{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T14:20:42Z","timestamp":1768746042882,"version":"3.49.0"},"reference-count":129,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T00:00:00Z","timestamp":1614816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Trypanosomatids are the causative agents of leishmaniasis and trypanosomiasis, which affect about 20 million people in the world\u2019s poorest countries, leading to 95,000 deaths per year. They are often associated with malnutrition, weak immune systems, low quality housing, and population migration. They are generally recognized as neglected tropical diseases. New drugs against these parasitic protozoa are urgently needed to counteract drug resistance, toxicity, and the high cost of commercially available drugs. Microbial bioprospecting for new molecules may play a crucial role in developing a new generation of antiparasitic drugs. This article reviews the current state of the available literature on chemically defined metabolites of microbial origin that have demonstrated antitrypanosomatid activity. In this review, bacterial and fungal metabolites are presented; they originate from a range of microorganisms, including cyanobacteria, heterotrophic bacteria, and filamentous fungi. We hope to provide a useful overview for future research to identify hits that may become the lead compounds needed to accelerate the discovery of new drugs against trypanosomatids.<\/jats:p>","DOI":"10.3390\/molecules26051388","type":"journal-article","created":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T00:39:07Z","timestamp":1614904747000},"page":"1388","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Microorganisms as a Potential Source of Molecules to Control Trypanosomatid Diseases"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2292-8825","authenticated-orcid":false,"given":"Manuel Jes\u00fas","family":"Chan-Bacab","sequence":"first","affiliation":[{"name":"Departamento de Microbiolog\u00eda Ambiental y Biotecnolog\u00eda, Universidad Aut\u00f3noma de Campeche, Av. Agust\u00edn Melgar s\/n, Campeche 24039, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Manuela","family":"Reyes-Estebanez","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda Ambiental y Biotecnolog\u00eda, Universidad Aut\u00f3noma de Campeche, Av. Agust\u00edn Melgar s\/n, Campeche 24039, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9306-2793","authenticated-orcid":false,"given":"Juan Carlos","family":"Camacho-Chab","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda Ambiental y Biotecnolog\u00eda, Universidad Aut\u00f3noma de Campeche, Av. Agust\u00edn Melgar s\/n, Campeche 24039, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjam\u00edn Otto","family":"Ortega-Morales","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda Ambiental y Biotecnolog\u00eda, Universidad Aut\u00f3noma de Campeche, Av. Agust\u00edn Melgar s\/n, Campeche 24039, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"537","DOI":"10.2174\/1386207319666160506123921","article-title":"Natural products as a source for antileishmanial and antitrypanosomal Agents","volume":"19","author":"Scotti","year":"2016","journal-title":"Comb. Chem. 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