{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T15:48:40Z","timestamp":1778687320379,"version":"3.51.4"},"reference-count":72,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T00:00:00Z","timestamp":1601942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Trypanosomiases are diseases caused by parasitic protozoan trypanosomes of the genus Trypanosoma. In humans, this includes Chagas disease and African trypanosomiasis. There are few therapeutic options, and there is low efficacy to clinical treatment. Therefore, the search for new drugs for the trypanosomiasis is urgent. This review describes studies of the trypanocidal properties of essential oils, an important group of natural products widely found in several tropical countries. Seventy-seven plants were selected from literature for the trypanocidal activity of their essential oils. The main chemical constituents and mechanisms of action are also discussed. In vitro and in vivo experimental data show the therapeutic potential of these natural products for the treatment of infections caused by species of Trypanosoma.<\/jats:p>","DOI":"10.3390\/molecules25194568","type":"journal-article","created":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T09:12:58Z","timestamp":1602061978000},"page":"4568","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Trypanocidal Essential Oils: A Review"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5967-9554","authenticated-orcid":false,"given":"Mayara Castro de","family":"Morais","sequence":"first","affiliation":[{"name":"Laboratory of Pharmaceutical Chemistry, Department of Pharmaceutical Sciences, Federal University of Para\u00edba, 58051-900 Jo\u00e3o Pessoa, Para\u00edba, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jucieudo Virgulino de","family":"Souza","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical Chemistry, Department of Pharmaceutical Sciences, Federal University of Para\u00edba, 58051-900 Jo\u00e3o Pessoa, Para\u00edba, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0628-5783","authenticated-orcid":false,"given":"Carlos","family":"da Silva Maia Bezerra Filho","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical Chemistry, Department of Pharmaceutical Sciences, Federal University of Para\u00edba, 58051-900 Jo\u00e3o Pessoa, Para\u00edba, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvio Santana","family":"Dolabella","sequence":"additional","affiliation":[{"name":"Laboratory of Entomology and Tropical Parasitology, Department of Morphology, Federal University of Sergipe, 49100-000 S\u00e3o Crist\u00f3v\u00e3o, Sergipe, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7180-4896","authenticated-orcid":false,"given":"Dami\u00e3o Pergentino de","family":"Sousa","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical Chemistry, Department of Pharmaceutical Sciences, Federal University of Para\u00edba, 58051-900 Jo\u00e3o Pessoa, Para\u00edba, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,6]]},"reference":[{"key":"ref_1","unstructured":"Silva, R.A.M.S., Seidl, A., Ramirez, L., and D\u00e1vila, A.M.R. 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