{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:11:36Z","timestamp":1791645096991,"version":"4.3.4"},"reference-count":34,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,3,6]],"date-time":"2021-03-06T00:00:00Z","timestamp":1614988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Rosacea is a skin inflammatory condition that is accompanied by not only redness and flushing but also unseen symptoms, such as burning, stinging, and itching. TRPV1 expression in UVB-exposed skin can lead to a painful burning sensation. Upregulated TRPV1 expression helps release neuropeptides, including calcitonin gene-related peptide, pituitary adenylate cyclase-activating polypeptide, and vasoactive intestinal peptide, which can activate macrophage and inflammatory molecules. In this study, we found that radiofrequency (RF) irradiation reduced TRPV1 activation and neuropeptide expression in a UVB-exposed in vivo model and UVB- or heat-treated in an in vitro model. RF irradiation attenuated neuropeptide-induced macrophage activation and inflammatory molecule expression. Interestingly, the burning sensation in the skin of UVB-exposed mice and patients with rosacea was significantly decreased by RF irradiation. These results can provide experimental and molecular evidence on the effective use of RF irradiation for the burning sensation in patients with rosacea.<\/jats:p>","DOI":"10.3390\/molecules26051424","type":"journal-article","created":{"date-parts":[[2021,3,7]],"date-time":"2021-03-07T21:52:15Z","timestamp":1615153935000},"page":"1424","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Radiofrequency Irradiation Modulates TRPV1-Related Burning Sensation in Rosacea"],"prefix":"10.3390","volume":"26","author":[{"given":"Seyeon","family":"Oh","sequence":"first","affiliation":[{"name":"Functional Cellular Networks Laboratory, Lee Gil Ya Cancer and Diabetes Institute, Gachon University College of Medicine, Incheon 21999, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9104-3991","authenticated-orcid":false,"given":"Myeongjoo","family":"Son","sequence":"additional","affiliation":[{"name":"Functional Cellular Networks Laboratory, Lee Gil Ya Cancer and Diabetes Institute, Gachon University College of Medicine, Incheon 21999, Korea"},{"name":"Department of Anatomy &amp; Cell Biology, Gachon University College of Medicine, Incheon 21936, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joonhong","family":"Park","sequence":"additional","affiliation":[{"name":"Maymorning Dermatologic Clinic, Sungnam 13306, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghwan","family":"Kang","sequence":"additional","affiliation":[{"name":"Jeisys Medical Inc., Seoul 08501, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyunghee","family":"Byun","sequence":"additional","affiliation":[{"name":"Functional Cellular Networks Laboratory, Lee Gil Ya Cancer and Diabetes Institute, Gachon University College of Medicine, Incheon 21999, Korea"},{"name":"Department of Anatomy &amp; Cell Biology, Gachon University College of Medicine, Incheon 21936, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1067\/mjd.2002.120625","article-title":"Standard classification of rosacea: Report of the national rosacea society expert committee on the classification and staging of rosacea","volume":"46","author":"Jonathan","year":"2002","journal-title":"J. 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