{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:40:21Z","timestamp":1790217621886,"version":"4.1.0"},"reference-count":87,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T00:00:00Z","timestamp":1600128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","award":["RSP-2020\/120"],"award-info":[{"award-number":["RSP-2020\/120"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Cyperus has been commonly used as a multi-use medicinal plant in folk medicine worldwide. The objectives of our study were to determine the different metabolites in the Cyperus conglomeratus Rottb. methanol extract, and to assess its in vivo gastroprotective effect in ethanol-induced gastric ulcer model in rats. Serum levels of galactin-3 and TNF-\u03b1 were employed as biochemical markers. To pinpoint for active agents, comprehensive metabolites profiling of extract via UPLC-qTOF-MS\/MS was employed. A total of 77 chromatographic peaks were detected, of which 70 were annotated. The detected metabolites were categorized into phenolic acids and their derivatives, flavonoids, stilbenes, aurones, quinones, terpenes, and steroids. Rats were divided into six groups; healthy control, ulcer control, standard drug group, and 25, 50, 100 mg\/kg of C. conglomeratus treated rats. Pre-treatment with C. conglomeratus alcohol extract significantly reduced galactin-3, and TNF-\u03b1 in ethanol-induced ulcer model at 25, 50, and 100 mg\/kg. Further histopathological and histochemical studies revealed moderate erosion of superficial epithelium, few infiltrated inflammatory cells, and depletion of gastric tissue glycoprotein in the ulcer group. Treatment with the extract protected the gastric epithelial cells in a dose-dependent manner. It could be concluded that C. conglomeratus extract provides significant gastroprotective activity in ethanol-induced gastric ulcer and ought to be included in nutraceuticals in the future for ulcer treatment.<\/jats:p>","DOI":"10.3390\/molecules25184234","type":"journal-article","created":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T20:26:40Z","timestamp":1600201600000},"page":"4234","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["UPLC-qTOF-MS Phytochemical Profile and Antiulcer Potential of Cyperus conglomeratus Rottb. Alcoholic Extract"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3302-3623","authenticated-orcid":false,"given":"Abdelsamed I.","family":"Elshamy","sequence":"first","affiliation":[{"name":"Department of Natural Compounds Chemistry, National Research Center, 33 El Bohouth St., Dokki, Giza 12622, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdel Razik H.","family":"Farrag","sequence":"additional","affiliation":[{"name":"Pathology Department, National Research Centre, 33 El Bohouth St., Dokki, Giza 12622, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2382-8241","authenticated-orcid":false,"given":"Iriny M.","family":"Ayoub","sequence":"additional","affiliation":[{"name":"Pharmacognosy Department, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karam A.","family":"Mahdy","sequence":"additional","affiliation":[{"name":"Medical Biochemistry Department, National Research Centre, 33 El Bohouth St., Dokki, Giza 12622, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehab F.","family":"Taher","sequence":"additional","affiliation":[{"name":"Department of Natural Compounds Chemistry, National Research Center, 33 El Bohouth St., Dokki, Giza 12622, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2435-7448","authenticated-orcid":false,"given":"Abd El-Nasser G. EI","family":"Gendy","sequence":"additional","affiliation":[{"name":"Medicinal and Aromatic Plants Research Department, National Research Centre, 33 El Bohouth St., Dokki, Giza 12622, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1639-3518","authenticated-orcid":false,"given":"Tarik A.","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Chemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza 12622, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salim S.","family":"Al-Rejaie","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8920-8278","authenticated-orcid":false,"given":"Yasser A.","family":"EI-Amier","sequence":"additional","affiliation":[{"name":"Department of Botany, Faculty of Science, Mansoura University, Mansoura 35516, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5903-6329","authenticated-orcid":false,"given":"Ahmed M.","family":"Abd-EIGawad","sequence":"additional","affiliation":[{"name":"Department of Botany, Faculty of Science, Mansoura University, Mansoura 35516, Egypt"},{"name":"Plant Production Department, College of Food &amp; Agriculture Sciences, King Saud University, P.O. Box 2460, Riyadh 11451, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"Farag","sequence":"additional","affiliation":[{"name":"Pharmacognosy Department, College of Pharmacy, Cairo University, Kasr el Aini St.,  Cairo P.B. 11562, Egypt"},{"name":"Chemistry Department, School of Sciences &amp; Engineering, The American University in Cairo, New Cairo 11835, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1080\/10942912.2018.1473876","article-title":"Gastroprotective effects of herbal medicines (roots)","volume":"21","author":"Asnaashari","year":"2018","journal-title":"Int. J. 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