{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T02:29:15Z","timestamp":1783132155558,"version":"3.54.6"},"reference-count":86,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T00:00:00Z","timestamp":1616716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004564","name":"Ministarstvo Prosvete, Nauke i Tehnolo\u0161kog Razvoja","doi-asserted-by":"publisher","award":["451-03-68\/2021-14\/200042"],"award-info":[{"award-number":["451-03-68\/2021-14\/200042"]}],"id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004564","name":"Ministarstvo Prosvete, Nauke i Tehnolo\u0161kog Razvoja","doi-asserted-by":"publisher","award":["451-03-68\/2021-14\/200122"],"award-info":[{"award-number":["451-03-68\/2021-14\/200122"]}],"id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004564","name":"Ministarstvo Prosvete, Nauke i Tehnolo\u0161kog Razvoja","doi-asserted-by":"publisher","award":["451-03-68\/2021-14\/200378"],"award-info":[{"award-number":["451-03-68\/2021-14\/200378"]}],"id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004329","name":"Javna Agencija za Raziskovalno Dejavnost RS","doi-asserted-by":"publisher","award":["P1-0175; funding in 2019-20"],"award-info":[{"award-number":["P1-0175; funding in 2019-20"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018992","name":"Serbian Academy of Sciences and Arts","doi-asserted-by":"publisher","award":["01-2019-F65"],"award-info":[{"award-number":["01-2019-F65"]}],"id":[{"id":"10.13039\/501100018992","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018992","name":"Serbian Academy of Sciences and Arts","doi-asserted-by":"publisher","award":["F128"],"award-info":[{"award-number":["F128"]}],"id":[{"id":"10.13039\/501100018992","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Three new silver(I) complexes [Ag(NO3)(tia)(H2O)]n (Ag1), [Ag(CF3SO3)(1,8-naph)]n (Ag2) and [Ag2(1,8-naph)2(H2O)1.2](PF6)2 (Ag3), where tia is thianthrene and 1,8-naph is 1,8-naphthyridine, were synthesized and structurally characterized by different spectroscopic and electrochemical methods and their crystal structures were determined by single-crystal X-ray diffraction analysis. Their antimicrobial potential was evaluated against four bacterial and three Candida species, and the obtained results revealed that these complexes showed significant activity toward the Gram-positive Staphylococcus aureus, Gram-negative Pseudomonas aeruginosa and the investigated Candida species with minimal inhibitory concentration (MIC) values in the range 1.56\u20137.81 \u03bcg\/mL. On the other hand, tia and 1,8-naph ligands were not active against the investigated strains, suggesting that their complexation with Ag(I) ion results in the formation of antimicrobial compounds. Moreover, low toxicity of the complexes was detected by in vivo model Caenorhabditis elegans. The interaction of the complexes with calf thymus DNA (ct-DNA) and bovine serum albumin (BSA) was studied to evaluate their binding affinity towards these biomolecules for possible insights into the mode of antimicrobial activity. The binding affinity of Ag1\u20133 to BSA was higher than that for DNA, indicating that proteins could be more favorable binding sites for these complexes in comparison to the nucleic acids.<\/jats:p>","DOI":"10.3390\/molecules26071871","type":"journal-article","created":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T06:59:42Z","timestamp":1616741982000},"page":"1871","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Structural Characterization, Antimicrobial Activity and BSA\/DNA Binding Affinity of New Silver(I) Complexes with Thianthrene and 1,8-Naphthyridine"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1098-400X","authenticated-orcid":false,"given":"Darko P.","family":"A\u0161anin","sequence":"first","affiliation":[{"name":"Department of Science, Institute for Information Technologies Kragujevac, University of Kragujevac, Jovana Cviji\u0107a bb, 34000 Kragujevac, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5159-9461","authenticated-orcid":false,"given":"Sanja","family":"Skaro Bogojevic","sequence":"additional","affiliation":[{"name":"Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444a, 11042 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8416-7291","authenticated-orcid":false,"given":"Franc","family":"Perdih","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ve\u010dna pot 113, SI-1000 Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina P.","family":"Andrejevi\u0107","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, University of Kragujevac, R. Domanovi\u0107a 12, 34000 Kragujevac, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dusan","family":"Milivojevic","sequence":"additional","affiliation":[{"name":"Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444a, 11042 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Aleksic","sequence":"additional","affiliation":[{"name":"Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444a, 11042 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2553-977X","authenticated-orcid":false,"given":"Jasmina","family":"Nikodinovic-Runic","sequence":"additional","affiliation":[{"name":"Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444a, 11042 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6343-8611","authenticated-orcid":false,"given":"Biljana \u0110.","family":"Gli\u0161i\u0107","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, University of Kragujevac, R. Domanovi\u0107a 12, 34000 Kragujevac, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6776-4062","authenticated-orcid":false,"given":"Iztok","family":"Turel","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ve\u010dna pot 113, SI-1000 Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milo\u0161 I.","family":"Djuran","sequence":"additional","affiliation":[{"name":"Serbian Academy of Sciences and Arts, Knez Mihailova 35, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/S1473-3099(18)30648-0","article-title":"Public health burden of antimicrobial resistance in Europe","volume":"19","author":"Tacconelli","year":"2019","journal-title":"Lancet Infect. Dis."},{"key":"ref_2","unstructured":"O\u2019Neill, J. (2014). Review on Antimicrobial Resistance Antimicrobial Resistance: Tackling a Crisis for the Health and Wealth of Nations, Wellcome Trust."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.burns.2014.09.009","article-title":"Silver in medicine: A brief history BC 335 to present","volume":"40","author":"Barillo","year":"2014","journal-title":"Burns"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"124","DOI":"10.2174\/157489110791233522","article-title":"Topical antimicrobials for burn wound infections","volume":"5","author":"Dai","year":"2010","journal-title":"Recent Pat. Antiinfect. Drug Discov."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jfluchem.2017.01.016","article-title":"Synthesis, characterization and in vitro biological assays of a silver(I) complex with 5-fluorouracil: A strategy to overcome multidrug resistant tumor cells","volume":"195","author":"Nunes","year":"2017","journal-title":"J. Fluor. Chem."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.jinorgbio.2010.01.004","article-title":"Pt(II) and Ag(I) complexes with acesulfame: Crystal structure and a study of their antitumoral, antimicrobial and antiviral activities","volume":"104","author":"Cavicchioli","year":"2010","journal-title":"J. Inorg. Biochem."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1002\/ejic.200300672","article-title":"Synthesis, characterization and in vitro study of the cytostatic and antiviral activity of new polymeric silver(I) complexes with ribbon structures derived from the conjugated heterocyclic thioamide 2-mercapto-3,4,5,6-tetra- hydropyrimidine","volume":"2004","author":"Zachariadis","year":"2004","journal-title":"Eur. J. Inorg. Chem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1159\/000093928","article-title":"Silver in health care: Antimicrobial effects and safety in use","volume":"33","author":"Lansdown","year":"2006","journal-title":"Curr. Probl. Dermatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1039\/C3CS60218D","article-title":"Nanosilver-based antibacterial drugs and devices: Mechanisms, methodological drawbacks, and guidelines","volume":"43","author":"Rizzello","year":"2014","journal-title":"Chem. Soc. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"5923","DOI":"10.1021\/acs.jmedchem.8b01439","article-title":"Medical uses of silver: History, myths, and scientific evidence","volume":"62","author":"Medici","year":"2019","journal-title":"J. Med. Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"4708","DOI":"10.1021\/cr300288v","article-title":"Nanobio silver: Its interactions with peptides and bacteria, and its uses in medicine","volume":"113","author":"Eckhardt","year":"2013","journal-title":"Chem. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.poly.2014.09.010","article-title":"Silver complexes with sulfathiazole and sulfamethoxazole: Synthesis, spectroscopic characterization, crystal structure and antibacterial assays","volume":"85","author":"Nunes","year":"2015","journal-title":"Polyhedron"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.2174\/092986709788186200","article-title":"Rhodanine as a privileged scaffold in drug discovery","volume":"16","year":"2009","journal-title":"Curr. Med. Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"762","DOI":"10.2174\/1389557515666150519104057","article-title":"Biological and pharmacological activities of 1,3,4-thiadiazole based compounds","volume":"15","author":"Matysiak","year":"2015","journal-title":"Mini Rev. Med. Chem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.ejmech.2014.11.053","article-title":"Structure activity relationship (SAR) study of benzimidazole scaffold for different biological activities: A mini-review","volume":"97","author":"Yadav","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.ejmech.2019.07.043","article-title":"Role of sulphur-heterocycles in medicinal chemistry: An update","volume":"180","author":"Pathania","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Kerru, N., Gummidi, L., Maddila, S., Gangu, K.K., and Jonnalagadda, S.B. (2020). A review on recent advances in nitrogen-containing molecules and their biological applications. Molecules, 25.","DOI":"10.3390\/molecules25081909"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"138","DOI":"10.14348\/molcells.2015.2193","article-title":"Raloxifene induces autophagy-dependent cell death in breast cancer cells via the activation of AMP-activated protein kinase","volume":"38","author":"Kim","year":"2015","journal-title":"Mol. Cells"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/fcp.12207","article-title":"Impact of rosiglitazone safety alerts on oral antidiabetic sales trends: A countrywide study in Portugal","volume":"30","author":"Herdeiro","year":"2016","journal-title":"Fundam. Clin. Pharmacol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.tiv.2015.12.018","article-title":"The fungicide thiabendazole causes apoptosis in rat hepatocytes","volume":"32","author":"Marion","year":"2016","journal-title":"Toxicol. In Vitro"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/med.21290","article-title":"Comprehensive review in current developments of imidazole-based medicinal chemistry","volume":"34","author":"Zhang","year":"2013","journal-title":"Med. Res. Rev."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"4920","DOI":"10.1016\/j.arabjc.2016.10.009","article-title":"Comprehensive review on current developments of quinoline-based anticancer agents","volume":"12","author":"Jain","year":"2019","journal-title":"Arabian J. Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1039\/C5MD00494B","article-title":"Silver(I) complexes with quinazoline and phthalazine: Synthesis, structural characterization and evaluation of biological activities","volume":"7","author":"Wadepohl","year":"2016","journal-title":"MedChemComm"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"13193","DOI":"10.1039\/C5RA26002G","article-title":"A comparative antimicrobial and toxicological study of gold(III) and silver(I) complexes with aromatic nitrogen-containing heterocycles: Synergistic activity and improved selectivity index of Au(III)\/Ag(I) complexes mixture","volume":"6","author":"Milivojevic","year":"2016","journal-title":"RSC Adv."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jinorgbio.2015.11.026","article-title":"Silver(I) complexes with phthalazine and quinazoline as effective agents against pathogenic Pseudomonas aeruginosa strains","volume":"155","author":"Senerovic","year":"2016","journal-title":"J. Inorg. Biochem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1023\/A:1020695923788","article-title":"Mode of anti-fungal activity of 1,10-phenanthroline and its Cu(II), Mn(II) and Ag(I) complexes","volume":"16","author":"Coyle","year":"2003","journal-title":"Biometals"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s10534-004-1229-5","article-title":"Synthesis and X-ray crystal structure of [Ag(phendio)2]ClO4 (phendio = 1,10-phenanthroline-5,6-dione) and its effects on fungal and mammalian cells","volume":"17","author":"McCann","year":"2004","journal-title":"Biometals"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s10534-008-9182-3","article-title":"Use of Galleria mellonella larvae to evaluate the in vivo anti-fungal activity of [Ag2(mal)(phen)3]","volume":"22","author":"Rowan","year":"2009","journal-title":"Biometals"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.ejmech.2018.07.049","article-title":"Mononuclear silver(I) complexes with 1,7-phenanthroline as potent inhibitors of Candida growth","volume":"156","author":"Vojnovic","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jinorgbio.2019.03.017","article-title":"Silver(I) complexes with 4,7-phenanthroline efficient in rescuing the zebrafish embryos of lethal Candida albicans infection","volume":"195","author":"Pavic","year":"2019","journal-title":"J. Inorg. Biochem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"110872","DOI":"10.1016\/j.jinorgbio.2019.110872","article-title":"New polynuclear 1,5-naphthyridine-silver(I) complexes as potential antimicrobial agents: The key role of the nature of donor coordinated to the metal center","volume":"203","author":"Vojnovic","year":"2020","journal-title":"J. Inorg. Biochem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.msec.2015.02.014","article-title":"Silver(I) complexes of N-methylbenzothiazole-2-thione: Synthesis, structures and antibacterial activity","volume":"50","author":"Aslanidis","year":"2015","journal-title":"Mat. Sci. Eng. C"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"15470","DOI":"10.1039\/C9RA01804B","article-title":"Silver derivatives of multi-donor heterocyclic thioamides as antimicrobial\/anticancer agents: Unusual bio-activity against methicillin resistant S. aureus, S. epidermidis, and E. faecalis and human bone cancer MG63 cell line","volume":"9","author":"Aulakh","year":"2019","journal-title":"RSC Adv."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/toxsci\/kfn121","article-title":"Caenorhabditis elegans: An emerging model in biomedical and environmental toxicology","volume":"106","author":"Leung","year":"2008","journal-title":"Toxicol. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.inoche.2015.01.024","article-title":"Synthesis, crystal structure and electrocatalytic activity of discrete and polymeric copper(II) complexes with bitopic bis(pyrazol-1-yl)methane ligands","volume":"53","author":"Potapov","year":"2015","journal-title":"Inorg. Chem. Commun."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1021\/ic00058a050","article-title":"Vibrational study of the trifluoromethanesulfonate anion: Unambiguous assignment of the asymmetric stretching modes","volume":"32","author":"Johnston","year":"1993","journal-title":"Inorg. Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0020-1693(96)05554-5","article-title":"Synthesis, spectroscopic properties and X-ray crystal structures of two dinuclear alkoxo-bridged copper(II) compounds with the ligand bis(1-methyl-2-benzimidazolyl) propane. A unique alkoxo-bridged Cu(II) dinuclear compound with an additional bidentate bridging triflate anion","volume":"260","author":"Smeets","year":"1997","journal-title":"Inorg. Chim. Acta"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.molstruc.2017.11.076","article-title":"Studies on the syntheses, structural characterization, antimicrobial of the co-crystal 1,10-phenanthrolin-1-ium(1,10-phenH+)-caffeine(caf)-hexafluorophosphate","volume":"1155","author":"Duhayon","year":"2018","journal-title":"J. Mol. Struct."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"6332","DOI":"10.1039\/c1cc11315a","article-title":"Synthesis and coordination behavior of CuI bis(phosphaethenyl)pyridine complexes","volume":"47","author":"Nakajima","year":"2011","journal-title":"Chem. Commun."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0020-1693(97)05953-7","article-title":"Synthesis and structure of a novel bis(\u03bc-\u03b72-thianthrene )disilver(I) bis(perchlorate)","volume":"271","author":"Munakata","year":"1998","journal-title":"Inorg. Chim. Acta"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"44481","DOI":"10.1039\/D0RA08731A","article-title":"Mononuclear gold(III) complexes with diazanaphthalenes: The influence of the position of nitrogen atoms in the aromatic rings on the complex crystalline properties","volume":"10","author":"Hoffmann","year":"2020","journal-title":"RSC Adv."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.poly.2008.09.029","article-title":"Syntheses, structures and bioactivities of silver(I) complexes with a tridentate heterocyclic N- and S-ligand","volume":"28","author":"Zhang","year":"2009","journal-title":"Polyhedron"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ica.2016.07.014","article-title":"Synthesis, characterization and antibacterial activity of a biocompatible silver complex based on 2,2\u2032-bipyridine and 5-sulfoisophthalate","volume":"451","author":"Jiang","year":"2016","journal-title":"Inorg. Chim. Acta"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"8178","DOI":"10.1039\/C5DT00403A","article-title":"Synthesis, characterization and antimicrobial activity of water-soluble silver(I) complexes of metronidazole drug and selected counter-ions","volume":"44","author":"Felczak","year":"2015","journal-title":"Dalton Trans."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jinorgbio.2016.11.003","article-title":"Synthesis of Ag(I) camphor sulphonylimine complexes and assessment of their cytotoxic properties against cisplatin-resistant A2780cisR and A2780 cell lines","volume":"166","author":"Cardoso","year":"2017","journal-title":"J. Inorg. Biochem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jphotobiol.2013.03.013","article-title":"Drug\u2013DNA interactions and their study by UV\u2013Visible, fluorescence spectroscopies and cyclic voltametry","volume":"124","author":"Sirajuddin","year":"2013","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1016\/j.ica.2006.10.043","article-title":"Synthesis, photoluminescence and electrochemical properties of a series of carbazole-functionalized ligands and their silver(I) complexes","volume":"360","author":"Wu","year":"2007","journal-title":"Inorg. Chim. Acta"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"20689","DOI":"10.1021\/jp406442j","article-title":"Strong and long-lived free-radical oxidizer based on silver(II). Mechanism of Ag(I) electrooxidation in concentrated H2SO4","volume":"117","author":"Jurczakowski","year":"2013","journal-title":"J. Phys. Chem. C"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"6084","DOI":"10.1039\/D0DT00518E","article-title":"Silver(I) complexes with different pyridine-4,5-dicarboxylate ligands as efficient agents for the control of cow mastitis associated pathogens","volume":"49","author":"Milivojevic","year":"2020","journal-title":"Dalton Trans."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"fty041","DOI":"10.1093\/femspd\/fty041","article-title":"Biofilm-forming ability and infection potential of Pseudomonas aeruginosa strains isolated from animals and humans","volume":"76","author":"Milivojevic","year":"2018","journal-title":"Pathog. Dis."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1039\/c3mt00046j","article-title":"Anti-proliferative and anti-tumor activity of silver(I) compounds","volume":"5","author":"Banti","year":"2013","journal-title":"Metallomics"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.3389\/fmicb.2016.01831","article-title":"Mechanistic basis of antimicrobial actions of silver nanoparticles","volume":"7","author":"Dakal","year":"2016","journal-title":"Front. Microbiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jinorgbio.2015.01.007","article-title":"(Aminophosphane)gold(I) and silver(I) complexes as antibacterial agents","volume":"146","author":"Ortego","year":"2015","journal-title":"J. Inorg. Biochem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"7904","DOI":"10.1128\/JB.01116-08","article-title":"Direct observation of Staphylococcus aureus cell wall digestion by lysostaphin","volume":"190","author":"Francius","year":"2008","journal-title":"J. Bacteriol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"9839","DOI":"10.1038\/s41598-017-10454-3","article-title":"An enhanced C. elegans based platform for toxicity assessment","volume":"7","author":"Xiong","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/jat.3357","article-title":"The C. elegans model in toxicity testing","volume":"37","author":"Hunt","year":"2017","journal-title":"J. Appl. Toxicol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1080\/07391102.2016.1213663","article-title":"In vitro study on binding interaction of quinapril with bovine serum albumin (BSA) using multi-spectroscopic and molecular docking methods","volume":"35","author":"Shi","year":"2017","journal-title":"J. Biomol. Struct. Dyn."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.saa.2012.11.034","article-title":"Intermolecular interaction of prednisolone with bovine serum albumin: Spectroscopic and molecular docking methods","volume":"103","author":"Shi","year":"2013","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.jlumin.2008.02.004","article-title":"Study on the binding of 2,3-diazabicyclo [2.2.2]oct-2-ene with bovine serum albumin by fluorescence spectroscopy","volume":"128","author":"Anbazhagan","year":"2008","journal-title":"J. Lumin."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.jphotobiol.2015.11.005","article-title":"Chiral manganese(IV) complexes derived from Schiff base ligands: Synthesis, characterization, in vitro cytotoxicity and DNA\/BSA interaction","volume":"153","author":"Li","year":"2015","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1021\/ic101534n","article-title":"Synthesis, electronic structure, DNA and protein binding, DNA cleavage, and anticancer activity of fluorophore-labeled copper(II) complexes","volume":"50","author":"Bhat","year":"2011","journal-title":"Inorg. Chem."},{"key":"ref_62","first-page":"3812050","article-title":"Antimicrobial activity and DNA\/BSA binding affinity of polynuclear silver(I) complexes with 1,2-bis(4-pyridyl)ethane\/ethene as bridging ligands","volume":"2020","author":"Vojnovic","year":"2020","journal-title":"Bioinorg. Chem. Appl."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1021\/ic501855k","article-title":"Syntheses, structures, and antimicrobial activity of new remarkably light-stable and water-soluble tris(pyrazolyl)methanesulfonate silver(I) derivatives of N-methyl-1,3,5-triaza-7-phosphaadamantane salt\u2014[mPTA]BF4","volume":"54","author":"Pettinari","year":"2015","journal-title":"Inorg. Chem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1021\/cr040704h","article-title":"Interactions of antitumor metallodrugs with serum proteins:\u2009 advances in characterization using modern analytical methodology","volume":"106","author":"Timerbaev","year":"2006","journal-title":"Chem. Rev."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1021\/bm101414w","article-title":"Interaction between DNA and microcystin-LR studied by spectra analysis and atomic force microscopy","volume":"12","author":"Shi","year":"2011","journal-title":"Biomacromolecules"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"8208","DOI":"10.1021\/ic700755p","article-title":"Mixed-ligand copper(II)-phenolate complexes:\u2009 effect of coligand on enhanced DNA and protein binding, DNA cleavage, and anticancer activity","volume":"46","author":"Rajendiran","year":"2007","journal-title":"Inorg. Chem."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"8869","DOI":"10.1039\/c1dt10322a","article-title":"Library of second-generation cycloruthenated compounds and evaluation of their biological properties as potential anticancer drugs: Passing the nanomolar barrier","volume":"40","author":"Fetzer","year":"2011","journal-title":"Dalton Trans."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1021\/acs.inorgchem.7b01959","article-title":"Half-sandwich iridium(III) and ruthenium(II) complexes containing P^P-chelating ligands: A new class of potent anticancer agents with unusual redox features","volume":"57","author":"Li","year":"2018","journal-title":"Inorg. Chem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1021\/ja0677564","article-title":"Methods to explore cellular uptake of ruthenium complexes","volume":"129","author":"Puckett","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1021\/cc9800071","article-title":"A knowledge-based approach in designing combinatorial or medicinal chemistry libraries for drug discovery. 1. A qualitative and quantitative characterization of known drug databases","volume":"1","author":"Ghose","year":"1999","journal-title":"J. Comb. Chem."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.2174\/156802611798040787","article-title":"Interactions of metal ions with DNA, its constituents and derivatives, which may be relevant for anticancer research","volume":"11","author":"Turel","year":"2011","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s00216-002-1309-8","article-title":"Spectral studies of the binding of lucigenin, a bisacridinium derivative, with double-helix DNA","volume":"373","author":"Wu","year":"2002","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.ijbiomac.2019.01.013","article-title":"Binding interaction of a heteroleptic silver(I) complex with DNA: A joint experimental and computational study","volume":"126","author":"Movahedi","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"A\u0161anin, D.P., Andrejevi\u0107, T.P., Skaro-Bogojevic, S., Stevanovi\u0107, N.L., Aleksic, I., Milivojevic, D., Perdih, F., Turel, I., Djuran, M.I., and Gli\u0161i\u0107, B.\u0110. (2020). Polynuclear silver(I) complex with thianthrene: Structural characterization, antimicrobial activity and interaction with biomolecules. Proceedings, 67.","DOI":"10.3390\/ASEC2020-07534"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"A\u0161anin, D.P., Andrejevi\u0107, T.P., Skaro-Bogojevic, S., Perdih, F., Turel, I., Nikodinovic-Runic, J., Djuran, M.I., and Gli\u0161i\u0107, B.\u0110. (2020, January 1\u201330). Antimicrobial activity and DNA\/BSA binding study of new silver(I) complexes with 1,8-naphthyridine. Proceedings of the 6th International Electronic Conference on Medicinal Chemistry, Session General: Presentations.","DOI":"10.3390\/ECMC2020-07372"},{"key":"ref_76","unstructured":"Agilent Technologies Ltd. (2013). CrysAlisPro, Version 1.171.39.46, Agilent Technologies."},{"key":"ref_77","first-page":"3","article-title":"SHELXT\u2014Integrated space-group and crystal-structure determination","volume":"A71","author":"Sheldrick","year":"2015","journal-title":"Acta Cryst."},{"key":"ref_78","first-page":"3","article-title":"Crystal structure refinement with SHELXL","volume":"C71","author":"Sheldrick","year":"2015","journal-title":"Acta Cryst."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1107\/S0021889808042726","article-title":"OLEX2: A complete structure solution, refinement and analysis program","volume":"42","author":"Dolomanov","year":"2009","journal-title":"J. Appl. Cryst."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"E246","DOI":"10.1111\/j.1469-0691.2012.03880.x","article-title":"EUCAST-AFST. EUCAST technical note on the EUCAST definitive document EDef 7.2: Method for the determination of broth dilution minimum inhibitory concentrations of antifungal agents for yeasts EDef 7.2 (EUCAST-AFST)","volume":"18","author":"Arendrup","year":"2012","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0022-1759(89)90397-9","article-title":"Re-examination and further development of a precise and rapid dye method for measuring cell growth\/cell kill","volume":"119","author":"Hansen","year":"1989","journal-title":"J. Immunol. Methods"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Stiernagle, T. (2006). Maintenance of C. elegans. WormBook, Oxford University Press.","DOI":"10.1895\/wormbook.1.101.1"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"32487","DOI":"10.1038\/srep32487","article-title":"Discovery of new diketopiperazines inhibiting Burkholderia cenocepacia quorum sensing in vitro and in vivo","volume":"6","author":"Scoffone","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1128\/AAC.00045-11","article-title":"Quorum sensing inhibitors increase the susceptibility of bacterial biofilms to antibiotics in vitro and in vivo","volume":"55","author":"Brackman","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"6392","DOI":"10.1021\/bi00394a013","article-title":"Polycyclic aromatic hydrocarbons physically intercalate into duplex regions of denatured DNA","volume":"26","author":"Wolfe","year":"1987","journal-title":"Biochemistry"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ijbiomac.2007.08.010","article-title":"Studies on the interaction of isoxazolcurcumin with calf thymus DNA","volume":"42","author":"Bera","year":"2008","journal-title":"Int. J. Biol. Macromol."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/26\/7\/1871\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:41:25Z","timestamp":1760161285000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/26\/7\/1871"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,26]]},"references-count":86,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2021,4]]}},"alternative-id":["molecules26071871"],"URL":"https:\/\/doi.org\/10.3390\/molecules26071871","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,26]]}}}