{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:52:20Z","timestamp":1790268740769,"version":"4.1.0"},"reference-count":97,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,12,25]],"date-time":"2020-12-25T00:00:00Z","timestamp":1608854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>An evaluation of antioxidant and anticancer activity was screened in Leptocarpha rivularis DC flower extracts using four solvents (n-hexane (Hex), dichloromethane (DCM), ethyl acetate (AcOEt), and ethanol (EtOH)). Extracts were compared for total extract flavonoids and phenol contents, antioxidant activity (2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH), ferric reducing antioxidant potential (FRAP), total reactive antioxidant properties (TRAP) and oxygen radical absorbance capacity (ORAC)) across a determined value of reduced\/oxidized glutathione (GSH\/GSSG), and cell viability (the sulforhodamine B (SRB) assay). The most active extracts were analyzed by chromatographic analysis (GC\/MS) and tested for apoptotic pathways. Extracts from Hex, DCM and AcOEt reduced cell viability, caused changes in cell morphology, affected mitochondrial membrane permeability, and induced caspase activation in tumor cell lines HT-29, PC-3, and MCF-7. These effects were generally less pronounced in the HEK-293 cell line (nontumor cells), indicating clear selectivity towards tumor cell lines. We attribute likely extract activity to the presence of sesquiterpene lactones, in combination with other components like steroids and flavonoids.<\/jats:p>","DOI":"10.3390\/molecules26010067","type":"journal-article","created":{"date-parts":[[2020,12,25]],"date-time":"2020-12-25T09:30:19Z","timestamp":1608888619000},"page":"67","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Chemical Composition, Antioxidant and Anticancer Activities of Leptocarpha rivularis DC Flower Extracts"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4187-951X","authenticated-orcid":false,"given":"Iv\u00e1n","family":"Montenegro","sequence":"first","affiliation":[{"name":"Escuela de Obstetricia y Puericultura, Facultad de Medicina, Universidad de Valpara\u00edso, Angamos 655, Re\u00f1aca, Vi\u00f1a del Mar 2520000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Moreira","sequence":"additional","affiliation":[{"name":"Escuela de Obstetricia y Puericultura, Facultad de Medicina, Universidad de Valpara\u00edso, Angamos 655, Re\u00f1aca, Vi\u00f1a del Mar 2520000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Centro de Biotecnolog\u00eda \u201cDr. Daniel Alkalay Lowitt\u201d, Universidad T\u00e9cnica Federico Santa Mar\u00eda, Avda. Espa\u00f1a 1680, Valpara\u00edso 2390123, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Dorta","sequence":"additional","affiliation":[{"name":"Centro de Biotecnolog\u00eda \u201cDr. Daniel Alkalay Lowitt\u201d, Universidad T\u00e9cnica Federico Santa Mar\u00eda, Avda. Espa\u00f1a 1680, Valpara\u00edso 2390123, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Centro de Biotecnolog\u00eda \u201cDr. Daniel Alkalay Lowitt\u201d, Universidad T\u00e9cnica Federico Santa Mar\u00eda, Avda. Espa\u00f1a 1680, Valpara\u00edso 2390123, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5393-8399","authenticated-orcid":false,"given":"Juan Felipe","family":"Alfaro","sequence":"additional","affiliation":[{"name":"Centro de Biotecnolog\u00eda \u201cDr. Daniel Alkalay Lowitt\u201d, Universidad T\u00e9cnica Federico Santa Mar\u00eda, Avda. Espa\u00f1a 1680, Valpara\u00edso 2390123, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8833-7382","authenticated-orcid":false,"given":"Manuel","family":"Valenzuela","sequence":"additional","affiliation":[{"name":"Laboratorio de Microbiolog\u00eda Celular, Instituto de Investigaci\u00f3n e Innovaci\u00f3n en Salud, Facultad de Ciencias de la Salud, Universidad Central de Chile, Santiago 8320000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Jara-Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Biom\u00e9dicas (CIB), Laboratorio de Estr\u00e9s Oxidativo, Escuela de Kinesiolog\u00eda, Facultad de Medicina, Universidad de Valpara\u00edso, Vi\u00f1a del Mar 2520000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ociel","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Institute of Food Science and Technology, University Austral of Chile, Valdivia 5090000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matias","family":"Alvear","sequence":"additional","affiliation":[{"name":"Laboratory of Industrial Chemistry, Process Chemistry Centre, \u00c5bo Akademi University, Biskopsgatan 8, FIN-20500 Turku\/\u00c5bo, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Werner","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias B\u00e1sicas, Campus Fernando May, Universidad del B\u00edo-B\u00edo, Avda. Andr\u00e9s Bello 720, Casilla 447, Chill\u00e1n 3780000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8977-7032","authenticated-orcid":false,"given":"Alejandro","family":"Madrid","sequence":"additional","affiliation":[{"name":"Laboratorio de Productos Naturales y S\u00edntesis Org\u00e1nica (LPNSO), Departamento de Qu\u00edmica, Facultad de Ciencias Naturales y Exactas, Universidad de Playa Ancha, Avda. Leopoldo Carvallo 270, Playa Ancha, Valpara\u00edso 2340000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3336-1454","authenticated-orcid":false,"given":"Joan","family":"Villena","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Biom\u00e9dicas (CIB), Facultad de Medicina, Campus de la Salud, Universidad de Valpara\u00edso, Angamos 655, Re\u00f1aca, Vi\u00f1a del Mar 2520000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Seeger","sequence":"additional","affiliation":[{"name":"Centro de Biotecnolog\u00eda \u201cDr. Daniel Alkalay Lowitt\u201d, Universidad T\u00e9cnica Federico Santa Mar\u00eda, Avda. Espa\u00f1a 1680, Valpara\u00edso 2390123, Chile"},{"name":"Laboratorio de Microbiolog\u00eda Molecular y Biotecnolog\u00eda Ambiental, Departamento de Qu\u00edmica, Universidad T\u00e9cnica Federico Santa Mar\u00eda, Avda. Espa\u00f1a 1680, Valpara\u00edso 2390123, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,25]]},"reference":[{"key":"ref_1","unstructured":"Riedemann, P., and Aldunate, G. (2011). Flora Nativa de Valor Ornamental. Identificaci\u00f3n y Propagaci\u00f3n. Chile\u2014Zona Sur, Editorial Andr\u00e9s Bello. [2nd ed.]."},{"key":"ref_2","unstructured":"Urban, O. (1934). Bot\u00e1nica de las Plantas End\u00e9micas de Chile, Editorial Universidad de Concepci\u00f3n. [1st ed.]."},{"key":"ref_3","unstructured":"Hoffman, A. (1982). Flora Silvestre de Chile. Zona Austral, Ediciones Fundaci\u00f3n Claudio Gay. [1st ed.]."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.4067\/S0717-97072006000400003","article-title":"Synthesis and conformational analysis of leptocarpin derivatives. 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