{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T14:26:37Z","timestamp":1772461597603,"version":"3.50.1"},"reference-count":174,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T00:00:00Z","timestamp":1604966400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004488","name":"Hrvatska Zaklada za Znanost","doi-asserted-by":"publisher","award":["IP-2016-06-4404"],"award-info":[{"award-number":["IP-2016-06-4404"]}],"id":[{"id":"10.13039\/501100004488","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical School, University of Zagreb","award":["X"],"award-info":[{"award-number":["X"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Most data published on curcumin and curcumin-based formulations are very promising. In cancer research, the majority of data has been obtained in vitro. Less frequently, researchers used experimental animals. The results of several clinical studies are conclusive, and these studies have established a good foundation for further research focusing on implementing curcumin in clinical oncology. However, the issues regarding timely data reporting and lack of disclosure of the exact curcumin formulations used in these studies should not be neglected. This article is a snapshot of the current status of publicly available data on curcumin clinical trials and a detailed presentation of results obtained so far with some curcumin formulations. Phenomena related to the observed effects of curcumin shown in clinical trials are presented, and its modifying effect on gut microbiota and metabolic reprogramming is discussed. Based on available data, there is a strong indication that curcumin and its metabolites present molecules that do not necessarily need to be abundant in order to act locally and benefit systemically. Future clinical studies should be designed in a way that will take that fact into consideration.<\/jats:p>","DOI":"10.3390\/molecules25225240","type":"journal-article","created":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T20:29:36Z","timestamp":1605040176000},"page":"5240","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Implementing Curcumin in Translational Oncology Research"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7501-7614","authenticated-orcid":false,"given":"Koraljka Gall","family":"Tro\u0161elj","sequence":"first","affiliation":[{"name":"Laboratory for Epigenomics, Ru\u0111er Bo\u0161kovi\u0107 Institute, Division of Molecular Medicine, 10000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivana","family":"Samar\u017eija","sequence":"additional","affiliation":[{"name":"Laboratory for Epigenomics, Ru\u0111er Bo\u0161kovi\u0107 Institute, Division of Molecular Medicine, 10000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marko","family":"Tomljanovi\u0107","sequence":"additional","affiliation":[{"name":"Laboratory for Epigenomics, Ru\u0111er Bo\u0161kovi\u0107 Institute, Division of Molecular Medicine, 10000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata Novak","family":"Kujund\u017ei\u0107","sequence":"additional","affiliation":[{"name":"Laboratory for Epigenomics, Ru\u0111er Bo\u0161kovi\u0107 Institute, Division of Molecular Medicine, 10000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikola","family":"\u0110akovi\u0107","sequence":"additional","affiliation":[{"name":"Institute for Clinical Medical Research and Education, University Hospital Centre Sisters of Charity, 10000 Zagreb, Croatia"},{"name":"Department of Clinical Oncology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anamarija","family":"Mojze\u0161","sequence":"additional","affiliation":[{"name":"Laboratory for Epigenomics, Ru\u0111er Bo\u0161kovi\u0107 Institute, Division of Molecular Medicine, 10000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1056\/NEJM194806032382301","article-title":"Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid","volume":"238","author":"Farber","year":"1948","journal-title":"N. 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