{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:46:00Z","timestamp":1790016360997,"version":"4.0.1"},"reference-count":176,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T00:00:00Z","timestamp":1606867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Capsaicin is a widespread spice known for its analgesic qualities. Although a comprehensive body of evidence suggests pleiotropic benefits of capsaicin, including anti-inflammatory, antioxidant, anti-proliferative, metabolic, or cardioprotective effects, it is frequently avoided due to reported digestive side-effects. As the gut bacterial profile is strongly linked to diet and capsaicin displays modulatory effects on gut microbiota, a new hypothesis has recently emerged about its possible applicability against widespread pathologies, such as metabolic and inflammatory diseases. The present review explores the capsaicin\u2013microbiota crosstalk and capsaicin effect on dysbiosis, and illustrates the intimate mechanisms that underlie its action in preventing the onset or development of pathologies like obesity, diabetes, or inflammatory bowel diseases. A possible antimicrobial property of capsaicin, mediated by the beneficial alteration of microbiota, is also discussed. However, as data are coming mostly from experimental models, caution is needed in translating these findings to humans.<\/jats:p>","DOI":"10.3390\/molecules25235681","type":"journal-article","created":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T20:25:49Z","timestamp":1606940749000},"page":"5681","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":90,"title":["Capsaicin and Gut Microbiota in Health and Disease"],"prefix":"10.3390","volume":"25","author":[{"given":"Adrian Eugen","family":"Rosca","sequence":"first","affiliation":[{"name":"Division of Physiology and Neuroscience, Department of Functional Sciences, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of Cardiology, Emergency University Hospital of Bucharest, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9766-1558","authenticated-orcid":false,"given":"Mara Ioana","family":"Iesanu","sequence":"additional","affiliation":[{"name":"Division of Physiology and Neuroscience, Department of Functional Sciences, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of Pediatric Gastroenterology, \u201cMarie Curie\u201d Children\u2019s Clinical Hospital, 041434 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen Denise Mihaela","family":"Zahiu","sequence":"additional","affiliation":[{"name":"Division of Physiology and Neuroscience, Department of Functional Sciences, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzana Elena","family":"Voiculescu","sequence":"additional","affiliation":[{"name":"Division of Physiology and Neuroscience, Department of Functional Sciences, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandru Catalin","family":"Paslaru","sequence":"additional","affiliation":[{"name":"Division of Physiology and Neuroscience, Department of Functional Sciences, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4302-629X","authenticated-orcid":false,"given":"Ana-Maria","family":"Zagrean","sequence":"additional","affiliation":[{"name":"Division of Physiology and Neuroscience, Department of Functional Sciences, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,2]]},"reference":[{"key":"ref_1","unstructured":"Chang, A., Rosani, A., and Quick, J. 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