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Natural sources, extraction methods, anticancer mechanisms, clinical studies, and pharmaceutical formulation are discussed in this review. Studies covered by this review should provide a solid foundation for researchers and physicians to enhance basic and clinical research on developing alternative anticancer therapies.<\/jats:p>","DOI":"10.3390\/molecules25225319","type":"journal-article","created":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T22:48:47Z","timestamp":1605566927000},"page":"5319","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":117,"title":["Plant-Derived Natural Products in Cancer Research: Extraction, Mechanism of Action, and Drug Formulation"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1942-8982","authenticated-orcid":false,"given":"Wamidh H.","family":"Talib","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy and Therapeutics, Applied Science Private University, Amman 11931, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izzeddin","family":"Alsalahat","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry and Pharmacognosy, Applied Science Private University, Amman 11931, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1958-6534","authenticated-orcid":false,"given":"Safa","family":"Daoud","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry and Pharmacognosy, Applied Science Private University, Amman 11931, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3895-2835","authenticated-orcid":false,"given":"Reem Fawaz","family":"Abutayeh","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry and Pharmacognosy, Applied Science Private University, Amman 11931, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asma Ismail","family":"Mahmod","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Therapeutics, Applied Science Private University, Amman 11931, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"Ca A Cancer J. 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