{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:42:52Z","timestamp":1761676972627,"version":"build-2065373602"},"reference-count":101,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T00:00:00Z","timestamp":1614297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Turku University Foundation","award":["080537"],"award-info":[{"award-number":["080537"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The use of bioresorbable fracture fixation plates made of aliphatic polyesters have good potential due to good biocompatibility, reduced risk of stress-shielding, and eliminated need for plate removal. However, polyesters are ductile, and their handling properties are limited. We suggested an alternative, PLAMA (PolyLActide functionalized with diMethAcrylate), for the use as the matrix phase for the novel concept of the in situ curable bioresorbable load-bearing composite plate to reduce the limitations of conventional polyesters. The purpose was to obtain a preliminary understanding of the chemical and physical properties and the biological safety of PLAMA from the prospective of the novel concept. Modifications with different molecular masses (PLAMA-500 and PLAMA-1000) were synthesized. The efficiency of curing was assessed by the degree of convergence (DC). The mechanical properties were obtained by tensile test and thermomechanical analysis. The bioresorbability was investigated by immersion in simulated body fluid. The biocompatibility was studied in cell morphology and viability tests. PLAMA-500 showed better DC and mechanical properties, and slower bioresorbability than PLAMA-1000. Both did not prevent proliferation and normal morphological development of cells. We concluded that PLAMA-500 has potential for the use as the matrix material for bioresorbable load-bearing composite fracture fixation plates.<\/jats:p>","DOI":"10.3390\/molecules26051256","type":"journal-article","created":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T04:36:24Z","timestamp":1614314184000},"page":"1256","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Polymer for Application as a Matrix Phase in a Concept of In Situ Curable Bioresorbable Bioactive Load-Bearing Continuous Fiber Reinforced Composite Fracture Fixation Plates"],"prefix":"10.3390","volume":"26","author":[{"given":"Artem","family":"Plyusnin","sequence":"first","affiliation":[{"name":"Turku Clinical Biomaterials Centre\u2014TCBC, Department of Biomaterials Science, Faculty of Medicine, Institute of Dentistry, University of Turku, FI-20014 Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingwei","family":"He","sequence":"additional","affiliation":[{"name":"College of Materials Science and Engineering, South China University of Technology, Guangzhou 510006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2108-7040","authenticated-orcid":false,"given":"Cindy","family":"Elschner","sequence":"additional","affiliation":[{"name":"Leibniz-Institut f\u00fcr Polymerforschung Dresden e. V., D-01005 Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miho","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Medicity Research Laboratory, Faculty of Medicine, University of Turku, FI-20014 Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2025-2665","authenticated-orcid":false,"given":"Julia","family":"Kulkova","sequence":"additional","affiliation":[{"name":"Turku Clinical Biomaterials Centre\u2014TCBC, Department of Biomaterials Science, Faculty of Medicine, Institute of Dentistry, University of Turku, FI-20014 Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axel","family":"Spickenheuer","sequence":"additional","affiliation":[{"name":"Leibniz-Institut f\u00fcr Polymerforschung Dresden e. V., D-01005 Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6958-1304","authenticated-orcid":false,"given":"Christina","family":"Scheffler","sequence":"additional","affiliation":[{"name":"Leibniz-Institut f\u00fcr Polymerforschung Dresden e. V., D-01005 Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lippo V. J.","family":"Lassila","sequence":"additional","affiliation":[{"name":"Turku Clinical Biomaterials Centre\u2014TCBC, Department of Biomaterials Science, Faculty of Medicine, Institute of Dentistry, University of Turku, FI-20014 Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niko","family":"Moritz","sequence":"additional","affiliation":[{"name":"Turku Clinical Biomaterials Centre\u2014TCBC, Department of Biomaterials Science, Faculty of Medicine, Institute of Dentistry, University of Turku, FI-20014 Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1002\/adma.201402975","article-title":"Functional Supramolecular Polymers for Biomedical Applications","volume":"27","author":"Dong","year":"2015","journal-title":"Adv. Mater."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s13346-015-0274-7","article-title":"A Concise Review on Smart Polymers for Controlled Drug Release","volume":"6","author":"Khoshnevis","year":"2016","journal-title":"Drug Deliv. Transl. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.ijpharm.2019.03.011","article-title":"Natural Biodegradable Polymers Based Nano-Formulations for Drug Delivery: A Review","volume":"561","author":"George","year":"2019","journal-title":"Int. J. Pharm."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.bios.2019.04.001","article-title":"Application of Conducting Polymers to Wound Care and Skin Tissue Engineering: A Review","volume":"135","author":"Talikowska","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.2147\/IJN.S222419","article-title":"Biodegradable Polymers for Gene-Delivery Applications","volume":"15","author":"Chen","year":"2020","journal-title":"Int. J. Nanomedicine"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"79","DOI":"10.17219\/pim\/131643","article-title":"Polymers with Antiviral Properties: A Brief Review","volume":"50","author":"Zmonarski","year":"2021","journal-title":"Polym. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"100033","DOI":"10.1016\/j.mtbio.2019.100033","article-title":"Janus Particles: Design, Preparation, and Biomedical Applications","volume":"4","author":"Su","year":"2019","journal-title":"Mater. Today Bio"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1902441","DOI":"10.1002\/smll.201902441","article-title":"Design of Hierarchical Beads for Efficient Label-Free Cell Capture","volume":"15","author":"Sun","year":"2019","journal-title":"Small"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"20200050","DOI":"10.1002\/VIW.20200050","article-title":"Recent Advances on Peptide-based Theranostic Nanomaterials","volume":"1","author":"Rong","year":"2020","journal-title":"View"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"20200020","DOI":"10.1002\/VIW.20200020","article-title":"Tumor Therapy Based on Self-assembling Peptides Nanotechnology","volume":"1","author":"Ma","year":"2020","journal-title":"View"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"10831","DOI":"10.1002\/anie.202001135","article-title":"FeOOH@Metal\u2013Organic Framework Core\u2013Satellite Nanocomposites for the Serum Metabolic Fingerprinting of Gynecological Cancers","volume":"59","author":"Pei","year":"2020","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1002\/anie.201913065","article-title":"Urine Metabolic Fingerprints Encode Subtypes of Kidney Diseases","volume":"59","author":"Yang","year":"2020","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1002\/jbm.b.33950","article-title":"Hydroxyapatite-Polymer Biocomposites for Bone Regeneration: A Review of Current Trends","volume":"106","author":"Ramesh","year":"2018","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.ijbiomac.2020.02.209","article-title":"Biodegradable Poly (Lactic Acid) Nanocomposites Reinforced and Toughened by Carbon Nanotubes\/Clay Hybrids","volume":"151","author":"Bai","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_15","first-page":"17","article-title":"Polymer-Bioactive Glass Composite Filaments for 3D Scaffold Manufacturing by Fused Deposition Modeling: Fabrication and Characterization","volume":"8","author":"Boccaccini","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Gagliardi, G.G., Ibrahim, A., Borello, D., and El-Kharouf, A. (2020). Composite Polymers Development and Application for Polymer Electrolyte Membrane Technologies\u2014A Review. Molecules, 25.","DOI":"10.3390\/molecules25071712"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Liao, C., Li, Y., and Tjong, S.C. (2020). Polyetheretherketone and Its Composites for Bone Replacement and Regeneration. Polymers, 12.","DOI":"10.3390\/polym12122858"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Zimina, A., Senatov, F., Choudhary, R., Kolesnikov, E., Anisimova, N., Kiselevskiy, M., Orlova, P., Strukova, N., Generalova, M., and Manskikh, V. (2020). Biocompatibility and Physico-Chemical Properties of Highly Porous PLA\/HA Scaffolds for Bone Reconstruction. Polymers, 12.","DOI":"10.3390\/polym12122938"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1002\/polb.22259","article-title":"Biomedical Applications of Biodegradable Polymers","volume":"49","author":"Ulery","year":"2011","journal-title":"J. Polym. Sci. Part B Polym. Phys."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1260\/2040-2295.3.2.243","article-title":"Bioresorbable Plates and Screws for Clinical Applications: A Review","volume":"3","author":"Pina","year":"2012","journal-title":"J. Healthc. Eng."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.colsurfb.2017.07.038","article-title":"Recent Applications of PLGA Based Nanostructures in Drug Delivery","volume":"159","author":"Mir","year":"2017","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e1446","DOI":"10.1002\/wnan.1446","article-title":"Recent Advances in Aliphatic Polyesters for Drug Delivery Applications: Aliphatic Polyesters for Drug Delivery Applications","volume":"9","author":"Washington","year":"2017","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jdsr.2018.03.003","article-title":"Overview of Innovative Advances in Bioresorbable Plate Systems for Oral and Maxillofacial Surgery","volume":"54","author":"Kanno","year":"2018","journal-title":"Jpn. Dent. Sci. Rev."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Li, G., Zhao, M., Xu, F., Yang, B., Li, X., Meng, X., Teng, L., Sun, F., and Li, Y. (2020). Synthesis and Biological Application of Polylactic Acid. Molecules, 25.","DOI":"10.3390\/molecules25215023"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1097\/00001665-200405000-00025","article-title":"New Method of Pediatric Cranioplasty for Skull Defect Utilizing Polylactic Acid Absorbable Plates and Carbonated Apatite Bone Cement","volume":"15","author":"Cohen","year":"2004","journal-title":"J. Craniofac. Surg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1097\/01.PRS.0000132856.69391.43","article-title":"Resorbable PLLA-PGA Plate and Screw Fixation in Pediatric Craniofacial Surgery: Clinical Experience in 1883 Patients","volume":"114","author":"Eppley","year":"2004","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/3-540-45734-8_1","article-title":"Aliphatic Polyesters: Synthesis, Properties and Applications","volume":"Volume 157","author":"Albertsson","year":"2002","journal-title":"Degradable Aliphatic Polyesters"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Brinson, H.F., and Brinson, L.C. (2015). Polymer Engineering Science and Viscoelasticity, Springer.","DOI":"10.1007\/978-1-4899-7485-3"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.proeng.2015.08.024","article-title":"Creep and Stress Relaxation Behaviour of PLA-PCL Fibres\u2014A Linear Modelling Approach","volume":"114","author":"Martins","year":"2015","journal-title":"Procedia Eng."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"56","DOI":"10.4028\/www.scientific.net\/MSF.730-732.56","article-title":"Visco-Elastic-Plastic Properties of Suture Fibers Made of PLA-PCL","volume":"730\u2013732","author":"Vieira","year":"2012","journal-title":"Mater. Sci. Forum"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1097\/00005537-200110000-00005","article-title":"Resorbable Fixation in Facial Plastic and Head and Neck Reconstructive Surgery: An Initial Report on Polylactic Acid Implants","volume":"111","author":"Moe","year":"2001","journal-title":"Laryngoscope"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.jhsa.2008.01.016","article-title":"Treatment of Scapholunate Dissociation with a Bioresorbable Polymer Plate: A Biomechanical Study","volume":"33","author":"Short","year":"2008","journal-title":"J. Hand Surg."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.arthro.2006.04.096","article-title":"Long-Term Absorption of Poly-L-Lactic Acid Interference Screws","volume":"22","author":"Barber","year":"2006","journal-title":"Arthrosc. J. Arthrosc. Relat. Surg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1016\/S0142-9612(00)00129-0","article-title":"Clinical Biocompatibility of Biodegradable Orthopaedic Implants for Internal Fixation: A Review","volume":"21","year":"2000","journal-title":"Biomaterials"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1002\/jor.22019","article-title":"Effects of Lactic Acid and Glycolic Acid on Human Osteoblasts: A Way to Understand PLGA Involvement in PLGA\/Calcium Phosphate Composite Failure","volume":"30","author":"Meyer","year":"2012","journal-title":"J. Orthop. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1016\/S0142-9612(02)00582-3","article-title":"Photoinitiated Crosslinked Degradable Copolymer Networks for Tissue Engineering Applications","volume":"24","author":"Davis","year":"2003","journal-title":"Biomaterials"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3801","DOI":"10.1016\/j.biomaterials.2009.03.055","article-title":"A Poly(d,l-Lactide) Resin for the Preparation of Tissue Engineering Scaffolds by Stereolithography","volume":"30","author":"Melchels","year":"2009","journal-title":"Biomaterials"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1021\/ma00056a005","article-title":"Bioerodible Hydrogels Based on Photopolymerized Poly (Ethylene Glycol)-Co-Poly(.Alpha.-Hydroxy Acid) Diacrylate Macromers","volume":"26","author":"Sawhney","year":"1993","journal-title":"Macromolecules"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"4365","DOI":"10.1016\/0032-3861(93)90203-M","article-title":"Synthesis of Bioabsorbable Networks from Methacrylate-Endcapped Polyesters","volume":"34","author":"Storey","year":"1993","journal-title":"Polymer"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.dental.2011.02.007","article-title":"Network Structures of Bis-GMA\/TEGDMA Resins Differ in DC, Shrinkage-Strain, Hardness and Optical Properties as a Function of Reducing Agent","volume":"27","author":"Furuse","year":"2011","journal-title":"Dent. Mater."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1177\/00220345880670010401","article-title":"Analysis of Photo-Initiators in Visible-Light-Cured Dental Composite Resins","volume":"67","author":"Taira","year":"1988","journal-title":"J. Dent. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/0300-5712(94)90064-7","article-title":"Effect of Photoinitiator on Degree of Conversion of Unfilled Light-Cured Resin","volume":"22","author":"Yoshida","year":"1994","journal-title":"J. Dent."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.jmbbm.2013.01.032","article-title":"Dissolution Behavior of High Strength Bioresorbable Glass Fibers Manufactured by Continuous Fiber Drawing","volume":"20","author":"Lehtonen","year":"2013","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"4868","DOI":"10.1016\/j.actbio.2012.08.052","article-title":"Resorbable Composites with Bioresorbable Glass Fibers for Load-Bearing Applications. In Vitro Degradation and Degradation Mechanism","volume":"9","author":"Lehtonen","year":"2013","journal-title":"Acta Biomater."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/(SICI)1097-4636(19971205)37:3<440::AID-JBM15>3.0.CO;2-F","article-title":"Surface Reaction Layer Formation in Vitro on a Bioactive Glass Fiber\/Polymeric Composite","volume":"37","author":"Marcolongo","year":"1997","journal-title":"J. Biomed. Mater. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1002\/jbm.820231106","article-title":"Study of the Osteoconductive Properties of Bioactive Glass Fibers","volume":"23","author":"Pazzaglia","year":"1989","journal-title":"J. Biomed. Mater. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"725","DOI":"10.4028\/www.scientific.net\/KEM.192-195.725","article-title":"Bioactive Glass Fiber\/Polylactide Composite","volume":"192\u2013195","author":"Pirhonen","year":"2000","journal-title":"Key Eng. Mater."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.actbio.2005.08.008","article-title":"Mechanical Properties of Bioactive Glass 9-93 Fibres","volume":"2","author":"Pirhonen","year":"2006","journal-title":"Acta Biomater."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1016\/j.biomaterials.2011.01.004","article-title":"A Review of the Biological Response to Ionic Dissolution Products from Bioactive Glasses and Glass-Ceramics","volume":"32","author":"Hoppe","year":"2011","journal-title":"Biomaterials"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.drudis.2018.01.049","article-title":"The Roles of Ions on Bone Regeneration","volume":"23","author":"Awale","year":"2018","journal-title":"Drug Discov. Today"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/1097-4636(200105)55:2<151::AID-JBM1001>3.0.CO;2-D","article-title":"Gene-Expression Profiling of Human Osteoblasts Following Treatment with the Ionic Products of Bioglass\u00ae 45S5 Dissolution","volume":"55","author":"Xynos","year":"2001","journal-title":"J. Biomed. Mater. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1006\/bbrc.2000.3503","article-title":"Ionic Products of Bioactive Glass Dissolution Increase Proliferation of Human Osteoblasts and Induce Insulin-like Growth Factor II MRNA Expression and Protein Synthesis","volume":"276","author":"Xynos","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0266-3538(02)00178-1","article-title":"Application of the Tailored Fibre Placement (TFP) Process for a Local Reinforcement on an \u201cOpen-Hole\u201d Tension Plate from Carbon\/Epoxy Laminates","volume":"63","author":"Gliesche","year":"2003","journal-title":"Compos. Sci. Technol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1177\/073168449801700901","article-title":"Tailored Fiber Placement-Mechanical Properties and Applications","volume":"17","author":"Mattheij","year":"1998","journal-title":"J. Reinf. Plast. Compos."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S1359-835X(99)00096-2","article-title":"3D Reinforced Stitched Carbon\/Epoxy Laminates Made by Tailored Fibre Placement","volume":"31","author":"Mattheij","year":"2000","journal-title":"Compos. Part Appl. Sci. Manuf."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1179\/174328908X309448","article-title":"Using Tailored Fibre Placement Technology for Stress Adapted Design of Composite Structures","volume":"37","author":"Spickenheuer","year":"2008","journal-title":"Plast. Rubber Compos."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jmbbm.2019.04.016","article-title":"Biostable Glass Fibre-Reinforced Dimethacrylate-Based Composites as Potential Candidates for Fracture Fixation Plates in Toy-Breed Dogs: Mechanical Testing and Finite Element Analysis","volume":"96","author":"Plyusnin","year":"2019","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jmbbm.2014.08.020","article-title":"Mechanical Properties and In Vivo Performance of Load-Bearing Fiber-Reinforced Composite Intramedullary Nails with Improved Torsional Strength","volume":"40","author":"Moritz","year":"2014","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.medengphy.2008.11.006","article-title":"Development of a Multi-Component Fiber-Reinforced Composite Implant for Load-Sharing Conditions","volume":"31","author":"Zhao","year":"2009","journal-title":"Med. Eng. Phys."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"3616","DOI":"10.1002\/app.11193","article-title":"Structure Modification and Crosslinking of Methacrylated Polylactide Oligomers: Methacrylated Polylactide Oligomers","volume":"86","author":"Helminen","year":"2002","journal-title":"J. Appl. Polym. Sci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1016\/j.biomaterials.2004.08.002","article-title":"Preparation of Biodegradable Networks by Photo-Crosslinking Lactide, \u03b5-Caprolactone and Trimethylene Carbonate-Based Oligomers Functionalized with Fumaric Acid Monoethyl Ester","volume":"26","author":"Grijpma","year":"2005","journal-title":"Biomaterials"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"9220","DOI":"10.1021\/acs.macromol.9b01439","article-title":"Characterization of Ultraviolet-Cured Methacrylate Networks: From Photopolymerization to Ultimate Mechanical Properties","volume":"52","author":"Anastasio","year":"2019","journal-title":"Macromolecules"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s10856-005-6445-1","article-title":"Influence of Light-Curing Procedures and Photo-Initiator\/Co-Initiator Composition on the Degree of Conversion of Light-Curing Resins","volume":"16","author":"Emami","year":"2005","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s10856-005-6441-5","article-title":"Residual Monomers Released from Glass-Fibre-Reinforced Composite Photopolymerised in Contact with Bone and Blood","volume":"16","author":"Tuusa","year":"2005","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"315","DOI":"10.2334\/josnusd.50.315","article-title":"Degree of Conversion and Plasticization of Dimethacrylate-Based Polymeric Matrices: Influence of Light-Curing Mode","volume":"50","author":"Filho","year":"2008","journal-title":"J. Oral Sci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.dental.2014.05.013","article-title":"Synthesis of Antibacterial and Radio-Opaque Dimethacrylate Monomers and Their Potential Application in Dental Resin","volume":"30","author":"He","year":"2014","journal-title":"Dent. Mater."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jmbbm.2014.03.012","article-title":"Preparation of Low Shrinkage Methacrylate-Based Resin System without Bisphenol A Structure by Using a Synthesized Dendritic Macromer (G-IEMA)","volume":"35","author":"Yu","year":"2014","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1089\/ten.2007.0093","article-title":"Review: Photopolymerizable and Degradable Biomaterials for Tissue Engineering Applications","volume":"13","author":"Ifkovits","year":"2007","journal-title":"Tissue Eng."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Niaounakis, M. (2013). Degradability on Demand. Biopolymers Reuse, Recycling, and Disposal, Elsevier.","DOI":"10.1016\/B978-1-4557-3145-9.00007-5"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1021\/bp980015p","article-title":"Characterization of the Degradation of Polylactic Acid Polymer in a Solid Substrate Environment","volume":"14","author":"Agarwal","year":"1998","journal-title":"Biotechnol. Prog."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/BF00700871","article-title":"Structure-Property Relationships in the Case of the Degradation of Massive Aliphatic Poly-(\u03b1-Hydroxy Acids) in Aqueous Media. Part 1: Poly(DL-Lactic Acid)","volume":"1","author":"Li","year":"1990","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1243\/EMED_JOUR_1981_010_004_02","article-title":"Enzymic Hydrolysis of Polylactic Acid","volume":"10","author":"Williams","year":"1981","journal-title":"Eng. Med."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1002\/jbm.a.36785","article-title":"Detoxification of Poly(Methyl Methacrylate) Bone Cement by Natural Antioxidant Intervention","volume":"107","author":"Choppadandi","year":"2019","journal-title":"J. Biomed. Mater. Res. A"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.jmbbm.2016.10.011","article-title":"Tailored Poly(Ethylene) Glycol Dimethacrylate Based Shape Memory Polymer for Orthopedic Applications","volume":"65","author":"Antony","year":"2017","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"ref_75","first-page":"10","article-title":"Biocompatibility of MG-63 Cells on Collagen, Poly-L-Lactic Acid, Hydroxyapatite Scaffolds with Different Parameters","volume":"13","author":"Cecen","year":"2015","journal-title":"J. Appl. Biomater. Funct. Mater."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1016\/S0266-3538(03)00275-6","article-title":"Bioresorbable and Bioactive Polymer\/Bioglass\u00ae Composites with Tailored Pore Structure for Tissue Engineering Applications","volume":"63","author":"Boccaccini","year":"2003","journal-title":"Compos. Sci. Technol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.msec.2015.07.013","article-title":"Improved Dimensional Stability with Bioactive Glass Fibre Skeleton in Poly(Lactide-Co-Glycolide) Porous Scaffolds for Tissue Engineering","volume":"56","author":"Haaparanta","year":"2015","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1016\/S0142-9612(00)00330-6","article-title":"Antibacterial Activity of Particulate Bioglass\u00ae against Supra- and Subgingival Bacteria","volume":"22","author":"Allan","year":"2001","journal-title":"Biomaterials"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/jbm.a.32564","article-title":"Antibacterial Effects and Dissolution Behavior of Six Bioactive Glasses","volume":"93","author":"Zhang","year":"2010","journal-title":"J. Biomed. Mater. Res. A"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"3166","DOI":"10.1016\/j.biomaterials.2011.01.033","article-title":"Osteoconductive Properties of Poly(96L\/4D-Lactide)\/Beta-Tricalcium Phosphate in Long Term Animal Model","volume":"32","author":"Daculsi","year":"2011","journal-title":"Biomaterials"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1023\/A:1018580816388","article-title":"Preparation and Mechanical Properties of Calcium Phosphate\/Copoly-L-Lactide Composites","volume":"8","author":"Kikuchi","year":"1997","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/S0142-9612(02)00433-7","article-title":"Surface Modification of Tricalcium Phosphate for Improvement of the Interfacial Compatibility with Biodegradable Polymers","volume":"24","author":"Kunze","year":"2003","journal-title":"Biomaterials"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.msec.2018.12.024","article-title":"Implantable Composite Devices of Unsintered Hydroxyapatite and Poly-l-Lactide with Dispersive Marbling Morphology to Enhance in Vivo Bioactivity and Bioresorbability","volume":"97","author":"Morizane","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.rvsc.2019.12.003","article-title":"Biological Response to an Experimental Implant for Tibial Tuberosity Advancement in Dogs: A Pre-Clinical Study","volume":"128","author":"Plyusnin","year":"2020","journal-title":"Res. Vet. Sci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"5542","DOI":"10.1016\/j.biomaterials.2005.02.016","article-title":"The Complete Process of Bioresorption and Bone Replacement Using Devices Made of Forged Composites of Raw Hydroxyapatite Particles\/Poly -Lactide (F-u-HA\/PLLA)","volume":"26","author":"Shikinami","year":"2005","journal-title":"Biomaterials"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/jbm.b.33364","article-title":"In Vitro and in Vivo Evaluation of a Polylactic Acid-bioactive Glass Composite for Bone Fixation Devices","volume":"104","author":"Vergnol","year":"2016","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.clineuro.2010.07.013","article-title":"Laboratory Confirmed Polymethyl-Methacrylate (Palacos\u00ae)-Hypersensitivity after Cranioplasty","volume":"112","author":"Gautschi","year":"2010","journal-title":"Clin. Neurol. Neurosurg."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1600-0536.1993.tb03430.x","article-title":"Occupational Allergic Contact Dermatitis Caused by Exposure to Acrylates during Work with Dental Prostheses","volume":"28","author":"Kanerva","year":"1993","journal-title":"Contact Dermat."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1600-0536.1997.tb02460.x","article-title":"10 Years of Patch Testing with the (Meth)Acrylate Series","volume":"37","author":"Kanerva","year":"1997","journal-title":"Contact Dermat."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Prajapati, P., Sethuraman, R., Bector, S., and Patel, J.R. (2013). Contact Dermatitis Due to Methyl Methacrylate: Uncommon and Unwanted Entity for Dentists. Case Rep., 2013.","DOI":"10.1136\/bcr-2013-200520"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/(SICI)1097-4636(199804)40:1<124::AID-JBM14>3.0.CO;2-O","article-title":"Free Radicals and Side Products Released during Methylmethacrylate Polymerization Are Cytotoxic for Osteoblastic Cells","volume":"40","author":"Moreau","year":"1998","journal-title":"J. Biomed. Mater. Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1002\/jbm.a.30697","article-title":"Polymethylmethacrylate Particles Inhibit Osteoblastic Differentiation of Bone Marrow Osteoprogenitor Cells","volume":"77A","author":"Chiu","year":"2006","journal-title":"J. Biomed. Mater. Res. A"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1002\/jbmr.5650080907","article-title":"Bone Resorption Activity of Particulate-Stimulated Macrophages","volume":"8","author":"Glant","year":"1993","journal-title":"J. Bone Miner. Res."},{"key":"ref_94","first-page":"7","article-title":"Polymethylmethacrylate-Induced Inflammatory Macrophages Resorb Bone","volume":"74","author":"Quinn","year":"1992","journal-title":"J. Bone Joint Surg. Br."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.indcrop.2018.02.053","article-title":"Use of Cardanol-Based Acrylate as Reactive Diluent in UV-Curable Castor Oil-Based Polyurethane Acrylate Resins","volume":"117","author":"Hu","year":"2018","journal-title":"Ind. Crops Prod."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"27226","DOI":"10.1038\/srep27226","article-title":"4D Printing Smart Biomedical Scaffolds with Novel Soybean Oil Epoxidized Acrylate","volume":"6","author":"Miao","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1021\/acsnano.9b01924","article-title":"Tough Ordered Mesoporous Elastomeric Biomaterials Formed at Ambient Conditions","volume":"14","author":"Rajasekharan","year":"2020","journal-title":"ACS Nano"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1002\/hed.23370","article-title":"Craniofacial Bone Reconstruction with Bioactive Fiber-Reinforced Composite Implant: Bioactive Fiber-Reinforced Composite Implant","volume":"36","author":"Aitasalo","year":"2014","journal-title":"Head Neck"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s00405-011-1607-x","article-title":"Novel Composite Implant in Craniofacial Bone Reconstruction","volume":"269","author":"Peltola","year":"2012","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.wneu.2015.01.014","article-title":"Outcomes of Cranioplasty with Synthetic Materials and Autologous Bone Grafts","volume":"83","author":"Piitulainen","year":"2015","journal-title":"World Neurosurg."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.1016\/j.biomaterials.2006.01.017","article-title":"How Useful Is SBF in Predicting in Vivo Bone Bioactivity?","volume":"27","author":"Kokubo","year":"2006","journal-title":"Biomaterials"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/26\/5\/1256\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:29:01Z","timestamp":1760160541000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/26\/5\/1256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,26]]},"references-count":101,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,3]]}},"alternative-id":["molecules26051256"],"URL":"https:\/\/doi.org\/10.3390\/molecules26051256","relation":{},"ISSN":["1420-3049"],"issn-type":[{"type":"electronic","value":"1420-3049"}],"subject":[],"published":{"date-parts":[[2021,2,26]]}}}