{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:14:54Z","timestamp":1791976494481,"version":"4.4.0"},"reference-count":133,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,4,24]],"date-time":"2021-04-24T00:00:00Z","timestamp":1619222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Yung Sheng Optical Co., Ltd.","award":["108598"],"award-info":[{"award-number":["108598"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Hyaluronic acid (HA) is a glycosaminoglycan that was first isolated and identified from the vitreous body of a bull\u2019s eye. HA is ubiquitous in the soft connective tissues of animals and therefore has high tissue compatibility for use in medication. Because of HA\u2019s biological safety and water retention properties, it has many ophthalmology-related applications, such as in intravitreal injection, dry eye treatment, and contact lenses. Due to its broad range of applications, the identification and quantification of HA is a critical topic. This review article discusses current methods for analyzing HA. Contact lenses have become a widely used medical device, with HA commonly used as an additive to their production material, surface coating, and multipurpose solution. HA molecules on contact lenses retain moisture and increase the wearer\u2019s comfort. HA absorbed by contact lenses can also gradually release to the anterior segment of the eyes to treat dry eye. This review discusses applications of HA in ophthalmology.<\/jats:p>","DOI":"10.3390\/molecules26092485","type":"journal-article","created":{"date-parts":[[2021,4,24]],"date-time":"2021-04-24T21:49:20Z","timestamp":1619300960000},"page":"2485","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":113,"title":["Applications of Hyaluronic Acid in Ophthalmology and Contact Lenses"],"prefix":"10.3390","volume":"26","author":[{"given":"Wan-Hsin","family":"Chang","sequence":"first","affiliation":[{"name":"Research and Development Center, Yung Sheng Optical Company, Daya District, Taichung 42881, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"Research and Development Center, Yung Sheng Optical Company, Daya District, Taichung 42881, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Hsuan","family":"Lin","sequence":"additional","affiliation":[{"name":"Research and Development Center, Yung Sheng Optical Company, Daya District, Taichung 42881, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Ju","family":"Lu","sequence":"additional","affiliation":[{"name":"Research and Development Center, Yung Sheng Optical Company, Daya District, Taichung 42881, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsuan-Yi","family":"Chou","sequence":"additional","affiliation":[{"name":"Research and Development Center, Yung Sheng Optical Company, Daya District, Taichung 42881, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Yu","family":"Nian","sequence":"additional","affiliation":[{"name":"Research and Development Center, Yung Sheng Optical Company, Daya District, Taichung 42881, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Ting","family":"Jiang","sequence":"additional","affiliation":[{"name":"Research and Development Center, Yung Sheng Optical Company, Daya District, Taichung 42881, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3423-2892","authenticated-orcid":false,"given":"Yuan-Hao Howard","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Tunghai University, Xitun District, Taichung 40704, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/srt.12228","article-title":"Human skin penetration of hyaluronic acid of different molecular weights as probed by Raman spectroscopy","volume":"22","author":"Essendoubi","year":"2016","journal-title":"Skin Res. 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