{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:39:48Z","timestamp":1791844788778,"version":"4.3.4"},"reference-count":140,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T00:00:00Z","timestamp":1603411200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Isocyanides have long been known as versatile chemical reagents in organic synthesis. Their ambivalent nature also allows them to function as a CO-substitute in palladium-catalyzed cross couplings. Over the past decades, isocyanides have emerged as practical and versatile C1 building blocks, whose inherent N-substitution allows for the rapid incorporation of nitrogeneous fragments in a wide variety of products. Recent developments in palladium catalyzed isocyanide insertion reactions have significantly expanded the scope and applicability of these imidoylative cross-couplings. This review highlights the advances made in this field over the past eight years.<\/jats:p>","DOI":"10.3390\/molecules25214906","type":"journal-article","created":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T08:59:28Z","timestamp":1603443568000},"page":"4906","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Recent Advances in Palladium-Catalyzed Isocyanide Insertions"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9988-0084","authenticated-orcid":false,"given":"Jurri\u00ebn W.","family":"Collet","sequence":"first","affiliation":[{"name":"Department of Chemistry and Pharmaceutical Sciences and Amsterdam Institute for Molecules, Medicines &amp; Systems (AIMMS), Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands"},{"name":"Organic Synthesis, Department of Chemistry, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R.","family":"Roose","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Pharmaceutical Sciences and Amsterdam Institute for Molecules, Medicines &amp; Systems (AIMMS), Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bram","family":"Weijers","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Pharmaceutical Sciences and Amsterdam Institute for Molecules, Medicines &amp; Systems (AIMMS), Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bert U. W.","family":"Maes","sequence":"additional","affiliation":[{"name":"Organic Synthesis, Department of Chemistry, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1105-3947","authenticated-orcid":false,"given":"Eelco","family":"Ruijter","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Pharmaceutical Sciences and Amsterdam Institute for Molecules, Medicines &amp; Systems (AIMMS), Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romano V. A.","family":"Orru","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Pharmaceutical Sciences and Amsterdam Institute for Molecules, Medicines &amp; Systems (AIMMS), Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands"},{"name":"Organic Chemistry, Aachen-Maastricht Institute for Biobased Materials, Maastricht University, Urmonderlaan 22, 6167 RD Geleen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"8082","DOI":"10.1002\/anie.201002238","article-title":"Factors Determining the Selection of Organic Reactions by Medicinal Chemists and the Use of These Reactions in Arrays (Small Focused Libraries)","volume":"49","author":"Cooper","year":"2010","journal-title":"Angew. Chem. Int. 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