{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T10:31:50Z","timestamp":1774261910558,"version":"3.50.1"},"reference-count":51,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T00:00:00Z","timestamp":1599177600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Royal Medic Group Holding Limited","award":["17181310CCLX07K003"],"award-info":[{"award-number":["17181310CCLX07K003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Allergic rhinitis and asthma are common chronic allergic diseases of the respiratory tract, which are accompanied by immunoglobulin E (IgE)-mediated inflammation and the involvement of type 2 T helper cells, mast cells, and eosinophils. Cordyceps sinensis (Berk.) Sacc is a fungal parasite on the larva of Lepidoptera. It has been considered to be a health-promoting food and, also, one of the best-known herbal remedies for the treatment of airway diseases, such as asthma and lung inflammation. In the present study, we demonstrated the antiallergic rhinitis effect of Cs-4, a water extract prepared from the mycelium culture of Cordyceps sinensis (Berk) Sacc, on ovalbumin (OVA)-induced allergic rhinitis in mice and the anti-asthmatic effect of Cs-4 in a rat model of asthma. Treatment with Cs-4 suppressed the nasal symptoms induced in OVA-sensitized and challenged mice. The inhibition was associated with a reduction in IgE\/OVA-IgE and interleukin (IL)-4\/IL-13 levels in the nasal fluid. Cs-4 treatment also decreased airway responsiveness and ameliorated the scratching behavior in capsaicin-challenged rats. It also reduced plasma IgE levels, as well as IgE and eosinophil peroxidase levels, in the bronchoalveolar fluid. Cs-4 treatment completely suppressed the increases in IL-4, IL-5, and IL-13 levels in rat lung tissue. In conclusion, our results suggest that Cs-4 has the potential to alleviate immune hypersensitivity reactions in allergic rhinitis and asthma.<\/jats:p>","DOI":"10.3390\/molecules25184051","type":"journal-article","created":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T12:20:06Z","timestamp":1599222006000},"page":"4051","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Anti-Inflammatory Effects of a Cordyceps sinensis Mycelium Culture Extract (Cs-4) on Rodent Models of Allergic Rhinitis and Asthma"],"prefix":"10.3390","volume":"25","author":[{"given":"Jihang","family":"Chen","sequence":"first","affiliation":[{"name":"School of Life and Health Science, The Chinese University of Hong Kong, Shenzhen 518172, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wing Man","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Life Science, The Hong Kong University of Science &amp; Technology, Clear Water Bay, Hong Kong SAR 999077, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoi Yan","family":"Leung","sequence":"additional","affiliation":[{"name":"Division of Life Science, The Hong Kong University of Science &amp; Technology, Clear Water Bay, Hong Kong SAR 999077, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pou Kuan","family":"Leong","sequence":"additional","affiliation":[{"name":"Division of Life Science, The Hong Kong University of Science &amp; Technology, Clear Water Bay, Hong Kong SAR 999077, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Choly Tat Ming","family":"Yan","sequence":"additional","affiliation":[{"name":"Royal Medic Group Holding Limited, 313 Castle Peak Road, Hong Kong SAR 999077, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kam Ming","family":"Ko","sequence":"additional","affiliation":[{"name":"Division of Life Science, The Hong Kong University of Science &amp; Technology, Clear Water Bay, Hong Kong SAR 999077, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"246","DOI":"10.3389\/fped.2019.00246","article-title":"Epidemiology of Asthma in Children and Adults","volume":"7","author":"Dharmage","year":"2019","journal-title":"Front. 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