{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:16:06Z","timestamp":1790432166799,"version":"4.1.0"},"reference-count":68,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Saliva is a biofluid that can be considered as a \u201cmirror\u201d reflecting our body\u2019s health status. Vibrational spectroscopy, Raman and infrared, can provide a detailed salivary fingerprint that can be used for disease biomarker discovery. We propose a systematic literature review based on the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines to evaluate the potential of vibrational spectroscopy to diagnose oral and general diseases using saliva as a biological specimen. Literature searches were recently conducted in May 2020 through MEDLINE-PubMed and Scopus databases, without date limitation. Finally, over a period of 10 years, 18 publications were included reporting on 10 diseases (three oral and seven general diseases), with very high diagnostic performance rates in terms of sensitivity, specificity, and accuracy. Thirteen articles were related to six different cancers of the following anatomical sites: mouth, nasopharynx, lung, esophagus, stomach, and breast. The other diseases investigated and included in this review were periodontitis, Sj\u00f6gren\u2019s syndrome, diabetes, and myocardial infarction. Moreover, most articles focused on Raman spectroscopy (n = 16\/18) and more specifically surface-enhanced Raman spectroscopy (n = 12\/18). Interestingly, vibrational spectroscopy appears promising as a rapid, label-free, and non-invasive diagnostic salivary biometric tool. Furthermore, it could be adapted to investigate subclinical diseases\u2014even if developmental studies are required.<\/jats:p>","DOI":"10.3390\/molecules25184142","type":"journal-article","created":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T22:58:01Z","timestamp":1599778681000},"page":"4142","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Vibrational Spectroscopy Saliva Profiling as Biometric Tool for Disease Diagnostics: A Systematic Literature Review"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1282-1311","authenticated-orcid":false,"given":"St\u00e9phane","family":"Derruau","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Reims Champagne-Ardenne, D\u00e9partement de Biologie Orale, UFR Odontologie, 2 rue du G\u00e9n\u00e9ral Koenig, 51100 Reims, France"},{"name":"P\u00f4le de M\u00e9decine Bucco-dentaire, Centre Hospitalier Universitaire de Reims, 45 rue Cognacq-Jay, 51092 Reims, France"},{"name":"Universit\u00e9 de Reims Champagne-Ardenne, BioSpecT-EA7506, UFR de Pharmacie, 51 rue Cognacq-Jay, 51097 Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Robinet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Reims Champagne-Ardenne, D\u00e9partement de Biologie Orale, UFR Odontologie, 2 rue du G\u00e9n\u00e9ral Koenig, 51100 Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3360-0171","authenticated-orcid":false,"given":"Val\u00e9rie","family":"Untereiner","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Reims Champagne-Ardenne, PICT, 51 rue Cognacq-Jay, 51097 Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7869-5242","authenticated-orcid":false,"given":"Olivier","family":"Piot","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Reims Champagne-Ardenne, BioSpecT-EA7506, UFR de Pharmacie, 51 rue Cognacq-Jay, 51097 Reims, France"},{"name":"Universit\u00e9 de Reims Champagne-Ardenne, PICT, 51 rue Cognacq-Jay, 51097 Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3160-4678","authenticated-orcid":false,"given":"Ganesh D.","family":"Sockalingum","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Reims Champagne-Ardenne, BioSpecT-EA7506, UFR de Pharmacie, 51 rue Cognacq-Jay, 51097 Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Lorimier","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Reims Champagne-Ardenne, D\u00e9partement de Biologie Orale, UFR Odontologie, 2 rue du G\u00e9n\u00e9ral Koenig, 51100 Reims, France"},{"name":"P\u00f4le de M\u00e9decine Bucco-dentaire, Centre Hospitalier Universitaire de Reims, 45 rue Cognacq-Jay, 51092 Reims, France"},{"name":"Universit\u00e9 de Reims Champagne-Ardenne, GRESPI-EA4694, UFR Sciences Exactes et Naturelles, 51687 Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/nrclinonc.2010.227","article-title":"Predictive, personalized, preventive, participatory (P4) cancer medicine","volume":"8","author":"Hood","year":"2011","journal-title":"Nat. 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