{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T08:44:47Z","timestamp":1791967487473,"version":"4.3.4"},"reference-count":76,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T00:00:00Z","timestamp":1611792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["INST208\/690-1"],"award-info":[{"award-number":["INST208\/690-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The dichloromethane extract from leaves of Melicope barbigera (Rutaceae), endemic to the Hawaiian island of Kaua\u2019i, yielded four new and three previously known acetophenones and 2H-chromenes, all found for the first time in M. barbigera. The structures of the new compounds obtained from the dichloromethane extract after purification by chromatographic methods were unambiguously elucidated by spectroscopic analyses including 1D\/2D NMR spectroscopy and HRESIMS. The absolute configuration was determined by modified Mosher\u2019s method. Compounds 2, 4 and the mixture of 6 and 7 exhibited moderate cytotoxic activities against the human ovarian cancer cell line A2780 with IC50 values of 30.0 and 75.7 \u00b5M for 2 and 4, respectively, in a nuclear shrinkage cytotoxicity assay.<\/jats:p>","DOI":"10.3390\/molecules26030688","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T22:02:01Z","timestamp":1611871321000},"page":"688","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["New Acetophenones and Chromenes from the Leaves of Melicope barbigera A. Gray"],"prefix":"10.3390","volume":"26","author":[{"given":"Kim-Thao","family":"Le","sequence":"first","affiliation":[{"name":"Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4282-0229","authenticated-orcid":false,"given":"Jan J.","family":"Bandolik","sequence":"additional","affiliation":[{"name":"Institute for Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9094-8481","authenticated-orcid":false,"given":"Matthias U.","family":"Kassack","sequence":"additional","affiliation":[{"name":"Institute for Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6446-1154","authenticated-orcid":false,"given":"Kenneth R.","family":"Wood","sequence":"additional","affiliation":[{"name":"National Tropical Botanical Garden, 3530 Papalina Road, Kalaheo, HI 96741, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Paetzold","sequence":"additional","affiliation":[{"name":"Institute of Systematics, Biodiversity and Evolution of Plants, Georg-August-University Goettingen, 37073 Goettingen, Germany"},{"name":"Division Botany and Molecular Evolution, Senckenberg Gesellschaft f\u00fcr Naturforschung, Senckenberganlage 25, 60325 Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc S.","family":"Appelhans","sequence":"additional","affiliation":[{"name":"Institute of Systematics, Biodiversity and Evolution of Plants, Georg-August-University Goettingen, 37073 Goettingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus M.","family":"Passreiter","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1111\/jse.12299","article-title":"Historical biogeography of Melicope (Rutaceae) and its close relatives with a special emphasis on Pacific dispersals","volume":"56","author":"Appelhans","year":"2018","journal-title":"J. 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