{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T22:40:10Z","timestamp":1781995210401,"version":"3.54.5"},"reference-count":57,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T00:00:00Z","timestamp":1615939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["PRELUDIUM UMO-2015\/19\/N\/NZ7\/01018"],"award-info":[{"award-number":["PRELUDIUM UMO-2015\/19\/N\/NZ7\/01018"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004569","name":"Ministerstwo Nauki i Szkolnictwa Wy\u017cszego","doi-asserted-by":"publisher","award":["0012\/IP3\/2015\/73 (Iuventus Plus)"],"award-info":[{"award-number":["0012\/IP3\/2015\/73 (Iuventus Plus)"]}],"id":[{"id":"10.13039\/501100004569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Nowadays anticancer drugs (ADs), like other pharmaceuticals, are recognized as new emerging pollutants, meaning that they are not commonly monitored in the environment; however, they have great potential to enter the environment and cause adverse effects there. The current scientific literature highlights the problem of their presence in the aquatic environment by publishing more and more results on their analytics and ecotoxicological evaluation. In order to properly assess the risk associated with the presence of ADs in the environment, it is also necessary to investigate the processes that are important in understanding the environmental fate of these compounds. However, the state of knowledge on mobility of ADs in the environment is still very limited. Therefore, the main aim of our study was to investigate the sorption potential of two anticancer drugs, 5-fluorouracil (5-FU) and methotrexate (MTX), onto different soils. Special attention was paid to the determination of the influence of pH and ionic strength as well as presence of co-contaminants (cadmium (Cd2+) and another pharmaceutical\u2014metoprolol (MET)) on the sorption of 5-FU and MTX onto soil. The obtained distribution coefficient values (Kd) ranged from 2.52 to 6.36 L\u00b7kg\u22121 and from 6.79 to 12.94 L\u00b7kg\u22121 for 5-FU and MTX, respectively. Investigated compounds may be classified as slightly or low mobile in the soil matrix (depending on soil). 5-FU may be recognized as more mobile in comparison to MET. It was proved that presence of other soil contaminants may strongly influence their mobility in soil structures. The investigated co-contaminant (MET) caused around 25-fold increased sorption of 5-FU, whereas diminished sorption of MTX. Moreover, the influence of environmental conditions such as pH and ionic strength on their sorption has been clearly demonstrated.<\/jats:p>","DOI":"10.3390\/molecules26061674","type":"journal-article","created":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T11:48:22Z","timestamp":1615981702000},"page":"1674","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Insight into the Sorption of 5-Fluorouracil and Methotrexate onto Soil\u2013pH, Ionic Strength, and Co-Contaminant Influence"],"prefix":"10.3390","volume":"26","author":[{"given":"Katarzyna","family":"Markiewicz","sequence":"first","affiliation":[{"name":"Department of Environmental Analysis, Faculty of Chemistry, University of Gdansk, ul. Wita Stwosza 63, PL-80-308 Gda\u0144sk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5673-3519","authenticated-orcid":false,"given":"Anna","family":"Bia\u0142k-Bieli\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Environmental Analysis, Faculty of Chemistry, University of Gdansk, ul. Wita Stwosza 63, PL-80-308 Gda\u0144sk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"\u0141ukaszewicz","sequence":"additional","affiliation":[{"name":"Department of Environmental Analysis, Faculty of Chemistry, University of Gdansk, ul. Wita Stwosza 63, PL-80-308 Gda\u0144sk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Stepnowski","sequence":"additional","affiliation":[{"name":"Department of Environmental Analysis, Faculty of Chemistry, University of Gdansk, ul. Wita Stwosza 63, PL-80-308 Gda\u0144sk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Do\u0142\u017conek","sequence":"additional","affiliation":[{"name":"Department of Environmental Analysis, Faculty of Chemistry, University of Gdansk, ul. Wita Stwosza 63, PL-80-308 Gda\u0144sk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.mrrev.2014.02.001","article-title":"Environmental Risk Assessment of Anti-Cancer Drugs and Their Transformation Products: A Focus on Their Genotoxicity Characterization-State of Knowledge and Short Comings","volume":"760","author":"Toolaram","year":"2014","journal-title":"Mutat. Res. Rev. Mutat. Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1016\/j.talanta.2011.08.034","article-title":"Analysis of Anticancer Drugs: A Review","volume":"85","author":"Nussbaumer","year":"2011","journal-title":"Talanta"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Tripathi, A.K., David, A., Govil, T., Rauniyar, S., Rathinam, N.K., Goh, K.M., and Sani, R.K. (2020). Environmental Remediation of Antineoplastic Drugs: Present Status, Challenges, and Future Directions. Processes, 8.","DOI":"10.3390\/pr8070747"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.scitotenv.2018.04.318","article-title":"Environmental Relevant Levels of the Cytotoxic Drug Cyclophosphamide Produce Harmful Effects in the Polychaete Nereis Diversicolor","volume":"636","author":"Fonseca","year":"2018","journal-title":"Sci. Total Environ."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.seppur.2019.05.016","article-title":"Treatment of Anticancer Drugs in Hospital and Wastewater Effluents Using Nanofiltration","volume":"224","author":"Torrejais","year":"2019","journal-title":"Sep. Purif. Technol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1016\/j.envpol.2019.05.095","article-title":"Effects of Mixtures of Anticancer Drugs in the Benthic Polychaete Nereis Diversicolor","volume":"252","author":"Fonseca","year":"2019","journal-title":"Environ. Pollut."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Heath, E., Isidori, M., Kosjek, T., and Filipi\u010d, M. (2020). Fate and Effects of Anticancer Drugs in the Environment, Springer.","DOI":"10.1007\/978-3-030-21048-9"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.ijheh.2011.08.002","article-title":"Emerging Pollutants in Wastewater: A Review of the Literature","volume":"214","author":"Deblonde","year":"2011","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"ref_9","first-page":"2","article-title":"Analysis, Removal, Effects and Risk of Pharmaceuticals in the Water Cycle Occurrence and Transformation in the Environment","volume":"62","author":"Petrovic","year":"2013","journal-title":"Compr. Anal. Chem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"172816","DOI":"10.1016\/j.ejphar.2019.172816","article-title":"Cytostatic Pharmaceuticals as Water Contaminants","volume":"866","author":"Jureczko","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.scitotenv.2013.11.145","article-title":"Prioritising Anticancer Drugs for Environmental Monitoring and Risk Assessment Purposes","volume":"473\u2013474","author":"Booker","year":"2014","journal-title":"Sci. Total Environ."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s002160050859","article-title":"Trace Enrichment, Chromatographic Separation and Biodegradation of Cytostatic Compounds in Surface Water","volume":"361","author":"Kiffmeyer","year":"1998","journal-title":"Fresenius. J. Anal. Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.envint.2011.10.002","article-title":"Anticancer Drugs in Surface Waters. What Can We Say about the Occurrence and Environmental Significance of Cytotoxic, Cytostatic and Endocrine Therapy Drugs?","volume":"39","author":"Besse","year":"2012","journal-title":"Environ. Int."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.chroma.2013.03.046","article-title":"Fluorouracil in the Environment: Analysis, Occurrence, Degradation and Transformation","volume":"1290","author":"Kosjek","year":"2013","journal-title":"J. Chromatogr. A"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.chemosphere.2014.01.013","article-title":"Acute and Chronic Toxicity of Six Anticancer Drugs on Rotifers and Crustaceans","volume":"115","author":"Parrella","year":"2014","journal-title":"Chemosphere"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jhazmat.2013.08.040","article-title":"Pharmaceuticals and Personal Care Products in the Aquatic Environment in China: A Review","volume":"262","author":"Bu","year":"2013","journal-title":"J. Hazard. Mater."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.watres.2015.03.025","article-title":"Assessment of Toxicity and Genotoxicity of Low Doses of 5-Fluorouracil in Zebrafish (Danio Rerio) Two-Generation Study","volume":"77","author":"Csenki","year":"2015","journal-title":"Water Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.scitotenv.2012.12.061","article-title":"Removal of Cytostatic Drugs from Aquatic Environment: A Review","volume":"445\u2013446","author":"Zhang","year":"2013","journal-title":"Sci. Total Environ."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.chroma.2013.01.114","article-title":"Optimization of Pressurized Liquid Extraction Using a Multivariate Chemometric Approach for the Determination of Anticancer Drugs in Sludge by Ultra High Performance Liquid Chromatography-Tandem Mass Spectrometry","volume":"1283","author":"Seira","year":"2013","journal-title":"J. Chromatogr. A"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.chemosphere.2006.05.051","article-title":"Fate of 5-Fluorouracil, Doxorubicin, Epirubicin, and Daunorubicin in Hospital Wastewater and Their Elimination by Activated Sludge and Treatment in a Membrane-Bio-Reactor System","volume":"66","author":"Mahnik","year":"2007","journal-title":"Chemosphere"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1007\/s00216-020-02600-0","article-title":"Cytostatic Compounds in Sludge and Sediment: Extraction and Determination by a Combination of Microwave-Assisted Extraction and UHPLC\u2013MS\/MS","volume":"412","author":"Halko","year":"2020","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"19021","DOI":"10.1007\/s11356-017-9525-0","article-title":"Distribution of Six Anticancer Drugs and a Variety of Other Pharmaceuticals, and Their Sorption onto Sediments, in an Urban Japanese River","volume":"24","author":"Azuma","year":"2017","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Azuma, T. (2018). Distribution of Anticancer Drugs in River Waters and Sediments of the Yodo River Basin, Japan. Appl. Sci., 8.","DOI":"10.3390\/app8112043"},{"key":"ref_24","first-page":"187","article-title":"Factors Affecting Sorption of Organic Compounds in Natural Sorbent\/Water Systems and Sorption Coefficients for Selected Pollutants. A Review","volume":"30","author":"Delle","year":"2001","journal-title":"J. Phys. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3397","DOI":"10.1021\/es0003021","article-title":"Sorption of Veterinary Pharmaceuticals in Soils: A Review","volume":"35","author":"Tolls","year":"2001","journal-title":"Environ. Sci. Technol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1080\/03601230500189691","article-title":"Effect of Agricultural Antibiotics on the Persistence and Transformation of 17beta-Estradiol in a Sequatchie Loam","volume":"40","author":"Chun","year":"2005","journal-title":"J. Environ. Sci. Health B"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.envpol.2013.05.022","article-title":"Co-Contaminants and Factors Affecting the Sorption Behaviour of Two Sulfonamides in Pasture Soils","volume":"180","author":"Srinivasan","year":"2013","journal-title":"Environ. Pollut."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.scitotenv.2015.11.002","article-title":"The Leaching Behavior of Cyclophosphamide and Ifosfamide from Soil in the Presence of Co-Contaminant\u2014Mixture Sorption Approach","volume":"542","author":"Mioduszewska","year":"2016","journal-title":"Sci. Total Environ."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"5937","DOI":"10.1007\/s00216-013-6794-4","article-title":"Development of a UPLC-MS\/MS Method for the Determination of Ten Anticancer Drugs in Hospital and Urban Wastewaters, and Its Application for the Screening of Human Metabolites Assisted by Information-Dependent Acquisition Tool (IDA) in Sewage Samples","volume":"405","year":"2013","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.envpol.2014.01.005","article-title":"Prevalence and Sunlight Photolysis of Controlled and Chemotherapeutic Drugs in Aqueous Environments","volume":"187","author":"Lin","year":"2014","journal-title":"Environ. Pollut."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.2175\/106143011X13075599870298","article-title":"Emerging Pollutants","volume":"83","author":"Bell","year":"2011","journal-title":"Water Environ. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"127976","DOI":"10.1016\/j.chemosphere.2020.127976","article-title":"Sorption of Pharmaceuticals on the Surface of Microplastics","volume":"263","author":"Puckowski","year":"2021","journal-title":"Chemosphere"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.chemosphere.2018.02.072","article-title":"Preliminary Evaluation of the Application of Carbon Nanotubes as Potential Adsorbents for the Elimination of Selected Anticancer Drugs from Water Matrices","volume":"201","author":"Paszkiewicz","year":"2018","journal-title":"Chemosphere"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1007\/s11814-019-0292-0","article-title":"Thermodynamic and Kinetic Studies Sorption of 5-Fluorouracil onto Single Walled Carbon Nanotubes Modified by Chitosan","volume":"36","author":"Karimidost","year":"2019","journal-title":"Korean J. Chem. Eng."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.trac.2011.04.007","article-title":"Occurrence, Fate and Determination of Cytostatic Pharmaceuticals in the Environment","volume":"30","author":"Kosjek","year":"2011","journal-title":"TrAC Trends Anal. Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.scitotenv.2014.06.023","article-title":"Beta-Blockers in the Environment: Part I. Mobility and Hydrolysis Study","volume":"493","author":"Maszkowska","year":"2014","journal-title":"Sci. Total Environ."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.chemosphere.2006.03.026","article-title":"A Global Perspective on the Use, Sales, Exposure Pathways, Occurrence, Fate and Effects of Veterinary Antibiotics (VAs) in the Environment","volume":"65","author":"Sarmah","year":"2006","journal-title":"Chemosphere"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.scitotenv.2017.04.214","article-title":"Science of the Total Environment Fate of Antibiotics in Soil and Their Uptake by Edible Crops","volume":"599\u2013600","author":"Pan","year":"2017","journal-title":"Sci. Total Environ."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.trac.2004.08.005","article-title":"Selected Drugs in Solid Matrices: A Review of Environmental Determination, Occurrence and Properties of Principal Substances","volume":"23","author":"Beausse","year":"2004","journal-title":"TrAC Trends Anal. Chem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ecolind.2007.06.002","article-title":"Veterinary Antibiotics in the Aquatic and Terrestrial Environment","volume":"8","author":"Kemper","year":"2008","journal-title":"Ecol. Indic."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.ijheh.2017.01.011","article-title":"Mixture toxicity of flubendazole and fenbendazole to Daphnia magna","volume":"220","author":"Puckowski","year":"2017","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Mohr, T.K.G. (2010). Environmental Investigation and Remediation: 1,4-Dioxane and Other Solvent Stabilizers, CRC Press.","DOI":"10.1201\/EBK1566706629-c9"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.trac.2017.09.009","article-title":"Overview of Experimental and Computational Methods for the Determination of the PKa Values of 5-Fluorouracil, Cyclophosphamide, Ifosfamide, Imatinib and Methotrexate","volume":"97","author":"Mioduszewska","year":"2017","journal-title":"Trends Anal. Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.scitotenv.2014.08.018","article-title":"The Sorption of Sulfamethazine on Soil Samples: Isotherms and Error Analysis","volume":"497\u2013498","author":"Pavlovic","year":"2014","journal-title":"Sci. Total Environ."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.procbio.2016.03.013","article-title":"Isotherm, Kinetic and Thermodynamic Characteristics of Adsorption of Paclitaxel onto Diaion HP-20","volume":"51","author":"Shin","year":"2016","journal-title":"Process Biochem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"9209","DOI":"10.1021\/es301036t","article-title":"Polyfunctional Ionogenic Compound Sorption: Challenges and New Approaches to Advance Predictive Models","volume":"46","author":"Mackay","year":"2012","journal-title":"Environ. Sci. Technol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1897\/05-232R.1","article-title":"The Effect of PH and Ionic Strength on the Sorption of Sulfachloropyridazine, Tylosin and Oxytetracycline to Soil","volume":"25","author":"Laak","year":"2006","journal-title":"Environ. Toxicol. Chem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"3607","DOI":"10.1007\/s11356-012-1432-9","article-title":"Removal of Highly Polar Micropollutants from Wastewater by Powdered Activated Carbon","volume":"20","author":"Kovalova","year":"2013","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"12182","DOI":"10.1007\/s11356-015-4445-3","article-title":"Sorption of Sulfisoxazole onto Soil-an Insight into Different Influencing Factors","volume":"22","author":"Maszkowska","year":"2015","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Kah, M.M., and Brown, C. (2006). Adsorption of Ionisable Pesticides in Soils. Reviews of Environmental Contamination and Toxicology, Springer.","DOI":"10.1007\/978-0-387-32964-2_5"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0016-7061(00)00027-6","article-title":"Sorption of Brilliant Blue FCF in Soils as Affected by PH and Ionic Strength","volume":"97","author":"Flury","year":"2000","journal-title":"Geoderma"},{"key":"ref_52","unstructured":"McLean, J., and Bledsoe, B. (1992). Behavior of Metals in Soils, EPA Ground Water Issue."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s11783-010-0265-3","article-title":"Sorption of Tetracycline to Sediments and Soils: Assessing the Roles of PH, the Presence of Cadmium and Properties of Sediments and Soils","volume":"4","author":"Zhang","year":"2010","journal-title":"Front. Environ. Sci. Eng. China"},{"key":"ref_54","unstructured":"Dziennik Ustaw 2002 nr 165 poz (2002). 1359 Rozporz\u0105dzenie Ministra \u015arodowiska z dnia 9 Wrze\u015bnia 2002."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1007\/s00216-009-3225-7","article-title":"The Challenge of Analyzing Beta-Blocker Drugs in Sludge and Wastewater","volume":"396","author":"Scheurer","year":"2010","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_56","unstructured":"Organization for Economic Cooperation and Development (2000). OECD 106 Adsorption-Desorption Using a Batch Equilibrium Method. OECD Guideline for the Testing of Chemicals 106, Organization for Economic Cooperation and Development."},{"key":"ref_57","unstructured":"Konieczka, P.N.J. (2004). Ocena i Kontrola Jako\u015bci Wynik\u00f3w Pomiar\u00f3w Analitycznych, CEEAM."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/26\/6\/1674\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:36:59Z","timestamp":1760161019000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/26\/6\/1674"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,17]]},"references-count":57,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,3]]}},"alternative-id":["molecules26061674"],"URL":"https:\/\/doi.org\/10.3390\/molecules26061674","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,17]]}}}