapes, berry skins and seeds, leaves, canes and stems and not-fermented and fermented pomaces represent large reusable and valuable wastes from agricultural and agro-industrial processes. This review summarizes studies that examine the extraction method, chemical characterization, and antifungal activity of phenolic and polyphenolic compounds from edible and non-edible V. vinifera matrices against human fungal pathogens. In the world, around one billion people have fungal diseases related to skin, nail or hair and around 150 million have systemic diseases caused by fungi. Few studies on antifungal activity of plant extracts have been performed. This review provides useful information for the application of V. vinifera phenolics in the field of antifungals for human use.<\/jats:p>","DOI":"10.3390\/molecules25163748","type":"journal-article","created":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T21:58:53Z","timestamp":1597701533000},"page":"3748","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":124,"title":["Antifungal Activity of Phenolic and Polyphenolic Compounds from Different Matrices of Vitis vinifera L. against Human Pathogens"],"prefix":"10.3390","volume":"25","author":[{"given":"Giovanna","family":"Simonetti","sequence":"first","affiliation":[{"name":"Department of Environmental Biology, Sapienza University of Rome, P. Aldo Moro 5, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0623-2705","authenticated-orcid":false,"given":"Elisa","family":"Brasili","sequence":"additional","affiliation":[{"name":"Department of Environmental Biology, Sapienza University of Rome, P. Aldo Moro 5, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Pasqua","sequence":"additional","affiliation":[{"name":"Department of Environmental Biology, Sapienza University of Rome, P. Aldo Moro 5, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Gintjee, T.J., Donnelley, M.A., and Thompson, G.R. (2020). Aspiring Antifungals: Review of Current Antifungal Pipeline Developments. J. Fungi, 6.","DOI":"10.3390\/jof6010028"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.sajb.2017.11.010","article-title":"Antibacterial and antifungal activities of phenolic compound-enriched ethyl acetate fraction from Cochlospermum regium (mart. Et. Schr.) Pilger roots: Mechanisms of action and synergism with tannin and gallic acid","volume":"114","author":"Carvalho","year":"2018","journal-title":"S. Afr. J. Bot."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1126\/science.1222236","article-title":"Tackling human fungal infections","volume":"336","author":"Brown","year":"2012","journal-title":"Science"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Mandras, N., Nostro, A., Roana, J., Scalas, D., Banche, G., Ghisetti, V., Del Re, S., Fucale, G., Cuffini, A.M., and Tullio, V. (2016). Liquid and vapour-phase antifungal activities of essential oils against Candida albicans and non-albicans Candida. BMC Complem. Altern., 16.","DOI":"10.1186\/s12906-016-1316-5"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1111\/j.1365-2672.2006.03191.x","article-title":"Antifungal activity of essential oils against filamentous fungi determined by broth microdilution and vapour contact methods","volume":"102","author":"Tullio","year":"2007","journal-title":"J. Appl. Microbiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"163","DOI":"10.4315\/0362-028X.JFP-19-163","article-title":"Plant phytochemicals in food preservation: Antifungal bioactivity: A review","volume":"83","author":"Villar","year":"2020","journal-title":"J. Food Prot."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mycmed.2016.10.002","article-title":"Anti-Candida albicans natural products, sources of new antifungal drugs: A review","volume":"27","author":"Zida","year":"2017","journal-title":"J. Mycol. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"6025","DOI":"10.1021\/jf501266s","article-title":"Antibacterial, antiviral, and antifungal properties of wines and winery byproducts in relation to their flavonoid content","volume":"62","author":"Friedman","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"ref_9","first-page":"1934578X150100066","article-title":"Activity of Vitis vinifera tendrils extract against phytopathogenic fungi","volume":"10","author":"Fraternale","year":"2015","journal-title":"Nat. Prod. Commun."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3389\/fphar.2018.00078","article-title":"Berry phenolic antioxidants\u2013implications for human health?","volume":"9","author":"Olas","year":"2018","journal-title":"Front Pharmacol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1002\/ptr.6419","article-title":"Polyphenols: A concise overview on the chemistry, occurrence, and human health","volume":"33","author":"Durazzo","year":"2019","journal-title":"Phytother. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1080\/10408398.2018.1540969","article-title":"Impact of plant extracts upon human health: A review","volume":"60","author":"Veiga","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3389\/fnut.2020.00060","article-title":"Bioactive phenolic compounds from agri-food wastes: An update on green and sustainable extraction methodologies","volume":"7","author":"Panzella","year":"2020","journal-title":"Front. Nutr."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1016\/j.foodres.2013.08.002","article-title":"Wine and grape polyphenols. A chemical perspective","volume":"54","author":"Garrido","year":"2013","journal-title":"Food Res. Int."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1755-0238.2000.tb00173.x","article-title":"Canopy microclimate and berry composition: The effect of bunch exposure on the phenolic composition of Vitis vinifera L cv. Shiraz grape berries","volume":"6","author":"Haselgrove","year":"2000","journal-title":"Aust. J. Grape Wine Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"127021","DOI":"10.1155\/2014\/127021","article-title":"Evaluation of anti-Candida activity of Vitis vinifera L. seed extracts obtained from wine and table cultivars","volume":"2014","author":"Simonetti","year":"2014","journal-title":"BioMed Res. Int."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1080\/11263504.2016.1174174","article-title":"Phenolics and antioxidant activity in different cultivars\/clones of Vitis vinifera L. seeds over two years","volume":"150","author":"Giannini","year":"2016","journal-title":"Plant Biosyst."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"248","DOI":"10.5344\/ajev.1986.37.4.248","article-title":"HPLC separation and characterization of flavonols in the skins of Vitis vinifera var. Cinsault","volume":"37","author":"Cheynier","year":"1986","journal-title":"Am. J. Enol. Vitic."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1021\/jf991171u","article-title":"Phenolic composition of grape stems","volume":"48","author":"Souquet","year":"2000","journal-title":"J. Agric. Food Chem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/ptr.5739","article-title":"Anti-Dermatophyte and Anti-Malassezia Activity of Extracts Rich in Polymeric Flavan-3-ols Obtained from Vitis vinifera Seeds","volume":"31","author":"Simonetti","year":"2017","journal-title":"Phytother. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"8987","DOI":"10.1021\/jf402586f","article-title":"Grape pomace as a sustainable source of bioactive compounds: Extraction, characterization, and biotechnological applications of phenolics","volume":"61","author":"Fontana","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s11130-012-0313-1","article-title":"Supercritical fluid extraction of phenolic compounds and antioxidants from grape (Vitis labrusca B.) seeds","volume":"67","author":"Ghafoor","year":"2012","journal-title":"Plant Foods Hum. Nutr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1021\/jf960493k","article-title":"Catechin and procyanidin composition of seeds from grape cultivars grown in Ontario","volume":"45","author":"Fuleki","year":"1997","journal-title":"J. Agric. Food Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.foodchem.2010.03.112","article-title":"The interactive effects of irrigation, nitrogen fertilisation rate, delayed harvest and storage on the polyphenol content in red grape (Vitis vinifera) berries: A factorial experimental design","volume":"122","author":"Cavaliere","year":"2010","journal-title":"Food Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1080\/14786419.2018.1457663","article-title":"Effects of ionizing radiation on bio-active plant extracts useful for preventing oxidative damages","volume":"33","author":"Mulinacci","year":"2019","journal-title":"Nat. Prod. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"651","DOI":"10.3390\/ijms13010651","article-title":"Antiproliferative and apoptotic effects triggered by grape seed extract (GSE) versus epigallocatechin and procyanidins on colon cancer cell lines","volume":"13","author":"Dinicola","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1080\/14786419.2014.924935","article-title":"Antitumoural activity of viniferin-enriched extracts from Vitis vinifera L. cell cultures","volume":"28","author":"Giovannelli","year":"2014","journal-title":"Nat. Prod. Res."},{"key":"ref_28","unstructured":"Pasqua, G., and Simonetti, G. (2016). Antimicrobial and antiviral activities of grape seed extracts. Grape Seeds, Nova Science Publishers."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Goufo, P., Singh, R.K., and Cortez, I. (2020). A Reference List of Phenolic Compounds (Including Stilbenes) in Grapevine (Vitis vinifera L.) Roots, Woods, Canes, Stems, and Leaves. Antioxidants, 9.","DOI":"10.3390\/antiox9050398"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"15","DOI":"10.31925\/farmacia.2020.1.3","article-title":"Phenolic content and antioxidant capacity of pomace and canes extracts of some Vitis vinifera varieties cultivated in Romania","volume":"68","author":"Moldovan","year":"2020","journal-title":"Farmacia"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Moldovan, M.L., Carpa, R., Fize\u0219an, I., Vlase, L., Bogdan, C., Iurian, S.M., Benedec, D., and Pop, A. (2020). Phytochemical Profile and Biological Activities of Tendrils and Leaves Extracts from a Variety of Vitis vinifera L.. Antioxidants, 9.","DOI":"10.3390\/antiox9050373"},{"key":"ref_32","unstructured":"Di Lorenzo, R., Gambino, C., and Scafidi, P. (2011). Summer pruning in table grape. Adv. Hortic. Sci., 143\u2013150."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1080\/14786419.2017.1410811","article-title":"Phenolic content and in vitro antifungal activity of unripe grape extracts from agro-industrial wastes","volume":"33","author":"Simonetti","year":"2019","journal-title":"Nat. Prod. Res."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Lucarini, M., Durazzo, A., Kiefer, J., Santini, A., Lombardi-Boccia, G., Souto, E.B., Romani, A., Lampe, A., Ferrari Nicoli, S., and Gabrielli, P. (2020). Grape seeds: Chromatographic profile of fatty acids and phenolic compounds and qualitative analysis by FTIR-ATR spectroscopy. Foods, 9.","DOI":"10.3390\/foods9010010"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1016\/j.lwt.2010.06.024","article-title":"Physico-chemical properties of cell wall materials obtained from ten grape varieties and their byproducts: Grape pomaces and stems","volume":"43","author":"Simal","year":"2010","journal-title":"LWT Food Sci. Technol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"4014","DOI":"10.1021\/jf9028283","article-title":"Subcritical solvent extraction of procyanidins from dried red grape pomace","volume":"58","author":"Monrad","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1016\/j.ultsonch.2014.01.021","article-title":"Effect of acoustic frequency and power density on the aqueous ultrasonic-assisted extraction of grape pomace (Vitis vinifera L.) a response surface approach","volume":"21","author":"Knoerzer","year":"2014","journal-title":"Ultrason. Sonochem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/1541-4337.12238","article-title":"Applications of wine pomace in the food industry: Approaches and functions","volume":"16","year":"2017","journal-title":"Compr. Rev. Food Sci. F"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.foodchem.2012.02.103","article-title":"Effect of extraction solvent, waste fraction and grape variety on the antimicrobial and antioxidant activities of extracts from wine residue from cool climate","volume":"134","author":"Cheng","year":"2012","journal-title":"Food Chem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.foodchem.2014.05.050","article-title":"A preliminary characterization of Aglianico (Vitis vinifera L. cv.) grape proanthocyanidins and evaluation of their reactivity towards salivary proteins","volume":"164","author":"Rinaldi","year":"2014","journal-title":"Food Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"11850","DOI":"10.1021\/jf303047k","article-title":"Proanthocyanidin composition and antioxidant potential of the stem winemaking byproducts from 10 different grape varieties (Vitis vinifera L.)","volume":"60","author":"Jourdes","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jfca.2004.10.009","article-title":"Oxygen radical absorbance capacities of grape\/wine industry byproducts and effect of solvent type on extraction of grape seed polyphenols","volume":"19","author":"Yilmaz","year":"2006","journal-title":"J. Food Compos. Anal."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.3923\/jas.2006.2944.2947","article-title":"Study on grape seeds extraction and optimization: An approach","volume":"6","author":"Youssef","year":"2006","journal-title":"J. Appl. Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"6929","DOI":"10.1021\/jf4010143","article-title":"Effect of pressurized hot water extraction on antioxidants from grape pomace before and after enological fermentation","volume":"61","author":"Bulnes","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.seppur.2005.07.006","article-title":"Extraction of polyphenols from grape seeds and concentration by ultrafiltration","volume":"48","author":"Nawaz","year":"2006","journal-title":"Sep. Purif. Technol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/j.foodchem.2007.01.068","article-title":"On the extraction and antioxidant activity of phenolic compounds from winery wastes","volume":"104","author":"Lafka","year":"2007","journal-title":"Food Chem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.1016\/j.biortech.2006.10.003","article-title":"Recovery of antioxidant phenolics from white vinification solid by-products employing water\/ethanol mixtures","volume":"98","author":"Makris","year":"2007","journal-title":"Biores. Technol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jfoodeng.2006.10.027","article-title":"Study of solid\u2013liquid extraction kinetics of total polyphenols from grape seeds","volume":"81","author":"Tomas","year":"2007","journal-title":"J. Food Eng."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.jbiotec.2012.09.014","article-title":"Antimicrobial activity and composition profile of grape (Vitis vinifera) pomace extracts obtained by supercritical fluids","volume":"164","author":"Oliveira","year":"2013","journal-title":"J. Biotechnol."},{"key":"ref_50","first-page":"9163","article-title":"Evaluation of antifungal effect of grape seed extract (GSE) on Candida glabrata and Candida krusei: In vitro study","volume":"28","author":"Eslami","year":"2017","journal-title":"Biomed. Res."},{"key":"ref_51","first-page":"440","article-title":"The Journal of Free Radicals and Antioxidants","volume":"143","author":"Va","year":"2016","journal-title":"Photon"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s12223-017-0549-0","article-title":"Resveratrol, pterostilbene, and baicalein: Plant-derived anti-biofilm agents","volume":"63","author":"Sigler","year":"2018","journal-title":"Folia Microbiol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Ruhnke, M. (2019). Clinical Syndromes: Candida and Candidosis. Clinically Relevant Mycoses, Springer.","DOI":"10.1007\/978-3-319-92300-0_4"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Simonetti, G., Palocci, C., Valletta, A., Kolesova, O., Chronopoulou, L., Donati, L., Di Nitto, A., Brasili, E., Tomai, P., and Gentili, A. (2019). Anti-Candida biofilm activity of pterostilbene or crude extract from non-fermented grape pomace entrapped in biopolymeric nanoparticles. Molecules, 24.","DOI":"10.3390\/molecules24112070"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/BF02977758","article-title":"Fungicidal effect of resveratrol on human infectious fungi","volume":"28","author":"Jung","year":"2005","journal-title":"Arch. Pharm. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0006-2952(01)00886-3","article-title":"Antimicrobial effect of resveratrol on dermatophytes and bacterial pathogens of the skin","volume":"63","author":"Chan","year":"2002","journal-title":"Biochem. Pharmacol."},{"key":"ref_57","first-page":"1225","article-title":"Antimicrobial properties of resveratrol: A review","volume":"Volume 2","author":"Paulo","year":"2011","journal-title":"Science Against Microbial Pathogens: Communicating Current Research and Technological Advances"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"103255","DOI":"10.1016\/j.fgb.2019.103255","article-title":"Antifungal resistance in dermatophytes: Recent trends and therapeutic implications","volume":"132","author":"Khurana","year":"2019","journal-title":"Fungal Genet Biol."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Ventoulis, I., Sarmourli, T., Amoiridou, P., Mantzana, P., Exindari, M., Gioula, G., and Vyzantiadis, T.A. (2020). Bloodstream Infection by Saccharomyces cerevisiae in Two COVID-19 Patients after Receiving Supplementation of Saccharomyces in the ICU. J. Fungi, 6.","DOI":"10.3390\/jof6030098"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Burns, T., Breathnach, S., Cox, N., and Griffiths, C. (2004). Mycology. Rook\u2019s Textbook of Dermatology, Blackwell Science. [7th ed.].","DOI":"10.1002\/9780470750520"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1021\/np5002576","article-title":"Antifungal activity of resveratrol derivatives against Candida species","volume":"77","author":"Houille","year":"2014","journal-title":"J. Nat. Prod."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1439-0507.2009.01763.x","article-title":"Resveratrol and its antifungal activity against Candida species","volume":"54","author":"Weber","year":"2011","journal-title":"Mycoses"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"S104","DOI":"10.1093\/mmy\/myy070","article-title":"Chronic pulmonary aspergillosis update: A year in review","volume":"57","author":"Barac","year":"2019","journal-title":"Med. Mycol."},{"key":"ref_64","first-page":"1312","article-title":"Antifungal and antibacterial properties of Grapevine (Vitis vinifera L.) leaves methanolic extract from Iran-in vitro study","volume":"14","author":"Miri","year":"2014","journal-title":"Am. Eurasian J. Agric. Environ. Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"e12756","DOI":"10.1111\/jfs.12756","article-title":"A comparative study of phenols composition, antioxidant, and antifungal potency of leaves extract from five Moroccan Vitis vinifera L. varieties","volume":"40","author":"Jediyi","year":"2020","journal-title":"J. Food Saf."},{"key":"ref_66","first-page":"124","article-title":"Evaluation of the in vitro antimicrobial effect of resveratrol on human pathogens","volume":"2","author":"Manimaran","year":"2017","journal-title":"Evaluation"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0308-8146(03)00157-2","article-title":"Resveratrol and its antioxidant and antimicrobial effectiveness","volume":"83","author":"Filip","year":"2003","journal-title":"Food Chem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.foodchem.2018.01.163","article-title":"Grape pomace as a source of phenolic compounds and diverse bioactive properties","volume":"253","author":"Peixoto","year":"2018","journal-title":"Food Chem."},{"key":"ref_69","first-page":"183","article-title":"Antioxidant and antimicrobial activities of methanol and water extracts of fruits, leaves and seeds of Vitis vinifera L. cv. Karaerik","volume":"21","year":"2009","journal-title":"Asian J. Chem."},{"key":"ref_70","first-page":"196","article-title":"In vitro anti-microbial activity and phytochemical analysis of selected fruit wastes","volume":"2","author":"Kumar","year":"2013","journal-title":"Int. J. Curr. Microbiol. App. Sci."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1080\/10826070902854417","article-title":"Comparison of components from red and white wines for antimicrobial activity by biodetection after OPLC separation","volume":"32","author":"Moricz","year":"2009","journal-title":"J. Liq. Chromatogr. R. T"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.phymed.2007.08.004","article-title":"Synergic effect of grape seed extract with amphotericin B against disseminated candidiasis due to Candida albicans","volume":"14","author":"Han","year":"2007","journal-title":"Phytomedicine"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.2217\/fmb-2018-0102","article-title":"Effect of pea protein plus grape seed dry extract on a murine model of Candida albicans induced vaginitis","volume":"13","author":"Esposito","year":"2018","journal-title":"Future Microbiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.5897\/JMPR2013.5100","article-title":"Dermatophytes and related keratinophilic fungi isolated from the soil in Gwalior region of India and in vitro evaluation of antifungal activity of the selected plant extracts against these fungi","volume":"7","author":"Shrivastav","year":"2013","journal-title":"J. Med. Plant Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.jaad.2003.12.034","article-title":"Skin diseases associated with Malassezia species","volume":"51","author":"Gupta","year":"2004","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3389\/fcimb.2020.00112","article-title":"Malassezia-Associated Skin Diseases, the Use of Diagnostics and Treatment","volume":"10","author":"Saunte","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s40257-016-0232-2","article-title":"Topical treatment of facial seborrheic dermatitis: A systematic review","volume":"18","author":"Gupta","year":"2017","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s13671-019-00274-1","article-title":"A Review of Botanicals Exhibiting Antifungal Activity Against Malassezia spp. Implicated in Common Skin Conditions","volume":"8","author":"Pintas","year":"2019","journal-title":"Curr. Dermatol. Rep."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"663","DOI":"10.4103\/0253-7613.169591","article-title":"Antimicrobial properties of black grape (Vitis vinifera L.) peel extracts against antibiotic-resistant pathogenic bacteria and toxin producing molds","volume":"47","author":"Yadav","year":"2015","journal-title":"Indian J. Pharmacol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"392","DOI":"10.4314\/jfas.v9i1.24","article-title":"Antioxidant, antibacterial and cell toxicity effects of polyphenols Fromahmeur bouamer grape seed extracts","volume":"9","author":"Ghouila","year":"2017","journal-title":"J. Fundam. Appl. Sci."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"S219","DOI":"10.1093\/mmy\/myy076","article-title":"Pathophysiological aspects of Aspergillus colonization in disease","volume":"57","author":"Gago","year":"2019","journal-title":"Med. Mycol."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Marquez, L., and Quave, C.L. (2020). Prevalence and Therapeutic Challenges of Fungal Drug Resistance: Role for Plants in Drug Discovery. Antibiotics, 9.","DOI":"10.3390\/antibiotics9040150"},{"key":"ref_83","unstructured":"Pasqua, G., Simonetti, G., D\u2019Auria, F.D., Santamaria, A.R., and Antonacci, D. (2014). Extracts Obtained from Seeds and\/or Skins of Vitis vinifera and Related Uses as Antifungal Agents. (No. IT1407378B1), Italy Patent."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1128\/AAC.01583-13","article-title":"In vitro and in vivo activities of pterostilbene against Candida albicans biofilms","volume":"58","author":"Li","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s00284-014-0734-1","article-title":"Novel antifungal mechanism of resveratrol: Apoptosis inducer in Candida albicans","volume":"70","author":"Lee","year":"2015","journal-title":"Curr. Microbiol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1093\/jac\/dkl124","article-title":"Tea polyphenol epigallocatechin-3-gallate inhibits ergosterol synthesis by disturbing folic acid metabolism in Candida albicans","volume":"57","year":"2006","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/ptr.5823","article-title":"Antifungal activity of gallic acid in vitro and in vivo","volume":"31","author":"Li","year":"2017","journal-title":"Phytother. Res."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Bitencourt, T.A., Komoto, T.T., Massaroto, B.G., Miranda, C.E.S., Beleboni, R.O., Marins, M., and Fachin, A.L. (2013). Trans-chalcone and quercetin down-regulate fatty acid synthase gene expression and reduce ergosterol content in the human pathogenic dermatophyte Trichophyton rubrum. BMC Complement. Altern. Med., 13.","DOI":"10.1186\/1472-6882-13-229"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Cheah, H.L., Lim, V., and Sandai, D. (2014). Inhibitors of the glyoxylate cycle enzyme ICL1 in Candida albicans for potential use as antifungal agents. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0095951"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Feldman, M., Tanabe, S., Howell, A., and Grenier, D. (2012). Cranberry proanthocyanidins inhibit the adherence properties of Candida albicans and cytokine secretion by oral epithelial cells. BMC Complement. Altern. Med., 12.","DOI":"10.1186\/1472-6882-12-6"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.5530\/jyp.2018.2s.10","article-title":"Cosmetic serum containing grape (Vitis vinifera L.) seed extract phytosome: Formulation and in vitro penetration study","volume":"10","author":"Surini","year":"2018","journal-title":"J. Young Pharm."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1080\/14786419.2015.1118631","article-title":"Ecophysiological and phytochemical response to ozone of wine grape cultivars of Vitis vinifera L.","volume":"30","author":"Valletta","year":"2016","journal-title":"Nat. Prod. Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J. Basic Clin. Pharm."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/j.jep.2019.112230","article-title":"Best practice in research\u2013overcoming common challenges in phytopharmacological research","volume":"246","author":"Heinrich","year":"2020","journal-title":"J. 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