{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T14:22:53Z","timestamp":1774448573210,"version":"3.50.1"},"reference-count":45,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T00:00:00Z","timestamp":1603238400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Malaria, despite many efforts, remains among the most problematic infectious diseases worldwide, mainly due to the development of drug resistance by Plasmodium falciparum. The antibiotic fosmidomycin (FSM) is also known for its antimalarial activity by targeting the non-mevalonate isoprenoid synthesis pathway, which is essential for the malaria parasites but is absent in mammalians. In this study, we synthesized and evaluated against the chloroquine-resistant P. falciparum FcB1\/Colombia strain, a series of FSM analogs, derivatives, and conjugates with other antimalarial agents, such as artemisinin (ART) and aminochloroquinoline (ACQ). The biological evaluation revealed four new compounds with higher antimalarial activity than FSM: two FSM-ACQ derivatives and two FSM-ART conjugates, with 3.5\u20135.4 and 41.5\u201323.1 times more potent activities than FSM, respectively.<\/jats:p>","DOI":"10.3390\/molecules25204858","type":"journal-article","created":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T02:01:42Z","timestamp":1603418502000},"page":"4858","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Synthesis and Antiplasmodial Activity of Novel Fosmidomycin Derivatives and Conjugates with Artemisinin and Aminochloroquinoline"],"prefix":"10.3390","volume":"25","author":[{"given":"Despina","family":"Palla","sequence":"first","affiliation":[{"name":"Synthetic Organic Chemistry Laboratory, Department of Chemistry, University of Patras, GR-26504 Patras, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8579-2999","authenticated-orcid":false,"given":"Antonia I.","family":"Antoniou","sequence":"additional","affiliation":[{"name":"Synthetic Organic Chemistry Laboratory, Department of Chemistry, University of Patras, GR-26504 Patras, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Baltas","sequence":"additional","affiliation":[{"name":"LSPCMIB, UMR-CNRS 5068, Universit\u00e9 Paul Sabatier-Toulouse III, CEDEX 9, 31062 Toulouse, France"},{"name":"CNRS, LCC (Laboratoire de Chimie, de Coordination), Universit\u00e9 de Tolouse, UPS, INPT, 205 Route de Narbonne, BP 44099, CEDEX 4 F-31077 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Menendez","sequence":"additional","affiliation":[{"name":"LSPCMIB, UMR-CNRS 5068, Universit\u00e9 Paul Sabatier-Toulouse III, CEDEX 9, 31062 Toulouse, France"},{"name":"CNRS, LCC (Laboratoire de Chimie, de Coordination), Universit\u00e9 de Tolouse, UPS, INPT, 205 Route de Narbonne, BP 44099, CEDEX 4 F-31077 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4153-0465","authenticated-orcid":false,"given":"Philippe","family":"Grellier","sequence":"additional","affiliation":[{"name":"MCAM, UMR 7245, Mus\u00e9um National d\u2019Histoire Naturelle, CNRS, CP52, 63 rue Buffon, 75005 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Mouray","sequence":"additional","affiliation":[{"name":"MCAM, UMR 7245, Mus\u00e9um National d\u2019Histoire Naturelle, CNRS, CP52, 63 rue Buffon, 75005 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7549-1911","authenticated-orcid":false,"given":"Constantinos M.","family":"Athanassopoulos","sequence":"additional","affiliation":[{"name":"Synthetic Organic Chemistry Laboratory, Department of Chemistry, University of Patras, GR-26504 Patras, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,21]]},"reference":[{"key":"ref_1","unstructured":"(2019, December 04). 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