{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:47:50Z","timestamp":1790880470212,"version":"4.1.0"},"reference-count":70,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T00:00:00Z","timestamp":1614643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Background: There is a growing interest in the correlation between antioxidants and periodontal disease. In this study, we aimed to investigate the effect of oxidative stress and the impact of two antioxidants, curcumin and rutin, respectively, in the etiopathology of experimentally induced periodontitis in diabetic rats. Methods: Fifty Wistar albino rats were randomly divided into five groups and were induced with diabetes mellitus and periodontitis: (1) (CONTROL)\u2014control group, (2) (DPP)\u2014experimentally induced diabetes mellitus and periodontitis, (3) (DPC)\u2014experimentally induced diabetes mellitus and periodontitis treated with curcumin (C), (4) (DPR)\u2014experimentally induced diabetes mellitus and periodontitis treated with rutin (R) and (5) (DPCR)\u2014experimentally induced diabetes mellitus and periodontitis treated with C and R. We evaluated malondialdehyde (MDA) as a biomarker of oxidative stress and reduced glutathione (GSH), oxidized glutathione (GSSG), GSH\/GSSG and catalase (CAT) as biomarkers of the antioxidant capacity in blood harvested from the animals we tested. The MDA levels and CAT activities were also evaluated in the gingival tissue. Results: The control group effect was statistically significantly different from any other groups, regardless of whether or not the treatment was applied. There was also a significant difference between the untreated group and the three treatment groups for variables MDA, GSH, GSSG, GSH\/GSSG and CAT. There was no significant difference in the mean effect for the MDA, GSH, GSSG, GSH\/GSSG and CAT variables in the treated groups of rats with curcumin, rutin and the combination of curcumin and rutin. Conclusions: The oral administration of curcumin and rutin, single or combined, could reduce the oxidative stress and enhance the antioxidant status in hyperglycemic periodontitis rats.<\/jats:p>","DOI":"10.3390\/molecules26051332","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T10:36:37Z","timestamp":1614681397000},"page":"1332","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["The Antioxidant Effect of Curcumin and Rutin on Oxidative Stress Biomarkers in Experimentally Induced Periodontitis in Hyperglycemic Wistar Rats"],"prefix":"10.3390","volume":"26","author":[{"given":"Gilda M.","family":"Iova","sequence":"first","affiliation":[{"name":"Dental Medicine Department, Faculty of Medicine and Pharmacy, University of Oradea, 410068 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horia","family":"Calniceanu","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dental Medicine, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania"},{"name":"Periodontal and Periimplant Diseases Research Center \u201cProf. Dr. Anton Sculean\u201d, Faculty of Dental Medicine, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelina","family":"Popa","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania"},{"name":"Orthodontic Research Center (ORTHO-CENTER), Faculty of Dental Medicine, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camelia A.","family":"Szuhanek","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania"},{"name":"Orthodontic Research Center (ORTHO-CENTER), Faculty of Dental Medicine, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Marcu","sequence":"additional","affiliation":[{"name":"Preclinics Department, Faculty of Medicine and Pharmacy, University of Oradea, 410068 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1417-5963","authenticated-orcid":false,"given":"Gabriela","family":"Ciavoi","sequence":"additional","affiliation":[{"name":"Dental Medicine Department, Faculty of Medicine and Pharmacy, University of Oradea, 410068 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2643-761X","authenticated-orcid":false,"given":"Ioana","family":"Scrobota","sequence":"additional","affiliation":[{"name":"Dental Medicine Department, Faculty of Medicine and Pharmacy, University of Oradea, 410068 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,2]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (WHO) (2017, October 01). 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