{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:06:08Z","timestamp":1787241968637,"version":"build-2736575974"},"reference-count":95,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T00:00:00Z","timestamp":1598486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903816"],"award-info":[{"award-number":["81903816"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Fundamental Research Funds for the Central Universities","award":["2019-JYB-JS-018"],"award-info":[{"award-number":["2019-JYB-JS-018"]}]},{"name":"the Fundamental Research Funds for the Central Universities","award":["2020-JYB-ZDGG-044"],"award-info":[{"award-number":["2020-JYB-ZDGG-044"]}]},{"name":"the Fundamental Research Funds for the Central Universities","award":["BUCM-2019-JCRC002"],"award-info":[{"award-number":["BUCM-2019-JCRC002"]}]},{"name":"the Fundamental Research Funds for the Central Universities","award":["2020-JYB-YJ-007"],"award-info":[{"award-number":["2020-JYB-YJ-007"]}]},{"name":"the Fundamental Research Funds for the Central Universities","award":["2019-JYB-TD005"],"award-info":[{"award-number":["2019-JYB-TD005"]}]},{"name":"the Fundamental Research Funds for the Central Universities","award":["BUCM-2018-2020"],"award-info":[{"award-number":["BUCM-2018-2020"]}]},{"name":"Beijing Key Laboratory for Basic and Development Research on Chinese Medicine","award":["Beijing, 100102"],"award-info":[{"award-number":["Beijing, 100102"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Glycyrrhizae Radix et Rhizoma is regarded as one of the most popular and commonly used herbal medicines and has been used in traditional Chinese medicine (TCM) prescriptions for over 2000 years. Pentacyclic triterpene saponins are common secondary metabolites in these plants, which are synthesized via the isoprenoid pathway to produce a hydrophobic triterpenoid aglycone containing a hydrophilic sugar chain. This paper systematically summarizes the chemical structures of triterpene saponins in Glycyrrhizae Radix et Rhizoma and reviews and updates their main biological activities studies. Furthermore, the solubilization characteristics, influences, and mechanisms of Glycyrrhizae Radix et Rhizoma are elaborated. Solubilization of the triterpene saponins from Glycyrrhizae Radix et Rhizoma occurs because they contain the nonpolar sapogenin and water-soluble sidechain. The possible factors affecting the solubilization of Glycyrrhizae Radix et Rhizoma are mainly other crude drugs and the pH of the decoction. Triterpene saponins represented by glycyrrhizin from Glycyrrhizae Radix et Rhizoma characteristically form micelles due to amphiphilicity, which makes solubilization possible. This overview provides guidance regarding a better understanding of GlycyrrhizaeRadix et Rhizoma and its TCM compatibility, alongside a theoretical basis for the further development and utilization of Glycyrrhizae Radix et Rhizoma.<\/jats:p>","DOI":"10.3390\/molecules25173904","type":"journal-article","created":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T09:47:02Z","timestamp":1598521622000},"page":"3904","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Review of Constituents and Biological Activities of Triterpene Saponins from Glycyrrhizae Radix et Rhizoma and Its Solubilization Characteristics"],"prefix":"10.3390","volume":"25","author":[{"given":"Feifei","family":"Li","sequence":"first","affiliation":[{"name":"School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China"},{"name":"Institute of Regulatory Science for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[{"name":"COFCO Nutrition and Health Research Institute, Beijing 102209, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Li","sequence":"additional","affiliation":[{"name":"School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianwen","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research &amp; Development, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhao","family":"Gu","sequence":"additional","affiliation":[{"name":"School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Li","sequence":"additional","affiliation":[{"name":"School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penglong","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9856-2631","authenticated-orcid":false,"given":"Tao","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haimin","family":"Lei","sequence":"additional","affiliation":[{"name":"School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China"},{"name":"Institute of Regulatory Science for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,27]]},"reference":[{"key":"ref_1","unstructured":"Editorial Committee of Flora of China (2010). 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