{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T15:25:58Z","timestamp":1783092358385,"version":"3.54.6"},"reference-count":25,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T00:00:00Z","timestamp":1602028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Authority for Scientific Research and Innovation as an Intermediate Body on behalf of the Ministry of European Founds as Managing Authority for Operational Program Competitiveness (POC)","award":["POC project no. 58\/05.09.2016, subcontract D no. 2626\/04.02.2017"],"award-info":[{"award-number":["POC project no. 58\/05.09.2016, subcontract D no. 2626\/04.02.2017"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>In this work, new evidence for the photodegradation reactions of acetaminophen (AC) is reported by photoluminescence (PL), Raman scattering and FTIR spectroscopy. Under excitation wavelength of 320 nm, AC shows a PL band in the spectral range of 340\u2013550 nm, whose intensity decreases by exposure to UV light. The chemical interaction of AC with the NaOH solutions, having the concentration ranging between 0.001 and 0.3 M, induces a gradual enhancement of the photoluminescence excitation (PLE) and PL spectra, when the exposure time of samples at the UV light increases until 140 min, as a result of the formation of p-aminophenol and sodium acetate. This behavior is not influenced by the excipients or other active compounds in pharmaceutical products as demonstrated by PLE and PL studies. Experimental arguments for the obtaining of p-aminophenol and sodium acetate, when AC has interacted with NaOH, are shown by Raman scattering and FTIR spectroscopy.<\/jats:p>","DOI":"10.3390\/molecules25194571","type":"journal-article","created":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T09:12:58Z","timestamp":1602061978000},"page":"4571","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Photoluminescence as a Valuable Tool in the Optical Characterization of Acetaminophen and the Monitoring of Its Photodegradation Reactions"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3178-5237","authenticated-orcid":false,"given":"Monica","family":"Daescu","sequence":"first","affiliation":[{"name":"Laboratory of Optical Processes in Nanostructured Materials, National Institute of Materials Physics, Atomistilor Street 405A, P.O. Box MG-7, 077125 Bucharest, Romania"},{"name":"Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Gh. Polizu St 1-7, 011061 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelina","family":"Matea","sequence":"additional","affiliation":[{"name":"Laboratory of Optical Processes in Nanostructured Materials, National Institute of Materials Physics, Atomistilor Street 405A, P.O. Box MG-7, 077125 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalin","family":"Negrila","sequence":"additional","affiliation":[{"name":"Nanoscale Condensed Matter Laboratory, National Institute of Materials Physics, Atomistilor Street 405A, P.O. Box MG-7, 077125 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantin","family":"Serbschi","sequence":"additional","affiliation":[{"name":"Bioelectronic SRL, Cercelus Street, no.54, Ploiesti, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina C.","family":"Ion","sequence":"additional","affiliation":[{"name":"Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Gh. Polizu St 1-7, 011061 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela","family":"Baibarac","sequence":"additional","affiliation":[{"name":"Laboratory of Optical Processes in Nanostructured Materials, National Institute of Materials Physics, Atomistilor Street 405A, P.O. Box MG-7, 077125 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s10194-010-0266-4","article-title":"Self-medication of migraine and tension type headache summary of the evidence based recommendations of the Deutsche Migrane und Kopbschmerzgesellschaft (DMKG), the Deutsch Gesellschaft fur Neurologie (DGN), the Osterreichische Kopfschmerzgesellschaft (OKSG) and the Schweizerische Kopfwegesellschaft (SKG)","volume":"12","author":"Haag","year":"2011","journal-title":"J. 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