{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:08:50Z","timestamp":1791925730654,"version":"4.3.4"},"reference-count":111,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T00:00:00Z","timestamp":1614124800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["119342"],"award-info":[{"award-number":["119342"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A series of fifteen silver (I) quinoline complexes Q1\u2013Q15 have been synthesized and studied for their biological activities. Q1\u2013Q15 were synthesized from the reactions of quinolinyl Schiff base derivatives L1\u2013L5 (obtained by condensing 2-quinolinecarboxaldehyde with various aniline derivatives) with AgNO3, AgClO4 and AgCF3SO3. Q1\u2013Q15 were characterized by various spectroscopic techniques and the structures of [Ag(L1)2]NO3Q1, [Ag(L1)2]ClO4Q6, [Ag(L2)2]ClO4Q7, [Ag(L2)2]CF3SO3Q12 and [Ag(L4)2]CF3SO3Q14 were unequivocally determined by single crystal X-ray diffraction analysis. In vitro antimicrobial tests against Gram-positive and Gram-negative bacteria revealed the influence of structure and anion on the complexes\u2032 moderate to excellent antibacterial activity. In vitro antioxidant activities of the complexes showed their good radical scavenging activity in ferric reducing antioxidant power (FRAP). Complexes with the fluorine substituent or the thiophene or benzothiazole moieties are more potent with IC50 between 0.95 and 2.22 mg\/mL than the standard used, ascorbic acid (2.68 mg\/mL). The compounds showed a strong binding affinity with calf thymus-DNA via an intercalation mode and protein through a static quenching mechanism. Cytotoxicity activity was examined against three carcinoma cell lines (HELA, MDA-MB231, and SHSY5Y). [Ag(L2)2]ClO4Q7 with a benzothiazole moiety and [Ag(L4)2]ClO4Q9 with a methyl substituent had excellent cytotoxicity against HELA cells.<\/jats:p>","DOI":"10.3390\/molecules26051205","type":"journal-article","created":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T02:36:13Z","timestamp":1614220573000},"page":"1205","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Quinoline Functionalized Schiff Base Silver (I) Complexes: Interactions with Biomolecules and In Vitro Cytotoxicity, Antioxidant and Antimicrobial Activities"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9287-5960","authenticated-orcid":false,"given":"Adesola A.","family":"Adeleke","sequence":"first","affiliation":[{"name":"School of Chemistry and Physics, Pietermaritzburg Campus, University of Kwazulu-Natal, Private Bag X01, Scottsville 3209, South Africa"},{"name":"Department of Chemical Sciences, Olabisi Onabanjo University, P. M. B. 2002, Ago-Iwoye 120107, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sizwe J.","family":"Zamisa","sequence":"additional","affiliation":[{"name":"School of Chemistry and Physics, Westville Campus, University of Kwazulu-Natal, Private Bag X54001, Westville 4001, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0309-9491","authenticated-orcid":false,"given":"Md. Shahidul","family":"Islam","sequence":"additional","affiliation":[{"name":"Discipline of Biochemistry, School of Life Sciences, Westville Campus, University of Kwazulu-Natal, Private Bag X54001, Durban 4000, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kolawole","family":"Olofinsan","sequence":"additional","affiliation":[{"name":"Discipline of Biochemistry, School of Life Sciences, Westville Campus, University of Kwazulu-Natal, Private Bag X54001, Durban 4000, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3796-4992","authenticated-orcid":false,"given":"Veronica F.","family":"Salau","sequence":"additional","affiliation":[{"name":"Discipline of Biochemistry, School of Life Sciences, Westville Campus, University of Kwazulu-Natal, Private Bag X54001, Durban 4000, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunderika","family":"Mocktar","sequence":"additional","affiliation":[{"name":"Discipline of Pharmaceutical Sciences, School of Health Sciences, Westville Campus, University of Kwazulu-Natal, Private Bag X54001, Durban 4000, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3003-6712","authenticated-orcid":false,"given":"Bernard","family":"Omondi","sequence":"additional","affiliation":[{"name":"School of Chemistry and Physics, Pietermaritzburg Campus, University of Kwazulu-Natal, Private Bag X01, Scottsville 3209, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4510648","DOI":"10.1155\/2018\/4510648","article-title":"Structural Properties and Reactive Site Selectivity of Some Transition Metal Complexes of 2,2\u2019(1E,1\u2019E)-(ethane-1,2-diylbis(azan-1-yl-1-ylidene))bis(phenylmethan-1-yl-1-yli dene)dibenzoic Acid: DFT, Conceptual DFT, QTAIM, and MEP Studies","volume":"2018","author":"Bine","year":"2018","journal-title":"Bioinorg. 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