{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T10:53:52Z","timestamp":1769079232213,"version":"3.49.0"},"reference-count":16,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T00:00:00Z","timestamp":1606521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Diverse harmful compounds can be emitted during the heating of tobacco sticks for heated tobacco products (HTPs). In this study, the generation of harmful compounds from the filter, instead of tobacco in tobacco sticks, was confirmed. The heat of a heated tobacco product device can be transferred to the tobacco stick filter, resulting in the generation of harmful compounds from the heated filter. Since the heating materials (tobacco consumable) of the tobacco sticks evaluated in this study were different depending on the brand, the harmful compounds emitted from the heated tobacco stick filters were examined by focusing on the carbonyl compounds, using three different tobacco stick parts. Acetaldehyde and propionaldehyde exhibited the highest concentrations in HTP aerosols produced by heating the tobacco consumable (conventional case) (63.5 \u00b1 18.4 \u00b5g\/stick and 1.71 \u00b1 0.123 \u00b5g\/stick, respectively). The aerosols produced by heating tobacco stick filters had higher formaldehyde and acrolein concentrations (0.945 \u00b1 0.214 \u00b5g\/stick and 0.519 \u00b1 0.379 \u00b5g\/stick) than the aerosols generated from heated tobacco consumable (0.641 \u00b1 0.092 \u00b5g\/stick and 0.220 \u00b1 0.102 \u00b5g\/stick). As such, formaldehyde and acrolein were produced by heating small parts of the mouthpiece of a tobacco stick, regardless of the heated tobacco product brand. In addition, acetone was only detected in the aerosols generated from heated filters (0.580 \u00b1 0.305 \u00b5g\/stick). Thus, safety evaluations of heated tobacco products should include considerations of the harmful compounds generated by heating tobacco stick mouthpieces for heated tobacco products in addition to those found in heated tobacco product aerosols.<\/jats:p>","DOI":"10.3390\/molecules25235612","type":"journal-article","created":{"date-parts":[[2020,11,29]],"date-time":"2020-11-29T21:55:31Z","timestamp":1606686931000},"page":"5612","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Carbonyl Compounds Containing Formaldehyde Produced from the Heated Mouthpiece of Tobacco Sticks for Heated Tobacco Products"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5299-3882","authenticated-orcid":false,"given":"Yong-Hyun","family":"Kim","sequence":"first","affiliation":[{"name":"Jeonbuk Department of Inhalation Research, Korea Institute of Toxicology, Jeongeup 56212, Korea"},{"name":"Human and Environmental Toxicology, University of Science and Technology, Daejeon 34113, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Ji","family":"An","sequence":"additional","affiliation":[{"name":"Department of Toxicology Evaluation, Konyang University, Daejeon 35365, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae-Won","family":"Shin","sequence":"additional","affiliation":[{"name":"Jeonbuk Department of Inhalation Research, Korea Institute of Toxicology, Jeongeup 56212, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.amepre.2010.12.007","article-title":"Tracking the rise in popularity of electronic nicotine delivery systems (electronic cigarettes) using search query surveillance","volume":"40","author":"Ayers","year":"2011","journal-title":"Am. 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