{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T22:29:27Z","timestamp":1779920967299,"version":"3.53.1"},"reference-count":38,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T00:00:00Z","timestamp":1602806400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The trifluoromethylation of aromatic and heteroaromatic cores has attracted considerable interest in recent years due to its pharmacological relevance. We studied the extension of a simple copper-catalyzed trifluoromethylation protocol to alkoxy-substituted iodopyridines and their benzologs. The trifluoromethylation proceeded smoothly in all cases, and the desired compounds were isolated and characterized. In the trifluoromethylation of 3-iodo-4-methoxyquinoline, we observed a concomitant O-N methyl migration, resulting in the trifluoromethylated quinolone as a product. Overall, the described procedure should facilitate the broader use of copper-catalyzed trifluoromethylation in medicinal chemistry.<\/jats:p>","DOI":"10.3390\/molecules25204766","type":"journal-article","created":{"date-parts":[[2020,10,17]],"date-time":"2020-10-17T08:14:50Z","timestamp":1602922490000},"page":"4766","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Copper-Catalyzed Trifluoromethylation of Alkoxypyridine Derivatives"],"prefix":"10.3390","volume":"25","author":[{"given":"Nandor","family":"Gyorfi","sequence":"first","affiliation":[{"name":"Servier Research Institute of Medicinal Chemistry, Z\u00e1hony u. 7., H-1031 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emese","family":"Farkas","sequence":"additional","affiliation":[{"name":"Servier Research Institute of Medicinal Chemistry, Z\u00e1hony u. 7., H-1031 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6800-1710","authenticated-orcid":false,"given":"Norbert","family":"Nemet","sequence":"additional","affiliation":[{"name":"Servier Research Institute of Medicinal Chemistry, Z\u00e1hony u. 7., H-1031 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Csaba","family":"Weber","sequence":"additional","affiliation":[{"name":"Servier Research Institute of Medicinal Chemistry, Z\u00e1hony u. 7., H-1031 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoltan","family":"Novak","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, E\u00f6tv\u00f6s Lor\u00e1nd Unversity, P\u00e1zm\u00e1ny P\u00e9ter s. 1\/A, H-1117 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7675-3864","authenticated-orcid":false,"given":"Andras","family":"Kotschy","sequence":"additional","affiliation":[{"name":"Servier Research Institute of Medicinal Chemistry, Z\u00e1hony u. 7., H-1031 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.5009\/gnl15502","article-title":"25 Years of Proton Pump Inhibitors: A Comprehensive Review","volume":"11","author":"Strand","year":"2017","journal-title":"Gut Liver"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/ja.2016.71","article-title":"The unique chemistry and biology of the piericidins","volume":"69","author":"Zhou","year":"2016","journal-title":"J. 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