{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:00:36Z","timestamp":1791320436177,"version":"4.3.1"},"reference-count":43,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T00:00:00Z","timestamp":1617667200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CNPq  Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","award":["437298\/2018-3"],"award-info":[{"award-number":["437298\/2018-3"]}]},{"name":"FAPEMIG FUNDA\u00c7\u00c3O DE AMPARO \u00c0 PESQUISA DO ESTADO DE MINAS GERAIS","award":["APQ-01668-18"],"award-info":[{"award-number":["APQ-01668-18"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>This paper reports on the synthesis and characterization of two new polypyridyl-hydrazone Schiff bases, (E)-N\u2032-(6-oxo-1,10-phenanthrolin-5(6H)-ylidene)thiophene-2-carbohydrazide (L1) and (E)-N\u2032-(6-oxo-1,10-phenanthrolin-5(6H)-ylidene)furan-2-carbohydrazide (L2), and their two Ru(II) complexes of the general formula [RuCl(DMSO)(phen)(Ln)](PF6). Considering that hydrazides are a structural part of severa l drugs and metal complexes containing phenanthroline derivatives are known to interact with DNA and to exhibit antitumor activity, more potent anticancer agents can be obtained by covalently linking the thiophene acid hydrazide or the furoic acid hydrazide to a 1,10-phenanthroline moiety. These ligands and the Ru(II) complexes were characterized by elemental analyses, electronic, vibrational, 1H NMR, and ESI-MS spectroscopies. Ru is bound to two different N-heterocyclic ligands. One chloride and one S-bonded DMSO in cis-configuration to each other complete the octahedral coordination sphere around the metal ion. The ligands are very effective in inhibiting cellular growth in a chronic myelogenous leukemia cell line, K562. Both complexes are able to interact with DNA and present moderate cytotoxic activity, but 5 min of UV-light exposure increases cytotoxicity by three times.<\/jats:p>","DOI":"10.3390\/molecules26072084","type":"journal-article","created":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T03:58:31Z","timestamp":1617681511000},"page":"2084","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Photocytotoxic Activity of Ruthenium(II) Complexes with Phenanthroline-Hydrazone Ligands"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9983-3840","authenticated-orcid":false,"given":"Priscila Pereira","family":"Silva-Caldeira","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica, Centro Federal de Educa\u00e7\u00e3o Tecnol\u00f3gica de Minas Gerais, Avenida Amazonas, 5253, Belo Horizontre (MG) 30421-169, Brazil"},{"name":"Departamento de Qu\u00edmica, Universidade Federal de Minas Gerais, Avenida Ant\u00f4nio Carlos, 6627, Belo Horizonte (MG) 31270-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f4nio Carlos Almendagna de","family":"Oliveira Junior","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Universidade Federal de Minas Gerais, Avenida Ant\u00f4nio Carlos, 6627, Belo Horizonte (MG) 31270-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2699-6232","authenticated-orcid":false,"given":"Elene Cristina","family":"Pereira-Maia","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Universidade Federal de Minas Gerais, Avenida Ant\u00f4nio Carlos, 6627, Belo Horizonte (MG) 31270-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.bbagen.2018.11.005","article-title":"Mechanisms underlying acquired platinum resistance in high grade serous ovarian cancer: A mini review","volume":"1863","author":"Binju","year":"2019","journal-title":"Biochim. 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