{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T02:48:29Z","timestamp":1787194109839,"version":"build-2736575974"},"reference-count":65,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T00:00:00Z","timestamp":1611014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["Grants 16\/212017-0 and 2016\/07196-6"],"award-info":[{"award-number":["Grants 16\/212017-0 and 2016\/07196-6"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["308127\/2018-8"],"award-info":[{"award-number":["308127\/2018-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["Finance Code 001"],"award-info":[{"award-number":["Finance Code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The increase in the prevalence of fungal infections worldwide and the rise in the occurrence of antifungal resistance suggest that new research to discover antifungal molecules is needed. The aim of this study was to evaluate the potential use of ellagic acid\u2013cyclodextrin complexes (EA\/HP-\u03b2-CD) for the treatment of oral candidiasis. First, the effect of EA\/HP-\u03b2-CD on C. albicans planktonic cells and biofilms was evaluated. Then, the cytotoxicity of the effective concentration was studied to ensure safety of in vivo testing. Finally, the in vivo effectiveness was determined by using a murine model of induced oral candidiasis. Data was statistically analyzed. The minimal inhibitory concentration of EA\/HP-\u03b2-CD was 25 \u00b5g\/mL and a concentration of 10 times MIC (250 \u00b5g\/mL) showed an inhibitory effect on C. albicans 48 h-biofilms. The complex at concentration 250 \u00b5g\/mL was classified as slightly cytotoxic. In vivo experiments showed a reduction in fungal epithelial invasion after treatment with EA\/HP-\u03b2-CD for 24 h and 96 h when compared to the negative control. In conclusion, the results demonstrated that EA\/HP-\u03b2-CD has antifungal and anti-inflammatory effects, reducing the invasive capacity of C. albicans, which suggests that EA\/HP-\u03b2-CD may be a promising alternative for the treatment of oral candidiasis.<\/jats:p>","DOI":"10.3390\/molecules26020505","type":"journal-article","created":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T11:39:55Z","timestamp":1611056395000},"page":"505","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Ellagic Acid\u2013Cyclodextrin Complexes for the Treatment of Oral Candidiasis"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9453-3905","authenticated-orcid":false,"given":"Aline da Gra\u00e7a","family":"Sampaio","sequence":"first","affiliation":[{"name":"Oral Biopathology Graduate Program, S\u00e3o Jos\u00e9 dos Campos Institute of Science &amp; Technology, S\u00e3o Paulo State University, UNESP, S\u00e3o Paulo 12245-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline Vidal Lacerda","family":"Gontijo","sequence":"additional","affiliation":[{"name":"Oral Biopathology Graduate Program, S\u00e3o Jos\u00e9 dos Campos Institute of Science &amp; Technology, S\u00e3o Paulo State University, UNESP, S\u00e3o Paulo 12245-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela de Morais Gouv\u00eaa","family":"Lima","sequence":"additional","affiliation":[{"name":"Oral Biopathology Graduate Program, S\u00e3o Jos\u00e9 dos Campos Institute of Science &amp; Technology, S\u00e3o Paulo State University, UNESP, S\u00e3o Paulo 12245-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Alcion\u00e9ia Carvalho","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Oral Biopathology Graduate Program, S\u00e3o Jos\u00e9 dos Campos Institute of Science &amp; Technology, S\u00e3o Paulo State University, UNESP, S\u00e3o Paulo 12245-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Soares Souto","family":"Lepesqueur","sequence":"additional","affiliation":[{"name":"Oral Biopathology Graduate Program, S\u00e3o Jos\u00e9 dos Campos Institute of Science &amp; Technology, S\u00e3o Paulo State University, UNESP, S\u00e3o Paulo 12245-000, Brazil"},{"name":"School of Dentistry, Santo Amaro University, S\u00e3o Paulo 04743-030, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2416-2173","authenticated-orcid":false,"given":"Cristiane Yumi","family":"Koga-Ito","sequence":"additional","affiliation":[{"name":"Oral Biopathology Graduate Program, S\u00e3o Jos\u00e9 dos Campos Institute of Science &amp; Technology, S\u00e3o Paulo State University, UNESP, S\u00e3o Paulo 12245-000, Brazil"},{"name":"Department of Environment Engineering, S\u00e3o Jos\u00e9 dos Campos Institute of Science &amp; Technology, S\u00e3o Paulo State University, UNESP, S\u00e3o Paulo 12247-016, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1590\/0037-8682-0241-2017","article-title":"Clinical and Laboratorial Features of Oral Candidiasis in HIV-Positive Patients","volume":"51","author":"Spalanzani","year":"2018","journal-title":"Rev. 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