{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:04:05Z","timestamp":1790694245470,"version":"4.1.0"},"reference-count":31,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T00:00:00Z","timestamp":1605225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Technology of Republic of China","award":["MOST 108-2113-M-032-001"],"award-info":[{"award-number":["MOST 108-2113-M-032-001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A synthetic approach to quinindoline derivatives by the Cu-catalyzed dual cyclization has been developed. This catalytic reaction is a practical method for the systematic synthesis of quinindoline core structure, which contains a limited-step synthetic strategy and can tolerant a wide variety of substituents. In addition, the mechanistic study reveals that the reaction initiates from a Lewis acid accelerated addition of aniline to nitrile and provides the indole substructure, and then the subsequent Cu-catalyzed C-N coupling reaction furnishes the quinoline subunit and affords the quinindoline structure.<\/jats:p>","DOI":"10.3390\/molecules25225303","type":"journal-article","created":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T10:32:47Z","timestamp":1605263567000},"page":"5303","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Copper-Catalyzed Dual Cyclization for the Synthesis of Quinindolines"],"prefix":"10.3390","volume":"25","author":[{"given":"Hung-Kai","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Chemistry, Tamkang University, New Taipei City 25137, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Lun","family":"Chio","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Tamkang University, New Taipei City 25137, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gangaram","family":"Pallikonda","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Tamkang University, New Taipei City 25137, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsyueh-Liang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Chemistry, National Taiwan Normal University, Taipei 11677, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haw-Lih","family":"Su","sequence":"additional","affiliation":[{"name":"Central Laboratories Unit, Qatar University, Doha 999043, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1975-7842","authenticated-orcid":false,"given":"Jen-Chieh","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Tamkang University, New Taipei City 25137, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1021\/np030392y","article-title":"Jusbetonin, the First Indolo[3,2-b]quinoline Alkaloid Glycoside, from Justicia betonica","volume":"67","author":"Subbaraju","year":"2004","journal-title":"J. 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