{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T05:03:48Z","timestamp":1782450228773,"version":"3.54.5"},"reference-count":65,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T00:00:00Z","timestamp":1614643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Many pathologies affecting muscles (muscular dystrophies, sarcopenia, cachexia, renal insufficiency, obesity, diabetes type 2, etc.) are now clearly linked to mechanisms involving oxidative stress. In this context, there is a growing interest in exploring plants to find new natural antioxidants to prevent the appearance and the development of these muscle disorders. In this study, we investigated the antioxidant properties of Arctium lappa leaves in a model of primary human muscle cells exposed to H2O2 oxidative stress. We identified using bioassay-guided purification, onopordopicrin, a sesquiterpene lactone as the main molecule responsible for the antioxidant activity of A. lappa leaf extract. According to our findings, onopordopicrin inhibited the H2O2-mediated loss of muscle cell viability, by limiting the production of free radicals and abolishing DNA cellular damages. Moreover, we showed that onopordopicrin promoted the expression of the nuclear factor-erythroid-2-related factor 2 (Nrf2) downstream target protein heme oxygenase-1 (HO-1) in muscle cells. By using siRNA, we demonstrated that the inhibition of the expression of Nrf2 reduced the protective effect of onopordopicrin, indicating that the activation of the Nrf2\/HO-1 signaling pathway mediates the antioxidant effect of onopordopicrin in primary human muscle cells. Therefore, our results suggest that onopordopicrin may be a potential therapeutic molecule to fight against oxidative stress in pathological specific muscle disorders.<\/jats:p>","DOI":"10.3390\/molecules26051328","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T10:36:37Z","timestamp":1614681397000},"page":"1328","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Identification of a Sesquiterpene Lactone from Arctium lappa Leaves with Antioxidant Activity in Primary Human Muscle Cells"],"prefix":"10.3390","volume":"26","author":[{"given":"Nour","family":"El Khatib","sequence":"first","affiliation":[{"name":"PhyMedExp, University of Montpellier, CNRS, INSERM, F34295 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Morel","sequence":"additional","affiliation":[{"name":"Laboratoire de Botanique, Phytochimie et Mycologie, CEFE, University of Montpellier, CNRS, EPHE, IRD, University of Paul Val\u00e9ry Montpellier 3, F34093 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0772-6173","authenticated-orcid":false,"given":"G\u00e9rald","family":"Hugon","sequence":"additional","affiliation":[{"name":"PhyMedExp, University of Montpellier, CNRS, INSERM, F34295 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9105-1561","authenticated-orcid":false,"given":"Sylvie","family":"Rapior","sequence":"additional","affiliation":[{"name":"Laboratoire de Botanique, Phytochimie et Mycologie, CEFE, University of Montpellier, CNRS, EPHE, IRD, University of Paul Val\u00e9ry Montpellier 3, F34093 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Carnac","sequence":"additional","affiliation":[{"name":"PhyMedExp, University of Montpellier, CNRS, INSERM, F34295 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5219-9486","authenticated-orcid":false,"given":"Nathalie","family":"Saint","sequence":"additional","affiliation":[{"name":"PhyMedExp, University of Montpellier, CNRS, INSERM, F34295 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"001","DOI":"10.17352\/2455-2976.000020","article-title":"Oxidative stress as \u201cmother\u201d of many human diseases at strong clinical impact","volume":"3","author":"Cacciapuoti","year":"2016","journal-title":"J. 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