{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:55:57Z","timestamp":1790488557445,"version":"4.1.0"},"reference-count":112,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T00:00:00Z","timestamp":1616112000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science foundation of China","award":["32070919"],"award-info":[{"award-number":["32070919"]}]},{"name":"Natural Science Foundation of Jiangsu Province","award":["BK20201442"],"award-info":[{"award-number":["BK20201442"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Inflammasomes are multiprotein complexes formed to regulate the maturation of pro-inflammatory caspases, in response to intracellular or extracellular stimulants. Accumulating studies showed that the inflammasomes are implicated in the pathogenesis of inflammatory bowel disease (IBD), although their activation is not a decisive factor for the development of IBD. Inflammasomes and related cytokines play an important role in the maintenance of gut immune homeostasis, while its overactivation might induce excess immune responses and consequently cause tissue damage in the gut. Emerging studies provide evidence that some genetic abnormalities might induce enhanced NLRP3 inflammasome activation and cause colitis. In these cases, the colonic inflammation can be ameliorated by blocking NLRP3 activation or its downstream cytokine IL-1\u03b2. A number of natural products were shown to play a role in preventing colon inflammation in various experimental colitis models. On the other hand, lack of inflammasome function also causes intestinal abnormalities. Thus, an appropriate regulation of inflammasomes might be a promising therapeutic strategy for IBD intervention. This review aims at summarizing the main findings in these studies and provide an outline for further studies that might contribute to our understanding of the role of inflammasomes in the pathogenesis and therapeutic treatment of IBD.<\/jats:p>","DOI":"10.3390\/molecules26061725","type":"journal-article","created":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T11:18:38Z","timestamp":1616152718000},"page":"1725","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Inflammasome Regulation: Therapeutic Potential for Inflammatory Bowel Disease"],"prefix":"10.3390","volume":"26","author":[{"given":"Qiuyun","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Immunology, School of Medicine, Nantong University, 19 Qixiu Road, Nantong 226019, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6120-7318","authenticated-orcid":false,"given":"Xiaorong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Medicine, Nantong University, 19 Qixiu Road, Nantong 226019, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren","family":"Strober","sequence":"additional","affiliation":[{"name":"Mucosal Immunity Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9740-820X","authenticated-orcid":false,"given":"Liming","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Medicine, Nantong University, 19 Qixiu Road, Nantong 226019, China"},{"name":"Basic Medical Research Center, School of Medicine, Nantong University, Nantong 226019, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/nri1132","article-title":"The immunological and genetic basis of inflammatory bowel disease","volume":"3","author":"Bouma","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1053\/j.gastro.2011.02.016","article-title":"Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases","volume":"140","author":"Strober","year":"2011","journal-title":"Gastroenterology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.pop.2017.07.010","article-title":"An update on inflammatory bowel disease","volume":"44","author":"Sairenji","year":"2017","journal-title":"Prim. Care"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1097\/MOG.0000000000000642","article-title":"The burden of cost in inflammatory bowel disease: A medical economic perspective","volume":"36","author":"Beard","year":"2020","journal-title":"Curr. Opin. Gastroenterol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.crohns.2013.01.010","article-title":"The burden of inflammatory bowel disease in Europe","volume":"7","author":"Burisch","year":"2013","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S2468-1253(19)30333-4","article-title":"The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990\u20132017: A systematic analysis for the Global Burden of Disease Study 2017","volume":"5","author":"Alatab","year":"2020","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nature10209","article-title":"Genetics and pathogenesis of inflammatory bowel disease","volume":"474","author":"Khor","year":"2011","journal-title":"Nature"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/s41586-020-2025-2","article-title":"Pathway paradigms revealed from the genetics of inflammatory bowel disease","volume":"578","author":"Graham","year":"2020","journal-title":"Nature"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1172\/JCI30587","article-title":"The fundamental basis of inflammatory bowel disease","volume":"117","author":"Strober","year":"2007","journal-title":"J. Clin. Invest."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.autrev.2013.06.004","article-title":"Innate and adaptive immunity in inflammatory bowel disease","volume":"13","author":"Geremia","year":"2014","journal-title":"Autoimmun. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"E2332","DOI":"10.1073\/pnas.1222669110","article-title":"Chemical and cytokine features of innate immunity characterize serum and tissue profiles in inflammatory bowel disease","volume":"110","author":"Knutson","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1097\/MOG.0b013e3282ff8b0c","article-title":"Innate immunity in inflammatory bowel disease: State of the art","volume":"24","author":"Hisamatsu","year":"2008","journal-title":"Curr. Opin. Gastroenterol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1056\/NEJMcibr1706536","article-title":"Inflammatory bowel disease and the NLRP3 inflammasome","volume":"377","author":"Kanneganti","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1007\/s10620-017-4650-7","article-title":"NLRP3 inflammasome in inflammatory bowel disease: Friend or foe?","volume":"62","author":"Liu","year":"2017","journal-title":"Dig. Dis. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","article-title":"The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-beta","volume":"10","author":"Martinon","year":"2002","journal-title":"Mol. Cell"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.cell.2010.01.040","article-title":"The inflammasomes","volume":"140","author":"Schroder","year":"2010","journal-title":"Cell"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/nri2851","article-title":"Central roles of NLRs and inflammasomes in viral infection","volume":"10","author":"Kanneganti","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1615\/CritRevImmunol.v30.i5.50","article-title":"Inflammasomes and their activation","volume":"30","author":"Khare","year":"2010","journal-title":"Crit. Rev. Immunol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.coi.2009.12.004","article-title":"The inflammasomes: Mechanisms of activation and function","volume":"22","author":"Latz","year":"2010","journal-title":"Curr. Opin. Immunol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1002\/eji.200940180","article-title":"Inflammasomes as microbial sensors","volume":"40","author":"Franchi","year":"2010","journal-title":"Eur. J. Immunol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"eaav1447","DOI":"10.1126\/sciimmunol.aav1447","article-title":"Gasdermin D activity in inflammation and host defense","volume":"4","author":"Lieberman","year":"2019","journal-title":"Sci. Immunol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"a036400","DOI":"10.1101\/cshperspect.a036400","article-title":"Mechanism and regulation of gasdermin-mediated cell death","volume":"12","author":"Xia","year":"2020","journal-title":"Cold Spring Harb Perspect. Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"100924","DOI":"10.1016\/j.mam.2020.100924","article-title":"An overview of the non-canonical inflammasome","volume":"76","author":"Downs","year":"2020","journal-title":"Mol. Aspects Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/imr.12283","article-title":"The NLRP1 inflammasomes","volume":"265","author":"Vance","year":"2015","journal-title":"Immunol. Rev."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.coi.2019.04.015","article-title":"The NLRP1 inflammasome: New mechanistic insights and unresolved mysteries","volume":"60","author":"Mitchell","year":"2019","journal-title":"Curr. Opin. Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/imr.12607","article-title":"The NLRC4 Inflammasome","volume":"281","author":"Duncan","year":"2018","journal-title":"Immunol. Rev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/s13238-012-2028-3","article-title":"Sensing bacterial infections by NAIP receptors in NLRC4 inflammasome activation","volume":"3","author":"Gong","year":"2012","journal-title":"Protein Cell"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.it.2011.02.002","article-title":"The Nlrp3 inflammasome: Contributions to intestinal homeostasis","volume":"32","author":"Zaki","year":"2011","journal-title":"Trends Immunol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/imm.13046","article-title":"Differential role of the NLRP3 inflammasome in infection and tumorigenesis","volume":"156","author":"Tartey","year":"2019","journal-title":"Immunology"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Fusco, R., Siracusa, R., Genovese, T., Cuzzocrea, S., and Di Paola, R. (2020). Focus on the role of NLRP3 inflammasome in diseases. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21124223"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s10875-019-00638-z","article-title":"CAPS and NLRP3","volume":"39","author":"Booshehri","year":"2019","journal-title":"J. Clin. Immunol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1002\/eji.200940191","article-title":"New insights into the nature of autoinflammatory diseases from mice with Nlrp3 mutations","volume":"40","author":"Meng","year":"2010","journal-title":"Eur. J. Immunol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.immuni.2009.04.012","article-title":"A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses","volume":"30","author":"Meng","year":"2009","journal-title":"Immunity"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1136\/gut.31.6.686","article-title":"Role of interleukin 1 in inflammatory bowel disease\u2014Enhanced production during active disease","volume":"31","author":"Ligumsky","year":"1990","journal-title":"Gut"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1084\/jem.20111453","article-title":"IL-1beta mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4(+) Th17 cells","volume":"209","author":"Coccia","year":"2012","journal-title":"J. Exp. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1136\/gut.2009.197822","article-title":"Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome","volume":"59","author":"Bauer","year":"2010","journal-title":"Gut"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1159\/000341681","article-title":"Protective and aggravating effects of Nlrp3 inflammasome activation in IBD models: Influence of genetic and environmental factors","volume":"30","author":"Bauer","year":"2012","journal-title":"Dig. Dis."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.immuni.2010.03.003","article-title":"The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis","volume":"32","author":"Zaki","year":"2010","journal-title":"Immunity"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.immuni.2010.02.012","article-title":"Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases","volume":"32","author":"Yeretssian","year":"2010","journal-title":"Immunity"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Wagatsuma, K., and Nakase, H. (2020). Contradictory effects of NLRP3 inflammasome regulatory mechanisms in colitis. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21218145"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.3389\/fimmu.2018.02566","article-title":"The role of NLRP3 and IL-1beta in the pathogenesis of inflammatory bowel disease","volume":"9","author":"Mao","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nature11535","article-title":"IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine","volume":"491","author":"Huber","year":"2012","journal-title":"Nature"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"13727","DOI":"10.1038\/ncomms13727","article-title":"The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by promoting proteasomal degradation of NLRP3","volume":"7","author":"Song","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Cui, S., Wang, C., Bai, W., Li, J., Pan, Y., Huang, X., Yang, H., Feng, Z., Xiang, Q., and Fei, L. (2020). CD1d1 intrinsic signaling in macrophages controls NLRP3 inflammasome expression during inflammation. Sci. Adv., 6.","DOI":"10.1126\/sciadv.aaz7290"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1172\/JCI83669","article-title":"NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22","volume":"126","author":"Spalinger","year":"2016","journal-title":"J. Clin. Invest."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1016\/j.cell.2015.10.072","article-title":"Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis","volume":"163","author":"Nowarski","year":"2015","journal-title":"Cell"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1038\/s41467-017-01917-2","article-title":"Remodelling of the gut microbiota by hyperactive NLRP3 induces regulatory T cells to maintain homeostasis","volume":"8","author":"Yao","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"10741","DOI":"10.4238\/2014.December.18.15","article-title":"Correlation between IRGM genetic polymorphisms and Crohn\u2019s disease risk: A meta-analysis of case-control studies","volume":"13","author":"Li","year":"2014","journal-title":"Genet. Mol. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.molcel.2018.11.018","article-title":"The Crohn\u2019s disease risk factor IRGM limits NLRP3 inflammasome activation by impeding its assembly and by mediating its selective autophagy","volume":"73","author":"Mehto","year":"2019","journal-title":"Mol. Cell"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Newton, K. (2020). Multitasking kinase RIPK1 regulates cell death and inflammation. Cold Spring Harb Perspect Biol., 12.","DOI":"10.1101\/cshperspect.a036368"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1073\/pnas.1813582116","article-title":"Human RIPK1 deficiency causes combined immunodeficiency and inflammatory bowel diseases","volume":"116","author":"Li","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s10875-017-0374-x","article-title":"Gastrointestinal manifestations in X-linked agammaglobulinemia","volume":"37","author":"Barmettler","year":"2017","journal-title":"J. Clin. Immunol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1172\/JCI128322","article-title":"Bruton tyrosine kinase deficiency augments NLRP3 inflammasome activation and causes IL-1beta-mediated colitis","volume":"130","author":"Mao","year":"2020","journal-title":"J. Clin. Invest."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1016\/j.celrep.2018.01.052","article-title":"PTPN2 regulates inflammasome activation and controls onset of intestinal inflammation and colon cancer","volume":"22","author":"Spalinger","year":"2018","journal-title":"Cell Rep."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"4107","DOI":"10.1096\/fj.201902200RR","article-title":"Jmjd3 regulates inflammasome activation and aggravates DSS-induced colitis in mice","volume":"34","author":"Huang","year":"2020","journal-title":"FASEB J."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1084\/jem.20160462","article-title":"Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome","volume":"214","author":"Neudecker","year":"2017","journal-title":"J. Exp. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1007\/s00011-014-0774-9","article-title":"NLRP3 gene is associated with ulcerative colitis (UC), but not Crohn\u2019s disease (CD), in Chinese Han population","volume":"63","author":"Zhang","year":"2014","journal-title":"Inflamm. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/ng.285","article-title":"Common variants in the NLRP3 region contribute to Crohn\u2019s disease susceptibility","volume":"41","author":"Villani","year":"2009","journal-title":"Nat. Genet."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.clinre.2017.09.003","article-title":"Association of NLRP3 single nucleotide polymorphisms with ulcerative colitis: A case-control study","volume":"42","author":"Hanaei","year":"2018","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1002\/ibd.21499","article-title":"Genetic association between NLRP3 variants and Crohn\u2019s disease does not replicate in a large UK panel","volume":"17","author":"Lewis","year":"2011","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jaci.2020.09.003","article-title":"Excessive deubiquitination of NLRP3-R779C variant contributes to very-early-onset inflammatory bowel disease development","volume":"147","author":"Zhou","year":"2021","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.3389\/fimmu.2018.02623","article-title":"Impaired COMMD10-mediated regulation of Ly6C(hi) monocyte-driven inflammation disrupts gut barrier function","volume":"9","author":"Mouhadeb","year":"2018","journal-title":"Front. Immunol"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1172\/JCI98642","article-title":"Loss-of-function CARD8 mutation causes NLRP3 inflammasome activation and Crohn\u2019s disease","volume":"128","author":"Mao","year":"2018","journal-title":"J. Clin. Invest."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1053\/j.gastro.2016.08.055","article-title":"Interleukin 1beta mediates intestinal inflammation in mice and patients with interleukin 10 receptor deficiency","volume":"151","author":"Shouval","year":"2016","journal-title":"Gastroenterology"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"3526","DOI":"10.1073\/pnas.1322831111","article-title":"IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans","volume":"111","author":"Smeekens","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"117591","DOI":"10.1016\/j.lfs.2020.117591","article-title":"Cardamonin: A new player to fight cancer via multiple cancer signaling pathways","volume":"250","author":"Nawaz","year":"2020","journal-title":"Life Sci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.bcp.2018.07.039","article-title":"Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR\/Nrf2\/NQO1 pathway","volume":"155","author":"Wang","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"3203","DOI":"10.1080\/13880209.2016.1216131","article-title":"Therapeutic potential of naringin: An overview","volume":"54","author":"Chen","year":"2016","journal-title":"Pharm. Biol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"13133","DOI":"10.1021\/acs.jafc.8b03942","article-title":"Protective effect of naringin on DSS-induced ulcerative colitis in mice","volume":"66","author":"Cao","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.fitote.2015.01.001","article-title":"Diversity, pharmacology and synthesis of bergenin and its derivatives: Potential materials for therapeutic usages","volume":"101","author":"Bajracharya","year":"2015","journal-title":"Fitoterapia"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.cbi.2018.10.020","article-title":"Preventive effect of bergenin against the development of TNBS-induced acute colitis in rats is associated with inflammatory mediators inhibition and NLRP3\/ASC inflammasome signaling pathways","volume":"297","author":"Rosillo","year":"2019","journal-title":"Chem. Biol. Interact."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.biochi.2019.04.008","article-title":"Palmatine: A review of its pharmacology, toxicity and pharmacokinetics","volume":"162","author":"Long","year":"2019","journal-title":"Biochimie"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.molimm.2018.10.015","article-title":"Palmatine attenuated dextran sulfate sodium (DSS)-induced colitis via promoting mitophagy-mediated NLRP3 inflammasome inactivation","volume":"105","author":"Mai","year":"2019","journal-title":"Mol. Immunol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.critrevonc.2017.09.004","article-title":"Genistein: Its role in metabolic diseases and cancer","volume":"119","author":"Mukund","year":"2017","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.intimp.2019.01.021","article-title":"Genistein protects against DSS-induced colitis by inhibiting NLRP3 inflammasome via TGR5-cAMP signaling","volume":"71","author":"Chen","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1080\/13543776.2018.1455829","article-title":"Bioactivity and pharmacological properties of alpha-mangostin from the mangosteen fruit: A review","volume":"28","author":"Chen","year":"2018","journal-title":"Expert Opin. Ther. Pat."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"15626","DOI":"10.1038\/s41598-019-52036-5","article-title":"Using high-throughput sequencing to explore the anti-inflammatory effects of alpha-mangostin","volume":"9","author":"Yin","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_78","first-page":"2695","article-title":"Roseburia intestinalisderived flagellin ameliorates colitis by targeting miR2233pmediated activation of NLRP3 inflammasome and pyroptosis","volume":"22","author":"Wu","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.tox.2018.11.010","article-title":"Sulphur dioxide ameliorates colitis related pathophysiology and inflammation","volume":"412","author":"Banerjee","year":"2019","journal-title":"Toxicology"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1039\/C8FO01699B","article-title":"The protective role of phloretin against dextran sulfate sodium-induced ulcerative colitis in mice","volume":"10","author":"Zhang","year":"2019","journal-title":"Food Funct."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1039\/C9FO02719J","article-title":"Protective effect of Lachnum polysaccharide on dextran sulfate sodium-induced colitis in mice","volume":"11","author":"Zong","year":"2020","journal-title":"Food Funct."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1007\/s40265-019-01229-3","article-title":"Dimethyl fumarate: A review in relapsing-remitting MS","volume":"79","author":"Blair","year":"2019","journal-title":"Drugs"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1093\/ecco-jcc\/jjv231","article-title":"Dimethyl fumarate reduces inflammatory responses in experimental colitis","volume":"10","author":"Casili","year":"2016","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.bcp.2016.05.002","article-title":"Dimethyl fumarate ameliorates dextran sulfate sodium-induced murine experimental colitis by activating Nrf2 and suppressing NLRP3 inflammasome activation","volume":"112","author":"Liu","year":"2016","journal-title":"Biochem. Pharmacol."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Li, S., Takasu, C., Lau, H., Robles, L., Vo, K., Farzaneh, T., Vaziri, N.D., Stamos, M.J., and Ichii, H. (2020). Dimethyl fumarate alleviates dextran sulfate sodium-induced colitis, through the activation of Nrf2-mediated antioxidant and anti-inflammatory pathways. Antioxidants, 9.","DOI":"10.3390\/antiox9040354"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"e1900272","DOI":"10.1002\/ardp.201900272","article-title":"Isatin-azole hybrids and their anticancer activities","volume":"353","author":"Hou","year":"2020","journal-title":"Arch. Pharm."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.intimp.2017.01.015","article-title":"Therapeutic efficacy of carboxyamidotriazole on 2,4,6-trinitrobenzene sulfonic acid-induced colitis model is associated with the inhibition of NLRP3 inflammasome and NF-kappaB activation","volume":"45","author":"Du","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"536","DOI":"10.3389\/fimmu.2016.00536","article-title":"Deoxycholic acid triggers NLRP3 inflammasome activation and aggravates DSS-induced colitis in mice","volume":"7","author":"Zhao","year":"2016","journal-title":"Front. Immunol."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Zhao, S., Gong, Z., Du, X., Tian, C., Wang, L., Zhou, J., Xu, C., Chen, Y., Cai, W., and Wu, J. (2018). Deoxycholic acid-mediated sphingosine-1-phosphate receptor 2 signaling exacerbates DSS-induced colitis through promoting cathepsin B release. J. Immunol. Res., 2018.","DOI":"10.1155\/2018\/2481418"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"240","DOI":"10.2174\/157488711304180911095818","article-title":"Rosmarinic acid as potential anti-inflammatory agent","volume":"13","author":"Colica","year":"2018","journal-title":"Rev. Recent Clin. Trials"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"6887","DOI":"10.1021\/acsnano.0c01018","article-title":"Nanoparticles derived from the natural antioxidant rosmarinic acid ameliorate acute inflammatory bowel disease","volume":"14","author":"Chung","year":"2020","journal-title":"ACS Nano"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Jin, B.R., Chung, K.S., Cheon, S.Y., Lee, M., Hwang, S., Noh Hwang, S., Rhee, K.J., and An, H.J. (2017). Rosmarinic acid suppresses colonic inflammation in dextran sulphate sodium (DSS)-induced mice via dual inhibition of NF-kappaB and STAT3 activation. Sci. Rep., 7.","DOI":"10.1038\/srep46252"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Formiga, R.O., Alves Junior, E.B., Vasconcelos, R.C., Guerra, G.C.B., Antunes de Araujo, A., Carvalho, T.G., Garcia, V.B., de Araujo Junior, R.F., Gadelha, F., and Vieira, G.C. (2020). p-cymene and rosmarinic acid ameliorate TNBS-induced intestinal inflammation upkeeping ZO-1 and MUC-2: Role of antioxidant system and immunomodulation. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21165870"},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Marinho, S., Illanes, M., Avila-Roman, J., Motilva, V., and Talero, E. (2021). Anti-inflammatory effects of rosmarinic acid-loaded Nanovesicles in acute colitis through modulation of NLRP3 inflammasome. Biomolecules, 11.","DOI":"10.3390\/biom11020162"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"573870","DOI":"10.3389\/fphar.2020.573870","article-title":"Evodiamine attenuates experimental colitis injury via activating autophagy and inhibiting NLRP3 inflammasome assembly","volume":"11","author":"Ding","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.biopha.2018.12.033","article-title":"Evodiamine prevents dextran sulfate sodium-induced murine experimental colitis via the regulation of NF-kappaB and NLRP3 inflammasome","volume":"110","author":"Shen","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"290","DOI":"10.3389\/fphar.2019.00290","article-title":"Evodiamine augments NLRP3 inflammasome activation and anti-bacterial responses through inducing alpha-tubulin acetylation","volume":"10","author":"Li","year":"2019","journal-title":"Front. Pharmacol"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.bbrc.2018.03.096","article-title":"Adipose-derived stem cells ameliorate colitis by suppression of inflammasome formation and regulation of M1-macrophage population through prostaglandin E2","volume":"498","author":"Park","year":"2018","journal-title":"Biochem. Biophys Res. Commun."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Chung, I.C., OuYang, C.N., Yuan, S.N., Lin, H.C., Huang, K.Y., Wu, P.S., Liu, C.Y., Tsai, K.J., Loi, L.K., and Chen, Y.J. (2019). Pretreatment with a heat-killed probiotic modulates the NLRP3 inflammasome and attenuates colitis-associated colorectal cancer in mice. Nutrients, 11.","DOI":"10.3390\/nu11030516"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/nri.2017.103","article-title":"Regulation of immunity and inflammation by hypoxia in immunological niches","volume":"17","author":"Taylor","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1056\/NEJMra0910283","article-title":"Hypoxia and inflammation","volume":"364","author":"Eltzschig","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/s41467-017-00213-3","article-title":"Hypoxia ameliorates intestinal inflammation through NLRP3\/mTOR downregulation and autophagy activation","volume":"8","author":"Simmen","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.cell.2011.04.022","article-title":"NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis","volume":"145","author":"Elinav","year":"2011","journal-title":"Cell"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1016\/j.cell.2015.10.048","article-title":"Microbiota-modulated metabolites shape the intestinal microenvironment by regulating NLRP6 inflammasome signaling","volume":"163","author":"Levy","year":"2015","journal-title":"Cell"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"7187","DOI":"10.4049\/jimmunol.1100412","article-title":"A functional role for Nlrp6 in intestinal inflammation and tumorigenesis","volume":"186","author":"Chen","year":"2011","journal-title":"J. Immunol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.celrep.2017.03.080","article-title":"NLRP6 protects Il10(-\/-) mice from colitis by limiting colonization of akkermansia muciniphila","volume":"19","author":"Seregin","year":"2017","journal-title":"Cell Rep."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/s41590-020-0681-x","article-title":"Deubiquitination of NLRP6 inflammasome by Cyld critically regulates intestinal inflammation","volume":"21","author":"Mukherjee","year":"2020","journal-title":"Nat. Immunol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.4049\/jimmunol.1402098","article-title":"The NLRP1 inflammasome attenuates colitis and colitis-associated tumorigenesis","volume":"194","author":"Williams","year":"2015","journal-title":"J. Immunol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"3728","DOI":"10.1038\/s41467-018-06125-0","article-title":"NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease","volume":"9","author":"Tye","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1053\/j.gastro.2017.11.276","article-title":"Pyrin inflammasome regulates tight junction integrity to restrict colitis and tumorigenesis","volume":"154","author":"Sharma","year":"2018","journal-title":"Gastroenterology"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/cmi.2016.35","article-title":"The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18\/IL-22\/STAT3 pathway","volume":"14","author":"Ratsimandresy","year":"2017","journal-title":"Cell Mol. Immunol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/mi.2012.8","article-title":"Cytosolic flagellin receptor NLRC4 protects mice against mucosal and systemic challenges","volume":"5","author":"Carvalho","year":"2012","journal-title":"Mucosal. Immunol."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/26\/6\/1725\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:38:16Z","timestamp":1760161096000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/26\/6\/1725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,19]]},"references-count":112,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,3]]}},"alternative-id":["molecules26061725"],"URL":"https:\/\/doi.org\/10.3390\/molecules26061725","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,19]]}}}