{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:41:11Z","timestamp":1770741671900,"version":"3.49.0"},"reference-count":32,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T00:00:00Z","timestamp":1601683200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18H02553"],"award-info":[{"award-number":["18H02553"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Society of Iodine Science (SIS)","award":["Research grant"],"award-info":[{"award-number":["Research grant"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The first example of a chiral halogen-bond donor with a sp3-hybridized carbon\u2013iodine moiety in a fluorobissulfonyl scaffold is described. The binaphthyl backbone was designed as a chiral source and the chiral halogen-bond donor (R)-1 was synthesized from (R)-1,1\u2032-binaphthol in 11 steps. An NMR titration experiment demonstrated that (R)-1 worked as a halogen-bond donor. The Mukaiyama aldol reaction and quinoline reduction were examined using (R)-1 as a catalyst to evaluate the asymmetric induction.<\/jats:p>","DOI":"10.3390\/molecules25194539","type":"journal-article","created":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T07:22:16Z","timestamp":1601709736000},"page":"4539","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Design and Synthesis of a Chiral Halogen-Bond Donor with a Sp3-Hybridized Carbon\u2013Iodine Moiety in a Chiral Fluorobissulfonyl Scaffold"],"prefix":"10.3390","volume":"25","author":[{"given":"Hiroto","family":"Uno","sequence":"first","affiliation":[{"name":"Department of Nanopharmaceutical Sciences, Nagoya, Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Matsuzaki","sequence":"additional","affiliation":[{"name":"Department of Nanopharmaceutical Sciences, Nagoya, Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoo","family":"Shiro","sequence":"additional","affiliation":[{"name":"Rigaku Corporation, 3-9-12, Matsubara-cho, Akishima-shi, Tokyo 196-8666, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3742-4064","authenticated-orcid":false,"given":"Norio","family":"Shibata","sequence":"additional","affiliation":[{"name":"Department of Nanopharmaceutical Sciences, Nagoya, Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555, Japan"},{"name":"Institute of Advanced Fluorine-Containing Materials, Zhejiang Normal University, 688 Yingbin Avenue, Jinhua 321004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6004","DOI":"10.1002\/anie.201707986","article-title":"Halogen Bonding in Solution: Anion Recognition, Templated Self-Assembly, and Organocatalysis","volume":"57","author":"Tepper","year":"2018","journal-title":"Angew. 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