{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:52:13Z","timestamp":1781650333489,"version":"3.54.5"},"reference-count":97,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T00:00:00Z","timestamp":1607644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015515","name":"Kementerian Pendidikan Malaysia","doi-asserted-by":"publisher","award":["FRGS\/1\/2018\/SKK10\/NRE\/02\/1"],"award-info":[{"award-number":["FRGS\/1\/2018\/SKK10\/NRE\/02\/1"]}],"id":[{"id":"10.13039\/501100015515","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Fungi are a rich source of secondary metabolites with several pharmacological activities such as antifungal, antioxidant, antibacterial and anticancer to name a few. Due to the large number of diverse structured chemical compounds they produce, fungi from the phyla Ascomycota, Basidiomycota and Muccoromycota have been intensively studied for isolation of bioactive compounds. Basidiomycetes-derived secondary metabolites are known as a promising source of antibacterial compounds with activity against Gram-positive bacteria. The continued emergence of antimicrobial resistance (AMR) poses a major challenge to patient health as it leads to higher morbidity and mortality, higher hospital-stay duration and substantial economic burden in global healthcare sector. One of the key culprits for AMR crisis is Staphylococcus aureus causing community-acquired infections as the pathogen develops resistance towards multiple antibiotics. The recent emergence of community strains of S. aureus harbouring methicillin-resistant (MRSA), vancomycin-intermediate (VISA) and vancomycin-resistant (VRSA) genes associated with increased virulence is challenging. Despite the few significant developments in antibiotic research, successful MRSA therapeutic options are still needed to reduce the use of scanty and expensive second-line treatments. This paper provides an overview of findings from various studies on antibacterial secondary metabolites from basidiomycetes, with a special focus on antistaphylococcal activity.<\/jats:p>","DOI":"10.3390\/molecules25245848","type":"journal-article","created":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T00:45:36Z","timestamp":1607906736000},"page":"5848","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["A Review on Antistaphylococcal Secondary Metabolites from Basidiomycetes"],"prefix":"10.3390","volume":"25","author":[{"given":"Vimalah","family":"Vallavan","sequence":"first","affiliation":[{"name":"Center for Diagnostic, Therapeutics &amp; Investigative Studies, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6593-7951","authenticated-orcid":false,"given":"Getha","family":"Krishnasamy","sequence":"additional","affiliation":[{"name":"Bioactivity Program, Natural Products Division, Forest Research Institute Malaysia (FRIM), Kepong 52109, Selangor, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noraziah Mohamad","family":"Zin","sequence":"additional","affiliation":[{"name":"Center for Diagnostic, Therapeutics &amp; Investigative Studies, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazlyzam","family":"Abdul Latif","sequence":"additional","affiliation":[{"name":"Center for Toxicology and Health Risk Studies, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,11]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2020, September 22). WHO Report on Surveillance of Antibiotic Consumption: 2016\u20132018 Early Implementation. Available online: https:\/\/www.who.int\/medicines\/areas\/rational_use\/oms-amr-amc-report-2016-2018\/en\/."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1469-0691.2011.03570.x","article-title":"Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: An international expert proposal for interim standard definitions for acquired resistance","volume":"18","author":"Magiorakos","year":"2012","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/4065603","article-title":"Multidrug resistant and extensively drug resistant bacteria: A study","volume":"2016","author":"Basak","year":"2016","journal-title":"J. Pathog."},{"key":"ref_4","unstructured":"Health Research & Educational Trust (2020, September 20). Multi-Drug Resistant Organism Infection Change Package: 2017 Update. Chicago. Available online: www.hret-hiin.org."},{"key":"ref_5","unstructured":"World Bank (2020, September 22). Drug-Resistant Infections: A Threat to Our Economic Future: Washington, DC, 2017. Available online: https:\/\/documents.worldbank.org\/curated\/en\/323311493396993758\/."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/S0140-6736(15)00474-2","article-title":"Access to effective antimicrobials: A worldwide challenge","volume":"387","author":"Laxminarayan","year":"2016","journal-title":"Lancet"},{"key":"ref_7","first-page":"974","article-title":"Prevalence of Methicillin, Vancomycin and Multidrug Resistance among Staphylococcus aureus","volume":"6","author":"Dhanalakshmi","year":"2012","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_8","first-page":"226","article-title":"On the antibacterial action of cultures of a penicillium with, special reference to their use in the isolation of B. influenzae","volume":"10","author":"Fleming","year":"1929","journal-title":"Br. J. Exp. Pathol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Bills, G.F., and Gloer, J.B. (2017). Biologically active secondary metabolites from the fungi. Fungal Kingd., 1087\u20131119.","DOI":"10.1128\/9781555819583.ch54"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Betts, J.W., and Wareham, D.W. (2014). In vitro activity of curcumin in combination with epigallocatechin gallate (EGCG) versus multidrug-resistant Acinetobacter baumannii. BMC Microbiol., 14.","DOI":"10.1186\/1471-2180-14-172"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Stodulkova, E., Cisarova, I., Kolarik, M., Chudickova, M., Novak, P., Man, P., and Flieger, M. (2015). Biologically active metabolites produced by the basidiomycete Quambalaria cyanescens. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0118913"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"492","DOI":"10.3109\/13880209.2010.526616","article-title":"Evaluation of antibacterial activity of Australian basidiomycetous macrofungi using a high-throughput 96-well plate assay","volume":"49","author":"Bala","year":"2011","journal-title":"Pharm. Biol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/j.1365-2672.2012.05347.x","article-title":"Antimicrobial activity of wild mushroom extracts against clinical isolates resistant to different antibiotics","volume":"113","author":"Alves","year":"2012","journal-title":"J. Appl. Microbiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13225-013-0265-2","article-title":"Bioactive metabolites from macrofungi: Ethnopharmacology, biological activities and chemistry","volume":"62","author":"Rapior","year":"2013","journal-title":"Fungal Divers."},{"key":"ref_15","first-page":"298","article-title":"Evaluation of Ganoderma lucidum strains for the production of bioactive components and their potential use as antimicrobial agents","volume":"7","author":"Kaur","year":"2015","journal-title":"J. Appl. Nat. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1615\/IntJMedMushr.v12.i1.10","article-title":"Medicinal mushroom science: History, current status, future trends, and unsolved problems","volume":"12","author":"Wasser","year":"2010","journal-title":"Int. J. Med. Mushroooms"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Beni, Z., Dekany, M., Kovacs, B., Csupor-Loffler, B., Zomborszki, Z.P., Kerekes, E., and Vanyolos, A. (2018). Bioactivity-guided isolation of antimicrobial and antioxidant metabolites from the mushroom Tapinella atrotomentosa. Molecules, 23.","DOI":"10.3390\/molecules23051082"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nature14098","article-title":"A new antibiotic kills pathogens without detectable resistance","volume":"517","author":"Ling","year":"2015","journal-title":"Nature"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Lindequist, U., Niedermeyer, T.H., and Julich, W.D. (2005). The pharmacological potential of mushrooms. Evid. Based Complement. Altern. Med., 2.","DOI":"10.1093\/ecam\/neh107"},{"key":"ref_20","unstructured":"Cecchini, M., Langer, J., and Slawomirski, L. (2015). Antimicrobial Resistance in G7 Countries and Beyond: Economic Issues, Policies and Options for Action, Organization for Economic Co-operation and Development."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/S0140-6736(15)00547-4","article-title":"Maximising access to achieve appropriate human antimicrobial use in low-income and middle-income countries","volume":"387","author":"Mendelson","year":"2016","journal-title":"Lancet"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1086\/513938","article-title":"Antimicrobial susceptibility testing: General principles and contemporary practices","volume":"26","author":"Jorgensen","year":"1998","journal-title":"Clin. Infect. Dis."},{"key":"ref_23","unstructured":"CLSI (2017). Performance Standards for Antimicrobial Susceptibility Testing, Clinical and Laboratory Standards Institute. [27th ed.]."},{"key":"ref_24","unstructured":"The European Committee on Antimicrobial Susceptibility Testing (2020). Breakpoint Tables for Interpretation of MICs and Zone Diameters, Available online: http:\/\/www.eucast.org."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1080\/13880200701575189","article-title":"Antibacterial activity in higher fungi (mushrooms) and endophytic fungi from Slovenia","volume":"45","author":"Janes","year":"2007","journal-title":"Pharm. Biol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1080\/13880200902950801","article-title":"Antimicrobial activity of ethanol extracts of Agaricus brasiliensis against mutants streptococci","volume":"47","author":"Lund","year":"2009","journal-title":"Pharm. Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"50","DOI":"10.22159\/ijpps.2018v10i8.26527","article-title":"Anti-MRSA of the ethyl acetate crude extract from Lasiodiplodia pseudotheobromae IBRL OS-64, an endophytic fungus isolated from leaf of Ocimum sanctum Linn","volume":"10","author":"Taufiq","year":"2018","journal-title":"Int. J. Pharm. Pharm. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.micpath.2016.02.009","article-title":"Breakthroughs in bacterial resistance mechanisms and the potential ways to combat them","volume":"95","author":"Khameneh","year":"2016","journal-title":"Microb. Pathog."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"779","DOI":"10.3389\/fmicb.2014.00779","article-title":"Antibiotic-specific differences in the response of Staphylococcus aureus to treatment with antimicrobials combined with manuka honey","volume":"5","author":"Liu","year":"2015","journal-title":"Front. Microbiol."},{"key":"ref_30","first-page":"1","article-title":"Antimicrobial resistance of Staphylococcus aureus isolates in Malaysian Tertiary Hospital","volume":"22","author":"Hassan","year":"2015","journal-title":"Int. Med. J."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13225-019-00430-9","article-title":"The amazing potential of fungi: 50 ways we can exploit fungi industrially","volume":"97","author":"Hyde","year":"2019","journal-title":"Fungal Divers."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.3389\/fimmu.2018.01830","article-title":"Aspects of gut microbiota and immune system interactions in infectious diseases, immunopathology, and cancer","volume":"9","author":"Lazar","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_33","first-page":"261","article-title":"The challenge of antibiotic-resistant Staphylococcus: Lessons from hospital nurseries in the mid-20th century","volume":"86","author":"Shaffer","year":"2013","journal-title":"Yale J. Biol. Med."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Adhikari, R., Pant, N.D., Neupane, S., Neupane, M., Bhattarai, R., Bhatta, S., and Lekhak, B. (2017). Detection of methicillin resistant Staphylococcus aureus and determination of minimum inhibitory concentration of vancomycin for Staphylococcus aureus isolated from pus\/wound swab samples of the patients attending a tertiary care hospital in Kathmandu, Nepal. Can. J. Infect. Dis. Med. Microbiol.","DOI":"10.1155\/2017\/2191532"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.18203\/2320-6012.ijrms20172085","article-title":"Prevalence of Methicillin-resistant Staphylococcus aureus (MRSA) infections among patients admitted in critical care units in a tertiary care hospital","volume":"5","author":"Arunkumar","year":"2017","journal-title":"Int. J. Res. Med. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0924-8579(98)00087-9","article-title":"Comparative efficacies of levofloxacin and ciprofloxacin against Streptococcus pneumoniae in a mouse model of experimental septicaemia","volume":"12","author":"Onyeji","year":"1999","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.ijantimicag.2007.07.011","article-title":"Reduced glycopeptide susceptibility in methicillin-resistant Staphylococcus aureus (MRSA)","volume":"30","author":"Appelbaum","year":"2007","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s13059-017-1252-9","article-title":"Methicillin-resistant Staphylococcus aureus emerged long before the introduction of methicillin into clinical practice","volume":"18","author":"Harkins","year":"2017","journal-title":"Genome Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"275","DOI":"10.4103\/0974-777X.68535","article-title":"Methicillin and vancomycin resistant S. aureus in hospitalized patients","volume":"2","author":"Loomba","year":"2010","journal-title":"J. Glob. Infect. Dis."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3934\/microbiol.2019.2.117","article-title":"Methicillin-resistant Staphylococcus aureus (MRSA) and anti-MRSA activities of extracts of some medicinal plants: A brief review","volume":"5","author":"Okwu","year":"2019","journal-title":"AIMS Microbiol."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Morales, E., Cots, F., Sala, M., Comas, M., Belvis, F., Riu, M., Salvado, M., Grau, S., and Horcajada, J. (2012). Hospital costs of nosocomial multi-drug resistant Pseudomonas aeruginosa acquisition. BMC Health Serv. Res., 12.","DOI":"10.1186\/1472-6963-12-122"},{"key":"ref_42","first-page":"9","article-title":"Burn wound infections and antibiotic susceptibility patterns at Pakistan Institute of Medical Sciences, Islamabad, Pakistan","volume":"4","author":"Saaiq","year":"2015","journal-title":"World J. Plastic Surg."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12879-017-2384-y","article-title":"Prevalence of methicillin-resistant Staphylococcus aureus (MRSA) infection and the molecular characteristics of MRSA bacteraemia over a two-year period in a tertiary teaching hospital in Malaysia","volume":"17","author":"Sit","year":"2017","journal-title":"BMC Infect. Dis."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.ijantimicag.2011.09.030","article-title":"Methicillin-resistant Staphylococcus aureus (MRSA): Global epidemiology and harmonisation of typing methods","volume":"39","author":"Stefani","year":"2012","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1093\/jac\/dkr024","article-title":"Spread of methicillin-resistant Staphylococcus aureus between the community and the hospitals in Asian countries: An ANSORP study","volume":"66","author":"Song","year":"2011","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/jac\/40.1.135","article-title":"Methicillin-resistant Staphylococcus aureus clinical strain with reduced vancomycin susceptibility","volume":"40","author":"Hiramatsu","year":"1997","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_47","unstructured":"Centers for Disease Control and Prevention (2002). Staphylococcus aureus resistant to vancomycin\u2014United States, 2002. MMWR Morb. Mortal. Wkly. Rep, 51, 565\u2013567."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1128\/CMR.00042-09","article-title":"Reduced vancomycin susceptibility in Staphylococcus aureus, including vancomycin-intermediate and heterogeneous vancomycin-intermediate strains: Resistance mechanisms, laboratory detection, and clinical implications","volume":"23","author":"Howden","year":"2010","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"309","DOI":"10.4103\/ijdvl.IJDVL_158_18","article-title":"In response to \u201cEffectiveness of topical green tea against multidrug-resistant Staphylococcus aureus in cases of primary pyoderma: An open controlled trial\u201d","volume":"84","author":"Bandyopadhyay","year":"2018","journal-title":"Indian J. Dermatol. Venereol. Leprol."},{"key":"ref_50","first-page":"10","article-title":"Occurrence of methicillin and vancomycin resistant Staphylococcus aureus in University of Abuja Teaching Hospital, Abuja, Nigeria","volume":"14","author":"Akanbi","year":"2013","journal-title":"Afr. J. Clin. Exp. Microbiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"358","DOI":"10.4103\/0256-4947.67077","article-title":"Methicillin-resistant Staphylococcus aureus nosocomial infection trends in Hospital Universiti Sains Malaysia during 2002-2007","volume":"30","author":"Yean","year":"2010","journal-title":"Ann. Saudi Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s00281-011-0295-3","article-title":"Neutrophils in innate host defense against Staphylococcus aureus infections","volume":"34","author":"Rigby","year":"2012","journal-title":"Semin. Immunopathol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1086\/317542","article-title":"Vancomycin-intermediate and-resistant Staphylococcus aureus: What the infectious disease specialist needs to know","volume":"32","author":"Weinstein","year":"2001","journal-title":"Clin. Infect. Dis."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.1172\/JCI68834","article-title":"Mechanisms of vancomycin resistance in Staphylococcus aureus","volume":"124","author":"Gardete","year":"2014","journal-title":"J. Clin. Investig."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"29","DOI":"10.4103\/0973-7847.156329","article-title":"Antibiotics and bioactive natural products in treatment of methicillin resistant Staphylococcus aureus: A brief review","volume":"9","author":"Kali","year":"2015","journal-title":"Pharmacogn. Rev."},{"key":"ref_56","unstructured":"Mc Nultty, C., Rodgers, G.L., and Mortenson, J.E. (2004). An overview of the topical antimicrobial agents used in the treatment of burn wounds. Contin. Edu. Top., 74\u201378."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1039\/C005001F","article-title":"Marine natural products","volume":"28","author":"Blunt","year":"2011","journal-title":"Nat. Prod. Rep."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s13225-010-0020-x","article-title":"Diversity and potential antifungal properties of fungi associated with a Mediterranean sponge","volume":"42","author":"Paz","year":"2010","journal-title":"Fungal Divers"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1039\/c0np00061b","article-title":"Secondary metabolites of fungi from marine habitats","volume":"28","author":"Rateb","year":"2011","journal-title":"Nat. Prod. Rep."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/S0040-4020(01)99267-1","article-title":"The structure of fusidic acid","volume":"18","author":"Godtfredsen","year":"1962","journal-title":"Tetrahedron"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1136\/bmj.1.5333.788","article-title":"Treatment of staphylococcal infections with \u201cfucidin\u201d","volume":"1","author":"Crosbie","year":"1963","journal-title":"Br. Med. J."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1073\/pnas.37.9.570","article-title":"Antibiotic substances from basidiomycetes: VIII. Pleurotus multilus (Fr.) Sacc. and Pleurotus passeckerianus Pilat","volume":"37","author":"Kavanagh","year":"1951","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1590\/S0074-02762003000700019","article-title":"Screening of Brazilian basidiomycetes for antimicrobial activity","volume":"98","author":"Rosa","year":"2003","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.phymed.2008.06.008","article-title":"Synergism between natural products and antibiotics against infectious diseases","volume":"15","author":"Hemaiswarya","year":"2008","journal-title":"Phytomedicine"},{"key":"ref_65","first-page":"1","article-title":"Submerged cultivation of basidiomycete fungi associated with root diseases for production of valuable bioactive metabolites","volume":"21","author":"Getha","year":"2009","journal-title":"J. Trop. For. Sci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1615\/IntJMedMushr.v3.i2-3.90","article-title":"Antimicrobial Activity of Basidiomycetes","volume":"3","author":"Smania","year":"2001","journal-title":"Int. J. Med. Mushroooms"},{"key":"ref_67","first-page":"9","article-title":"Evaluation of antibacterial activity of different Ganoderma lucidum extracts","volume":"3","author":"Quereshi","year":"2010","journal-title":"J. Sci. Res."},{"key":"ref_68","first-page":"371","article-title":"Current techniques for the cultivation of Ganoderma lucidum for the production of biomass, ganoderic acid and polysaccharides","volume":"41","author":"Wagner","year":"2003","journal-title":"Food Technol. Biotechnol."},{"key":"ref_69","first-page":"249","article-title":"Taxonomy and diversity of Ganoderma from the Western parts of Maharashtra (India)","volume":"1","author":"Bhosle","year":"2010","journal-title":"Mycosphere"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1002\/cbdv.201400004","article-title":"New triterpenoids from the fruiting bodies of Ganoderma lucidum and their bioactivities","volume":"11","author":"Liu","year":"2014","journal-title":"Chem. Biodivers."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1021\/np990381y","article-title":"Ganomycins A and B, new antimicrobial farnesyl hydroquinones from the basidiomycete Ganoderma pfeifferi","volume":"63","author":"Mothana","year":"2000","journal-title":"J. Nat. Prod."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.foodchem.2017.10.088","article-title":"Multifunctions of Pleurotus sajor-caju (Fr.) Singer: A highly nutritious food and a source for bioactive compounds","volume":"245","author":"Finimundy","year":"2018","journal-title":"Food Chem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"3653","DOI":"10.3390\/molecules17043653","article-title":"In vitro antimicrobial and antioxidant activities of ethanolic extract of lyophilized mycelium of Pleurotus ostreatus PQMZ91109","volume":"17","author":"Vamanu","year":"2012","journal-title":"Molecules"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1089\/jmf.2009.0090","article-title":"Antimicrobial and antioxidant activities of mycelia of 10 wild mushroom species","volume":"13","author":"Kalyoncu","year":"2010","journal-title":"J. Med. Food"},{"key":"ref_75","first-page":"79","article-title":"In-vitro antimicrobial activity of ethyl acetate extract of two common edible mushrooms","volume":"5","author":"Roy","year":"2016","journal-title":"J. Pharmacol."},{"key":"ref_76","first-page":"1637","article-title":"Antibacterial activity of methanolic extract of basidiomycetes","volume":"22","author":"Karthiga","year":"2010","journal-title":"Asian J. Chem."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1021\/acs.jnatprod.5b00950","article-title":"Laxitextines A and B, cyathane xylosides from the tropical fungus Laxitextum incrustatum","volume":"79","author":"Mudalungu","year":"2016","journal-title":"J. Nat. Prod."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1021\/acs.jnatprod.7b00525","article-title":"Anti-Staphylococcal Calopins from Fruiting Bodies of Caloboletus radicans","volume":"81","author":"Tareq","year":"2018","journal-title":"J. Nat. Prod."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.foodchem.2013.07.124","article-title":"New benzoate derivatives and hirsutane type sesquiterpenoids with antimicrobial activity and cytotoxicity from the solid-state fermented rice by the medicinal mushroom Stereum hirsutum","volume":"143","author":"Ma","year":"2014","journal-title":"Food Chem."},{"key":"ref_80","first-page":"861","article-title":"Antibacterial and antifungal activities of culture filtrate extract of Pyrofomes demidoffii (Basidiomycete)","volume":"10","author":"Bitew","year":"2010","journal-title":"World Appl. Sci. J."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4172\/2254-609X.100063","article-title":"Antimicrobial activity of mushroom (Agaricus bisporus) and fungal (Trametes gibbosa) extracts from mushrooms and fungi of egerton main campus, Njoro Kenya","volume":"6","author":"Waithaka","year":"2017","journal-title":"J. Biomed. Sci."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"72","DOI":"10.2174\/138620711794474079","article-title":"Screening of antioxidant, antimicrobial activities and chemical contents of edible mushrooms wildly grown in the Black Sea region of Turkey","volume":"14","author":"Ozen","year":"2011","journal-title":"Comb. Chem. High Throughput Screen."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"707","DOI":"10.3109\/13880209.2013.764327","article-title":"Antimicrobial activities of some mushrooms in Turkey","volume":"51","author":"Dogan","year":"2013","journal-title":"Pharm. Biol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"977","DOI":"10.5897\/AJMR2016.8052","article-title":"Antibacterial properties of wild edible and non-edible mushrooms found in Zimbabwe","volume":"10","author":"Reid","year":"2016","journal-title":"Afr. J. Microbiol. Res."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Gebreyohannes, G., Nyerere, A., Bii, C., and Sbhatu, D.B. (2019). Investigation of Antioxidant and Antimicrobial Activities of Different Extracts of Auricularia and Termitomyces Species of Mushrooms. Sci. World J.","DOI":"10.1155\/2019\/7357048"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.indcrop.2015.10.030","article-title":"Antibacterial and cytotoxic activities of wild mushroom Fomes fomentarius (L.) Fr., Polyporaceae","volume":"79","author":"Kolundzic","year":"2016","journal-title":"Ind. Crops Prod."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.foodres.2014.11.035","article-title":"Biological potential of extracts of the wild edible Basidiomycete mushroom Grifola frondosa","volume":"67","author":"Klaus","year":"2015","journal-title":"Food Res. Int."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Gebreyohannes, G., Nyerere, A., Bii, C., and Sbhatu, D.B. (2019). Determination of antimicrobial activity of extracts of indigenous wild mushrooms against pathogenic organisms. Evid. Based Complement. Altern. Med., 2019.","DOI":"10.1155\/2019\/6212673"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Ogidi, O.C., Oyetayo, V.O., and Akinyele, B.J. (2015). In vitro evaluation of antimicrobial efficacy of extracts obtained from raw and fermented wild macrofungus, Lenzites quercina. Int. J. Microbiol.","DOI":"10.1155\/2015\/106308"},{"key":"ref_90","first-page":"508","article-title":"Antibacterial Bioactive Compound from The Fungus Drechslera Halodes (Drechsler) Subram. Jain Isolated from Soil of Basrah, Iraq","volume":"1","author":"Muhsin","year":"2013","journal-title":"Sci. J. Univ. Zakho"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.phytochem.2013.10.004","article-title":"Antimicrobial and cytotoxic secondary metabolites from tropical leaf endophytes: Isolation of antibacterial agent pyrrocidine C from Lewia infectoria SNB-GTC2402","volume":"96","author":"Casella","year":"2013","journal-title":"Phytochemistry"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.phytochem.2010.03.016","article-title":"Antibacterial metabolites from Australian macrofungi from the genus Cortinarius","volume":"71","author":"Beattie","year":"2010","journal-title":"Phytochemistry"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1086\/595857","article-title":"Changing epidemiology of antimicrobial-resistant Streptococcus pneumoniae in the United States, 2004\u20132005","volume":"48","author":"Richter","year":"2009","journal-title":"Clin. Infect. Dis."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1177\/0748233712463775","article-title":"Antioxidant activity via DPPH, gram-positive and gram-negative antimicrobial potential in edible mushrooms","volume":"30","author":"Ahmad","year":"2014","journal-title":"Toxicol. Ind. Health"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1007\/s13197-012-0656-5","article-title":"Important nutritional constituents, flavour components, antioxidant and antibacterial properties of Pleurotus sajor-caju","volume":"51","author":"Gogavekar","year":"2014","journal-title":"J. Food Sci. Technol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"4812","DOI":"10.5897\/AJMR2013.5841","article-title":"Antimicrobial screening of crude extracts from the indigenous Ganoderma lucidum mushrooms in Namibia","volume":"7","author":"Shikongo","year":"2013","journal-title":"Afr. J. Microbiol. Res."},{"key":"ref_97","first-page":"188","article-title":"Analysis on essential fatty acid esters of mushroom Pleurotus eous and its antibacterial activity","volume":"6","author":"Suseem","year":"2013","journal-title":"Asian J. Pharm. Clin. Res."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/25\/24\/5848\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:43:39Z","timestamp":1760179419000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/25\/24\/5848"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,11]]},"references-count":97,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2020,12]]}},"alternative-id":["molecules25245848"],"URL":"https:\/\/doi.org\/10.3390\/molecules25245848","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,11]]}}}