{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T23:02:51Z","timestamp":1781737371500,"version":"3.54.5"},"reference-count":94,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T00:00:00Z","timestamp":1605744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Thuja occidentalis L. (Cupressaceae) has its origins in Eastern North America and is cultivated in Europe and Brazil as an ornamental tree, being known as the \u201ctree of life\u201d or \u201cwhite cedar\u201d. In traditional medicine, it is commonly used to treat liver diseases, bullous bronchitis, psoriasis, enuresis, amenorrhea, cystitis, uterine carcinomas, diarrhea, and rheumatism. The chemical constituents of T. occidentalis have been of research interest for decades, due to their contents of essential oil, coumarins, flavonoids, tannins, and proanthocyanidines. Pharmacology includes antioxidant, anti-inflammatory, antibacterial, antifungal, anticancer, antiviral, protective activity of the gastrointestinal tract, radioprotection, antipyretic, and lipid metabolism regulatory activity. Therefore, the present review represents the synthesis of all the relevant information for T. occidentalis, its ethnobotany, phytochemistry, and a thorough analysis of their pharmacological activities, in order to promote all the biological activities shown so far, rather than the antitumor activity that has promoted it as a medicinal species.<\/jats:p>","DOI":"10.3390\/molecules25225416","type":"journal-article","created":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T10:46:26Z","timestamp":1605782786000},"page":"5416","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Thuja occidentalis L. (Cupressaceae): Ethnobotany, Phytochemistry and Biological Activity"],"prefix":"10.3390","volume":"25","author":[{"given":"Sonia","family":"Caruntu","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy, Vasile Goldis Western University of Arad, Rebreanu 86, 310414 Arad, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Ciceu","sequence":"additional","affiliation":[{"name":"\u201cAurel Ardelean\u201d Institute of Life Sciences, Vasile Godis Western University of Arad, Rebreanu 86, 310414 Arad, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5204-6885","authenticated-orcid":false,"given":"Neli Kinga","family":"Olah","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Vasile Goldis Western University of Arad, Rebreanu 86, 310414 Arad, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioan","family":"Don","sequence":"additional","affiliation":[{"name":"\u201cPavel Covaci\u201d University Botanical Garden from Macea, Vasile Goldis Western University of Arad, Rebreanu 86, 310414 Arad, Romania"},{"name":"Faculty of Economics, Computer Science and Engineering, Vasile Godis Western University of Arad, Rebreanu 86, 310414 Arad, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8510-6653","authenticated-orcid":false,"given":"Anca","family":"Hermenean","sequence":"additional","affiliation":[{"name":"\u201cAurel Ardelean\u201d Institute of Life Sciences, Vasile Godis Western University of Arad, Rebreanu 86, 310414 Arad, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coralia","family":"Cotoraci","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Vasile Goldis Western University of Arad, Rebreanu 86, 310414 Arad, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jep.2011.03.073","article-title":"Ethnopharmacological survey and in vitro evaluation of wound-healing plants used in South-western Nigeria","volume":"137","author":"Adetutu","year":"2011","journal-title":"J. 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