{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:57:42Z","timestamp":1787029062002,"version":"build-2736575974"},"reference-count":42,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T00:00:00Z","timestamp":1604016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>In this study, the aerial parts of Moricandia sinaica were evaluated for their in vivo analgesic, anti-inflammatory and antipyretic activities. The analgesic activities were examined using acetic acid-induced writhing, the hot plate test and the tail flick method. The anti-inflammatory and the antipyretic activities were evaluated using carrageenan-induced paw edema in rats and brewer\u2019s yeast-induced pyrexia in mice, respectively. The aqueous fraction of the methanol extract (MS-3) showed to be the most bioactive among the other investigated fractions. At the dose of 500 mg\/kg, the fraction (MS-3) showed a significant percentage inhibition of the carrageenan-induced edema by 52.4% (p &lt; 0.05). In addition, MS-3 exhibited a significant inhibition of acetic acid-induced writhes by 44.4% and 61.5% (p &lt; 0.001) at 250-mg\/kg and 500-mg\/kg doses, respectively. At 120 min post-treatment, the rat groups treated with MS-3 displayed statistically significant reduction in rectal temperature (p &lt; 0.001) by 1.7 \u00b0C and 2.2 \u00b0C at 250- and 500-mg\/kg doses, respectively. The phytochemical composition of the fraction (MS-3) was characterized by high-performance liquid chromatography-mass spectrometry (HPLC-PDA-MS\/MS). Molecular docking studies demonstrated that the polyphenols identified in MS-3 revealed good binding energy upon docking to some target proteins involved in pain response and inflammation, such as the cannabinoid receptors CB1 and CB2, the fatty acid amide hydrolase (FAAH) and the cyclooxygenase COX-1 and COX-2 enzymes. Based on the findings from the present work, it could be concluded that the aerial parts extract of M. sinaica exerts potential analgesic, anti-inflammatory and antipyretic effects in rats.<\/jats:p>","DOI":"10.3390\/molecules25215049","type":"journal-article","created":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T21:34:47Z","timestamp":1604093687000},"page":"5049","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["A Polyphenols-Rich Extract from Moricandia sinaica Boiss. Exhibits Analgesic, Anti-Inflammatory and Antipyretic Activities In Vivo"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0826-6968","authenticated-orcid":false,"given":"Sahar","family":"El-mekkawy","sequence":"first","affiliation":[{"name":"Department of Chemistry of Natural Compounds, National Research Centre, Dokki, Giza 12622, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0456-3196","authenticated-orcid":false,"given":"Abdelaaty A.","family":"Shahat","sequence":"additional","affiliation":[{"name":"Pharmacognosy Department, Medicinal Aromatic and Poisonous Plants Research Center, College of Pharmacy King Saud University, Riyadh 11451, Saudi Arabia"},{"name":"Chemistry of Medicinal Plants Department, National Research Centre, Dokki, Giza 12622, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1034-7441","authenticated-orcid":false,"given":"Ali S.","family":"Alqahtani","sequence":"additional","affiliation":[{"name":"Pharmacognosy Department, Medicinal Aromatic and Poisonous Plants Research Center, College of Pharmacy King Saud University, Riyadh 11451, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansour S.","family":"Alsaid","sequence":"additional","affiliation":[{"name":"Pharmacognosy Department, Medicinal Aromatic and Poisonous Plants Research Center, College of Pharmacy King Saud University, Riyadh 11451, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.O.","family":"Abdelfattah","sequence":"additional","affiliation":[{"name":"College of Engineering and Technology, American University of the Middle East, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2860-467X","authenticated-orcid":false,"given":"Riaz","family":"Ullah","sequence":"additional","affiliation":[{"name":"Pharmacognosy Department, Medicinal Aromatic and Poisonous Plants Research Center, College of Pharmacy King Saud University, Riyadh 11451, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7741-7435","authenticated-orcid":false,"given":"Mahmoud","family":"Emam","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Science &amp; Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China"},{"name":"Phytochemistry and Plant Systematics Department, National Research Centre, Dokki, Giza 12622, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7513-9037","authenticated-orcid":false,"given":"Abdelaziz","family":"Yasri","sequence":"additional","affiliation":[{"name":"AgroBioSciences Research Division, Mohammed VI Polytechnic University, Lot 660\u2013Hay MoulayRachid, 43150 Ben-Guerir, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7875-4510","authenticated-orcid":false,"given":"Mansour","family":"Sobeh","sequence":"additional","affiliation":[{"name":"AgroBioSciences Research Division, Mohammed VI Polytechnic University, Lot 660\u2013Hay MoulayRachid, 43150 Ben-Guerir, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e37822","DOI":"10.5812\/aapm.37822","article-title":"The role of non-steroidal anti-inflammatory drugs (NSAIDs) in the treatment of patients with hepatic disease: A review article","volume":"6","author":"Soleimanpour","year":"2016","journal-title":"Anesth. 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