{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:35:44Z","timestamp":1791506144610,"version":"4.3.4"},"reference-count":37,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T00:00:00Z","timestamp":1617753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Korea Institute for Advancement of Technology (KIAT)","award":["P0002162"],"award-info":[{"award-number":["P0002162"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Hair loss by excessive stress from work and lifestyle changes has become a growing concern, particularly among young individuals. However, most drugs for alopecia impose a plethora of side effects. We have found the powerful impact of Malva verticillata seed extracts on alleviating hair loss. This study further isolated effective chemicals in M. verticillata seed extracts by liquid silica gel column chromatography. Under the screening for the growth rate (%) of human follicles dermal papilla cells (HFDPCs), we identified linoleic acid (LA) and oleic acid in n-hexane of M. verticillate (MH)2 fraction. LA treatment activated Wnt\/\u03b2-catenin signaling and induced HFDPCs growth by increasing the expression of cell cycle proteins such as cyclin D1 and cyclin-dependent kinase 2. LA treatment also increased several growth factors, such as vascular endothelial growth factor, insulin-like growth factor-1, hepatocyte growth factor, and keratinocyte growth factor, in a dose-dependent manner. Besides, LA significantly inhibited Dickkopf-related protein expression (DKK-1), a primary alopecia signaling by dihydrotestosterone. Our findings suggest that LA treatment may alleviate a testosterone-induced signaling molecule and induces HFDPCs growth by activating Wnt\/\u03b2-catenin signaling.<\/jats:p>","DOI":"10.3390\/molecules26082117","type":"journal-article","created":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T11:31:59Z","timestamp":1617795119000},"page":"2117","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Activation of Hair Cell Growth Factors by Linoleic Acid in Malva verticillata Seed"],"prefix":"10.3390","volume":"26","author":[{"given":"Hwa Sun","family":"Ryu","sequence":"first","affiliation":[{"name":"Bio Convergence R&amp;D Center, CoSeedBioPharm Corporation, Heungdeok-gu, Cheongju, Chungbuk 28161, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JiYeon","family":"Jeong","sequence":"additional","affiliation":[{"name":"Bio Convergence R&amp;D Center, CoSeedBioPharm Corporation, Heungdeok-gu, Cheongju, Chungbuk 28161, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun Mong","family":"Lee","sequence":"additional","affiliation":[{"name":"Future Science Research Center, Coreana Cosmetics Corporation, Cheonan, Chungnam 31041, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang Sik","family":"Lee","sequence":"additional","affiliation":[{"name":"Future Science Research Center, Coreana Cosmetics Corporation, Cheonan, Chungnam 31041, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-No","family":"Lee","sequence":"additional","affiliation":[{"name":"Bio Convergence R&amp;D Center, CoSeedBioPharm Corporation, Heungdeok-gu, Cheongju, Chungbuk 28161, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Min","family":"Park","sequence":"additional","affiliation":[{"name":"Bio Convergence R&amp;D Center, CoSeedBioPharm Corporation, Heungdeok-gu, Cheongju, Chungbuk 28161, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1551-9206","authenticated-orcid":false,"given":"Yong-Moon","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk 28644, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Son, K.H., Suh, B.S., Jeong, H.S., Nam, M.W., Kim, H., and Kim, H.C. 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