{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T05:35:33Z","timestamp":1790573733785,"version":"4.1.0"},"reference-count":93,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T00:00:00Z","timestamp":1616716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81860634"],"award-info":[{"award-number":["81860634"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005147","name":"Applied Basic Research Key Project of Yunnan Province","doi-asserted-by":"publisher","award":["202001BB050029"],"award-info":[{"award-number":["202001BB050029"]}],"id":[{"id":"10.13039\/501100005147","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Major Science and Technology Projects of Yunnan Province","award":["202002AA100007"],"award-info":[{"award-number":["202002AA100007"]}]},{"name":"Project of Innovative Research Team of Yunnan Province","award":["202005AE160005"],"award-info":[{"award-number":["202005AE160005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Actinomycetes are regarded as important sources for the generation of various bioactive secondary metabolites with rich chemical and bioactive diversities. Amycolatopsis falls under the rare actinomycete genus with the potential to produce antibiotics. In this review, all literatures were searched in the Web of Science, Google Scholar and PubMed up to March 2021. The keywords used in the search strategy were \u201cAmycolatopsis\u201d, \u201csecondary metabolite\u201d, \u201cnew or novel compound\u201d, \u201cbioactivity\u201d, \u201cbiosynthetic pathway\u201d and \u201cderivatives\u201d. The objective in this review is to summarize the chemical structures and biological activities of secondary metabolites from the genus Amycolatopsis. A total of 159 compounds derived from 8 known and 18 unidentified species are summarized in this paper. These secondary metabolites are mainly categorized into polyphenols, linear polyketides, macrolides, macrolactams, thiazolyl peptides, cyclic peptides, glycopeptides, amide and amino derivatives, glycoside derivatives, enediyne derivatives and sesquiterpenes. Meanwhile, they mainly showed unique antimicrobial, anti-cancer, antioxidant, anti-hyperglycemic, and enzyme inhibition activities. In addition, the biosynthetic pathways of several potent bioactive compounds and derivatives are included and the prospect of the chemical substances obtained from Amycolatopsis is also discussed to provide ideas for their implementation in the field of therapeutics and drug discovery.<\/jats:p>","DOI":"10.3390\/molecules26071884","type":"journal-article","created":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T13:17:53Z","timestamp":1616764673000},"page":"1884","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Secondary Metabolites of the Genus Amycolatopsis: Structures, Bioactivities and Biosynthesis"],"prefix":"10.3390","volume":"26","author":[{"given":"Zhiqiang","family":"Song","sequence":"first","affiliation":[{"name":"Yunnan Institute of Microbiology, School of Life Sciences, Yunnan University, Kunming 650091, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tangchang","family":"Xu","sequence":"additional","affiliation":[{"name":"Yunnan Institute of Microbiology, School of Life Sciences, Yunnan University, Kunming 650091, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfei","family":"Wang","sequence":"additional","affiliation":[{"name":"Yunnan Institute of Microbiology, School of Life Sciences, Yunnan University, Kunming 650091, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yage","family":"Hou","sequence":"additional","affiliation":[{"name":"Yunnan Institute of Microbiology, School of Life Sciences, Yunnan University, Kunming 650091, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuansheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Yunnan Institute of Microbiology, School of Life Sciences, Yunnan University, Kunming 650091, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sisi","family":"Liu","sequence":"additional","affiliation":[{"name":"Yunnan Institute of Microbiology, School of Life Sciences, Yunnan University, Kunming 650091, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4972-7449","authenticated-orcid":false,"given":"Shaohua","family":"Wu","sequence":"additional","affiliation":[{"name":"Yunnan Institute of Microbiology, School of Life Sciences, Yunnan University, Kunming 650091, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1023\/A:1010287600557","article-title":"Rare genera of Actinomycetes as potential producers of new antibiotics","volume":"78","author":"Lazzarini","year":"2000","journal-title":"Anton. Leeuw. Int. J. Gen."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1099\/00207713-36-1-29","article-title":"2 New genera of nocardioform Actinomycetes-Amycolata gen. nov and Amycolatopsis gen. nov.","volume":"36","author":"Lechevalier","year":"1986","journal-title":"Int. J. Syst. Bacteriol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1099\/00207713-47-2-479","article-title":"Proposal for a new hierarchic classification system, actinobacteria classis","volume":"47","author":"Stackebrandt","year":"1997","journal-title":"Int. J. Syst. Bacteriol."},{"key":"ref_4","first-page":"262","article-title":"Rifomycin. I. Isolation and properties of rifomycin B and rifomycin complex","volume":"7","author":"Sensi","year":"1959","journal-title":"Antibiot. Annu."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1146\/annurev.mi.38.100184.002011","article-title":"The structure and mode of action of glycopeptide antibiotics of the vancomycin group","volume":"38","author":"Barna","year":"1984","journal-title":"Annu. Rev. Microbiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1517\/13543776.14.2.141","article-title":"Patents on glycopeptides of the vancomycin family and their derivatives as antimicrobials: January 1999-June 2003","volume":"14","author":"Preobrazhenskaya","year":"2004","journal-title":"Expert. Opin. Ther. Pat."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"6915","DOI":"10.1021\/ja00361a029","article-title":"Vancomycin-structure and transformation to Cdp-I","volume":"105","author":"Harris","year":"1983","journal-title":"J. Am. Chem. Soc."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"4688","DOI":"10.1002\/1521-3773(20011217)40:24<4688::AID-ANIE4688>3.0.CO;2-M","article-title":"The biosynthesis of vancomycin-type glycopeptide antibiotics-The order of the cyclization steps","volume":"40","author":"Bischoff","year":"2001","journal-title":"Angew. Chem. Int. Edit."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"8048","DOI":"10.1002\/anie.201802856","article-title":"In vitro reconstitution of OxyC activity enables total chemoenzymatic syntheses of vancomycin aglycone variants","volume":"57","author":"Forneris","year":"2018","journal-title":"Angew. Chem. Int. Edit."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e03201-16","DOI":"10.1128\/AEM.03201-16","article-title":"RifZ(AMED_0655) is a pathway-specific regulator for rifamycin biosynthesis in Amycolatopsis mediterranei","volume":"83","author":"Li","year":"2017","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Lei, C., Wang, J., Liu, Y., Liu, X., Zhao, G., and Wang, J. (2018). A feedback regulatory model for RifQ-mediated repression of rifamycin export in &ITAmycolatopsis mediterranei&IT. Microb. Cell. Fact., 17.","DOI":"10.1186\/s12934-018-0863-5"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/cbic.201500542","article-title":"Progress in understanding the genetic information and biosynthetic pathways behind Amycolatopsis antibiotics, with implications for the continued discovery of novel drugs","volume":"17","author":"Chen","year":"2016","journal-title":"Chembiochem"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.7164\/antibiotics.56.1004","article-title":"Kigamicins, novel antitumor antibiotics-I. Taxonomy, isolation, physico-chemical properties and biological activities","volume":"56","author":"Setsuko","year":"2003","journal-title":"J. Antibiot."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/s00253-017-8648-z","article-title":"Amexanthomycins A\u2013J, pentangular polyphenols produced by Amycolatopsis mediterranei S699 Delta rifA","volume":"102","author":"Li","year":"2018","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/ja.2008.95","article-title":"Mutactimycin E, a new anthracycline antibiotic with gram-positive activity","volume":"61","author":"Hopp","year":"2008","journal-title":"J. Antibiot."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"200","DOI":"10.4014\/mbl.1705.05001","article-title":"Anti-proliferative and antioxidant activities of 1-methoxy-3-methyl-8-hydroxy-anthraquinone, a hydroxyanthraquinoid extrolite produced by Amycolatopsis thermoflava strain SFMA-103","volume":"45","author":"Kumar","year":"2017","journal-title":"Microbiol. Biotechnol. Lett."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1080\/01480545.2018.1551406","article-title":"Anti-hyperglycemic and genotoxic studies of 1-O-methyl chrysophanol, a new anthraquinone isolated from Amycolatopsis thermoflava strain SFMA-103","volume":"44","author":"Chandrasekhar","year":"2019","journal-title":"Drug. Chem. Toxicol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.fitote.2019.04.011","article-title":"A new phthalazinone derivative and a new isoflavonoid glycoside from lichen-associated Amycolatopsis sp.","volume":"135","author":"Zheng","year":"2019","journal-title":"Fitoterapia"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1007\/s00284-020-02049-5","article-title":"Diverse secondary metabolites from a lichen-derived Amycolatopsis Strain","volume":"77","author":"Liu","year":"2020","journal-title":"Curr. Microbiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1080\/14786419.2018.1434639","article-title":"Pradimicin-IRD from Amycolatopsis sp. IRD-009 and its antimicrobial and cytotoxic activities","volume":"33","author":"Bauermeister","year":"2019","journal-title":"Natl. Prod. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1055\/s-0031-1280097","article-title":"Cytotoxic angucyclines from Amycolatopsis sp. HCa1, a rare actinobacteria derived from Oxya chinensis","volume":"77","author":"Guo","year":"2011","journal-title":"Planta Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"7490","DOI":"10.1016\/j.bmcl.2012.10.048","article-title":"Angucyclines from an insect-derived actinobacterium Amycolatopsis sp. HCa1 and their cytotoxic activity","volume":"22","author":"Guo","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.3390\/md12042326","article-title":"A new benzofuran glycoside and indole alkaloids from a sponge-associated rare actinomycete, Amycolatopsis sp.","volume":"12","author":"Kwon","year":"2014","journal-title":"Mar. Drugs"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/ja.2006.74","article-title":"Genomic analyses lead to novel secondary metabolites","volume":"59","author":"Banskota","year":"2006","journal-title":"J. Antibiot."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0040-4039(01)02171-2","article-title":"Isolation and structure elucidation of vancoresmycin\u2014A new antibiotic from Amycolatopsis sp ST 101170","volume":"43","author":"Hopmann","year":"2002","journal-title":"Tetrahedron. Lett."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/ja.2017.119","article-title":"Amycolatopsins A\u2013C: Antimycobacterial glycosylated polyketide macrolides from the Australian soil Amycolatopsis sp. MST-108494","volume":"70","author":"Khalil","year":"2017","journal-title":"J. Antibiot."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1021\/acs.orglett.5b01055","article-title":"Succinylated apoptolidins from Amycolatopsis sp. ICBB 8242","volume":"17","author":"Sheng","year":"2015","journal-title":"Org. Lett."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1021\/acs.orglett.8b03792","article-title":"Isolation of 11,12-seco-Rifamycin W derivatives reveals a cleavage pattern of the rifamycin ansa chain","volume":"21","author":"Shi","year":"2019","journal-title":"Org. Lett."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1039\/C7OB00614D","article-title":"Rifamorpholines A\u2013E, potential antibiotics from locust-associated actinobacteria Amycolatopsis sp. Hca4","volume":"15","author":"Xiao","year":"2017","journal-title":"Org. Biomol. Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1021\/acs.orglett.6b03831","article-title":"Macrotermycins A\u2013D, glycosylated macrolactams from a termite-associated Amycolatopsis sp. M39","volume":"19","author":"Beemelmanns","year":"2017","journal-title":"Org. Lett."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1080\/10286020.2017.1285909","article-title":"Abscisic acid-type sesquiterpenes and ansamycins from Amycolatopsis alba DSM 44262","volume":"19","author":"Li","year":"2017","journal-title":"J. Asian Nat. Prod. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/ja.2007.70","article-title":"Isolation and structure elucidation of thiazomycin\u2014A potent thiazolyl peptide antibiotic from Amycolatopsis fastidiosa","volume":"60","author":"Jayasuriya","year":"2007","journal-title":"J. Antibiot."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"8818","DOI":"10.1016\/j.bmc.2008.08.079","article-title":"Isolation, structure, and antibacterial activity of thiazomycin A, a potent thiazolyl peptide antibiotic from Amycolatopsis fastidiosa","volume":"16","author":"Zhang","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/ja.2007.71","article-title":"Antibacterial evaluations of thiazomycin-A potent thiazolyl peptide antibiotic from Amycolatopsis fastidiosa","volume":"60","author":"Singh","year":"2007","journal-title":"J. Antibiot."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1021\/np800783b","article-title":"Thiazomycins, thiazolyl peptide antibiotics from Amycolatopsis fastidiosa","volume":"72","author":"Zhang","year":"2009","journal-title":"J. Nat. Prod."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3014","DOI":"10.1021\/acs.orglett.0c00776","article-title":"Thioamycolamides A\u2013E, sulfur-containing cycliclipopeptides produced by the rare Actinomycete Amycolatopsis sp.","volume":"22","author":"Pan","year":"2020","journal-title":"Org. Lett."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/ja.2008.54","article-title":"Pargamicin a, a novel cyclic peptide antibiotic from Amycolatopsis sp.","volume":"61","author":"Igarashi","year":"2008","journal-title":"J. Antibiot."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/ja.2017.34","article-title":"Structure and antibacterial activities of new cyclic peptide antibiotics, pargamicins B, C and D, from Amycolatopsis sp. ML1-hF4","volume":"70","author":"Hashizume","year":"2017","journal-title":"J. Antibiot."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Hashizume, H., Iijima, K., Yamashita, K., Kimura, T., Wada, S.I., Sawa, R., and Igarashi, M. (2017). Valgamicin C, a novel cyclic depsipeptide containing the unusual amino acid cleonine, and related valgamicins A, T and V produced by Amycolatopsis sp. ML1-hF4. J. Antibiot.","DOI":"10.1038\/ja.2017.135"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.7164\/antibiotics.41.1506","article-title":"New glycopeptide antibiotics. 2. The isolation and structures of chloroorienticins","volume":"41","author":"Tsuji","year":"1988","journal-title":"J. Antibiot."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"931","DOI":"10.7164\/antibiotics.43.931","article-title":"MM 47761 and MM 49721, glycopeptide antibiotics produced by a new strain of Amycolatopsis-orientalis-Isolation, purification and structure determination","volume":"43","author":"Box","year":"1990","journal-title":"J. Antibiot."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1134\/S1068162009040128","article-title":"The structure of antibiotic eremomycin B","volume":"35","author":"Berdnikova","year":"2009","journal-title":"Russ. J. Bioorg. Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s10534-015-9842-z","article-title":"Isolation and structure determination of new siderophore albachelin from Amycolatopsis alba","volume":"28","author":"Kodani","year":"2015","journal-title":"Biometals"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Wu, Q.H., Deering, R.W., Zhang, G.Y., Wang, B.X., Li, X., Sun, J.D., Chen, J.W., Zhang, H.W., Rowley, D.C., and Wang, H. (2018). Albisporachelin, a new hydroxamate type siderophore from the deep ocean sediment-derived Actinomycete Amycolatopsis albispora WP1(T). Mar. Drugs, 16.","DOI":"10.3390\/md16060199"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/ja.2007.88","article-title":"A-102395, a new inhibitor of bacterial translocase I, produced by Amycolatopsis sp. SANK 60206","volume":"60","author":"Murakami","year":"2007","journal-title":"J. Antibiot."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"3514","DOI":"10.1080\/14786419.2019.1574783","article-title":"Carbamothioic S-acid derivative and kigamicins, the activated production of silent metabolites in Amycolatopsis alba DSM 44262 Delta abm9 elicited by N-acetyl-D-glucosamine","volume":"34","author":"Li","year":"2019","journal-title":"Nat. Prod. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s12223-018-0642-z","article-title":"Echinosporin antibiotics isolated from Amycolatopsis strain and their antifungal activity against root-rot pathogens of the Panax notoginseng","volume":"64","author":"Xu","year":"2019","journal-title":"Folia. Microbiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/s41429-018-0028-0","article-title":"Dipyrimicin A and B, microbial compounds isolated from Amycolatopsis sp. K16-0194","volume":"71","author":"Izuta","year":"2018","journal-title":"J. Antibiot."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.micres.2011.12.003","article-title":"Novel Pyridinium compound from marine actinomycete, Amycolatopsis alba var. nov. DVR D4 showing antimicrobial and cytotoxic activities in vitro","volume":"167","author":"Dasari","year":"2012","journal-title":"Microbiol. Res."},{"key":"ref_50","first-page":"69","article-title":"Siderochelins with anti-mycobacterial activity from Amycolatopsis sp. LZ149","volume":"13","author":"Lu","year":"2015","journal-title":"Chin. J. Nat. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"900","DOI":"10.7164\/antibiotics.50.900","article-title":"Epoxyquinomicins A, B, C and D, new antibiotics from Amycolatopsis. 1. Taxonomy, fermentation, isolation and antimicrobial activities","volume":"50","author":"Matsumoto","year":"1997","journal-title":"J. Antibiot."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.3891\/acta.chem.scand.52-1239","article-title":"Tigloside: A new tigloylated tetrasaccharide from Amycolatopsis sp.","volume":"52","author":"Breinholt","year":"1998","journal-title":"Acta Chem. Scand."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/cbdv.201200224","article-title":"Actinotetraoses I\u2013K: Tetrasaccharide metabolites produced by an insect-derived Actinobacteria, Amycolatopsis sp. HCa1","volume":"10","author":"Guo","year":"2013","journal-title":"Chem. Biodivers."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1080\/10286020.2015.1052413","article-title":"Actinotetraose L, a new tetrasaccharide derivative isolated from the mycelia of Amycolatopsis sp. HCa1","volume":"17","author":"Guo","year":"2015","journal-title":"J. Asian. Nat. Prod. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"6208","DOI":"10.1021\/acs.orglett.7b03113","article-title":"Amycolamycins A and B, two enediyne-derived compounds from a locust-associated Actinomycete","volume":"19","author":"Ma","year":"2017","journal-title":"Org. Lett."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"227","DOI":"10.3109\/07388551.2010.513677","article-title":"Extraction and analysis of polyphenols: Recent trends","volume":"31","author":"Ajila","year":"2011","journal-title":"Crit. Rev. Biotechnol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"S249","DOI":"10.1016\/j.jaci.2007.12.985","article-title":"Using phenolic compounds to reduce the allergenic properties of peanut extracts and peanut butter slurries","volume":"121","author":"Chung","year":"2008","journal-title":"J. Allergy. Clin. Immunol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1111\/j.1349-7006.2004.tb03247.x","article-title":"Kigamicin D, a novel anticancer agent based on a new anti-austerity strategy targeting cancer cells\u2019 tolerance to nutrient starvation","volume":"95","author":"Lu","year":"2004","journal-title":"Cancer. Sci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.bcp.2019.06.016","article-title":"Pradimicin-IRD exhibits antineoplastic effects by inducing DNA damage in colon cancer cells","volume":"168","author":"Bauermeister","year":"2019","journal-title":"Biochem. Pharmacol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.bcp.2005.10.012","article-title":"Natural products-The future scaffolds for novel antibiotics?","volume":"71","author":"Butler","year":"2006","journal-title":"Biochem. Pharmacol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1021\/acschembio.7b00733","article-title":"Mode of action and heterologous expression of the natural product antibiotic vancoresmycin","volume":"13","author":"Kepplinger","year":"2018","journal-title":"ACS Chem. Biol."},{"key":"ref_62","first-page":"506","article-title":"Comparative clinical laboratory studies of penicillin V and penicillin G","volume":"3","author":"Griffith","year":"1955","journal-title":"Antibiot. Annu."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.2174\/1568026617666170224121658","article-title":"Recent advances in ynthesis and identification of cyclic peptides for bioapplications","volume":"17","author":"Ong","year":"2017","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"10608","DOI":"10.1002\/chem.201403117","article-title":"Peptides come round: Using SICLOPPS Libraries for early stage drug discovery","volume":"20","author":"Lennard","year":"2014","journal-title":"Chem. Eur. J."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/ja.2010.29","article-title":"Biological activities of pargamicin A, a novel cyclic peptide antibiotic from Amycolatopsis sp.","volume":"63","author":"Hashizume","year":"2010","journal-title":"J. Antibiot."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.3389\/fmicb.2020.01173","article-title":"Glycopeptide antibiotic resistance genes: Distribution and function in the producer Actinomycetes","volume":"11","author":"Yushchuk","year":"2020","journal-title":"Front. Microbiol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"906","DOI":"10.7164\/antibiotics.50.906","article-title":"Epoxyquinomicins A, B, C and D, new antibiotics from Amycolatopsis. 2. Effect on type II collagen-induced arthritis in mice","volume":"50","author":"Matsumoto","year":"1997","journal-title":"J. Antibiot."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1007\/s11274-014-1622-3","article-title":"Current biotechnological applications of the genus Amycolatopsis","volume":"30","author":"Costa","year":"2014","journal-title":"World J. Microbiol. Biotechnol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1007\/s00253-011-3867-1","article-title":"Degradation of the novel herbicide ZJ0273 by Amycolatopsis sp. M3-1 isolated from soil","volume":"96","author":"Cai","year":"2012","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1002\/etc.3339","article-title":"Pharmaceuticals in the environment-global occurrences and perspectives","volume":"35","author":"Weber","year":"2016","journal-title":"Environ. Toxicol. Chem."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Alanis-Sanchez, B.M., Perez-Tapia, S.M., Vazquez-Leyva, S., Mejia-Calvo, I., Macias-Palacios, Z., Vallejo-Castillo, L., Flores-Ortiz, C.M., Guerrero-Barajas, C., Cruz-Maya, J.A., and Jan-Roblero, J. (2019). Utilization of naproxen by Amycolatopsis sp. Poz 14 and detection of the enzymes involved in the degradation metabolic pathway. World J. Microbiol. Biotechnol., 35.","DOI":"10.1007\/s11274-019-2764-0"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3389\/fmicb.2019.02834","article-title":"Actinobacteria as promising candidate for polylactic acid type bioplastic degradation","volume":"10","author":"Butbunchu","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.csbj.2021.01.019","article-title":"An extracellular lipase from Amycolatopsis mediterannei is a cutinase with plastic degrading activity","volume":"19","author":"Tan","year":"2021","journal-title":"Comput. Struct. Biotec."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"4951","DOI":"10.1039\/C5GC01165E","article-title":"Towards lignin consolidated bioprocessing: Simultaneous lignin depolymerization and product generation by bacteria","volume":"17","author":"Salvachua","year":"2015","journal-title":"Green Chem."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1128\/AEM.02358-12","article-title":"Investigation of the Amycolatopsis sp. Strain ATCC 39116 vanillin dehydrogenase and its impact on the biotechnical production of vanillin","volume":"79","author":"Fleige","year":"2013","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/bab.1247","article-title":"Characterization of a novel cytochrome P450 from Amycolatopsis sp. CGMCC1149 for hydroxylation of lovastatin","volume":"62","author":"Zong","year":"2015","journal-title":"Biotechnol. Appl. Biochem."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s00253-012-4341-4","article-title":"Advances in the bioconversion mechanism of lovastatin to wuxistatin by Amycolatopsis sp. CGMCC 1149","volume":"97","author":"Zong","year":"2013","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/jobm.200700360","article-title":"Copper bioaccumulation by the actinobacterium Amycolatopsis sp. ABO","volume":"48","author":"Albarracin","year":"2008","journal-title":"J. Basic Microbiol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1099\/ijs.0.010587-0","article-title":"Amycolatopsis tucumanensis sp. nov., a copper-resistant actinobacterium isolated from polluted sediments","volume":"60","author":"Albarracin","year":"2010","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ibiod.2011.12.001","article-title":"Indigenous microorganisms as potential bioremediators for environments contaminated with heavy metals","volume":"69","author":"Colin","year":"2012","journal-title":"Int. Biodeter. Biodegr."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.jhazmat.2013.08.005","article-title":"Production of bioemulsifiers by Amycolatopsis tucumanensis DSM 45259 and their potential application in remediation technologies for soils contaminated with hexavalent chromium","volume":"261","author":"Colin","year":"2013","journal-title":"J. Hazard. Mater."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"761834","DOI":"10.1155\/2015\/761834","article-title":"Resistance to and accumulation of heavy metals by actinobacteria isolated from abandoned mining areas","volume":"2015","author":"Baz","year":"2015","journal-title":"Sci. World J."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1002\/tcr.201700015","article-title":"Elucidation of biosynthetic pathways of natural products","volume":"17","author":"Kishimoto","year":"2017","journal-title":"Chem. Rec."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"13710","DOI":"10.1074\/jbc.M115.646414","article-title":"The biosynthesis of capuramycin-type antibiotics identification of the A-102395 biosynthetic gene cluster, mechanism of self-resistance, and formation of uridine-5\u2032-carboxamide","volume":"290","author":"Cai","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0960-894X(00)00114-1","article-title":"Synthesis of NF-\u03ba\u03b2 activation inhibitors derived from epoxyquinomicin C","volume":"10","author":"Matsumoto","year":"2000","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"21142","DOI":"10.1074\/jbc.M114.572636","article-title":"Modification of rifamycin polyketide backbone leads to improved drug activity against rifampicin-resistant Mycobacterium tuberculosis","volume":"289","author":"Nigam","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Singhvi, N., Singh, P., Prakash, O., Gupta, V., Lal, S., Bechthold, A., Singh, Y., Singh, R.K., and Lal, R. (2021). Differential mass spectrometry-based proteome analyses unveil major regulatory hubs in rifamycin B production in Amycolatopsis mediterranei. J. Proteom., 104168.","DOI":"10.1016\/j.jprot.2021.104168"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"3937","DOI":"10.1002\/anie.201411028","article-title":"Construction of a new class of tetracycline lead structures with potent antibacterial activity through biosynthetic engineering","volume":"54","author":"Lesnik","year":"2015","journal-title":"Angew. Chem. Int. Edit."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1099\/mic.0.070995-0","article-title":"Identification of the chelocardin biosynthetic gene cluster from Amycolatopsis sulphurea: A platform for producing novel tetracycline antibiotics","volume":"159","author":"Lukezic","year":"2013","journal-title":"Microbiology"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"W81","DOI":"10.1093\/nar\/gkz310","article-title":"antiSMASH 5.0: Updates to the secondary metabolite genome mining pipeline","volume":"47","author":"Blin","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"W49","DOI":"10.1093\/nar\/gkx320","article-title":"PRISM 3: Expanded prediction of natural product chemical structures from microbial genomes","volume":"45","author":"Skinnider","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Bergeijk, D.A.V., Terlouw, B.R., Medema, M.H., and Wezel, G.P.V. (2020). Ecology and genomics of Actinobacteria: New concepts for natural product discovery. Nat. Rev. Microbiol., 546\u2013558.","DOI":"10.1038\/s41579-020-0379-y"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1021\/acs.joc.0c02660","article-title":"Amycolapeptins A and B, cyclic nonadepsipeptides produced by combined-culture of Amycolatopsis sp. and Tsukamurella pulmonis","volume":"86","author":"Pan","year":"2021","journal-title":"J. Org. Chem."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/26\/7\/1884\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T13:25:15Z","timestamp":1760361915000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/26\/7\/1884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,26]]},"references-count":93,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2021,4]]}},"alternative-id":["molecules26071884"],"URL":"https:\/\/doi.org\/10.3390\/molecules26071884","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,26]]}}}