{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T17:18:23Z","timestamp":1778001503975,"version":"3.51.4"},"reference-count":39,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T00:00:00Z","timestamp":1599177600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["279380"],"award-info":[{"award-number":["279380"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A new class of phosphorus dendritic compounds (PDCs) having a cyclotriphosphazene (P3N3) core and decorated with six \u03b2-cyclodextrin (\u03b2CD) units, named P3N3-[O-C6H4-O-(CH2)n-\u03b2CD]6, where n = 3 or 4 was designed, and the synthesis was performed using copper (I) catalyzed alkyne-azide cycloaddition (CuAAC). To obtain the complete substitution of the P3N3, two linkers consisting of an aromatic ring and an aliphatic chain of two different lengths were assessed. We found that, with both linkers, the total modification of the periphery was achieved. The two new obtained dendritic compounds presented a considerably high water solubility (&gt;1 g\/mL). The compounds comprised in this new class of PDCs are potential drug carrier candidates, since the conjugation of the \u03b2CD units to the P3N3 core through the primary face will not only serve as surface cover but, also, provide them the faculty to encapsulate various drugs inside the \u03b2CDs cavities.<\/jats:p>","DOI":"10.3390\/molecules25184034","type":"journal-article","created":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T12:20:06Z","timestamp":1599222006000},"page":"4034","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["First Class of Phosphorus Dendritic Compounds Containing \u03b2-Cyclodextrin Units in the Periphery Prepared by CuAAC"],"prefix":"10.3390","volume":"25","author":[{"given":"Kendra","family":"Sorroza-Mart\u00ednez","sequence":"first","affiliation":[{"name":"Instituto de Investigaciones en Materiales, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Circuito Exterior, Ciudad Universitaria, Mexico City CP 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Israel","family":"Gonz\u00e1lez-M\u00e9ndez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones en Materiales, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Circuito Exterior, Ciudad Universitaria, Mexico City CP 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mireille","family":"Vonlanthen","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones en Materiales, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Circuito Exterior, Ciudad Universitaria, Mexico City CP 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9478-347X","authenticated-orcid":false,"given":"Kathleen I.","family":"Moineau-Chane Ching","sequence":"additional","affiliation":[{"name":"CNRS, LCC (Laboratoire de Chimie de Coordination), 205 route de Narbonne, BP 44099, F-31077 Toulouse, CEDEX 4, France"},{"name":"LCC-CNRS, Universit\u00e9 de Toulouse, CNRS, 31077 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8487-3578","authenticated-orcid":false,"given":"Anne-Marie","family":"Caminade","sequence":"additional","affiliation":[{"name":"CNRS, LCC (Laboratoire de Chimie de Coordination), 205 route de Narbonne, BP 44099, F-31077 Toulouse, CEDEX 4, France"},{"name":"LCC-CNRS, Universit\u00e9 de Toulouse, CNRS, 31077 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4864-3975","authenticated-orcid":false,"given":"Javier","family":"Illescas","sequence":"additional","affiliation":[{"name":"Tecnol\u00f3gico Nacional de M\u00e9xico\/Instituto Tecnol\u00f3gico de Toluca, Avenida Tecnol\u00f3gico S\/N Col. Agr\u00edcola Bellavista, Metepec CP 52140, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernesto","family":"Rivera","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones en Materiales, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Circuito Exterior, Ciudad Universitaria, Mexico City CP 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jconrel.2015.09.056","article-title":"One-component nanomedicine","volume":"219","author":"Su","year":"2015","journal-title":"J. Control. Release."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1021\/mp200394t","article-title":"Nanomedicine(s) under the microscope","volume":"8","author":"Duncan","year":"2011","journal-title":"Mol. 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