{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:23:39Z","timestamp":1778621019847,"version":"3.51.4"},"reference-count":150,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T00:00:00Z","timestamp":1615766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Sneezing (sternutatio) is a poorly understood polysynaptic physiologic reflex phenomenon. Sneezing has exerted a strange fascination on humans throughout history, and induced sneezing was widely used by physicians for therapeutic purposes, on the assumption that sneezing eliminates noxious factors from the body, mainly from the head. The present contribution examines the various mixtures used for inducing sneezes (remedia sternutatoria) over the centuries. The majority of the constituents of the sneeze-inducing remedies are modulators of transient receptor potential (TRP) channels. The TRP channel superfamily consists of large heterogeneous groups of channels that play numerous physiological roles such as thermosensation, chemosensation, osmosensation and mechanosensation. Sneezing is associated with the activation of the wasabi receptor, (TRPA1), typical ligand is allyl isothiocyanate and the hot chili pepper receptor, (TRPV1), typical agonist is capsaicin, in the vagal sensory nerve terminals, activated by noxious stimulants.<\/jats:p>","DOI":"10.3390\/molecules26061627","type":"journal-article","created":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T11:38:58Z","timestamp":1615808338000},"page":"1627","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Remedia Sternutatoria over the Centuries: TRP Mediation"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0641-8462","authenticated-orcid":false,"given":"Lujain","family":"Aloum","sequence":"first","affiliation":[{"name":"Department of Pharmacology, College of Medicine and Health Sciences, Khalifa University of Science and Technology, Abu Dhabi 127788, United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4584-9166","authenticated-orcid":false,"given":"Eman","family":"Alefishat","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Medicine and Health Sciences, Khalifa University of Science and Technology, Abu Dhabi 127788, United Arab Emirates"},{"name":"Center for Biotechnology, Khalifa University of Science and Technology, Abu Dhabi 127788, United Arab Emirates"},{"name":"Department of Biopharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, The University of Jordan, Amman 11941, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5099-183X","authenticated-orcid":false,"given":"Janah","family":"Shaya","sequence":"additional","affiliation":[{"name":"Pre-Medicine Bridge Program, College of Medicine and Health Sciences, Khalifa University of Science and Technology, Abu Dhabi 127788, United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg A.","family":"Petroianu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Medicine and Health Sciences, Khalifa University of Science and Technology, Abu Dhabi 127788, United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2170\/jjphysiol.50.3","article-title":"Physiological and pathophysiological implications of upper airway reflexes in humans","volume":"50","author":"Nishino","year":"2000","journal-title":"Jpn. J. Physiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0304-3940(94)90049-3","article-title":"Influence of vagal afferents in the sneeze reflex in cats","volume":"177","author":"Macron","year":"1994","journal-title":"Neurosci. Lett."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0034-5687(95)00025-9","article-title":"Activities of vagal receptors in the different phases of sneeze in cats","volume":"101","author":"Wallois","year":"1995","journal-title":"Respir. Physiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/nrd3456","article-title":"Transient receptor potential channels as therapeutic targets","volume":"10","author":"Moran","year":"2011","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Frias, B., and Merighi, A. (2016). Capsaicin, Nociception and Pain. Molecules, 21.","DOI":"10.3390\/molecules21060797"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"15859","DOI":"10.1021\/jacs.5b10162","article-title":"A Potent and Site-Selective Agonist of TRPA1","volume":"137","author":"Takaya","year":"2015","journal-title":"J. Am. Chem. Soc."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nature14367","article-title":"Structure of the TRPA1 ion channel suggests regulatory mechanisms","volume":"520","author":"Paulsen","year":"2015","journal-title":"Nature"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1080\/10408398.2013.772090","article-title":"Biological Activities of Red Pepper (Capsicum annuum) and Its Pungent Principle Capsaicin: A Review","volume":"56","author":"Srinivasan","year":"2016","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1001\/jama.1919.02610340017004","article-title":"The physiology of sneezing","volume":"73","author":"Brubaker","year":"1919","journal-title":"J. Med. Assoc."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1177\/1753465809340571","article-title":"Sneeze reflex: Facts and fiction","volume":"3","author":"Songu","year":"2009","journal-title":"Ther. Adv. Respir. Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1136\/pgmj.66.777.549","article-title":"The history of sneezing","volume":"66","author":"Askenasy","year":"1990","journal-title":"Postgrad Med. J."},{"key":"ref_12","unstructured":"Justus Arnemann, L.A.K. (1813). Justus Arnemann\u2019s, Ehemaligen Professors der Medizin zu G\u00f6ttingen, Chirurgische Arzneimittellehre, Vandenhoeck & Ruprecht."},{"key":"ref_13","unstructured":"(2021, February 01). The London Medical Dictionary Vol1 | by Bartholomew Parr. Available online: https:\/\/chestofbooks.com\/health\/reference\/London-Medical-Dictionary\/index.html."},{"key":"ref_14","unstructured":"Dioscorides, P., and Beck, L.Y. (2005). De Materia Medica, Olms-Weidmann."},{"key":"ref_15","unstructured":"Amida, A.D. (1549). Aetii Medici Graeci Contractae ex Veteribus Medicinae Tetrabiblos, Froben."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1258\/jmb.2011.011026","article-title":"Bernard de Gordon (fl. 1270\u20131330): Medieval physician and teacher","volume":"21","author":"Pearn","year":"2013","journal-title":"J. Med. Biogr."},{"key":"ref_17","unstructured":"Leonhart, F. (1567). Opera: Dispensatorium Perfectum, Feyrabend et Huterus."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1007\/s00264-013-2111-2","article-title":"The Renaissance and the universal surgeon: Giovanni Andrea Della Croce, a master of traumatology","volume":"37","author":"Tarabella","year":"2013","journal-title":"Int. Orthop."},{"key":"ref_19","unstructured":"Bencze, J. (1964). Franciscus Joel. Gy\u00f3gyszer\u00e9szet, 386\u2013388."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"F255","DOI":"10.1136\/fn.82.3.F255","article-title":"Laurent Joubert of Montpellier (1529\u201382) and his Erreurs Populaires","volume":"82","author":"Dunn","year":"2000","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"key":"ref_21","unstructured":"(2021, February 01). Encyclopedia.com. Available online: https:\/\/www.encyclopedia.com\/religion\/encyclopedias-almanacs-transcripts-and-maps\/zacutus-lusitanus."},{"key":"ref_22","unstructured":"Chalmeteus, A. (1560). Enchiridion Chirvrgicvm, Externorvm Morborvm Remedia ... Complectens. Quibus, Morbi Venerei Curandi Methodus, Andreas Wechelus."},{"key":"ref_23","unstructured":"(2021, February 01). Martin Schoock. Available online: https:\/\/en.wikipedia.org\/wiki\/Martin_Schoock."},{"key":"ref_24","unstructured":"(2021, February 01). The Library. Available online: https:\/\/mineralogicalrecord.com\/libdetail.asp?id=1512."},{"key":"ref_25","unstructured":"(2021, February 01). Justus Arnemann. Available online: https:\/\/de.wikipedia.org\/wiki\/Justus_Arnemann."},{"key":"ref_26","unstructured":"(2021, February 01). Bartholomew Parr. Available online: https:\/\/en.wikipedia.org\/wiki\/Bartholomew_Parr#:~:text=Dr%20Bartholomew%20Parr%20FRS%20FRSE,British%20physician%20and%20medical%20author."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1007\/s00268-008-9703-9","article-title":"Franz Kaspar Hesselbach (1759\u20131816): Anatomist and Surgeon","volume":"32","author":"Tubbs","year":"2008","journal-title":"World J. Surg."},{"key":"ref_28","unstructured":"Plantnet (2021, February 02). Cuminum cyminum (Jansen, 1981). Available online: https:\/\/uses.plantnet-project.org\/en\/Cuminum_cyminum_(Jansen,_1981)."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10408398.2010.500223","article-title":"Chemistry, Technology, and Nutraceutical Functions of Cumin (cuminum cyminum L): An Overview","volume":"53","author":"Sowbhagya","year":"2013","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"11238","DOI":"10.1038\/s41598-020-68013-2","article-title":"New natural agonists of the transient receptor potential Ankyrin 1 (TRPA1) channel","volume":"10","author":"Legrand","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1080\/10408390601062054","article-title":"Black pepper and its pungent principle-piperine: A review of diverse physiological effects","volume":"47","author":"Srinivasan","year":"2007","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13765-020-00521-1","article-title":"Chemical composition and antioxidant capacity of black pepper pericarp","volume":"63","author":"Lee","year":"2020","journal-title":"Appl. Biol. Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/nau.20343","article-title":"TRPV1 is involved in stretch-evoked contractile changes in the rat autonomous bladder model: A study with piperine, a new TRPV1 agonist","volume":"26","author":"Gevaert","year":"2007","journal-title":"Neurourol. Urodyn."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.ejphar.2013.07.041","article-title":"Piperine exerts anti-seizure effects via the TRPV1 receptor in mice","volume":"714","author":"Chen","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.bbrc.2019.06.039","article-title":"A distinct structural mechanism underlies TRPV1 activation by piperine","volume":"516","author":"Dong","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s13238-016-0353-7","article-title":"Understand spiciness: Mechanism of TRPV1 channel activation by capsaicin","volume":"8","author":"Yang","year":"2017","journal-title":"Protein Cell"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1016\/j.bcp.2013.04.017","article-title":"GABAA receptor modulation by piperine and a non-TRPV1 activating derivative","volume":"85","author":"Khom","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1271\/bbb.90964","article-title":"Activation of TRPV1 and TRPA1 by black pepper components","volume":"74","author":"Okumura","year":"2010","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"S86","DOI":"10.3177\/jnsv.61.S86","article-title":"Food Compounds Activating Thermosensitive TRP Channels in Asian Herbal and Medicinal Foods","volume":"61","author":"Watanabe","year":"2015","journal-title":"J. Nutr.Sci. Vitaminol."},{"key":"ref_40","unstructured":"J\u00f6rg, J.C.G. (1825). Materialien zu einer k\u00fcnftigen heilmittellehre durch versuche der arzneyen an gesunden menschen gewonnen und gesammelt, C. Cnobloch."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/BF00994195","article-title":"Pheromonal activity of single castoreum constituents in beaver, Castor canadensis","volume":"17","author":"Houlihan","year":"1991","journal-title":"J. Chem. Ecol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1074\/jbc.RA118.005504","article-title":"Catechol estrogens stimulate insulin secretion in pancreatic \u03b2-cells via activation of the transient receptor potential A1 (TRPA1) channel","volume":"294","author":"Ma","year":"2019","journal-title":"J. Biol. Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1007\/s00204-016-1703-1","article-title":"The involvement of TRP channels in sensory irritation: A mechanistic approach toward a better understanding of the biological effects of local irritants","volume":"90","author":"Lehmann","year":"2016","journal-title":"Arch. Toxicol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/0306-4522(89)90269-8","article-title":"Resiniferatoxin, a phorbol-related diterpene, acts as an ultrapotent analog of capsaicin, the irritant constituent in red pepper","volume":"30","author":"Szallasi","year":"1989","journal-title":"Neuroscience"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/FBP.0000000000000499","article-title":"Ultra-low doses of the transient receptor potential vanilloid 1 agonist, resiniferatoxin, prevents vomiting evoked by diverse emetogens in the least shrew (Cryptotis parva)","volume":"31","author":"Darmani","year":"2020","journal-title":"Behav. Pharmacol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Stampanoni Bassi, M., Gentile, A., Iezzi, E., Zagaglia, S., Musella, A., Simonelli, I., Gilio, L., Furlan, R., Finardi, A., and Marfia, G.A. (2019). Transient Receptor Potential Vanilloid 1 Modulates Central Inflammation in Multiple Sclerosis. Front. Neurol., 10.","DOI":"10.3389\/fneur.2019.00030"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Lee, Y.C., Lu, S.C., and Hsieh, Y.L. (2018). Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1. J. Vis. Exp. JoVE, 56651.","DOI":"10.3791\/56651"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jpha.2016.09.005","article-title":"N-alkylamide profiling of Achillea ptarmica and Achillea millefolium extracts by liquid and gas chromatography\u2013mass spectrometry","volume":"7","author":"Veryser","year":"2017","journal-title":"J. Pharm. Anal."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"6428","DOI":"10.3390\/molecules19056428","article-title":"Antiprotozoal activity of Achillea ptarmica (Asteraceae) and its main alkamide constituents","volume":"19","author":"Althaus","year":"2014","journal-title":"Molecules"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1600474","DOI":"10.1002\/mnfr.201600474","article-title":"Nonivamide, a capsaicin analogue, exhibits anti-inflammatory properties in peripheral blood mononuclear cells and U-937 macrophages","volume":"61","author":"Walker","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"316","DOI":"10.3389\/fphar.2017.00316","article-title":"The Alkamide trans-Pellitorine Targets PPAR\u03b3 via TRPV1 and TRPA1 to Reduce Lipid Accumulation in Developing 3T3-L1 Adipocytes","volume":"8","author":"Lieder","year":"2017","journal-title":"Front. Pharm."},{"key":"ref_52","first-page":"44","article-title":"Pellitorine, an extract of Tetradium daniellii, is an antagonist of the ion channel TRPV1","volume":"34","author":"Pecze","year":"2017","journal-title":"Phytomed. Int. J. Phytother. Phytopharmacol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1007\/BF00505327","article-title":"Local and systemic capsaicin pretreatment inhibits sneezing and the increase in nasal vascular permeability induced by certain chemical irritants","volume":"326","author":"Lundblad","year":"1984","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.chroma.2007.06.065","article-title":"Analyses of tobacco alkaloids by cation-selective exhaustive injection sweeping microemulsion electrokinetic chromatography","volume":"1164","author":"Huang","year":"2007","journal-title":"J. Chromatogr. A"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1038\/nn.2379","article-title":"Nicotine activates the chemosensory cation channel TRPA1","volume":"12","author":"Talavera","year":"2009","journal-title":"Nat. Neurosci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1164\/rccm.201811-2087OC","article-title":"Electronic Cigarette Vapor with Nicotine Causes Airway Mucociliary Dysfunction Preferentially via TRPA1 Receptors","volume":"200","author":"Chung","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1124\/jpet.113.205971","article-title":"Bimodal concentration-response of nicotine involves the nicotinic acetylcholine receptor, transient receptor potential vanilloid type 1, and transient receptor potential ankyrin 1 channels in mouse trachea and sensory neurons","volume":"347","author":"Kichko","year":"2013","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1152\/jn.00922.2003","article-title":"Nicotine Inhibits Voltage-Dependent Sodium Channels and Sensitizes Vanilloid Receptors","volume":"91","author":"Liu","year":"2004","journal-title":"J. Neurophysiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"151","DOI":"10.4103\/0257-7941.144618","article-title":"Chemical composition and antimicrobial activity of the essential oil of Ocimum basilicum L. (sweet basil) from Western Ghats of North West Karnataka, India","volume":"33","author":"Joshi","year":"2014","journal-title":"Anc. Sci. Life"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1177\/0967033518807998","article-title":"Rapid detection of the component contents in caryophylli flos by a handheld near infrared spectrometer based on digital light processing technology","volume":"26","author":"Yan","year":"2018","journal-title":"J. Near Infrared Spectrosc."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0896-6273(04)00150-3","article-title":"Noxious Cold Ion Channel TRPA1 Is Activated by Pungent Compounds and Bradykinin","volume":"41","author":"Bandell","year":"2004","journal-title":"Neuron"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.neuroscience.2013.12.047","article-title":"Activation of transient receptor potential ankyrin 1 by eugenol","volume":"261","author":"Chung","year":"2014","journal-title":"Neuroscience"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.neuroscience.2012.02.040","article-title":"Presynaptic enhancement by eugenol of spontaneous excitatory transmission in rat spinal substantia gelatinosa neurons is mediated by transient receptor potential A1 channels","volume":"210","author":"Inoue","year":"2012","journal-title":"Neuroscience"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1177\/154405910308201004","article-title":"Activation of Vanilloid Receptor 1 (VR1) by Eugenol","volume":"82","author":"Yang","year":"2003","journal-title":"J. Dent. Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.pain.2009.03.016","article-title":"Molecular mechanism for local anesthetic action of eugenol in the rat trigeminal system","volume":"144","author":"Park","year":"2009","journal-title":"Pain"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Boscaro, V., Boffa, L., Binello, A., Amisano, G., Fornasero, S., Cravotto, G., and Gallicchio, M. (2018). Antiproliferative, Proapoptotic, Antioxidant and Antimicrobial Effects of Sinapis nigra L. and Sinapis alba L. Extracts. Molecules, 23.","DOI":"10.20944\/preprints201810.0509.v1"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1111\/1750-3841.15383","article-title":"Relationship between mustard pungency and allyl-isothiocyanate content: A comparison of sensory and chemical evaluations","volume":"85","author":"Eib","year":"2020","journal-title":"J. Food Sci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1016\/j.foodchem.2012.10.119","article-title":"The potential to intensify sulforaphane formation in cooked broccoli (Brassica oleracea var. italica) using mustard seeds (Sinapis alba)","volume":"138","author":"Ghawi","year":"2013","journal-title":"Food Chem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.foodchem.2014.05.126","article-title":"Chemical composition, antimicrobial property and microencapsulation of Mustard (Sinapis alba) seed essential oil by complex coacervation","volume":"165","author":"Peng","year":"2014","journal-title":"Food Chem."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.cell.2006.02.023","article-title":"TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents","volume":"124","author":"Bautista","year":"2006","journal-title":"Cell"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.cub.2011.01.031","article-title":"The Capsaicin Receptor TRPV1 Is a Crucial Mediator of the Noxious Effects of Mustard Oil","volume":"21","author":"Everaerts","year":"2011","journal-title":"Curr. Biol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"R1494","DOI":"10.1152\/ajpregu.00645.2009","article-title":"Intragastric administration of allyl isothiocyanate increases carbohydrate oxidation via TRPV1 but not TRPA1 in mice","volume":"300","author":"Mori","year":"2011","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1080\/09168451.2017.1407234","article-title":"Allyl isothiocyanate increases carbohydrate oxidation through enhancing insulin secretion by TRPV1","volume":"82","author":"Mori","year":"2018","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1007\/s00128-012-0535-9","article-title":"Chemical composition and in vitro cytotoxic, genotoxic effects of essential oil from Urtica dioica L.","volume":"88","author":"Demirci","year":"2012","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/nn1692","article-title":"Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels","volume":"9","author":"Xu","year":"2006","journal-title":"Nat. Neurosci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.exer.2009.09.020","article-title":"Functional expression of transient receptor potential vanilloid 3 (TRPV3) in corneal epithelial cells: Involvement in thermosensation and wound healing","volume":"90","author":"Yamada","year":"2010","journal-title":"Exp. Eye Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.cbi.2016.11.009","article-title":"Carvacrol reduces irinotecan-induced intestinal mucositis through inhibition of inflammation and oxidative damage via TRPA1 receptor activation","volume":"260","author":"Alvarenga","year":"2016","journal-title":"Chem. Biol. Interact."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/jb\/mvaa057","article-title":"Non-electrophilic TRPA1 agonists, menthol, carvacrol and clotrimazole, open epithelial tight junctions via TRPA1 activation","volume":"168","author":"Mukaiyama","year":"2020","journal-title":"J. Biochem."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.bios.2018.11.046","article-title":"The investigation of allosteric regulation mechanism of analgesic effect using SD rat taste bud tissue biosensor","volume":"126","author":"Xiao","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Noumi, E., Snoussi, M., Alreshidi, M.M., Rekha, P.D., Saptami, K., Caputo, L., De Martino, L., Souza, L.F., Msaada, K., and Mancini, E. (2018). Chemical and Biological Evaluation of Essential Oils from Cardamom Species. Molecules, 23.","DOI":"10.3390\/molecules23112818"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1111\/jnc.13433","article-title":"1,8- and 1,4-cineole enhance spontaneous excitatory transmission by activating different types of transient receptor potential channels in the rat spinal substantia gelatinosa","volume":"136","author":"Jiang","year":"2016","journal-title":"J. Neurochem."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1744-8069-8-86","article-title":"1,8-cineole, a TRPM8 agonist, is a novel natural antagonist of human TRPA1","volume":"8","author":"Takaishi","year":"2012","journal-title":"Mol. Pain"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"9874","DOI":"10.1523\/JNEUROSCI.2221-07.2007","article-title":"Bimodal Action of Menthol on the Transient Receptor Potential Channel TRPA1","volume":"27","author":"Karashima","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1111\/1750-3841.14723","article-title":"Promotion of Mitochondrial Biogenesis via Activation of AMPK-PGC1\u0251 Signaling Pathway by Ginger (Zingiber officinale Roscoe) Extract, and Its Major Active Component 6-Gingerol","volume":"84","author":"Deng","year":"2019","journal-title":"J. Food Sci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"142979","DOI":"10.1155\/2015\/142979","article-title":"Ginger and its constituents: Role in prevention and treatment of gastrointestinal cancer","volume":"2015","author":"Prasad","year":"2015","journal-title":"Gastroenterol. Res. Pract."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1017\/S0007114512005715","article-title":"Grains of paradise (Aframomum melegueta) extract activates brown adipose tissue and increases whole-body energy expenditure in men","volume":"110","author":"Sugita","year":"2013","journal-title":"Br. J. Nutr."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"3581","DOI":"10.1021\/acs.jafc.7b00577","article-title":"Construction of Prediction Models for the Transient Receptor Potential Vanilloid Subtype 1 (TRPV1)-Stimulating Activity of Ginger and Processed Ginger Based on LC-HRMS Data and PLS Regression Analyses","volume":"65","author":"Yoshitomi","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1111\/j.1476-5381.2009.00307.x","article-title":"Compounds from Sichuan and Melegueta peppers activate, covalently and non-covalently, TRPA1 and TRPV1 channels","volume":"157","author":"Riera","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.3892\/ijmm.2016.2791","article-title":"Effects of ginger and its pungent constituents on transient receptor potential channels","volume":"38","author":"Kim","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1271\/bbb.100133","article-title":"Galangal pungent component, 1\u2032-acetoxychavicol acetate, activates TRPA1","volume":"74","author":"Narukawa","year":"2010","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"43","DOI":"10.4103\/phrev.phrev_55_16","article-title":"A Review on the Pharmacological Activities and Phytochemicals of Alpinia officinarum (Galangal) Extracts Derived from Bioassay-Guided Fractionation and Isolation","volume":"11","author":"Basri","year":"2017","journal-title":"Pharmacogn. Rev."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1080\/09168451.2015.1132148","article-title":"Activation of transient receptor potential ankyrin 1 by quercetin and its analogs","volume":"80","author":"Nakamura","year":"2016","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/ffj.2730070506","article-title":"Compositon of the essential oil of rhizomes of kaempferia galanga L.","volume":"7","author":"Wong","year":"1992","journal-title":"Flavour Fragr. J."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"2870","DOI":"10.1021\/jf011128i","article-title":"Coriander essential oil composition from two genotypes grown in different environmental conditions","volume":"50","author":"Gil","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/ptr.6827","article-title":"Lavender and coriander essential oils and their main component linalool exert a protective effect against amyloid-\u03b2 neurotoxicity","volume":"35","author":"Caputo","year":"2020","journal-title":"Phytother. Res. PTR"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Fothergill, L.J., Callaghan, B., Rivera, L.R., Lieu, T., Poole, D.P., Cho, H.J., Bravo, D.M., and Furness, J.B. (2016). Effects of Food Components That Activate TRPA1 Receptors on Mucosal Ion Transport in the Mouse Intestine. Nutrients, 8.","DOI":"10.3390\/nu8100623"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"8438101","DOI":"10.1155\/2018\/8438101","article-title":"Inhibitory Effects of Glycyrrhiza glabra and Its Major Constituent Glycyrrhizin on Inflammation-Associated Corneal Neovascularization","volume":"2018","author":"Shah","year":"2018","journal-title":"Evid. Based Complement. Altern. Med. eCAM"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.jcmgh.2017.12.005","article-title":"Activation of Myofibroblast TRPA1 by Steroids and Pirfenidone Ameliorates Fibrosis in Experimental Crohn\u2019s Disease","volume":"5","author":"Kurahara","year":"2018","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3389\/fphar.2019.00057","article-title":"The Regulatory Effects of Paeoniflorin and Its Derivative Paeoniflorin-6\u2032-O-Benzene Sulfonate CP-25 on Inflammation and Immune Diseases","volume":"10","author":"Tu","year":"2019","journal-title":"Front. Pharmacol."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Yan, Z., Xie, L., Tian, Y., Li, M., Ni, J., Zhang, Y., and Niu, L. (2020). Insights into the Phytochemical Composition and Bioactivities of Seeds from Wild Peony Species. Plants, 9.","DOI":"10.3390\/plants9060729"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/JLB.3MA0220-355R","article-title":"Paeoniflorin relieves LPS-induced inflammatory pain in mice by inhibiting NLRP3 inflammasome activation via transient receptor potential vanilloid 1","volume":"108","author":"Yin","year":"2020","journal-title":"J. Leukoc. Biol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.3892\/ol.2013.1520","article-title":"Composition and potential anticancer activities of essential oils obtained from myrrh and frankincense","volume":"6","author":"Chen","year":"2013","journal-title":"Oncol. Lett."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1080\/10412905.2003.9712264","article-title":"Constituents of the Essential Oil of Commiphora myrrha (Nees) Engl. var. molmol","volume":"15","author":"Saeedi","year":"2003","journal-title":"J. Essent. Oil Res."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"3710821","DOI":"10.1155\/2017\/3710821","article-title":"A Combined Water Extract of Frankincense and Myrrh Alleviates Neuropathic Pain in Mice via Modulation of TRPV1","volume":"2017","author":"Hu","year":"2017","journal-title":"Neural Plast."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"5434","DOI":"10.3390\/molecules18055434","article-title":"Camphor--a fumigant during the Black Death and a coveted fragrant wood in ancient Egypt and Babylon\u2014A review","volume":"18","author":"Chen","year":"2013","journal-title":"Molecules"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"8924","DOI":"10.1523\/JNEUROSCI.2574-05.2005","article-title":"Camphor activates and strongly desensitizes the transient receptor potential vanilloid subtype 1 channel in a vanilloid-independent mechanism","volume":"25","author":"Xu","year":"2005","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1007\/s00424-012-1204-x","article-title":"Bimodal effects of cinnamaldehyde and camphor on mouse TRPA1","volume":"465","author":"Alpizar","year":"2013","journal-title":"Pfl\u00fcg. Arch. Eur. J. Physiol."},{"key":"ref_108","first-page":"472","article-title":"The Genus Asarum L.: A Phytochemical and Ethnopharmacological Review","volume":"11","author":"Antsyshkina","year":"2020","journal-title":"Syst. Rev. Pharm."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1093\/chemse\/bjt032","article-title":"Gustatory receptor neurons in Manduca sexta contain a TrpA1-dependent signaling pathway that integrates taste and temperature","volume":"38","author":"Afroz","year":"2013","journal-title":"Chem. Senses"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Moon, H., Kim, M.J., Son, H.J., Kweon, H.J., Kim, J.T., Kim, Y., Shim, J., Suh, B.C., and Rhyu, M.R. (2015). Five hTRPA1 Agonists Found in Indigenous Korean Mint, Agastache rugosa. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0127060"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1080\/10412905.2003.9712267","article-title":"Essential Oil of Nigella damascena L. (Ranunculaceae) Seeds","volume":"15","author":"Fico","year":"2003","journal-title":"J. Essent. Oil Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1080\/10412905.2004.9698804","article-title":"Volatile Components of Nigella damascena L. and Nigella sativa L. Seeds","volume":"16","author":"Rchid","year":"2004","journal-title":"J. Essent. Oil Res."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1080\/10412905.2004.9698690","article-title":"Essential Oils of Nigella sativa L. and Nigella damascena L. Seed","volume":"16","author":"Moretti","year":"2004","journal-title":"J. Essent. Oil Res."},{"key":"ref_114","unstructured":"Aikkal, R. (2016). Phytochemical analysis, carminative, enzyme inhibitor, and anticancer activities of beta-elemene. Retrieved March."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Andriana, Y., Xuan, T.D., Quy, T.N., Tran, H.D., and Le, Q.T. (2019). Biological Activities and Chemical Constituents of Essential Oils from Piper cubeba Bojer and Piper nigrum L.. Molecules, 24.","DOI":"10.3390\/molecules24101876"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Alminderej, F., Bakari, S., Almundarij, T.I., Snoussi, M., Aouadi, K., and Kadri, A. (2020). Antioxidant Activities of a New Chemotype of Piper cubeba L. Fruit Essential Oil (Methyleugenol\/Eugenol): In Silico Molecular Docking and ADMET Studies. Plants, 9.","DOI":"10.3390\/plants9111534"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1007\/s00436-011-2695-7","article-title":"In vitro efficacy of the essential oil of Piper cubeba L. (Piperaceae) against Schistosoma mansoni","volume":"110","author":"Wakabayashi","year":"2012","journal-title":"Parasitol. Res."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1080\/10412905.2007.9699217","article-title":"Essential Oil Constituents of Piper cubeba L. fils. from Indonesia","volume":"19","author":"Bos","year":"2007","journal-title":"J. Essent. Oil Res."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1073\/pnas.0303329101","article-title":"Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4","volume":"101","author":"Vriens","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.neuron.2006.03.042","article-title":"TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction","volume":"50","author":"Kwan","year":"2006","journal-title":"Neuron"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/nature05910","article-title":"The menthol receptor TRPM8 is the principal detector of environmental cold","volume":"448","author":"Bautista","year":"2007","journal-title":"Nature"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1152\/physiol.00026.2008","article-title":"Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control","volume":"23","author":"Bessac","year":"2008","journal-title":"Physiology"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/nrn2149","article-title":"TRP channels in mechanosensation: Direct or indirect activation?","volume":"8","author":"Christensen","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1080\/23328940.2015.1040604","article-title":"TRP ion channels in thermosensation, thermoregulation and metabolism","volume":"2","author":"Wang","year":"2015","journal-title":"Temperature"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s00210-008-0321-8","article-title":"Roles of TRP channels in the development of cardiac hypertrophy","volume":"378","author":"Nishida","year":"2008","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. pharmacol."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Liu, H., Dilger, J.P., and Lin, J. (2020). The Role of Transient Receptor Potential Melastatin 7 (TRPM7) in Cell Viability: A Potential Target to Suppress Breast Cancer Cell Cycle. Cancers, 12.","DOI":"10.3390\/cancers12010131"},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Liu, H., Dilger, J.P., and Lin, J. (2021). Lidocaine Suppresses Viability and Migration of Human Breast Cancer Cells: TRPM7 as a Target for Some Breast Cancer Cell Lines. Cancers, 13.","DOI":"10.3390\/cancers13020234"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.yjmcc.2006.10.020","article-title":"Upregulation of TRPC1 in the development of cardiac hypertrophy","volume":"42","author":"Ohba","year":"2007","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/112_2014_18","article-title":"The TRPA1 channel in inflammatory and neuropathic pain and migraine","volume":"167","author":"Nassini","year":"2014","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"707","DOI":"10.3858\/emm.2012.44.12.080","article-title":"Human skeletal dysplasia caused by a constitutive activated transient receptor potential vanilloid 4 (TRPV4) cation channel mutation","volume":"44","author":"Kang","year":"2012","journal-title":"Exp. Mol. Med."},{"key":"ref_131","first-page":"655","article-title":"TRP channel antagonists for pain--opportunities beyond TRPV1","volume":"10","author":"Bevan","year":"2009","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1007\/s13238-017-0395-5","article-title":"TRPV1 and TRPA1 in cutaneous neurogenic and chronic inflammation: Pro-inflammatory response induced by their activation and their sensitization","volume":"8","author":"Gouin","year":"2017","journal-title":"Protein Cell"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/j.1476-5381.2012.01851.x","article-title":"The functions of TRPA1 and TRPV1: Moving away from sensory nerves","volume":"166","author":"Fernandes","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0092-8674(03)00158-2","article-title":"ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures","volume":"112","author":"Story","year":"2003","journal-title":"Cell"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13223-015-0074-0","article-title":"The role of flavor and fragrance chemicals in TRPA1 (transient receptor potential cation channel, member A1) activity associated with allergies","volume":"11","author":"Mihara","year":"2015","journal-title":"Allergy Asthma Clin. Immunol. Off. J. Can. Soc. Allergy Clin. Immunol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"15167","DOI":"10.1074\/jbc.M110.106153","article-title":"Contribution of TRPV1-TRPA1 Interaction to the Single Channel Properties of the TRPA1 Channel","volume":"285","author":"Staruschenko","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/978-981-10-7757-9_6","article-title":"Transient Receptor Potential (TRP) Channels","volume":"87","author":"Samanta","year":"2018","journal-title":"Sub-cell. Biochem."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Aloum, L., Alefishat, E., Adem, A., and Petroianu, G. (2020). Ionone Is More than a Violet\u2019s Fragrance: A Review. Molecules, 25.","DOI":"10.3390\/molecules25245822"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.jaci.2013.08.026","article-title":"Capsaicin treatment reduces nasal hyperreactivity and transient receptor potential cation channel subfamily V, receptor 1 (TRPV1) overexpression in patients with idiopathic rhinitis","volume":"133","author":"Alpizar","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S1063-5823(06)57003-6","article-title":"Chapter 4 TRPV1: A Polymodal Sensor in the Nociceptor Terminal","volume":"Volume 57","author":"Caterina","year":"2006","journal-title":"Current Topics in Membranes"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1085\/jgp.200810138","article-title":"Polymodal Ligand Sensitivity of TRPA1 and Its Modes of Interactions","volume":"133","author":"Bang","year":"2009","journal-title":"J. Gen. Physiol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1387\/ijdb.150232dg","article-title":"Human transient receptor potential (TRP) channel expression profiling in carcinogenesis","volume":"59","author":"Bernardini","year":"2015","journal-title":"Int. J. Dev. Biol."},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Ben\u00edtez-Angeles, M., Morales-L\u00e1zaro, S.L., Ju\u00e1rez-Gonz\u00e1lez, E., and Rosenbaum, T. (2020). TRPV1: Structure, Endogenous Agonists, and Mechanisms. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21103421"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"26008","DOI":"10.1073\/pnas.1913929116","article-title":"TRPA1 modulation by piperidine carboxamides suggests an evolutionarily conserved binding site and gating mechanism","volume":"116","author":"Gianti","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1152\/jn.00524.2018","article-title":"TRPA1: A molecular view","volume":"121","author":"Meents","year":"2019","journal-title":"J. Neurophysiol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"19564","DOI":"10.1073\/pnas.0609598103","article-title":"TRP channel activation by reversible covalent modification","volume":"103","author":"Hinman","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nature05544","article-title":"Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines","volume":"445","author":"Macpherson","year":"2007","journal-title":"Nature"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/nchembio.1835","article-title":"Structural mechanism underlying capsaicin binding and activation of the TRPV1 ion channel","volume":"11","author":"Yang","year":"2015","journal-title":"Nat. Chem. Biol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"E137","DOI":"10.1073\/pnas.1517288113","article-title":"Understanding TRPV1 activation by ligands: Insights from the binding modes of capsaicin and resiniferatoxin","volume":"113","author":"Elokely","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.bmcl.2015.01.039","article-title":"Discovery of non-electrophilic capsaicinoid-type TRPA1 ligands","volume":"25","author":"Caprioglio","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/26\/6\/1627\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:35:53Z","timestamp":1760160953000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/26\/6\/1627"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,15]]},"references-count":150,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,3]]}},"alternative-id":["molecules26061627"],"URL":"https:\/\/doi.org\/10.3390\/molecules26061627","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,15]]}}}