{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T12:32:50Z","timestamp":1780403570887,"version":"3.54.1"},"reference-count":58,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T00:00:00Z","timestamp":1619481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of South Florida","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"name":"Shirley W. and William L. 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Herein, the methods for the chemical synthesis and subsequent characterization of specific members of the fatty acid amide family are described. The synthetically prepared fatty acid amides and those obtained commercially are used as standards for the characterization and quantification of the fatty acid amides produced by biological systems, a fatty acid amidome. The fatty acid amidomes from mouse N18TG2 cells, sheep choroid plexus cells, Drosophila melanogaster, Bombyx mori, Apis mellifera, and Tribolium castaneum are presented.<\/jats:p>","DOI":"10.3390\/molecules26092543","type":"journal-article","created":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T06:19:11Z","timestamp":1619504351000},"page":"2543","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Synthesis, Quantification, and Characterization of Fatty Acid Amides from In Vitro and In Vivo Sources"],"prefix":"10.3390","volume":"26","author":[{"given":"Ruidong","family":"Ni","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of South Florida, 4202 E. 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Omega-3 Fatty Acids in Brain and Neurological Health, Academic Press."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.tips.2015.02.008","article-title":"Endocannabinoid Signaling at the Periphery: 50 Years after THC","volume":"36","author":"Maccarrone","year":"2015","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.plipres.2016.02.002","article-title":"Endocannabinoids and Endocannabinoid-Related Mediators: Targets, Metabolism and Role in Neurological Disorders","volume":"62","author":"Iannotti","year":"2016","journal-title":"Prog. Lipid Res."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Battista, N., Bari, M., and Bisogno, T. (2019). N-Acyl Amino Acids: Metabolism, Molecular Targets, and Role in Biological Processes. Biomolecules, 9.","DOI":"10.3390\/biom9120822"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1002\/pen.21963","article-title":"Control of the Migration Behavior of Slip Agents in Polyolefin-Based Films","volume":"52","author":"Llop","year":"2011","journal-title":"Polym. Eng. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1042\/bst0030591","article-title":"A Note on the Life of J.L.W. Thudichum (1829\u20131901)","volume":"3","author":"Hawthorne","year":"1975","journal-title":"Biochem. Soc. Trans."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"5577","DOI":"10.1021\/ja01577a066","article-title":"The Identification of N-(2-Hydroxyethyl)-Palmitamide as a Naturally Occurring Anti-Inflammatory Agent","volume":"79","author":"Kuehl","year":"1957","journal-title":"J. Am. Chem. Soc."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1016\/0024-3205(89)90278-6","article-title":"Identification of Fatty Acid Amides in Human Plasma","volume":"45","author":"Arafat","year":"1989","journal-title":"Life Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1126\/science.1470919","article-title":"Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor","volume":"258","author":"Devane","year":"1992","journal-title":"Science"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1126\/science.276.5314.945","article-title":"An Elicitor of Plant Volatiles from Beet Armyworm Oral Secretion","volume":"276","author":"Alborn","year":"1997","journal-title":"Science"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1126\/science.7770779","article-title":"Chemical Characterization of a Family of Brain Lipids that Induce Sleep","volume":"268","author":"Cravatt","year":"1995","journal-title":"Science"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1006\/abbi.1996.0272","article-title":"Fatty Acid Amide Biosynthesis: A Possible New Role for Peptidylglycine \u03b1-Amidating Enzyme and Acyl-CoA:Glycine N-Acyltransferase","volume":"330","author":"Merkler","year":"1996","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1194\/jlr.M018606","article-title":"Primary Fatty Acid Amide Metabolism: Conversion of Fatty Acids and an Ethanolamine in N18TG2 and SCP Cells","volume":"53","author":"Farrell","year":"2012","journal-title":"J. Lipid Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1194\/jlr.M062042","article-title":"Glycine N-Acyltransferase-like 3 is Responsible for Long-chain N-Acylglycine Formation in N18TG2 Cells","volume":"57","author":"Jeffries","year":"2016","journal-title":"J. Lipid Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.febslet.2013.12.027","article-title":"Identification of an Arylalkylamine N-Acyltransferase from Drosophila melanogaster that Catalyzes the Formation of Long-chain N-Acylserotonins","volume":"588","author":"Dempsey","year":"2014","journal-title":"FEBS Lett."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1016\/j.febslet.2014.02.051","article-title":"Drosophila melanogaster as a Model System to Study Long-chain Fatty Acid Amide Metabolism","volume":"588","author":"Jeffries","year":"2014","journal-title":"FEBS Lett."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.plefa.2018.06.001","article-title":"Bm-iAANAT and Its Potential Role in Fatty Acid Amide Biosynthesis in Bombyx mori","volume":"135","author":"Anderson","year":"2018","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Wood, P.L. (2021). Characterization and Quantification of the Fatty Acid Amidome. Metabolomics, Humana Press.","DOI":"10.1007\/978-1-0716-0864-7"},{"key":"ref_21","unstructured":"Mitchell, P.R. (2015). The Detection and Quantitative Analysis of Endocannabinoids and Endogenous Fatty Acid Amides in Apis mellifera and Tribolium castneum. [Master\u2019s Thesis, University of South Florida]."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1039\/C0OB00355G","article-title":"Alkyl Sulfonyl Derivatized PAMAM-G2 Dendrimers as Nonviral Gene Delivery Vectors with Improved Transfection Efficiencies","volume":"9","year":"2011","journal-title":"Org. Biomol. Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"41686","DOI":"10.1039\/C7RA07244A","article-title":"Thixotropic Stiff Hydrogels from a New Class of Oleoyl-D-Glutamine-Based Low-Molecular-Weight Gelators","volume":"7","author":"Ohsedo","year":"2017","journal-title":"RSC Adv."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Ji, Y.-F., Yan, H., and Jiang, Q.-B. (2015). Effective Nitration of Anilides and Acrylamides by tert-Butyl Nitrite. Eur. J. Org. Chem., 2051\u20132060.","DOI":"10.1002\/ejoc.201403510"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1006\/bbrc.1997.7431","article-title":"The Sleep Inducing Factor Oleamide is Produced by Mouse Neuroblastoma Cells","volume":"239","author":"Bisogno","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1042\/bj3160977","article-title":"Biosynthesis of Anandamide and Related Acylethanolamides in Mouse J774 Macrophages and N18 Neuroblastoma Cells","volume":"316","author":"Sepe","year":"1996","journal-title":"Biochem. J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1006\/bbrc.1999.1977","article-title":"Induction of Peptidylglycine \u03b1-Amidating Monooxygenase in N18TG2 Cells: A Model for Studying Oleamide Biosynthesis","volume":"267","author":"Driscoll","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"12667","DOI":"10.1021\/bi049529p","article-title":"Oleic Acid Derived Metabolites on Mouse Neuroblastoma N18TG2 Cells","volume":"43","author":"Merkler","year":"2004","journal-title":"Biochemistry"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nrn3921","article-title":"Development and Functions of the Choroid Plexus-Cerebrospinal Fluid System","volume":"16","author":"Lun","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/0006-8993(93)91091-6","article-title":"Expression of Neuropeptide Processing Enzymes and Neurosecretory Proteins in Ependyma and Choroid Plexus Epithelium","volume":"617","author":"Gee","year":"1993","journal-title":"Brain Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"229","DOI":"10.2169\/internalmedicine.34.229","article-title":"Increased Peptidylglycine \u03b1-Amidating Monooxygease Activity in Cerebrospinal Fluid of Patients with Multiple Schlerosis","volume":"34","author":"Tsukamoto","year":"1995","journal-title":"Intern. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0306-4522(89)90361-8","article-title":"Changes in Lipid Composition of Neuroblastoma C1300 N18 Cell During Differentiation","volume":"30","author":"Gulaya","year":"1989","journal-title":"Neuroscience"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.aca.2018.06.016","article-title":"Recent Advances in LC-MS\/MS Methods to Determine Endocannabinoids in Biological Samples: Application in Neurodegenerative Diseases","volume":"1044","author":"Marchioni","year":"2018","journal-title":"Anal. Chim. Acta"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0083-6729(09)81008-X","article-title":"Novel Endogenous N-Acyl Glycines: Identification and Characterization","volume":"81","author":"Bradshaw","year":"2009","journal-title":"Vitam. Horm."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.prostaglandins.2009.04.006","article-title":"Orphan Endogenous Lipids and Orphan GPCRs: A Good Match","volume":"89","author":"Bradshaw","year":"2009","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3389\/fmolb.2018.00066","article-title":"Insect Arylalkylamine N-Acyltransferases: Mechanism and Role in Fatty Acid Amide Biosynthesis","volume":"5","author":"Suarez","year":"2018","journal-title":"Front. Mol. Biosci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/cne.1078","article-title":"Cannabinoid Receptors are Absent in Insects","volume":"436","author":"McParland","year":"2001","journal-title":"J. Comp. Neurol."},{"key":"ref_38","unstructured":"Suarez, G., and Merkler, D.J. (2021). University of South Florida, Tampa, FL, USA, Unpublished work."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Tortoriello, G., Rhodes, B.P., Takacs, S.M., Stuart, J.M., Basnet, A., Raboune, S., Widlanski, T.S., Doherty, P., Harkany, T., and Bradshaw, H.B. (2013). Target Lipidomic in Drosophila melanogaster Identified Novel 2-Monoacylglycerols and N-Acyl Amides. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0067865"},{"key":"ref_40","first-page":"1","article-title":"Silkworm: A Promising Model Organism in Life Science","volume":"17","author":"Meng","year":"2017","journal-title":"J. Insect Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"101576","DOI":"10.1016\/j.jspr.2020.101576","article-title":"Response of Different Population Sizes to Traps and Effect of Spinosad on the Trap Catch and Progeny Adult Emergence in Tribolium castaneum (Herbst) (Coleoptera: Tenebrionidae)","volume":"86","author":"Dissanayaka","year":"2020","journal-title":"J. Stored Prod. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.biopsych.2015.07.028","article-title":"An Introduction to the Endogenous Cannabinoid System","volume":"79","author":"Lu","year":"2016","journal-title":"Biol. Psychiatry"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.neubiorev.2016.10.005","article-title":"Endocannabinoids and Sleep","volume":"71","year":"2016","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1016\/j.drudis.2014.06.007","article-title":"Harnessing the Anti-Inflammatory Potential of Palmitoylethanolamide","volume":"19","author":"Alhouayek","year":"2014","journal-title":"Drug Discov. Today"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1016\/j.cell.2015.05.045","article-title":"A Global Map of Lipid-Binding Proteins ant Their Ligandability in Cells","volume":"161","author":"Niphakis","year":"2015","journal-title":"Cell"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Merkler, D.J., and Leahy, J.W. (2018). Binding-Based Proteomic Profiling and the Fatty Acid Amides. Trends Res., 1.","DOI":"10.15761\/TR.1000120"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1042\/bj20040031","article-title":"Biosynthesis of Anandamide and N-Palmitoylethanolamine by Sequential Actions of Phospholipase A2 and Lysophospholipase D","volume":"380","author":"Sun","year":"2004","journal-title":"Biochem. J."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1016\/j.bbalip.2010.08.010","article-title":"Enzymological Studies on the Biosynthesis of N-Acylethanolamines","volume":"1801","author":"Ueda","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"166","DOI":"10.3389\/fnmol.2017.00166","article-title":"Metabolism of the Endocannabinoid Anandamide: Open Questions after 25 Years","volume":"10","author":"Maccarrone","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1096\/fj.09-148551","article-title":"Identification of Glycine N-Acyltransferase-like 2 (GLYATL2) as a Transferase that Produces N-Acyl Glycines in Humans","volume":"24","author":"Waluk","year":"2010","journal-title":"FASEB J."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.bmcl.2008.10.087","article-title":"Alcohol Dehydrogenase-Catalyzed In Vitro Oxidation of Anandamide to N-Arachidonoyl Glycine, a Lipid Mediator: Synthesis of N-Acyl Glycinals","volume":"19","author":"Aneetha","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.pep.2014.02.007","article-title":"Expression, Purification, and Characterization of Mouse Glycine N-Acyltransferase in Esherichia coli","volume":"97","author":"Dempsey","year":"2014","journal-title":"Protein Expr. Purif."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"5899","DOI":"10.1021\/cr2002799","article-title":"Endocannabinoid Oxygenation by Cyclooxygenases, Lipoxygenases, and Cytochromes P450: Cross-Talk between the Eicosanoid and Endocannabinoid Signaling Pathways","volume":"111","author":"Rouzer","year":"2011","journal-title":"Chem. Rev."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"444","DOI":"10.2174\/157017809789124885","article-title":"Selective Synthesis of Unsaturated N-Acylethanolamines by Lipase-Catalyzed N-Acylation of Ethanolamine with Unsaturated Fatty Acids","volume":"6","author":"Plastina","year":"2009","journal-title":"Lett. Org. Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1023\/B:BILE.0000036597.25673.33","article-title":"Chemo-Enzymatic Synthesis of N-Arachidonoyl Glycine","volume":"26","author":"Goujard","year":"2004","journal-title":"Biotechnol. Lett."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1021\/jm0209679","article-title":"Modifications of the Ethanolamine Head in N-Palmitoylethanolamine Synthesis and Evaluation of New Agents Interfering with the Metabolism of Anandamide","volume":"46","author":"Vandevoorde","year":"2003","journal-title":"J. Med. Chem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1016\/j.bmc.2010.12.046","article-title":"Evaluation of Endogenous Fatty Acid Amides with Their Synthetic Analogues as Potential Anti-inflammatory Leads","volume":"19","author":"Dang","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.chroma.2005.10.027","article-title":"Sample Preparation and Gas Chromatography of Primary Fatty Acid Amides","volume":"1101","author":"Sultana","year":"2006","journal-title":"J. Chromatogr. 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