{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:41:23Z","timestamp":1792075283990,"version":"4.4.0"},"reference-count":114,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T00:00:00Z","timestamp":1600646400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Flavonoids are metabolites of plants and fungus. Flavonoid research has been paid special attention to in recent times after the observation of their beneficial effects on the cardiovascular system. These favorable effects are exerted by flavonoids mainly due to their antioxidant properties, which result from the ability to decrease the oxidation of low-density lipoproteins, thus improving the lipid profiles. The other positive effect exerted on the cardiovascular system is the ability of flavonoids to produce vasodilation and regulate the apoptotic processes in the endothelium. Researchers suggested that these effects, including their anti-inflammatory function, are consequences of flavonoids\u2019 potent antioxidant properties, but recent studies have shown multiple signaling pathways linked to them, thus suggesting that there are more mechanisms involved in the beneficial effect of the flavonoids on the human body. This review aims to present the latest data on the classification of these substances, their main mechanisms of action in the human body, and the beneficial effects on the physiological and pathological status of the cardiovascular system.<\/jats:p>","DOI":"10.3390\/molecules25184320","type":"journal-article","created":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T08:18:01Z","timestamp":1600676281000},"page":"4320","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":408,"title":["The Effects of Flavonoids in Cardiovascular Diseases"],"prefix":"10.3390","volume":"25","author":[{"given":"Lorena","family":"Cium\u0103rnean","sequence":"first","affiliation":[{"name":"Department 5\u2014Internal Medicine, 4th Medical Clinic, Faculty of Medicine, \u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy, 400015 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5087-9282","authenticated-orcid":false,"given":"Mircea Vasile","family":"Milaciu","sequence":"additional","affiliation":[{"name":"Department 5\u2014Internal Medicine, 4th Medical Clinic, Faculty of Medicine, \u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy, 400015 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Octavia","family":"Runcan","sequence":"additional","affiliation":[{"name":"Regional Institute of Gastroenterology and Hepatology \u2018Octavian Fodor\u2019 Cluj-Napoca, 400162 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4549-3526","authenticated-orcid":false,"given":"\u0218tefan Cristian","family":"Vesa","sequence":"additional","affiliation":[{"name":"Department 2\u2014Functional Sciences, Discipline of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, \u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreea Liana","family":"R\u0103chi\u0219an","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400177 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasile","family":"Negrean","sequence":"additional","affiliation":[{"name":"Department 5\u2014Internal Medicine, 4th Medical Clinic, Faculty of Medicine, \u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy, 400015 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirela-Georgiana","family":"Pern\u00e9","sequence":"additional","affiliation":[{"name":"Department 5\u2014Internal Medicine, 4th Medical Clinic, Faculty of Medicine, \u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy, 400015 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valer Ioan","family":"Donca","sequence":"additional","affiliation":[{"name":"Department of Geriatrics-Gerontology, \u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy, 400139 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2756-5784","authenticated-orcid":false,"given":"Teodora-Gabriela","family":"Alexescu","sequence":"additional","affiliation":[{"name":"Department 5\u2014Internal Medicine, 4th Medical Clinic, Faculty of Medicine, \u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy, 400015 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioana","family":"Para","sequence":"additional","affiliation":[{"name":"Department 5\u2014Internal Medicine, 4th Medical Clinic, Faculty of Medicine, \u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy, 400015 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Dogaru","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine &amp; Rehabilitation, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, Louis Pasteur Street 6, 400349 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.coph.2019.04.014","article-title":"Flavonoids in hypertension: A brief review of the underlying mechanisms","volume":"45","author":"Maaliki","year":"2019","journal-title":"Curr. 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