{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T03:44:25Z","timestamp":1789789465010,"version":"4.0.1"},"reference-count":75,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T00:00:00Z","timestamp":1612483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000785","name":"Education, Audiovisual and Culture Executive Agency","doi-asserted-by":"publisher","award":["EOHUB project 600873EPP-1-2018-1ES-EPPKA2-KA"],"award-info":[{"award-number":["EOHUB project 600873EPP-1-2018-1ES-EPPKA2-KA"]}],"id":[{"id":"10.13039\/501100000785","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Lantana rhodesiensis Moldenke is a plant widely used to treat diseases, such as rheumatism, diabetes, and malaria in traditional medicine. To better understand the traditional uses of this plant, a phytochemical study was undertaken, revealing a higher proportion of polyphenols, including flavonoids in L. rhodesiensis leaf extract and moderate proportion in stem and root extracts. The antioxidant activity of the extracts was also determined using three different assays: the radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity, the FRAP method (Ferric-reducing antioxidant power) and the \u03b2-carotene bleaching test. The anti-malarial activity of each extract was also evaluated using asexual erythrocyte stages of Plasmodium falciparum, chloroquine-sensitive strain 3D7. The results showed that the leaf extract exhibited higher antioxidant and anti-malarial activities in comparison with the stem and root extracts, probably due to the presence of higher quantities of polyphenols including flavonoids in the leaves. A positive linear correlation was established between the phenolic compound content (total polyphenols including flavonoids and tannins; and total flavonoids) and the antioxidant activity of all extracts. Furthermore, four flavones were isolated from leaf dichloromethane and ethyl acetate fractions: a new flavone named rhodescine (5,6,3\u2032,5\u2032-tetrahydroxy-7,4\u2032-dimethoxyflavone) (1), 5-hydroxy-6,7,3\u2032,4\u2032,5\u2032-pentamethoxyflavone (2), 5-hydroxy-6,7,3\u2032,4\u2032-tetramethoxyflavone (3), and 5,6,3\u2032-trihydroxy-7,4\u2032-dimethoxyflavone (4). Their structures were elucidated by 1H, 13CNMR, COSY, HSQC, HMBC, and MS-EI spectral methods. Aside from compound 2, all other molecules were described for the first time in this plant species.<\/jats:p>","DOI":"10.3390\/molecules26040846","type":"journal-article","created":{"date-parts":[[2021,2,7]],"date-time":"2021-02-07T14:04:13Z","timestamp":1612706653000},"page":"846","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Phytochemical Investigation and Biological Activities of Lantana rhodesiensis"],"prefix":"10.3390","volume":"26","author":[{"given":"Fatimata","family":"Nea","sequence":"first","affiliation":[{"name":"Laboratory of Constitution and Reaction of Matter, UFR-SSMT, University F\u00e9lix Houphou\u00ebt-Boigny, 01 BP 582 Abidjan 01, Ivory Coast"},{"name":"Laboratory of Chemistry of Natural Molecules, Gembloux Agro-Bio Tech, University of Li\u00e8ge, Passage des D\u00e9port\u00e9s 2, 5030 Gembloux, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel Boni","family":"Bitchi","sequence":"additional","affiliation":[{"name":"Laboratory of Constitution and Reaction of Matter, UFR-SSMT, University F\u00e9lix Houphou\u00ebt-Boigny, 01 BP 582 Abidjan 01, Ivory Coast"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manon","family":"Genva","sequence":"additional","affiliation":[{"name":"Laboratory of Chemistry of Natural Molecules, Gembloux Agro-Bio Tech, University of Li\u00e8ge, Passage des D\u00e9port\u00e9s 2, 5030 Gembloux, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4052-6336","authenticated-orcid":false,"given":"Allison","family":"Ledoux","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacognosy, Center for Interdisciplinary Research on Medicines (CIRM), University of Li\u00e8ge, Avenue Hippocrate 15, 4000 Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alembert Tiabou","family":"Tchinda","sequence":"additional","affiliation":[{"name":"Laboratory of Phytochemistry, Centre for Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants Studies, P.O. Box 13033 Yaound\u00e9, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Damblon","sequence":"additional","affiliation":[{"name":"MolSys Research Unit, Faculty of Sciences, University of Li\u00e8ge, 4000 Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Frederich","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacognosy, Center for Interdisciplinary Research on Medicines (CIRM), University of Li\u00e8ge, Avenue Hippocrate 15, 4000 Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zanahi F\u00e9lix","family":"Tonzibo","sequence":"additional","affiliation":[{"name":"Laboratory of Constitution and Reaction of Matter, UFR-SSMT, University F\u00e9lix Houphou\u00ebt-Boigny, 01 BP 582 Abidjan 01, Ivory Coast"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2027-3896","authenticated-orcid":false,"given":"Marie-Laure","family":"Fauconnier","sequence":"additional","affiliation":[{"name":"Laboratory of Chemistry of Natural Molecules, Gembloux Agro-Bio Tech, University of Li\u00e8ge, Passage des D\u00e9port\u00e9s 2, 5030 Gembloux, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,5]]},"reference":[{"key":"ref_1","first-page":"1","article-title":"Antidiabetic and Safety of Lantana rhodesiensis in Alloxan Induced Diabetic Rats","volume":"4","author":"Ngugi","year":"2015","journal-title":"J. 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