{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T07:57:42Z","timestamp":1764403062572,"version":"build-2065373602"},"reference-count":37,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T00:00:00Z","timestamp":1615852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003086","name":"Eusko Jaurlaritza","doi-asserted-by":"publisher","award":["GV, IT 992-16"],"award-info":[{"award-number":["GV, IT 992-16"]}],"id":[{"id":"10.13039\/501100003086","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010198","name":"Ministerio de Econom\u00eda, Industria y Competitividad, Gobierno de Espa\u00f1a","doi-asserted-by":"publisher","award":["CTQ-2015-67871R"],"award-info":[{"award-number":["CTQ-2015-67871R"]}],"id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>An Ugi three-component reaction using preformed \u03b1-phosphorated N-tosyl ketimines with different isocyanides in the presence of a carboxylic acid affords tetrasubstituted \u03b1-aminophosphonates. Due to the high steric hindrance, the expected acylated amines undergo a spontaneous elimination of the acyl group. The reaction is applicable to \u03b1-aryl ketimines bearing a number of substituents and several isocyanides. In addition, the densely substituted \u03b1-aminophosphonate substrates showed in vitro cytotoxicity, inhibiting the growth of carcinoma human tumor cell line A549 (carcinomic human alveolar basal epithelial cell).<\/jats:p>","DOI":"10.3390\/molecules26061654","type":"journal-article","created":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T12:01:02Z","timestamp":1615896062000},"page":"1654","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Ugi Reaction on \u03b1-Phosphorated Ketimines for the Synthesis of Tetrasubstituted \u03b1-Aminophosphonates and Their Applications as Antiproliferative Agents"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6363-2246","authenticated-orcid":false,"given":"Adri\u00e1n","family":"L\u00f3pez-Franc\u00e9s","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica I, Centro de Investigaci\u00f3n y Estudios Avanzados \u201cLucio Lascaray\u201d, Facultad de Farmacia, University of the Basque Country, UPV\/EHU Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6973-0912","authenticated-orcid":false,"given":"Xabier","family":"del Corte","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica I, Centro de Investigaci\u00f3n y Estudios Avanzados \u201cLucio Lascaray\u201d, Facultad de Farmacia, University of the Basque Country, UPV\/EHU Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1167-0240","authenticated-orcid":false,"given":"Edorta","family":"Mart\u00ednez de Marigorta","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica I, Centro de Investigaci\u00f3n y Estudios Avanzados \u201cLucio Lascaray\u201d, Facultad de Farmacia, University of the Basque Country, UPV\/EHU Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Palacios","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica I, Centro de Investigaci\u00f3n y Estudios Avanzados \u201cLucio Lascaray\u201d, Facultad de Farmacia, University of the Basque Country, UPV\/EHU Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8976-0991","authenticated-orcid":false,"given":"Javier","family":"Vicario","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica I, Centro de Investigaci\u00f3n y Estudios Avanzados \u201cLucio Lascaray\u201d, Facultad de Farmacia, University of the Basque Country, UPV\/EHU Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Trabocchi, A. (2013). Diversity-Oriented Synthesis, Willey.","DOI":"10.1002\/9781118618110"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/ncomms1081","article-title":"Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules","volume":"1","author":"Galloway","year":"2010","journal-title":"Nat. Commun."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1126\/science.287.5460.1964","article-title":"Target-oriented and diversity-oriented organic synthesis in drug discovery","volume":"287","author":"Schreiber","year":"2000","journal-title":"Science"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3758","DOI":"10.1002\/anie.201609394","article-title":"Modern Synthetic Avenues for the Preparation of Functional Fluorophores","volume":"56","author":"Kielland","year":"2017","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1021\/acs.accounts.6b00403","article-title":"Multicomponent Hetero-[4 + 2] Cycloaddition\/Allylboration Reaction: From Natural Product Synthesis to Drug Discovery","volume":"49","author":"Hall","year":"2016","journal-title":"Acc. Chem. Res."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Zhu, J., Wang, Q., and Wang, M.-X. (2015). Multicomponent Reactions in Organic Synthesis, Wiley-VCH.","DOI":"10.1002\/9783527678174"},{"key":"ref_7","unstructured":"M\u00fcller, T.J.J. (2014). Science of Synthesis, Multicomponent Reactions, Thieme."},{"key":"ref_8","first-page":"386","article-title":"Versuche mit Isonitrilen","volume":"71","author":"Ugi","year":"1959","journal-title":"Angew. Chem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.1002\/1521-3773(20000915)39:18<3168::AID-ANIE3168>3.0.CO;2-U","article-title":"Multicomponent Reactions with Isocyanides","volume":"39","author":"Ugi","year":"2000","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1021\/cr0505728","article-title":"Recent developments in isocyanide based multicomponent reactions in applied chemistry","volume":"106","year":"2006","journal-title":"Chem. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.1021\/cr100233r","article-title":"Chemistry and Biology of Multicomponent Reactions","volume":"112","author":"Wang","year":"2012","journal-title":"Chem. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"42644","DOI":"10.1039\/D0RA07501A","article-title":"Two decades of recent advances of Ugi reactions: Synthetic and pharmaceutical applications","volume":"10","author":"Fouad","year":"2020","journal-title":"RSC Adv."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4439","DOI":"10.1021\/cr800296p","article-title":"Natural Product Synthesis Using Multicomponent Reaction Strategies","volume":"109","author":"Hall","year":"2009","journal-title":"Chem. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"301","DOI":"10.2174\/1568011013354543","article-title":"Aminophosphonic Acids of Potential Medical Importance","volume":"1","author":"Kafarski","year":"2001","journal-title":"Curr. Med. Chem. Anti-Cancer Agents"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1271\/bbb.61.211","article-title":"Aminophosphonic and Aminoboronic Acids as Key Elements of a Transition State Analogue Inhibitor of Enzymes","volume":"61","author":"Hiratake","year":"1997","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1080\/10426509108029443","article-title":"Biological Activity of Aminophosphonic Acids B","volume":"63","author":"Kafarski","year":"1991","journal-title":"Phosphorus. Sulfur. Silicon"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.2174\/138527205774913088","article-title":"Computer-Aided Analysis and Design of Phosphonic and Phosphinic Enzyme Inhibitors as Potential Drugs and Agrochemicals","volume":"9","author":"Berlicki","year":"2005","journal-title":"Curr. Org. Chem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1021\/cr800315j","article-title":"Direct Phosphonylation of Aromatic Azaheterocycles","volume":"109","author":"Stevens","year":"2009","journal-title":"Chem. Rev."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Barrett, G., and Elmore, D. (1998). Amino Acids and Peptides, Cambridge University Press.","DOI":"10.1017\/CBO9781139163828"},{"key":"ref_20","unstructured":"Kukhar, V.P., and Hudson, H.R. (2000). Aminophosphonic and Aminophosphinic Acids. Chemistry and Biological Activity, Wiley."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3762\/bjoc.10.3","article-title":"Studies on the interaction of isocyanides with imines: Reaction scope and mechanistic variations","volume":"10","author":"Ghashghaei","year":"2014","journal-title":"Beilstein J. Org. Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1021\/acs.orglett.7b03977","article-title":"Aza-Riley Oxidation of Ugi-Azide and Ugi-3CR Products toward Vicinal Tricarbonyl Amides: Two-Step MCR-Oxidation Methodology Accessing Functionalized \u03b1,\u03b2-Diketoamides and \u03b1,\u03b2-Diketotetrazoles","volume":"20","author":"Foley","year":"2018","journal-title":"Org. Lett."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Christoffers, J., and Baro, A. (2006). Quaternary Stereocentres: Challenges and Solutions for Organic Synthesis, Wiley-VCH.","DOI":"10.1002\/3527606858"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Yamada, T., Yanagi, T., Omote, Y., Miyazawa, T., Kuwata, S., Sugiura, M., and Matsumoto, K. (1990). Four-component condensation (Ugi reaction) at high pressure: Novel synthesis of peptides containing very bulky \u03b1,\u03b1-disubstituted glycines. J. Chem. Soc. Chem. Commun., 1640\u20131641.","DOI":"10.1039\/C39900001640"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1039\/b212473b","article-title":"An improved approach for the synthesis of \u03b1,\u03b1-dialkyl glycine derivatives by the Ugi\u2013Passerini reaction","volume":"1","author":"Costa","year":"2003","journal-title":"Org. Biomol. Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"8184","DOI":"10.1016\/j.tet.2006.05.078","article-title":"Synthesis and kinetic investigation of the selective acidolysis of para-substituted N-benzyl- or N-phenyl-N-phenylacetyl-\u03b1,\u03b1-dialkylglycine cyclohexylamides","volume":"62","author":"Pinto","year":"2006","journal-title":"Tetrahedron"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1080\/10426507.2018.1528258","article-title":"Enantioselective synthesis of functionalized \u03b1-aminophosphonic acid derivatives","volume":"194","author":"Maestro","year":"2019","journal-title":"Phosphorus. Sulfur. Silicon"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1002\/adsc.201200516","article-title":"Asymmetric Cyanation of \u03b1-Ketiminophosphonates Catalyzed by Cinchona Alkaloids. Enantioselective Synthesis of Tetrasubstituted \u03b1-Aminophosphonic Acid Derivatives from Trisubstituted \u03b1-Aminophosphonates","volume":"354","author":"Vicario","year":"2012","journal-title":"Adv. Synth. Catal."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Vicario, J., Ortiz, P., and Palacios, F. (2013). Synthesis of Tetrasubstituted \u03b1-Aminophosphonic Acid Derivatives from Trisubstituted \u03b1-Aminophosphonates. Eur. J. Org. Chem., 7095\u20137100.","DOI":"10.1002\/ejoc.201300950"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1021\/jo502233m","article-title":"Asymmetric Synthesis of Functionalized Tetrasubstituted \u03b1\u2011Aminophosphonates through Enantioselective Aza-Henry Reaction of Phosphorylated Ketimines","volume":"80","author":"Vicario","year":"2015","journal-title":"J. Org. Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"9473","DOI":"10.1021\/acs.orglett.9b03669","article-title":"Enantioselective Aza-Reformatsky Reaction with Ketimines","volume":"21","author":"Maestro","year":"2019","journal-title":"Org. Lett."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"6729","DOI":"10.1016\/j.tet.2016.09.002","article-title":"All-carbon quaternary centers in natural products and medicinal chemistry: Recent advances","volume":"72","author":"Ling","year":"2016","journal-title":"Tetrahedron"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.ejmech.2018.09.011","article-title":"Synthesis of novel antiproliferative hybrid bis-(3-indolyl)methane phosphonate derivatives","volume":"158","author":"Maestro","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.ejmech.2017.06.056","article-title":"Design, synthesis and biological studies of a library of NK1-Receptor Ligands Based on a 5-arylthiosubstituted 2-amino-4,6-diaryl-3-cyano-4H-pyran core: Switch from antagonist to agonist effect by chemical modification","volume":"138","author":"Recio","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1126\/science.1131943","article-title":"Fluorine in pharmaceuticals: Looking beyond intuition","volume":"317","author":"Faeh","year":"2007","journal-title":"Science"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1080\/14756360701425014","article-title":"The role of fluorine in medicinal chemistry","volume":"22","author":"Shah","year":"2007","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"B\u00e9gu\u00e9, J.P., and Bonnet-Delpon, D. (2007). Bioorganic and Medicinal Chemistry of Fluorine, Wiley.","DOI":"10.1002\/9780470281895"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/26\/6\/1654\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:36:39Z","timestamp":1760160999000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/26\/6\/1654"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,16]]},"references-count":37,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,3]]}},"alternative-id":["molecules26061654"],"URL":"https:\/\/doi.org\/10.3390\/molecules26061654","relation":{},"ISSN":["1420-3049"],"issn-type":[{"type":"electronic","value":"1420-3049"}],"subject":[],"published":{"date-parts":[[2021,3,16]]}}}