{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T10:14:07Z","timestamp":1784628847196,"version":"3.55.0"},"reference-count":74,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T00:00:00Z","timestamp":1611187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Despite its uniqueness, the Bargellini multicomponent reaction remains barely known by the most part of chemists. This can be ascribed to the fact that this transformation has not been adequately reviewed in the classic books of named reactions in organic chemistry. Nevertheless, several works on this reaction have been carried out over the years, many of them were written in Italian in the period 1929\u20131966. In this review article we extensively cover, in a chronological order, the most important applications of the Bargellini reaction reported to date, with the hope that this knowledge-sharing will help chemists to properly use this multicomponent transformation and imagine novel reactivities based on it.<\/jats:p>","DOI":"10.3390\/molecules26030558","type":"journal-article","created":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T03:31:30Z","timestamp":1611286290000},"page":"558","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The 115 Years Old Multicomponent Bargellini Reaction: Perspectives and New Applications"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5305-8359","authenticated-orcid":false,"given":"Marta","family":"Serafini","sequence":"first","affiliation":[{"name":"Dipartimento di Scienza del Farmaco, Universit\u00e0 del Piemonte Orientale, Largo Donegani 2, 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3351-6770","authenticated-orcid":false,"given":"Ilaria","family":"Murgia","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienza del Farmaco, Universit\u00e0 del Piemonte Orientale, Largo Donegani 2, 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6856-414X","authenticated-orcid":false,"given":"Mariateresa","family":"Giustiniano","sequence":"additional","affiliation":[{"name":"Dipartimento di Farmacia, Universit\u00e0 degli Studi di Napoli \u201cFederico II\u201d, Via D. Montesano 49, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3936-4787","authenticated-orcid":false,"given":"Tracey","family":"Pirali","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienza del Farmaco, Universit\u00e0 del Piemonte Orientale, Largo Donegani 2, 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2394-400X","authenticated-orcid":false,"given":"Gian Cesare","family":"Tron","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienza del Farmaco, Universit\u00e0 del Piemonte Orientale, Largo Donegani 2, 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,21]]},"reference":[{"key":"ref_1","unstructured":"Link, B. (1894). (No. 28. R 665-D.R.P 80986), Patent."},{"key":"ref_2","first-page":"1055","article-title":"Correspondenz aus Florenz","volume":"5","author":"Schiff","year":"1872","journal-title":"Ber. Deut. Chem. Ges."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/BF01516840","article-title":"\u00dcber den Nachweis von Jodoform, Naphtol und Chloroform in thierischen Fl\u00fcssigkeiten und Organen","volume":"3","author":"Lustgarten","year":"1882","journal-title":"Mon. f\u00fcr Chem."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1002\/ardp.19713041103","article-title":"Reaktion des Resorcins mit Halogenmethanen unter alkalischen Bedingungen","volume":"304","author":"Brieskorn","year":"1971","journal-title":"Arch. Pharm."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/ardp.19723050213","article-title":"Reaktionen der Naphthole mit Halogenmethanen unter alkalischen Bedingungen","volume":"305","author":"Brieskorn","year":"1972","journal-title":"Arch. Pharm."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1002\/cber.187600901247","article-title":"Ueber die Einwirkung von Chloroform auf alkalische Phenolate","volume":"9","author":"Reimer","year":"1876","journal-title":"Chem. Ber."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1021\/cr60204a003","article-title":"The Reimer-Tiemann Reaction","volume":"60","author":"Wynberg","year":"1960","journal-title":"Chem. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1039\/C6CS00444J","article-title":"To Each his Own: Isonitriles for All Flavors. Functionalized Isocyanides as Valuable Tools in Organic Synthesis","volume":"46","author":"Giustiniano","year":"2017","journal-title":"Chem. Soc. Rev."},{"key":"ref_9","first-page":"329","article-title":"Azione del Cloroformio e Idrato Sodico sui Fenoli in Soluzione nell\u2019cetone","volume":"36","author":"Bargellini","year":"1906","journal-title":"Gazz. Chim. Ital."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"10870","DOI":"10.3390\/molecules180910870","article-title":"Pulici, Italian Chemists\u2019 Contributions to Named Reactions in Organic Synthesis: An Historical Perspective","volume":"18","author":"Papeo","year":"2013","journal-title":"Molecules"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1002\/cber.190003301163","article-title":"Studien \u00fcber Verkettungen. XLIII. \u03b1-Phenoxy-Butters\u00e4ure, -Isobutters\u00e4ure und -Isovalerians\u00e4ure und deren Ester","volume":"33","author":"Bischoff","year":"1900","journal-title":"Ber. Deut. Chem. Ges."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"6057","DOI":"10.1021\/ja00723a042","article-title":"Alpha-Lactones from Diphenylketene and Di-tert-butylketene","volume":"92","author":"Wheland","year":"1970","journal-title":"J. Am. Chem. Soc."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Ruggiero, G.D., and Williams, I.H. (2001). Oxiranones: \u03b1-lactones or zwitterions? Insights from calculated electron density distribution analysis. J. Chem Soc. Perkin Trans. 2, 733\u2013737.","DOI":"10.1039\/b100587l"},{"key":"ref_14","first-page":"1558","article-title":"Necrologio","volume":"XLV","year":"1963","journal-title":"Chim. e l\u2019Industria"},{"key":"ref_15","first-page":"47","article-title":"1,2,3-Trihydroxyflavone. Contribution to the knowledge of the constitution of scutellarein","volume":"49","author":"Bargellini","year":"1919","journal-title":"Gazz. Chim. Ital."},{"key":"ref_16","first-page":"945","article-title":"Fenilcumarine","volume":"55","author":"Bargellini","year":"1925","journal-title":"Gazz. Chim. Ital."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Wang, Z. (2010). Bargellini Condensation. Comprehensive Organic Name Reactions and Reagents, Wiley.","DOI":"10.1002\/9780470638859.conrr050"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1139\/v80-078","article-title":"Studies on the Rearrangement of (Trichloromethyl)carbinols to \u03b1-Chloroacetic Acids","volume":"58","author":"Reeve","year":"1980","journal-title":"Can. J. Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1021\/ja00031a069","article-title":"A General, Catalytic, and Enantioselective Synthesis of \u03b1-Amino Acids","volume":"114","author":"Corey","year":"1192","journal-title":"J. Am. Chem. Soc."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3998\/ark.5550190.0013.204","article-title":"Recent Applications of Gem-Dichloroepoxide Intermediates in Synthesis","volume":"2","author":"Snowden","year":"2012","journal-title":"Arkivoc"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1021\/ja01183a082","article-title":"The Synthesis of \u03b1-Alkoxyisobutyric Acids and Alkyl Methacrylates from Acetonechloroform","volume":"70","author":"Weizmann","year":"1948","journal-title":"J. Am. Chem. Soc."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1021\/ja01162a024","article-title":"Carbon Dichloride as an Intermediate in the Basic Hydrolysis of Chloroform. A Mechanism for Substitution Reactions at a Saturated Carbon Atom","volume":"72","author":"Hine","year":"1950","journal-title":"J. Am. Chem. Soc."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"5773","DOI":"10.1021\/jo100390p","article-title":"\u201cCarbon Dichloride\u201d: Dihalocarbenes Sixty Years after Hine","volume":"75","author":"Moss","year":"2010","journal-title":"J. Org. Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1021\/jm201306q","article-title":"Synthesis, Characterization and Biological Evaluation of Ureidofibrate-Like Derivatives Endowed with Peroxisome Proliferator-Activated Receptor Activity","volume":"55","author":"Porcelli","year":"2012","journal-title":"J. Med. Chem."},{"key":"ref_25","first-page":"352","article-title":"An Efficient Method for the Synthesis of Alkyl 2-(4-benzoylphenoxy)-2-methyl Propanoates","volume":"29","author":"Rehman","year":"2007","journal-title":"J. Chem. Soc. Pak."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/cber.19771100111","article-title":"Zur Reaktion des Makosza-Reagens mit Aldehyden und Ketonen","volume":"110","author":"Merz","year":"1977","journal-title":"Chem. Ber."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/jps.3030480707","article-title":"The Kinetics of Degradation of Chlorobutanol","volume":"48","author":"Nair","year":"1959","journal-title":"J. Am. Pharm. Assoc."},{"key":"ref_28","first-page":"671","article-title":"Action of Alkaline Solutions on Trichloro Organic Compounds","volume":"41","author":"Bressanin","year":"1911","journal-title":"Gazz. Chim. Ital."},{"key":"ref_29","first-page":"825","article-title":"Phasentransfer-katalysierte Reaktionen; Vl1. Synthese von 1-Chlorocyclohexancarbons\u00e4ure aus Cyclohexanon","volume":"12","author":"Kuhl","year":"1976","journal-title":"Synthesis"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1021\/jo3001063","article-title":"One-Pot in Situ Formation and Reaction of Trimethyl(trichloromethyl)silane: Application to the Synthesis of 2,2,2-Trichloromethylcarbinols","volume":"77","author":"Henegar","year":"2012","journal-title":"J. Org. Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1021\/ja01318a014","article-title":"The Kinetics of the Decomposition of the Trichloroacetates in Various Solvents","volume":"56","author":"Verhoek","year":"1934","journal-title":"J. Am. Chem. Soc."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"8560","DOI":"10.1021\/jo051027+","article-title":"An Efficient Synthesis of a Dual PPAR \u03b1\/\u03b3 Agonist and the Formation of a Sterically Congested \u03b1-Aryloxyisobutyric Acid via a Bargellini Reaction","volume":"70","author":"Cvetovich","year":"2005","journal-title":"J. Org. Chem."},{"key":"ref_33","first-page":"1248","article-title":"Synthesis of Novel Phenoxy\u2014Isobutyric Acid Derivatives, Reaction of Ketone under Bargellinic Reaction Conditions","volume":"8","author":"Ramalakshmi","year":"2015","journal-title":"Int. J. Chem. Tech. Res."},{"key":"ref_34","first-page":"431","article-title":"Sintesi di Alcuni Derivati \u03b1-Isobutirrici","volume":"77","author":"Galimberti","year":"1947","journal-title":"Gazz. Chim. Ital."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"6644","DOI":"10.1021\/ja01629a077","article-title":"Some Substituted \u03b1-(Aryloxy)-isobutyric Acids and Amides","volume":"77","author":"Gilman","year":"1955","journal-title":"J. Am. Chem. Soc."},{"key":"ref_36","unstructured":"Julia, M., Baillarge, M., and Tchernoff, G. (1956). Sur Quelques nouveaux d\u00e9riv\u00e9s aryloxyisobutyriques et apparent\u00e9s. Bull. Soc. Chim. Fr., 776\u2013783."},{"key":"ref_37","first-page":"1959","article-title":"Improved Method for the Synthesis of 2-Methyl-2-Aryloxypropanoic Acid Derivatives","volume":"12","author":"Davis","year":"2004","journal-title":"Synthesis"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1080\/00397910600636527","article-title":"Selective Phenol Alkylation: An Improved Preparation of Efaproxiral","volume":"36","author":"Anderson","year":"2006","journal-title":"Synth. Commun."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1016\/j.tetlet.2005.03.025","article-title":"Water-Based Biphasic Media for Exothermic Reactions: Green Chemistry Strategy for the Large Scale Preparation of Clofibric Acid and Analogues","volume":"46","author":"Bose","year":"2005","journal-title":"Tetrahedron Lett."},{"key":"ref_40","first-page":"819","article-title":"Azione del Cloretone e Potassa sulle Basi Aromatiche Primarie","volume":"59","author":"Banti","year":"1929","journal-title":"Gazz. Chim. Ital."},{"key":"ref_41","first-page":"847","article-title":"New \u03b1-substituted aryl thioacetic derivatives forming analogues of clofibrate","volume":"30","author":"Andreani","year":"1975","journal-title":"Il Farmaco"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1134\/S1070363216020183","article-title":"The Bargellini reaction in a series of Heterocyclic Thiols","volume":"86","author":"Melnikova","year":"2016","journal-title":"Russ. J. Gen. Chem."},{"key":"ref_43","first-page":"522","article-title":"Su Alcuni Derivati \u03b1-Isobutirrici","volume":"102","author":"Carminati","year":"1963","journal-title":"Boll. Chim. Farm."},{"key":"ref_44","first-page":"91","article-title":"Nuove Sintesi di Derivati Idantoinici","volume":"102","author":"Buttini","year":"1963","journal-title":"Boll. Chim. Farm."},{"key":"ref_45","first-page":"156","article-title":"Nuova Sintesi di Derivati Tiazolidonici","volume":"102","author":"Buttini","year":"1963","journal-title":"Boll. Chim. Farm."},{"key":"ref_46","first-page":"1112","article-title":"Introduzione del Radicale alfa-Isobutirrico su Semicarbazide, Tiosemicarbazide e Relativi 1 e 4 Fenilderivati","volume":"54","author":"Buttini","year":"1964","journal-title":"Ann. Chim."},{"key":"ref_47","first-page":"1259","article-title":"New Synthesis of the Glycocyamidine Group","volume":"56","author":"Melandri","year":"1966","journal-title":"Ann. Chim."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1021\/jo01292a054","article-title":"Hindered Amines. Novel Synthesis of 1,3,3,5,5-Pentasubstitued 2-Piperazinones","volume":"45","author":"Lai","year":"1980","journal-title":"J. Org. Chem."},{"key":"ref_49","first-page":"357","article-title":"Synthesis of Electron-Deficient N1-(Hetero)aryl 3,3,5,5-Tetramethyl Piperazinones","volume":"28","author":"Alanine","year":"2017","journal-title":"Synlett"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"6363","DOI":"10.1021\/jo9808831","article-title":"Synthesis of Chiral Nitroxides and an Unusual Racemization Reaction","volume":"63","author":"Rychnovsky","year":"1998","journal-title":"J. Org. Chem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"456","DOI":"10.2533\/chimia.2018.456","article-title":"Radicals and Polymers","volume":"72","author":"Nesvadba","year":"2018","journal-title":"Chimia"},{"key":"ref_52","unstructured":"Nesvadba, P., Kramer, A., and Zink, M.-O. (2000). Heterocyclic Alkoxyamine Polymerization Composition Useful as Regulator in Free-Radical Polymerization to Obtain Low-Polydispersity Polymeric Resins. (DE19949352A1), German Patent."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"3671","DOI":"10.1021\/jo01306a025","article-title":"Hindered Amines. 2. Synthesis of Hindered Acyclic \u03b1-Aminoacetamides","volume":"45","author":"Lai","year":"1980","journal-title":"J. Org. Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"4386","DOI":"10.1016\/j.tetlet.2016.08.057","article-title":"Practical Synthesis of 3,3-Substituted Dihydroquinoxalin-2-ones from Aryl 1,2-Diamines using the Bargellini Reaction","volume":"57","author":"Alanine","year":"2016","journal-title":"Tetrahedron Lett."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1007\/s10593-017-2052-6","article-title":"3,4-Dihydroquinoxalin-2-ones: Recent Advances in Synthesis and Bioactivities (microreview)","volume":"53","author":"Kristoffersen","year":"2017","journal-title":"Chem. Heterocycl. Compd."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0040-4039(00)02019-0","article-title":"Totally Hindered Phenols. 2,6-Di-t-butyl-4-(1,1-dialkyl-1-acetamide)-phenols and their Persistent Phenoxy Radicals","volume":"42","author":"Lai","year":"2001","journal-title":"Tetrahedron Lett."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1016\/j.tetlet.2009.03.044","article-title":"Aromatic Amines as Nucleophiles in the Bargellini Reaction","volume":"50","author":"Butcher","year":"2009","journal-title":"Tetrahedron Lett."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"4772","DOI":"10.1016\/j.tetlet.2010.07.029","article-title":"KF-Alumina-Mediated Bargellini Reaction","volume":"51","author":"Rohman","year":"2010","journal-title":"Tetrahedron Lett."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1055\/s-0032-1317297","article-title":"Synthesis of Novel 1,4-Benzodiazepine-3,5-dione Derivatives: Reaction of 2-Aminobenzamides under Bargellini Reaction Conditions","volume":"23","author":"Mahdavi","year":"2012","journal-title":"Synlett"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.scient.2011.09.021","article-title":"Dithiocarbamic Acids and Thiols as Nucleophiles in the Bargellini Reaction","volume":"19","author":"Aryanasab","year":"2012","journal-title":"Sci. Iran."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1039\/C5NJ03455H","article-title":"Bargellini Condensation of Ninhydrin as a Ketone and Substituted Anilines as Nucleophiles","volume":"40","author":"Rashid","year":"2016","journal-title":"New J. Chem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/cber.19630960103","article-title":"\u00dcber die Synthese von Grisanonen-(3)","volume":"96","author":"Korger","year":"1963","journal-title":"Chem. Ber."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1039\/b200103a","article-title":"Formal Syntheses of Heliannuols A and D, Allelochemicals from Helianthus annus","volume":"6","author":"Tuhina","year":"2002","journal-title":"Chem. Commun."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.tet.2006.11.014","article-title":"Synthesis of Heliannuols A and K, Allelochemicals from Cultivar Sunflowers and the Marine Metabolite Heliane, Unusual Sesquiterpene Containing a Benzoxocane Ring System","volume":"63","author":"Ghosh","year":"2007","journal-title":"Tetrahedron"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1080\/00397911.2017.1344860","article-title":"Synthesis of (\u00b1)-heliannuol C","volume":"47","author":"Biswas","year":"2017","journal-title":"Synth. Commun."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1080\/00397911.2014.979948","article-title":"Total Syntheses of Heliannuols: An Overview","volume":"45","author":"Chen","year":"2015","journal-title":"Synth. Commun."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"6794","DOI":"10.1002\/ejoc.201100706","article-title":"Total Synthesis of (+)-7,11-Helianane and (+)-5-Chloro-7,11-helianane through Stereoselective Aromatic Claisen Rearrangement","volume":"2011","author":"Quartieri","year":"2011","journal-title":"Eur. J. Org. Chem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"8741","DOI":"10.1016\/j.tetlet.2005.10.045","article-title":"Bargellini Condensation of Coumarins. Expeditious Synthesis of o-Carboxyvinylphenoxyisobutyric Acids","volume":"46","author":"Sen","year":"2005","journal-title":"Tetrahedron Lett."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"4782","DOI":"10.1021\/ja01045a034","article-title":"Directed Conversion of the Phenoxy Grouping into a Variety of Cyclic Polyfunctional Systems","volume":"91","author":"Corey","year":"1969","journal-title":"J. Am. Chem. Soc."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"11467","DOI":"10.1021\/acs.joc.6b02130","article-title":"A Successful Replacement of Phenols with Isocyanides in the Bargellini Reaction: Synthesis of 3-Carboxamido-Isobutyric Acids","volume":"81","author":"Giustiniano","year":"2016","journal-title":"J. Org. Chem."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Farhid, H., Nazeri, M.T., Shaabani, A., Armaghan, M., and Janiak, C. (2020). Isocyanide-based Consecutive Bargellini\/Ugi Reactions: An Efficient Method for the Synthesis of Pseudo-peptides Containing Three Amide Bonds. Amino Acids.","DOI":"10.1007\/s00726-020-02917-1"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1021\/acs.jmedchem.7b00315","article-title":"Natural-Products-inspired Use of the Gem-dimethyl Group in Medicinal Chemistry","volume":"61","author":"Talele","year":"2018","journal-title":"J. Med. Chem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"6297","DOI":"10.1016\/S0040-4039(03)01524-7","article-title":"The Synthesis of Aza-\u03b2-lactams via Tandem Petasis\u2013Ugi Multi-component Condensation and 1,3-Diisopropylcarbodiimide (DIC) Condensation Reaction","volume":"44","author":"Naskar","year":"2003","journal-title":"Tetrahedron Lett."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0040-4039(02)02619-9","article-title":"A Tandem Petasis\u2013Ugi Multi Component Condensation Reaction: Solution Phase Synthesis of Six Dimensional Libraries","volume":"44","author":"Portlock","year":"2003","journal-title":"Tetrahedron Lett."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/26\/3\/558\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:13:46Z","timestamp":1760159626000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/26\/3\/558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,21]]},"references-count":74,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,2]]}},"alternative-id":["molecules26030558"],"URL":"https:\/\/doi.org\/10.3390\/molecules26030558","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,21]]}}}