{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T13:44:16Z","timestamp":1779889456324,"version":"3.53.1"},"reference-count":53,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T00:00:00Z","timestamp":1607990400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A polyolefin with certified biocompatibility according to USP class VI was used by our group as feedstock for filament-based 3D printing to meet the highest medical standards in order to print personal protective equipment for our university hospital during the ongoing pandemic. Besides the chemical resistance and durability, as well as the ability to withstand steam sterilization, this polypropylene (PP) copolymer is characterized by its high purity, as achieved by highly efficient and selective catalytic polymerization. As the PP copolymer is suited to be printed with all common printers in fused filament fabrication (FFF), it offers an eco-friendly cost\u2013benefit ratio, even for large-scale production. In addition, a digital workflow was established focusing on common desktop FFF printers in the medical sector. It comprises the simulation-based optimization of personalized print objects, considering the inherent material properties such as warping tendency, through to validation of the process chain by 3D scanning, sterilization, and biocompatibility analysis of the printed part. This combination of digital data processing and 3D printing with a sustainable and medically certified material showed great promise in establishing decentralized additive manufacturing in everyday hospital life to meet peaks in demand, supply bottlenecks, and enhanced personalized patient treatment.<\/jats:p>","DOI":"10.3390\/molecules25245929","type":"journal-article","created":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T09:12:57Z","timestamp":1608023577000},"page":"5929","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Pandemic-Driven Development of a Medical-Grade, Economic and Decentralized Applicable Polyolefin Filament for Additive Fused Filament Fabrication"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0011-4134","authenticated-orcid":false,"given":"Felix","family":"Burkhardt","sequence":"first","affiliation":[{"name":"Center for Dental Medicine, Department of Prosthetic Dentistry, Faculty of Medicine, University of Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8631-6038","authenticated-orcid":false,"given":"Carl G.","family":"Schirmeister","sequence":"additional","affiliation":[{"name":"Freiburg Materials Research Center FMF and Institute for Macromolecular Chemistry, Albert-Ludwigs-University Freiburg, Stefan-Meier-Str. 21, 79104 Freiburg, Germany"},{"name":"Basell Sales &amp; Marketing B.V., LyondellBasell Industries, Industriepark H\u00f6chst, 65926 Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9158-3015","authenticated-orcid":false,"given":"Christian","family":"Wesemann","sequence":"additional","affiliation":[{"name":"Center for Dental Medicine, Department of Prosthetic Dentistry, Faculty of Medicine, University of Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Nutini","sequence":"additional","affiliation":[{"name":"Basell Poliolefine Italia Srl, LyondellBasell Industries, P. le Privato G. Donegani 12, 44122 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0061-8612","authenticated-orcid":false,"given":"Stefano","family":"Pieralli","sequence":"additional","affiliation":[{"name":"Center for Dental Medicine, Department of Prosthetic Dentistry, Faculty of Medicine, University of Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4115-1839","authenticated-orcid":false,"given":"Erik H.","family":"Licht","sequence":"additional","affiliation":[{"name":"Basell Sales &amp; Marketing B.V., LyondellBasell Industries, Industriepark H\u00f6chst, 65926 Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4893-7594","authenticated-orcid":false,"given":"Marc","family":"Metzger","sequence":"additional","affiliation":[{"name":"Center of Dental Medicine, Department of Oral and Maxillofacial Surgery, University of Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Wenz","sequence":"additional","affiliation":[{"name":"Board of Directors, Faculty of Medicine, University of Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"M\u00fclhaupt","sequence":"additional","affiliation":[{"name":"Freiburg Materials Research Center FMF and Institute for Macromolecular Chemistry, Albert-Ludwigs-University Freiburg, Stefan-Meier-Str. 21, 79104 Freiburg, Germany"},{"name":"Sustainability Center Freiburg, Ecker-Str. 4, 79104 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1702-1679","authenticated-orcid":false,"given":"Benedikt C.","family":"Spies","sequence":"additional","affiliation":[{"name":"Center for Dental Medicine, Department of Prosthetic Dentistry, Faculty of Medicine, University of Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"106054","DOI":"10.1016\/j.ijantimicag.2020.106054","article-title":"Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2): A global pandemic and treatment strategies","volume":"56","author":"Sharma","year":"2020","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1111\/risa.13500","article-title":"Consideration of the aerosol transmission for COVID-19 and public health","volume":"40","author":"Anderson","year":"2020","journal-title":"Risk Anal."},{"key":"ref_3","first-page":"1","article-title":"Aerosol-generating otolaryngology procedures and the need for enhanced PPE during the COVID-19 pandemic: A literature review","volume":"49","author":"Mick","year":"2020","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1631\/jzus.B2010010","article-title":"Possible aerosol transmission of COVID-19 and special precautions in dentistry","volume":"21","author":"Ge","year":"2020","journal-title":"J. Zhejiang Univ. Sci. B"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1016\/S0140-6736(20)31142-9","article-title":"Physical distancing, face masks, and eye protection to prevent person-to-person transmission of SARS-CoV-2 and COVID-19: A systematic review and meta-analysis","volume":"395","author":"Chu","year":"2020","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.matdes.2015.06.053","article-title":"Fused deposition modeling with polypropylene","volume":"83","author":"Carneiro","year":"2015","journal-title":"Mater. Des."},{"key":"ref_7","first-page":"152","article-title":"3D printing of high density polyethylene by fused filament fabrication","volume":"28","author":"Schirmeister","year":"2019","journal-title":"Addit. Manuf."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"10212","DOI":"10.1021\/acs.chemrev.7b00074","article-title":"Polymers for 3D printing and customized additive manufacturing","volume":"117","author":"Ligon","year":"2017","journal-title":"Chem. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"5340616","DOI":"10.1155\/2019\/5340616","article-title":"The role of 3D printing in medical applications: A state of the art","volume":"2019","author":"Aimar","year":"2019","journal-title":"J. Healthc. Eng."},{"key":"ref_10","unstructured":"Crump, S.S. (1992). Apparatus and Method for Creating Three-Dimensional Objects. (US5121329A)."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ejps.2015.11.005","article-title":"Ethylene vinyl acetate (EVA) as a new drug carrier for 3D printed medical drug delivery devices","volume":"90","author":"Genina","year":"2016","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Tan, D., Maniruzzaman, M., and Nokhodchi, A. (2018). Advanced pharmaceutical applications of hot-melt extrusion coupled with fused deposition modelling (FDM) 3D printing for personalised drug delivery. Pharmaceutics, 10.","DOI":"10.3390\/pharmaceutics10040203"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Jeong, H.M., Weon, K.-Y., Shin, B.S., and Shin, S. (2020). 3D-Printed gastroretentive sustained release drug delivery system by applying design of experiment approach. Molecules, 25.","DOI":"10.3390\/molecules25102330"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ejpb.2017.02.014","article-title":"Assessment of different polymers and drug loads for fused deposition modeling of drug loaded implants","volume":"115","author":"Kempin","year":"2017","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Chaudhari, V.S., Malkar, T.K., Murty, U.S., and Banerjee, S. (2020). Extruded filaments derived 3D printed medicated skin patch to mitigate destructive pulmonary tuberculosis: Design to delivery. Expert Opin. Drug Deliv.","DOI":"10.1080\/17425247.2021.1845648"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Pieralli, S., Spies, B.C., Hromadnik, V., Nicic, R., Beuer, F., and Wesemann, C. (2020). How accurate is oral implant installation using surgical guides printed from a degradable and steam-sterilized biopolymer?. J. Clin. Med., 9.","DOI":"10.3390\/jcm9082322"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Wesemann, C., Pieralli, S., Fretwurst, T., Nold, J., Nelson, K., Schmelzeisen, R., Hellwig, E., and Spies, B.C. (2020). 3-D printed protective equipment during COVID-19 pandemic. Materials, 13.","DOI":"10.3390\/ma13081997"},{"key":"ref_18","first-page":"183","article-title":"Use of free CAD software for 3D printing individualized face masks based on face scans","volume":"23","author":"Cortes","year":"2020","journal-title":"Int. J. Comput. Dent."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1080\/17452759.2016.1274490","article-title":"A review on composite materials and process parameters optimisation for the fused deposition modelling process","volume":"12","author":"Mohan","year":"2017","journal-title":"Virtual Phys. Prototyp."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1080\/10408436.2018.1549977","article-title":"Process-Structure-Properties in Polymer Additive Manufacturing via Material Extrusion: A Review","volume":"45","author":"Goh","year":"2020","journal-title":"Crit. Rev. Solid State Mater. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1108\/RPJ-06-2014-0076","article-title":"Wear behavior of FDM parts fabricated by composite material feed stock filament","volume":"22","author":"Singh","year":"2016","journal-title":"Rapid Prototyp. J."},{"key":"ref_22","unstructured":"(2020, October 28). Solvay. Available online: https:\/\/www.solvay.com\/en\/chemical-categories\/specialty-polymers\/additive-manufacturing."},{"key":"ref_23","unstructured":"(2020, October 28). Vestakeep PEEK. Available online: https:\/\/medical.evonik.com\/product\/peek-industrial\/downloads\/vestakeep-polymers-for-medical-applications-en.pdf."},{"key":"ref_24","unstructured":"(2020, October 25). Fibre Tuff II. Available online: https:\/\/img1.wsimg.com\/blobby\/go\/4fc374e5-752e-4d9c-9806-458efb923e97\/downloads\/FibreTuff%20II%20Data%20Sheet.pdf?ver=1603046414315."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1021\/acs.chemrev.5b00310","article-title":"From multisite polymerization catalysis to sustainable materials and all-polyolefin composites","volume":"116","author":"Mihan","year":"2016","journal-title":"Chem. Rev."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/macp.201200439","article-title":"Green polymer chemistry and bio-based plastics: Dreams and reality","volume":"214","year":"2013","journal-title":"Macromol. Chem. Phys."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"6","DOI":"10.5923\/j.ijbe.20110101.02","article-title":"A review of the history and role of UHMWPE as a component in total joint replacements","volume":"1","author":"Musib","year":"2012","journal-title":"Int. J. Biol. Eng."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Malpass, D.B. (2010). Introduction to Industrial Polyethylene: Properties, Catalysts, Processes, Scrivener, Wiley.","DOI":"10.1002\/9780470900468"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Malpass, D.B., and Band, E.I. (2012). Introduction to Industrial Polypropylene: Properties, Catalysts, Processes, John Wiley & Sons.","DOI":"10.1002\/9781118463215"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Ehrenstein, G.W. (2011). Polymer-Werkstoffe: Struktur\u2014Eigenschaften\u2014Anwendung, Hanser. [3rd ed.].","DOI":"10.1007\/978-3-446-42967-3"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"8264","DOI":"10.1021\/es101640n","article-title":"Sustainability metrics: Life cycle assessment and green design in polymers","volume":"44","author":"Tabone","year":"2010","journal-title":"Environ. Sci. Technol."},{"key":"ref_32","unstructured":"(2020, October 20). LyonellBasell. Available online: https:\/\/www.lyondellbasell.com\/en\/news-events\/corporate--financial-news\/lyondellbasell-successfully-starts-up-new-pilot-molecular-recycling-facility\/."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1007\/s00170-006-0556-9","article-title":"A model research for prototype warp deformation in the FDM process","volume":"33","author":"Wang","year":"2007","journal-title":"Int. J. Adv. Manuf. Technol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"48545","DOI":"10.1002\/app.48545","article-title":"Material extrusion-based additive manufacturing of polypropylene: A review on how to improve dimensional inaccuracy and warpage","volume":"137","author":"Spoerk","year":"2020","journal-title":"J. Appl. Polym. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.compositesa.2018.06.018","article-title":"Anisotropic properties of oriented short carbon fibre filled polypropylene parts fabricated by extrusion-based additive manufacturing","volume":"113","author":"Spoerk","year":"2018","journal-title":"Compos. Part A Appl. Sci. Manuf."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1700143","DOI":"10.1002\/mame.201700143","article-title":"Shrinkage and warpage optimization of expanded-perlite-filled polypropylene composites in extrusion-based additive manufacturing","volume":"302","author":"Spoerk","year":"2017","journal-title":"Macromol. Mater. Eng."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.polymer.2017.02.055","article-title":"Effect of fused layer modeling (FLM) processing parameters on impact strength of cellular polypropylene","volume":"113","author":"Wang","year":"2017","journal-title":"Polymer"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1108\/RPJ-02-2013-0017","article-title":"A review of melt extrusion additive manufacturing processes: II. Materials, dimensional accuracy, and surface roughness","volume":"21","author":"Turner","year":"2015","journal-title":"Rapid Prototyp. J."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.procir.2015.12.078","article-title":"Compensating warpage of 3D printed parts using free-form deformation","volume":"41","author":"Schmutzler","year":"2016","journal-title":"Procedia CIRP"},{"key":"ref_40","unstructured":"(2020, November 18). USP Class VI, Chapter 88. Available online: http:\/\/www.uspbpep.com\/usp29\/v29240\/usp29nf24s0_c88.html."},{"key":"ref_41","unstructured":"(2020, October 24). Prusa Printers. Available online: https:\/\/www.prusaprinters.org\/de\/prints\/25857-prusa-face-shield."},{"key":"ref_42","unstructured":"Wunderlich, B. (2014). Thermal Aanalysis TX Z, Elsevier Science."},{"key":"ref_43","unstructured":"ISO 9001 (2020, November 12). Quality Management Systems\u2014Requirements. Available online: https:\/\/www.iso.org\/standard\/62085.html."},{"key":"ref_44","unstructured":"ISO 13485 (2020, November 12). Medical Devices\u2014Quality Management Systems\u2014Requirements for Regulatory Purposes. Available online: https:\/\/www.iso.org\/standard\/59752.html."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1111\/cts.12315","article-title":"Regulatory considerations in the design and manufacturing of implanTable 3D-printed medical devices: Regulatory considerations of 3D-printed implants","volume":"8","author":"Morrison","year":"2015","journal-title":"Clin. Transl. Sci."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Drossel, W.-G., Ihlemann, J., Landgraf, R., Oelsch, E., and Schmidt, M. (2020). Basic research for additive manufacturing of rubber. Polymers, 12.","DOI":"10.3390\/polym12102266"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1177\/0731684414522536","article-title":"Production of graded porous polyamide structures and polyamide-epoxy composites via selective laser sintering","volume":"33","author":"Jande","year":"2014","journal-title":"J. Reinf. Plast. Comp."},{"key":"ref_48","unstructured":"ISO 10993-1 (2020, November 12). Biological Evaluation of Medical Devices. Available online: https:\/\/www.iso.org\/standard\/68936.html."},{"key":"ref_49","unstructured":"(2020, November 06). Medical Device and Diagnostic Industry. Available online: https:\/\/www.mddionline.com\/news\/fda-grapples-future-regulation-3-d-printed-medical-devices."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Sharma, N., Cao, S., Msallem, B., Kunz, C., Brantner, P., Honigmann, P., and Thieringer, F.M. (2020). Effects of steam sterilization on 3D printed biocompatible resin materials for surgical guides\u2014An accuracy assessment study. J. Clin. Med., 9.","DOI":"10.3390\/jcm9051506"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"American Dental Association (1996). Infection control reccommendations for the dental office and the dental laboratory. J. Am. Dent. Assoc., 127, 672\u2013680.","DOI":"10.14219\/jada.archive.1996.0280"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1097\/ID.0000000000000908","article-title":"Effect of steam heat sterilization on the accuracy of 3D printed surgical guides","volume":"28","author":"Marei","year":"2019","journal-title":"Implant Dent."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"72","DOI":"10.2174\/1874210601812010072","article-title":"Evaluation of dimensional changes of 3D printed models after sterilization: A pilot study","volume":"12","author":"Shaheen","year":"2018","journal-title":"Open Dent. 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