{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:57:41Z","timestamp":1787029061916,"version":"build-2736575974"},"reference-count":53,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T00:00:00Z","timestamp":1597795200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Complexes with mixed ligands [Cu(N-N)2(pmtp)](ClO4)2 ((1) N-N: 2,2\u2032-bipyridine; (2) L: 1,10-phenanthroline and pmpt: 5-phenyl-7-methyl-1,2,4-triazolo[1,5-a]pyrimidine) were synthesized and structurally and biologically characterized. Compound (1) crystallizes into space group Pa and (2) in P-1. Both complexes display an intermediate stereochemistry between the two five-coordinated ones. The biological tests indicated that the two compounds exhibited superoxide scavenging capacity, intercalative DNA properties, and metallonuclease activity. Tests on various cell systems indicated that the two complexes neither interfere with the proliferation of Saccharomyces cerevisiae or BJ healthy skin cells, nor cause hemolysis in the active concentration range. Nevertheless, the compounds showed antibacterial potential, with complex (2) being significantly more active than complex (1) against all tested bacterial strains, both in planktonic and biofilm growth state. Both complexes exhibited a very good activity against B16 melanoma cells, with a higher specificity being displayed by compound (1). Taken together, the results indicate that complexes (1) and (2) have specific biological relevance, with potential for the development of antitumor or antimicrobial drugs.<\/jats:p>","DOI":"10.3390\/molecules25173777","type":"journal-article","created":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T21:37:40Z","timestamp":1597873060000},"page":"3777","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Copper(II) Complexes with Mixed Heterocycle Ligands as Promising Antibacterial and Antitumor Species"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8190-9512","authenticated-orcid":false,"given":"Arpad Mihai","family":"Rostas","sequence":"first","affiliation":[{"name":"National Institute of Materials Physics, 405A Atomi\u015ftilor Str., 077125 M\u0103gurele-Ilfov, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela","family":"Badea","sequence":"additional","affiliation":[{"name":"Department of Inorganic Chemistry, Faculty of Chemistry, University of Bucharest, 90\u201392 Panduri Str., 050663 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lavinia L.","family":"Ruta","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Biochemistry and Catalysis, Faculty of Chemistry, University of Bucharest, 90\u201392 Panduri Str., 050663 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4901-7896","authenticated-orcid":false,"given":"Ileana C.","family":"Farcasanu","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Biochemistry and Catalysis, Faculty of Chemistry, University of Bucharest, 90\u201392 Panduri Str., 050663 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6033-3710","authenticated-orcid":false,"given":"Catalin","family":"Maxim","sequence":"additional","affiliation":[{"name":"Department of Inorganic Chemistry, Faculty of Chemistry, University of Bucharest, 90\u201392 Panduri Str., 050663 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6098-1857","authenticated-orcid":false,"given":"Mariana Carmen","family":"Chifiriuc","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Biology, University of Bucharest, 1\u20133 Aleea Portocalelor Str., 060101 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Popa","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Biology, University of Bucharest, 1\u20133 Aleea Portocalelor Str., 060101 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3386-6754","authenticated-orcid":false,"given":"Mirela","family":"Luca","sequence":"additional","affiliation":[{"name":"Department of Inorganic Chemistry, Faculty of Chemistry, University of Bucharest, 90\u201392 Panduri Str., 050663 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1484-5165","authenticated-orcid":false,"given":"Natasa","family":"Celan Korosin","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ve\u010dna pot 113, 1000 Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3486-5219","authenticated-orcid":false,"given":"Romana","family":"Cerc Korosec","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ve\u010dna pot 113, 1000 Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7309-6002","authenticated-orcid":false,"given":"Mihaela","family":"Bacalum","sequence":"additional","affiliation":[{"name":"Department of Life and Environmental Physics, Horia Hulubei National Institute for Physics and Nuclear Engineering, 30 Reactorului Str., 077125 M\u0103gurele-Ilfov, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Raileanu","sequence":"additional","affiliation":[{"name":"Department of Life and Environmental Physics, Horia Hulubei National Institute for Physics and Nuclear Engineering, 30 Reactorului Str., 077125 M\u0103gurele-Ilfov, Romania"},{"name":"Department of Electricity, Solid State and Biophysics, Faculty of Physics, University of Bucharest, 405A Atomi\u015ftilor Str., 077125 M\u0103gurele-Ilfov, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4208-0972","authenticated-orcid":false,"given":"Rodica","family":"Olar","sequence":"additional","affiliation":[{"name":"Department of Inorganic Chemistry, Faculty of Chemistry, University of Bucharest, 90\u201392 Panduri Str., 050663 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.jinorgbio.2009.04.003","article-title":"Toward the development of metal-based synthetic nucleases: DNA binding and oxidative DNA cleavage of a mixed copper (II) complex with N-(9H-purin-6-yl) benzenesulfonamide and 1,10-phenanthroline. 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