{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T22:42:13Z","timestamp":1768516933256,"version":"3.49.0"},"reference-count":40,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2020,9,12]],"date-time":"2020-09-12T00:00:00Z","timestamp":1599868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Foundation of Korea funded by the Ministry of Education, Science and Technology","award":["NRF-2019R1F1A1061198"],"award-info":[{"award-number":["NRF-2019R1F1A1061198"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Mast cells are effector cells that initiate allergic inflammatory immune responses by inducing inflammatory mediators. Boehmeria nivea (Linn.) Gaudich is a natural herb in the nettle family Urticaceae that possesses numerous pharmacological properties. Despite the various pharmacological benefits of Boehmeria nivea, its effects on allergic inflammation have not yet been determined. Here, we investigated the effect of the ethanol extract of Boehmeria nivea (BNE) on degranulation rat basophilic leukemia (RBL)-2H3 mast cells stimulated with anti-dinitrophenyl (anti-DNP) and bovine serum albumin (BSA) during immunoglobulin E (IgE)-mediated allergic immune response. The results showed inhibition of the release of \u03b2-hexosaminidase and histamine from the cells. BNE suppressed pro-inflammatory cytokines (Tumor necrosis factor (TNF)-\u03b1, Interleukin (IL)-1\u03b2, and IL-6) and reduced T helper (Th)2 cytokine IL-4 expression and\/or secretion correlated with the downregulation of p38, extracellular signal-regulated kinases (ERK) mitogen-activated protein kinase (MAPK), and nuclear factor-\u03baB (NF-\u03baB) signaling pathways in treated RBL-2H3 mast cells. In passive cutaneous anaphylaxis, treatment with BNE during IgE-mediated local allergic reaction triggered a reduction in mouse ear pigmentation and thickness. Taken together, these results indicated that BNE suppressed mast cell-mediated inflammation, suggesting that BNE might be a candidate for the treatment of various allergic disorders.<\/jats:p>","DOI":"10.3390\/molecules25184178","type":"journal-article","created":{"date-parts":[[2020,9,13]],"date-time":"2020-09-13T22:01:01Z","timestamp":1600034461000},"page":"4178","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Extract of Boehmeria nivea Suppresses Mast Cell-Mediated Allergic Inflammation by Inhibiting Mitogen-Activated Protein Kinase and Nuclear Factor-\u03baB"],"prefix":"10.3390","volume":"25","author":[{"given":"Ji-Ye","family":"Lim","sequence":"first","affiliation":[{"name":"Department of Immunology and Institute of Medical Sciences, Medical School, Jeonbuk (Chonbuk) National University, Jeonju, Jeonbuk 54907, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Immunology and Institute of Medical Sciences, Medical School, Jeonbuk (Chonbuk) National University, Jeonju, Jeonbuk 54907, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo-Ri","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Oriental Pharmacy, College of Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University, Iksan, Jeonbuk 54538, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi Ae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Third Medicine, Professional Graduate School of Korean Medicine, Wonkwang University, Iksan, Jeonbuk 54538, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Mi","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Oriental Pharmacy, College of Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University, Iksan, Jeonbuk 54538, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae-Ki","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Immunology and Institute of Medical Sciences, Medical School, Jeonbuk (Chonbuk) National University, Jeonju, Jeonbuk 54907, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Kyeong","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Immunology and Institute of Medical Sciences, Medical School, Jeonbuk (Chonbuk) National University, Jeonju, Jeonbuk 54907, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nri2018","article-title":"Role of mast cells in allergic and non-allergic immune responses: Comparison of human and murine data","volume":"7","author":"Bischoff","year":"2007","journal-title":"Nat. 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