{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T13:08:38Z","timestamp":1790341718542,"version":"4.1.0"},"reference-count":46,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T00:00:00Z","timestamp":1598313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Educational and Scientific Research Project for Young and Middle-aged Teachers of Education Department of Fujian Province","award":["JAT170167"],"award-info":[{"award-number":["JAT170167"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The total synthesis of a natural product alkaloid fusaric acid (FA), which exhibits herbicide, fungicide, insecticide and even diverse notable pharmacological activities, was accomplished in four steps using commercially available materials. The synthesis, based on a unified and flexible strategy using 6-bromonicotinaldehyde as a common intermediate, is concise, convergent, practical and can be carried out on a two-gram scale. This approach could be readily applicable to the synthesis of its analogues. In addition, FA had a wide range of inhibitory activities against 14 plant pathogenic fungi in this study, which demonstrated that as a leading compound, and it has great potential to be further developed as an agricultural fungicide.<\/jats:p>","DOI":"10.3390\/molecules25173859","type":"journal-article","created":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T10:48:24Z","timestamp":1598352504000},"page":"3859","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Concise Total Synthesis and Antifungal Activities of Fusaric Acid, a Natural Product"],"prefix":"10.3390","volume":"25","author":[{"given":"Bin Bin","family":"Huang","sequence":"first","affiliation":[{"name":"Key Laboratory of Biopesticide and Chemical Biology (Ministry of Education), Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biopesticide and Chemical Biology (Ministry of Education), Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng Fei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biopesticide and Chemical Biology (Ministry of Education), Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi Cheng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biopesticide and Chemical Biology (Ministry of Education), Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-An","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biopesticide and Chemical Biology (Ministry of Education), Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,25]]},"reference":[{"key":"ref_1","first-page":"8","article-title":"A Progress on the study of the agricultural microbial fungicides","volume":"42","author":"Zhao","year":"2003","journal-title":"Pesticides"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"170","DOI":"10.17221\/42\/2015-PPS","article-title":"Fungicide resistance: Facing the challenge","volume":"51","author":"Hollomon","year":"2015","journal-title":"Plant Prot. 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