{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T11:12:25Z","timestamp":1783163545908,"version":"3.54.6"},"reference-count":33,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T00:00:00Z","timestamp":1602547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Deputyship for Research &amp; Innovation, Ministry of Education in Saudi Arabia","award":["Project number IFT20166"],"award-info":[{"award-number":["Project number IFT20166"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Plants that synthesize bioactive compounds that have high antioxidant value and elicitation offer a reliable in vitro technique to produce important nutraceutical compounds. The objective of this study is to promote the biosynthesis of these phenolic compounds on a large scale using elicitors in date palm cell suspension culture. Elicitors such as pectin, yeast extract (YE), salicylic acid (SA), cadmium chloride (CdCl2), and silver nitrate (AgNO3) at 50, 100, and 200 mg\/L concentrations are used. The effects of elicitors on cell culture were determined in terms of biomass [packed cell volume (PCV), fresh and dry weight], antioxidant activity, and phenolic compounds (catechin, caffeic acid, kaempferol, apigenin) were determined using high-performance liquid chromatography (HPLC). Results revealed that enhanced PCV (12.3%), total phenolic content [317.9 \u00b1 28.7 mg gallic acid equivalents (GAE)\/100 g of dry weight (DW)], and radical scavenging activity (86.0 \u00b1 4.5%) were obtained in the 50 mg\/L SA treated cell culture of Murashige and Skoog (MS) medium. The accumulation of optimum catechin (26.6 \u00b1 1.3 \u00b5g\/g DW), caffeic acid (31.4 \u00b1 3.8 \u00b5g\/g DW), and kaempferol (13.6 \u00b1 1.6 \u00b5g\/g DW) was found in the 50 mg\/L SA-treated culture when compared to the control. These outcomes could be of great importance in the nutraceutical and agronomic industries.<\/jats:p>","DOI":"10.3390\/molecules25204669","type":"journal-article","created":{"date-parts":[[2020,10,17]],"date-time":"2020-10-17T07:23:22Z","timestamp":1602919402000},"page":"4669","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Elicitor-Induced Production of Biomass and Pharmaceutical Phenolic Compounds in Cell Suspension Culture of Date Palm (Phoenix dactylifera L.)"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9507-0201","authenticated-orcid":false,"given":"Jameel Mohammed","family":"Al-Khayri","sequence":"first","affiliation":[{"name":"Department of Agricultural Biotechnology, College of Agriculture and Food Sciences, King Faisal University, P.O. Box 420, Al-Ahsa 31982, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0957-1083","authenticated-orcid":false,"given":"Poornananda Madhava","family":"Naik","sequence":"additional","affiliation":[{"name":"Department of Agricultural Biotechnology, College of Agriculture and Food Sciences, King Faisal University, P.O. Box 420, Al-Ahsa 31982, Saudi Arabia"},{"name":"Department of Botany, Karnatak University, Dharwad 580003, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1590\/1413-70542017414000217","article-title":"Date palm micropropagation: Advances and applications","volume":"41","author":"Naik","year":"2017","journal-title":"Cienc. 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