{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T21:16:06Z","timestamp":1778966166857,"version":"3.51.4"},"reference-count":71,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T00:00:00Z","timestamp":1616544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Phytophthora is a genus of microorganisms that cause devastating dieback and root-rot diseases in thousands of plant hosts worldwide. The economic impact of Phytophthora diseases on crops and native ecosystems is estimated to be billions of dollars per annum. These invasive pathogens are extremely difficult to control using existing chemical means, and the effectiveness of the few treatments available is being jeopardized by increasing rates of resistance. There is an urgent need to identify new chemical treatments that are effective against Phytophthora diseases. Natural products have long been regarded as \u201cNature\u2019s medicine chest\u201d, providing invaluable leads for developing front-line drugs and agrochemical agents. Here, we have screened a natural product-inspired library of 328 chemicals against two key Phytophthora species: Phytophthora cinnamomi and Phytophthora agathidicida. The library was initially screened for inhibition of zoospore germination. From these screens, we identified twenty-one hits that inhibited germination of one or both species. These hits were further tested in mycelial growth inhibition studies to determine their half-maximal inhibitory concentrations (IC50s). Four compounds had IC50 values of approximately 10 \u00b5M or less, and our best hit had IC50s of approximately 3 \u00b5M against both Phytophthora species tested. Overall, these hits may serve as promising leads for the development of new anti-Phytophthora agrochemicals<\/jats:p>","DOI":"10.3390\/molecules26071819","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T21:36:51Z","timestamp":1616621811000},"page":"1819","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Screening a Natural Product-Inspired Library for Anti-Phytophthora Activities"],"prefix":"10.3390","volume":"26","author":[{"given":"Scott A.","family":"Lawrence","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of Otago, Dunedin 9054, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4032-892X","authenticated-orcid":false,"given":"Hannah F.","family":"Robinson","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, Victoria University of Wellington, Wellington 6140, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel P.","family":"Furkert","sequence":"additional","affiliation":[{"name":"School of Chemical Sciences, University of Auckland, Auckland 1142, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7086-4096","authenticated-orcid":false,"given":"Margaret A.","family":"Brimble","sequence":"additional","affiliation":[{"name":"School of Chemical Sciences, University of Auckland, Auckland 1142, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7959-7852","authenticated-orcid":false,"given":"Monica L.","family":"Gerth","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, Victoria University of Wellington, Wellington 6140, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1126\/science.290.5493.972","article-title":"A kingdom-level phylogeny of eukaryotes based on combined protein data","volume":"290","author":"Baldauf","year":"2000","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/mpp.12190","article-title":"The top 10 oomycete pathogens in molecular plant pathology","volume":"16","author":"Kamoun","year":"2015","journal-title":"Mol. 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